Construction of a system that simultaneously evaluates CYP1A1 and CYP1A2 induction in a stable human-derived cell line using a dual reporter plasmid

Drug Metabolism and Pharmacokinetics

Volumn 25, Issue 2, 2010, Pages 180-189

  Sato, Wataru ^a   Suzuki, Hiroyuki ^a   Sasaki, Takamitsu ^a   Kumagai, Takeshi ^a   Sakaguchi, Shuhei ^a   Mizugaki, Michinao ^a   Miyairi, Shinichi ^b   Yamazoe, Yasushi ^c   Nagata, Kiyoshi ^a  

^a TOHOKU PHARMACEUTICAL UNIVERSITY   (Japan)

^b NIHON UNIVERSITY   (Japan)

^c TOHOKU UNIVERSITY   (Japan)

Author keywords

AhR; CYP1A1; CYP1A2; In vitro reporter assay; Stably cell line; XRE

Indexed keywords

ALKALINE PHOSPHATASE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; MESSENGER RNA;

ACCURACY; ANALYTIC METHOD; ARTICLE; CELL LINE; CHROMOSOME 15; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME RELEASE; GENE CONTROL; GENETIC TRANSCRIPTION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; PLASMID; PREDICTION; TRANSCRIPTION INITIATION;

EID: 77952647500     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.25.180     Document Type: Article

References (39)

1. Yang, S. K.: Stereoselectivity of cytochrome P-450 isozymes and epoxide hydrolase in the metabolism of polycyclic aromatic hydrocarbons. Biochem. Pharmacol., 37: 61-70 (1988).
2. Hankinson, O.: The aryl hydrocarbon receptor complex. Annu. Rev. Pharmacol. Toxicol., 35: 307-340 (1995).
3. Whitlock, J. P. Jr.: Induction of cytochrome P4501A1. Annu. Rev. Pharmacol. Toxicol., 39: 103-125 (1999).
4. Denison, M. S. and Whitlock, J. P. Jr.: Xenobiotic-inducible transcription of cytochrome P450 genes. J. Biol. Chem., 270: 18175-18178 (1995).
5. Cherng, S. H., Lin, P., Yang, J. L., Hsu, S. L. and Lee, H.: Benzo[g,h,i]perylene synergistically transactivates benzo[a]pyrene-i-nduced CYP1A1 gene expression by aryl hydrocarbon receptor pathway. Toxicol. Appl. Pharmacol., 170: 63-68 (2001).
6. Huang, S-M. and Stifano, T.: Guidance for industry: drug interaction studies-study design, data analysis, and implications for dosing and labeling, Draft Guidance, (2006). http://www.fda.gov/downloads/Drugs/Guidance-ComplianceRegulatoryInformation/Guidances/UCM072101.pdf
7. LeCluyse, E., Madan, A., Hamilton, G., Carroll, K., DeHaan, R. and Parkinson, A.: Expression and regulation of cytochrome P450 enzymes in primary cultures of human hepatocytes. J. Biochem. Mol. Toxicol., 14: 177-188 (2000).
8. Binda, D., Lasserre-Bigot, D., Bonet, A., Thomassin, M., Come, M. P., Guinchard, C., Bars, R., Jacqueson, A. and Richert, L.: Time course of cytochromes P450 decline during rat hepatocyte isolation and culture: effect of L-NAME. Toxicol. In Vitro., 17: 59-67 (2003).
9. Runge, D., Kohler, C., Kostrubsky, V. E., Jager, D., Lehmann, T., Runge, D. M., May, U., Stolz, D. B., Strom, S. C., Fleig, W. E. and Michalopoulos, G. K.: Induction of cytochrome P450 (CYP)1A1, CYP1A2, and CYP3A4 but not of CYP2C9, CYP2C19, multidrug resistance (MDR-1) and multidrug resistance associated protein (MRP-1) by prototypical inducers in human hepatocytes. Biochem. Biophys. Res. Commun., 273: 333-341 (2000).
10. Yueh, M. F., Kawahara, M. and Raucy, J.: Cell-based high-throughput bioassays to assess induction and inhibition of CYP1A enzymes. Toxicol. In Vitro, 19: 275-287 (2005).
11. Corchero, J., Pimprale, S., Kimura, S. and Gonzalez, F. J.: Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation. Pharmacogenetics, 11: 1-6 (2001).
12. Chao, H. R., Tsou, T. C., Li, L. A., Tsai, F. Y., Wang, Y. F., Tsai, C. H., Chang, E. E., Miao, Z. F., Wu, C. H. and Lee, W. J.: Arsenic inhibits induction of cytochrome P450 1A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin in human hepatoma cells. J. Hazard. Mater., 137: 716-722 (2006).
13. Long, M., Laier, P., Vinggaard, A. M., Andersen, H. R., Lynggaard, J. and Bonefeld-Jorgensen, E. C.: Effects of currently used pesticides in the AhR-CALUX assay: comparison between the human TV101L and the rat H4IIE cell line. Toxicology, 194: 77-93 (2003).
14. Ueda, R., Iketaki, H., Nagata, K., Kimura, S., Gonzalez, F. J., Kusano, K., Yoshimura, T. and Yamazoe, Y.: A common regulatory region functions bidirectionally in transcriptional activation of the human CYP1A1 and CYP1A2 genes. Mol. Pharmacol., 69: 1924-1930 (2006).
15. Hoessel, R., Leclerc, S., Endicott, J. A., Nobel, M. E., Lawrie, A., Tunnah, P., Leost, M., Damiens, E., Marie, D., Marko, D., Niederberger, E., Tang, W., Eisenbrand, G. and Meijer, L.: Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat. Cell Biol., 1: 60-67 (1999).
16. Piper, W. N., Rose, J. Q. and Gehring, P. J.: Excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Environ. Health Perspect., 5: 241-244 (1973).
17. Vinopal, J. H. and Casida, J. E.: Metabolic stability of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in mammalian liver microsomal systems and in living mice. Arch. Environ. Contam. Toxicol., 1: 122-132 (1973).
18. Rose, J. Q., Ramsey, J. C., Wentzler, T. H., Hummel, R. A. and Gehring, P. J.: The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat. Toxicol. Appl. Pharmacol., 36: 209-226 (1976).
19. Pirkle, J. L., Wolfe, W. H., Patterson, D. G., Needham, L. L., Michalek, J. E., Miner, J. C., Peterson, M. R. and Phillips, D. L.: Estimates of the half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Vietnam Veterans of Operation Ranch Hand. J. Toxicol. Environ. Health, 27: 165-171 (1989).
20. Aylward, L. L., Brunet, R. C., Carrier, G., Hays, S. M., Cushing, C. A., Needham, L. L., Patterson, D. G., Jr., Gerthoux, P. M., Brambilla, P. and Mocarelli, P.: Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort. J. Expo. Anal. Environ. Epidemiol., 15: 51-65 (2005).
21. Flesher, J. W., Horn, J. and Lehner, A. F.: Carcinogenicity of 1-hydroxy-3-methylcholanthrene and its electrophilic sulfate ester 1-sulfooxy-3-methylcholanthrene in Sprague-Dawley rats. Biochem. Biophys. Res. Commun., 243: 30-35 (1998).
22. Adachi, J., Mori, Y., Matsui, S. and Matsuda, T.: Comparison of gene expression patterns between 2,3,7,8-tetrachlorodibenzo-p-dioxin and a natural arylhydrocarbon receptor ligand, indirubin. Toxicol. Sci., 80: 161-169 (2004).
23. Daujat, M., Peryt, B., Lesca, P., Fourtanier, G., Domergue, J. and Maurel, P.: Omeprazole, an inducer of human CYP1A1 and 1A2, is not a ligand for the Ah receptor. Biochem. Biophys. Res. Commun., 188: 820-825 (1992).
24. Quattrochi, L.C., and Tukey, R.H.: Nuclear uptake of the Ah (dioxin) receptor in response to omeprazole: transcriptional activation of the human CYP1A1 gene. Mol. Pharmacol., 43: 504-508 (1993).
25. Lesca, P., Peryt, B., Larrieu, G., Alvinerie, M., Galtier, P., Daujat, M., Maurel, P. and Hoogenboom, L.: Evidence for the ligand-independent activation of the AH receptor. Biochem. Biophys. Res. Commun., 209: 474-482 (1995).
26. Daujat, M., Charrasse, S., Fabre, I., Lesca, P., Jounaidi, Y., Larroque C., Poellinger, L. and Maurel, P.: Induction of CYP1A1 gene by benzimidazole derivatives during Caco-2 cell differentiation. Evidence for an aryl-hydrocarbon receptor-mediated mechanism. Eur. J. Biochem., 237: 642-652 (1996).
27. Dzeletovic, N., McGuire, J., Daujat, M., Tholander, J., Ema, M., Fujii-Kuriyama, Y., Bergman, J., Maurel, P. and Poellinger, L.: Regulation of dioxin receptor function by omeprazole. J. Biol. Chem., 272: 12705-12713 (1997).
28. Knowles, B. B., Howe, C. C. and Aden, D. P.: Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen. Science, 209: 497-499 (1980).
29. LeCluyse, E. L.: Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation. Eur. J. Pharm. Sci., 13: 343-368 (2001).
30. Worboys, P. D. and Carlile, D.J.: Implications and consequences of enzyme induction on preclinical and clinical drug development. Xenobiotica, 31: 539-556 (2001).
31. Shimada, T., Inoue, K., Suzuki, Y., Kawai, T., Azuma, E., Nakajima, T., Shindo, M., Kurose, K., Sugie, A., Yamagishi, Y., Fujii-Kuriyama, Y. and Hashimoto, M.: Arylhydrocarbon receptordependent induction of liver and lung cytochromes P450 1A1, 1A2, and 1B1 by polycyclic aromatic hydrocarbons and polychlorinated biphenyls in genetically engineered C57BL/6J mice. Carcinogenesis, 23: 1199-1207 (2002).
32. Hill, S. J., Baker, J. G. and Rees, S.: Reporter-gene systems for the study of G-protein-coupled receptors. Curr. Opin. Pharmacol., 1: 526-532 (2001).
33. Postlind, H., Vu, T. P., Tukey, R. H. and Quattrochi, L. C.: Response of human CYP1-luciferase plasmids to 2,3,7,8-tetrachlorodibenzo-p-dioxin and polycyclic aromatic hydrocarbons. Toxicol. Appl. Pharmacol., 118: 255-262 (1993).
34. Allen, S. W., Mueller, L., Williams, S. N., Quattrochi, L. C. and Raucy, J.: The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human CYP1A1 expression. Drug Metab. Dispos., 29: 1074-1079 (2001).
35. Zhang, Z. Y., Pelletier, R. D., Wong, Y. N., Sugawara, M., Zhao, N. and Littlefield, B. A.: Preferential inducibility of CYP1A1 and CYP1A2 by TCDD: differential regulation in primary human hepatocytes versus transformed human cells. Biochem. Biophys. Res. Commun., 341: 399-407 (2006).
36. Westerink, W. M., Stevenson, J. C. and Schoonen, W. G.: Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch. Toxicol., 82: 909-921 (2008).
37. Skupinska, K., Misiewicz, I. and Kasprzycka-Guttman, T.: A comparison of the concentration-effect relationships of PAHs on CYP1A induction in HepG2 and Mcf7 cells. Arch. Toxicol., 81: 183-200 (2007).
38. Jones, J. M. and Anderson, J. W.: Relative potencies of PAHs and PCBs based on the response of human cells. Environ. Toxicol. Pharmcol., 7: 19-26 (1999)
39. Misaki, K., Matsui, S. and Matsuda, T.: Metabolic enzyme induction by HepG2 cells exposed to oxygenated and nonoxygenated polycyclic aromatic hydrocarbons. Chem. Res. Toxicol., 20: 277-283 (2007).