메뉴 건너뛰기




Volumn 22, Issue 4, 2011, Pages 130-135

27-Hydroxycholesterol: The first identified endogenous SERM

Author keywords

[No Author keywords available]

Indexed keywords

26 HYDROXYCHOLESTEROL; CHOLESTANETRIOL 26 MONOOXYGENASE; ESTRADIOL; ESTROGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXYSTEROL; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TRIACYLGLYCEROL;

EID: 79953160837     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tem.2011.01.003     Document Type: Review
Times cited : (95)

References (48)
  • 1
    • 0002366905 scopus 로고    scopus 로고
    • Selective estrogen receptor modulators (SERMs): a first step in the development of perfect hormone replacement therapy regimen
    • McDonnell D.P. Selective estrogen receptor modulators (SERMs): a first step in the development of perfect hormone replacement therapy regimen. J. Soc. Gynecol. Investig. 2000, 7:S10-S15.
    • (2000) J. Soc. Gynecol. Investig. , vol.7
    • McDonnell, D.P.1
  • 2
    • 4344632533 scopus 로고    scopus 로고
    • The molecular determinants of estrogen receptor pharmacology
    • McDonnell D.P. The molecular determinants of estrogen receptor pharmacology. Maturitas 2004, 48(Suppl. 1):S7-12.
    • (2004) Maturitas , vol.48 , Issue.SUPPL. 1
    • McDonnell, D.P.1
  • 3
    • 34948820661 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen
    • Umetani M., et al. 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen. Nat. Med. 2007, 13:1185-1192.
    • (2007) Nat. Med. , vol.13 , pp. 1185-1192
    • Umetani, M.1
  • 4
    • 66349134159 scopus 로고    scopus 로고
    • Fifty years of advances in bile acid synthesis and metabolism
    • Russell D.W. Fifty years of advances in bile acid synthesis and metabolism. J. Lipid. Res. 2009, 50(Suppl.):S120-S125.
    • (2009) J. Lipid. Res. , vol.50 , Issue.SUPPL.
    • Russell, D.W.1
  • 5
    • 67349262029 scopus 로고    scopus 로고
    • Interactions of oxysterols with membranes and proteins
    • Olkkonen V.M., Hynynen R. Interactions of oxysterols with membranes and proteins. Mol. Aspects Med. 2009, 30:123-133.
    • (2009) Mol. Aspects Med. , vol.30 , pp. 123-133
    • Olkkonen, V.M.1    Hynynen, R.2
  • 6
    • 0029805887 scopus 로고    scopus 로고
    • An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha
    • Janowski B.A., et al. An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature 1996, 383:728-731.
    • (1996) Nature , vol.383 , pp. 728-731
    • Janowski, B.A.1
  • 7
    • 66349136255 scopus 로고    scopus 로고
    • Are side-chain oxidized oxysterols regulators also in vivo?
    • Björkhem I. Are side-chain oxidized oxysterols regulators also in vivo?. J. Lipid Res. 2009, 50(Suppl):S213-S218.
    • (2009) J. Lipid Res. , vol.50 , Issue.SUPPL.
    • Björkhem, I.1
  • 8
    • 0034595445 scopus 로고    scopus 로고
    • Disruption of the oxysterol 7alpha-hydroxylase gene in mice
    • Li-Hawkins J., et al. Disruption of the oxysterol 7alpha-hydroxylase gene in mice. J. Biol. Chem. 2000, 275:16536-16542.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16536-16542
    • Li-Hawkins, J.1
  • 9
    • 0034672672 scopus 로고    scopus 로고
    • Oxysterol biosynthetic enzymes
    • Russell D.W. Oxysterol biosynthetic enzymes. Biochim. Biophys. Acta 2000, 1529:126-135.
    • (2000) Biochim. Biophys. Acta , vol.1529 , pp. 126-135
    • Russell, D.W.1
  • 10
    • 0032890337 scopus 로고    scopus 로고
    • Oxysterols and atherosclerosis
    • Brown A.J., Jessup W. Oxysterols and atherosclerosis. Atherosclerosis 1999, 142:1-28.
    • (1999) Atherosclerosis , vol.142 , pp. 1-28
    • Brown, A.J.1    Jessup, W.2
  • 11
    • 77952304021 scopus 로고    scopus 로고
    • Cerebrotendinous xanthomatosis: an inborn error in bile acid synthesis with defined mutations but still a challenge
    • Björkhem I., Hansson M. Cerebrotendinous xanthomatosis: an inborn error in bile acid synthesis with defined mutations but still a challenge. Biochem. Biophys. Res. Commun. 2010, 396:46-49.
    • (2010) Biochem. Biophys. Res. Commun. , vol.396 , pp. 46-49
    • Björkhem, I.1    Hansson, M.2
  • 12
    • 77950599782 scopus 로고    scopus 로고
    • Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis
    • Schule R., et al. Marked accumulation of 27-hydroxycholesterol in SPG5 patients with hereditary spastic paresis. J. Lipid Res. 2010, 51:819-823.
    • (2010) J. Lipid Res. , vol.51 , pp. 819-823
    • Schule, R.1
  • 13
    • 59149088091 scopus 로고    scopus 로고
    • Serum concentration of 27-hydroxycholesterol predicts the effects of high-cholesterol diet on plasma LDL cholesterol level
    • Hirayama T., et al. Serum concentration of 27-hydroxycholesterol predicts the effects of high-cholesterol diet on plasma LDL cholesterol level. Hepatol. Res. 2009, 39:149-156.
    • (2009) Hepatol. Res. , vol.39 , pp. 149-156
    • Hirayama, T.1
  • 14
    • 40949116379 scopus 로고    scopus 로고
    • Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample
    • Lee C.Y., et al. Measurement of F2-isoprostanes, hydroxyeicosatetraenoic products, and oxysterols from a single plasma sample. Free Radic. Biol. Med. 2008, 44:1314-1322.
    • (2008) Free Radic. Biol. Med. , vol.44 , pp. 1314-1322
    • Lee, C.Y.1
  • 15
    • 0033386688 scopus 로고    scopus 로고
    • Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1
    • Wu Z., et al. Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1. J. Lipid Res. 1999, 40:2195-2203.
    • (1999) J. Lipid Res. , vol.40 , pp. 2195-2203
    • Wu, Z.1
  • 16
    • 70350417597 scopus 로고    scopus 로고
    • CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions
    • Stiles A.R., et al. CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions. J. Biol. Chem. 2009, 284:28485-28489.
    • (2009) J. Biol. Chem. , vol.284 , pp. 28485-28489
    • Stiles, A.R.1
  • 17
    • 14544305043 scopus 로고    scopus 로고
    • Early onset of puberty and early ovarian failure in CYP7B1 knockout mice
    • Omoto Y., et al. Early onset of puberty and early ovarian failure in CYP7B1 knockout mice. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:2814-2819.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 2814-2819
    • Omoto, Y.1
  • 18
    • 38049008502 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator
    • DuSell C.D., et al. 27-Hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol. Endocrinol. 2008, 22:65-77.
    • (2008) Mol. Endocrinol. , vol.22 , pp. 65-77
    • DuSell, C.D.1
  • 19
    • 34648837875 scopus 로고    scopus 로고
    • Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers
    • Burkard I., et al. Lipoprotein distribution and biological variation of 24S- and 27-hydroxycholesterol in healthy volunteers. Atherosclerosis 2007, 194:71-78.
    • (2007) Atherosclerosis , vol.194 , pp. 71-78
    • Burkard, I.1
  • 20
    • 0032769064 scopus 로고    scopus 로고
    • 27-Hydroxycholesterol: production rates in normal human subjects
    • Duane W.C., Javitt N.B. 27-Hydroxycholesterol: production rates in normal human subjects. J. Lipid Res. 1999, 40:1194-1199.
    • (1999) J. Lipid Res. , vol.40 , pp. 1194-1199
    • Duane, W.C.1    Javitt, N.B.2
  • 21
    • 0031576814 scopus 로고    scopus 로고
    • Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques
    • Crisby M., et al. Localization of sterol 27-hydroxylase immuno-reactivity in human atherosclerotic plaques. Biochim. Biophys. Acta 1997, 1344:278-285.
    • (1997) Biochim. Biophys. Acta , vol.1344 , pp. 278-285
    • Crisby, M.1
  • 22
    • 0036172426 scopus 로고    scopus 로고
    • Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis
    • Upston J.M., et al. Disease stage-dependent accumulation of lipid and protein oxidation products in human atherosclerosis. Am. J. Pathol. 2002, 160:701-710.
    • (2002) Am. J. Pathol. , vol.160 , pp. 701-710
    • Upston, J.M.1
  • 23
    • 33745187361 scopus 로고    scopus 로고
    • Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity
    • Yamamoto Y., et al. Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity. J. Biol. Chem. 2006, 281:16625-16631.
    • (2006) J. Biol. Chem. , vol.281 , pp. 16625-16631
    • Yamamoto, Y.1
  • 24
    • 33644638521 scopus 로고    scopus 로고
    • Estrogen receptors and human disease
    • Deroo B.J., Korach K.S. Estrogen receptors and human disease. J. Clin. Invest. 2006, 116:561-570.
    • (2006) J. Clin. Invest. , vol.116 , pp. 561-570
    • Deroo, B.J.1    Korach, K.S.2
  • 25
    • 0033542402 scopus 로고    scopus 로고
    • The protective effects of estrogen on the cardiovascular system
    • Mendelsohn M.E., Karas R.H. The protective effects of estrogen on the cardiovascular system. N. Engl. J. Med. 1999, 340:1801-1811.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1801-1811
    • Mendelsohn, M.E.1    Karas, R.H.2
  • 26
    • 0035936528 scopus 로고    scopus 로고
    • Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta
    • Brouchet L., et al. Estradiol accelerates reendothelialization in mouse carotid artery through estrogen receptor-alpha but not estrogen receptor-beta. Circulation 2001, 103:423-428.
    • (2001) Circulation , vol.103 , pp. 423-428
    • Brouchet, L.1
  • 27
    • 0037205290 scopus 로고    scopus 로고
    • Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury
    • Pare G., et al. Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury. Circ. Res. 2002, 90:1087-1092.
    • (2002) Circ. Res. , vol.90 , pp. 1087-1092
    • Pare, G.1
  • 28
    • 77955006975 scopus 로고    scopus 로고
    • Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice
    • Chambliss K.L., et al. Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice. J. Clin. Invest. 2010, 120:2319-2330.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2319-2330
    • Chambliss, K.L.1
  • 29
    • 0037127027 scopus 로고    scopus 로고
    • Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta
    • Zhu Y., et al. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science 2002, 295:505-508.
    • (2002) Science , vol.295 , pp. 505-508
    • Zhu, Y.1
  • 30
    • 0036892157 scopus 로고    scopus 로고
    • Minireview: estrogen and mouse models of atherosclerosis
    • Hodgin J.B., Maeda N. Minireview: estrogen and mouse models of atherosclerosis. Endocrinology 2002, 143:4495-4501.
    • (2002) Endocrinology , vol.143 , pp. 4495-4501
    • Hodgin, J.B.1    Maeda, N.2
  • 31
    • 20444398494 scopus 로고    scopus 로고
    • Molecular and cellular basis of cardiovascular gender differences
    • Mendelsohn M.E., Karas R.H. Molecular and cellular basis of cardiovascular gender differences. Science 2005, 308:1583-1587.
    • (2005) Science , vol.308 , pp. 1583-1587
    • Mendelsohn, M.E.1    Karas, R.H.2
  • 32
    • 0023099735 scopus 로고
    • Menopause and the risk of coronary heart disease in women
    • Colditz G.A., et al. Menopause and the risk of coronary heart disease in women. N. Engl. J. Med. 1987, 316:1105-1110.
    • (1987) N. Engl. J. Med. , vol.316 , pp. 1105-1110
    • Colditz, G.A.1
  • 33
    • 3042852097 scopus 로고    scopus 로고
    • Current controversies regarding the cardiovascular effects of hormone therapy
    • Karas R.H. Current controversies regarding the cardiovascular effects of hormone therapy. Clin. Obstet. Gynecol. 2004, 47:489-499.
    • (2004) Clin. Obstet. Gynecol. , vol.47 , pp. 489-499
    • Karas, R.H.1
  • 34
    • 2542540731 scopus 로고    scopus 로고
    • Hormone therapy: physiological complexity belies therapeutic simplicity
    • Turgeon J.L., et al. Hormone therapy: physiological complexity belies therapeutic simplicity. Science 2000, 304:1269-1273.
    • (2000) Science , vol.304 , pp. 1269-1273
    • Turgeon, J.L.1
  • 35
    • 0032547326 scopus 로고    scopus 로고
    • Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group
    • Hulley S., et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA 1998, 280:605-613.
    • (1998) JAMA , vol.280 , pp. 605-613
    • Hulley, S.1
  • 36
    • 0037125379 scopus 로고    scopus 로고
    • Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial
    • Rossouw J.E., et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial. JAMA 2002, 288:321-333.
    • (2002) JAMA , vol.288 , pp. 321-333
    • Rossouw, J.E.1
  • 37
    • 77955868505 scopus 로고    scopus 로고
    • Postmenopausal hormone therapy: an Endocrine Society scientific statement
    • Santen R., et al. Postmenopausal hormone therapy: an Endocrine Society scientific statement. J. Clin. Endocrinol. Metab. 2010, 95(Suppl. 1):s1-s66.
    • (2010) J. Clin. Endocrinol. Metab. , vol.95 , Issue.SUPPL. 1
    • Santen, R.1
  • 38
    • 0037434599 scopus 로고    scopus 로고
    • Understanding the divergent data on postmenopausal hormone therapy
    • Grodstein F., et al. Understanding the divergent data on postmenopausal hormone therapy. N. Engl. J Med. 2003, 348:645-650.
    • (2003) N. Engl. J Med. , vol.348 , pp. 645-650
    • Grodstein, F.1
  • 39
    • 0033599278 scopus 로고    scopus 로고
    • Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study
    • Strong J.P., et al. Prevalence and extent of atherosclerosis in adolescents and young adults: implications for prevention from the Pathobiological Determinants of Atherosclerosis in Youth Study. JAMA 1999, 281:727-735.
    • (1999) JAMA , vol.281 , pp. 727-735
    • Strong, J.P.1
  • 40
    • 0014282153 scopus 로고
    • Distribution of coronary and aortic atherosclerosis by geographic location, race, and sex
    • Tejada C., et al. Distribution of coronary and aortic atherosclerosis by geographic location, race, and sex. Lab. Invest. 1968, 18:509-526.
    • (1968) Lab. Invest. , vol.18 , pp. 509-526
    • Tejada, C.1
  • 41
    • 18844393948 scopus 로고    scopus 로고
    • Controversies about HRT - lessons from monkey models
    • Clarkson T.B., Appt S.E. Controversies about HRT - lessons from monkey models. Maturitas 2005, 51:64-74.
    • (2005) Maturitas , vol.51 , pp. 64-74
    • Clarkson, T.B.1    Appt, S.E.2
  • 42
    • 85007758538 scopus 로고    scopus 로고
    • ABC of breast diseases. Breast cancer - epidemiology, risk factors, and genetics
    • McPherson K., et al. ABC of breast diseases. Breast cancer - epidemiology, risk factors, and genetics. BMJ 2000, 321:624-628.
    • (2000) BMJ , vol.321 , pp. 624-628
    • McPherson, K.1
  • 43
    • 34748827491 scopus 로고    scopus 로고
    • Optimizing the antihormonal treatment and prevention of breast cancer
    • Patel R.R., et al. Optimizing the antihormonal treatment and prevention of breast cancer. Breast Cancer 2007, 14:113-122.
    • (2007) Breast Cancer , vol.14 , pp. 113-122
    • Patel, R.R.1
  • 44
    • 33751009646 scopus 로고    scopus 로고
    • What do we know about the mechanisms of aromatase inhibitor resistance?
    • Chen S., et al. What do we know about the mechanisms of aromatase inhibitor resistance?. J. Steroid. Biochem. Mol. Biol. 2006, 102:232-240.
    • (2006) J. Steroid. Biochem. Mol. Biol. , vol.102 , pp. 232-240
    • Chen, S.1
  • 46
    • 13644268580 scopus 로고    scopus 로고
    • Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women
    • Orozco P. Atherogenic lipid profile and elevated lipoprotein (a) are associated with lower bone mineral density in early postmenopausal overweight women. Eur. J. Epidemiol. 2004, 19:1105-1112.
    • (2004) Eur. J. Epidemiol. , vol.19 , pp. 1105-1112
    • Orozco, P.1
  • 47
    • 0037262545 scopus 로고    scopus 로고
    • Does serum cholesterol contribute to vertebral bone loss in postmenopausal women?
    • Tanko L.B., et al. Does serum cholesterol contribute to vertebral bone loss in postmenopausal women?. Bone 2003, 32:8-14.
    • (2003) Bone , vol.32 , pp. 8-14
    • Tanko, L.B.1
  • 48
    • 77954892925 scopus 로고    scopus 로고
    • The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis
    • DuSell C.D., et al. The endogenous selective estrogen receptor modulator 27-hydroxycholesterol is a negative regulator of bone homeostasis. Endocrinology 2010, 151:3675-3685.
    • (2010) Endocrinology , vol.151 , pp. 3675-3685
    • DuSell, C.D.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.