Modification of an in vitro model simulating the whole digestive process to investigate cellular endpoints of chemoprevention

British Journal of Nutrition

Volumn 105, Issue 5, 2011, Pages 678-687

  Stein, Katrin ^a   Borowicki, Anke ^a   Scharlau, Daniel ^a   Scheu, Kerstin ^b   Brenner Weiß, Gerald ^b   Obst, Ursula ^b   Hollmann, Jürgen ^c   Lindhauer, Meinolf ^c   Wachter, Norbert ^d   Glei, Michael ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b KARLSRUHE INSTITUTE OF TECHNOLOGY   (Germany)

^c FEDERAL RESEARCH INSTITUTE OF NUTRITION AND FOOD   (Germany)

^d Kampffmeyer Food Service GmbH   (Germany)

Author keywords

Chemoprevention; Deoxycholic acid; Fermentation; SCFA; Wheat

Indexed keywords

BILE ACID; CHOLIC ACID; DEOXYCORTICOSTERONE ACETATE; CHOLIC ACID DERIVATIVE; VOLATILE FATTY ACID;

AEROBIC FERMENTATION; ARTICLE; CANCER CELL; CELL COUNT; CELL CULTURE; CELL GROWTH; CHEMOPROPHYLAXIS; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY TEST; FERMENTATION MODEL; FLOUR; GASTROINTESTINAL TRACT; GROWTH INHIBITION; HUMAN; HUMAN CELL; PH; WHEAT; ADENOCARCINOMA; ANIMAL; BILE; BIOLOGICAL MODEL; CATTLE; CELL LINE; CEREAL; COLON; COLON TUMOR; CYTOLOGY; DIGESTION; DRUG EFFECT; FERMENTATION; METABOLISM; TUMOR CELL LINE;

TRITICUM AESTIVUM;

ADENOCARCINOMA; ANIMALS; BILE; CATTLE; CELL LINE; CELL LINE, TUMOR; CEREALS; CHOLIC ACIDS; COLON; COLONIC NEOPLASMS; DIGESTION; FATTY ACIDS, VOLATILE; FERMENTATION; FLOUR; HUMANS; MODELS, BIOLOGICAL; TRITICUM;

EID: 79953157829     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114510004320     Document Type: Article

References (49)

1. Doll R & Peto R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66, 1191-1308.
2. Pool-Zobel B, van Loo J, Rowland I, et al. (2002) Experimental evidences on the potential of prebiotic fructans to reduce the risk of colon cancer. Br J Nutr 87, Suppl. 2, S273-S281.
3. World Cancer Research Fund/American Institute for Cancer Research (2007) Food, Nutrition, Physical Activity and the Prevention of Cancer: a Global Perspective. Washington DC: AIRC.
4. Tan KY & Seow-Choen F (2007) Fiber and colorectal diseases: separating fact from fiction. World J Gastroenterol 13, 4161-4167.
5. Glei M, Hofmann T, Kuster K, et al. (2006) Both wheat (Triticum aestivum) bran arabinoxylans and gut floramediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxide. J Agric Food Chem 54, 2088-2095.
6. Beyer-Sehlmeyer G, Glei M, Hartmann E, et al. (2003) Butyrate is only one of several growth inhibitors produced during gut flora-mediated fermentation of dietary fibre sources. Br J Nutr 90, 1057-1070.
7. Fassler C, Gill CI, Arrigoni E, et al. (2007) Fermentation of resistant starches: influence of in vitro models on colon carcinogenesis. Nutr Cancer 58, 85-92.
8. Klinder A, Gietl E, Hughes R, et al. (2004) Gut fermentation products of inulin-derived prebiotics beneficially modulate markers of tumour progression in human colon tumour cells. Int J Cancer Prev 1, 19-32.
9. Barry JL, Hoebler C, Macfarlane GT, et al. (1995) Estimation of the fermentability of dietary fibre in vitro: a European interlaboratory study. Br J Nutr 74, 303-322.
10. Minekus M, Marteau P, Havenaar R, et al. (1995) A multicompartmental dynamic computer-controlled model simulating the stomach and small-intestine. Altern Lab Anim 23, 197-209.
11. Gibson GR, Cummings JH & Macfarlane GT (1988) Use of a 3-stage continuous culture system to study the effect of mucin on dissimilatory sulfate reduction and methanogenesis by mixed populations of human gut bacteria. Appl Environ Microbiol 54, 2750-2755.
12. Macfarlane GT, Cummings JH, Macfarlane S, et al. (1989) Influence of retention time on degradation of pancreatic enzymes by human colonic bacteria grown in a 3-stage continuous culture system. J Appl Bacteriol 67, 520-527.
13. Minekus M, Smeets-Peeters M, Bernalier A, et al. (1999) A computer-controlled system to simulate conditions of the large intestine with peristaltic mixing, water absorption and absorption of fermentation products. Appl Microbiol Biotechnol 53, 108-114.
14. Molly K, Vande WM & Verstraete W (1993) Development of a 5-step multi-chamber reactor as a simulation of the human intestinal microbial ecosystem. Appl Microbiol Biotechnol 39, 254-258.
15. Aura AM (2005) In vitro digestion models for dietary phenolic compounds. PhD Dissertation, Helsinki University of Technology.
16. Lapré JA & Van der Meer R (1992) Diet-induced increase of colonic bile acids stimulates lytic activity of fecal water and proliferation of colonic cells. Carcinogenesis 13, 41-44.
17. Rafter JJ, Child P, Anderson AM, et al. (1987) Cellular toxicity of fecal water depends on diet. Am J Clin Nutr 45, 559-563.
18. Venturi M, Hambly RJ, Glinghammar B, et al. (1997) Genotoxic activity in human faecal water and the role of bile acids: a study using the alkaline comet assay. Carcinogenesis 18, 2353-2359.
19. Aura AM, Härkönen H, Fabritius M, et al. (1999) Development of an in vitro enzymatic digestion method for removal of starch and protein and assessment of its performance using rye and wheat breads. J Cereal Sci 29, 139-152.
20. Borowicki A, Stein K, Scharlau D, et al. (2010) Fermented wheat aleurone inhibits growth and induces apoptosis in human HT29 colon adenocarcinoma cells. Br J Nutr 103, 360-369.
21. Bhagavan NV (2002) Gastrointestinal digestion and absorption. In Medical Biochemistry, 4th ed., pp. 216-217 [S Harcourt Science and Technology Company, editor]. New York: Academic Press.
22. Burkard I, von Eckardstein A & Rentsch KM (2005) Differentiated quantification of human bile acids in serum by high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 826, 147-159.
23. Hollmann J & Lindhauer MG (2005) Pilot-scale isolation of glucuronoarabinoxylans from wheat bran. Carbohydr Polym 59, 225-230.
24. Wang JF, Zhu YH, Li DF, et al. (2004) In vitro fermentation of various fiber and starch sources by pig fecal inocula. J Anim Sci 82, 2615-2622.
25. Rousset M (1986) The human colon carcinoma cell lines HT-29 and caco-2: two in vitro models for the study of intestinal differentiation. Biochimie 68, 1035-1040.
26. Radu M, Munteanu MC, Petrache S, et al. (2010) Depletion of intracellular glutathione and increased lipid peroxidation mediate cytotoxicity of hematite nanoparticles in MRC-5 cells. Acta Biochim Pol 57, 355-360.
27. Sauer J, Richter KK & Pool-Zobel BL (2007) Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells. J Nutr Biochem 18, 736-745.
28. Glei M, Klenow S, Sauer J, et al. (2006) Hemoglobin and hemin induce DNA damage in human colon tumor cells HT29 clone 19A and in primary human colonocytes. Mutat Res 594, 162-171.
29. Vantikommu J, Palle S, Surendra RP, et al. (2010) Synthesis and cytotoxicity evaluation of novel 1,4-disubstituted 1,2,3-triazoles via CuI catalysed 1,3-dipolar cycloaddition. Eur J Med Chem 45, 5044-5050.
30. Klenow S, Glei M, Haber B, et al. (2008) Carob fibre compounds modulate parameters of cell growth differently in human HT29 colon adenocarcinoma cells than in LT97 colon adenoma cells. Food Chem Toxicol 46, 1389-1397.
31. Wong JM, de SR, Kendall CW, et al. (2006) Colonic health: fermentation and short chain fatty acids. J Clin Gastroenterol 40, 235-243.
32. Cummings JH (1981) Short chain fatty acids in the human colon. Gut 22, 763-779.
33. Scheppach W, Bartram P, Richter A, et al. (1992) Effect of short-chain fatty acids on the human colonic mucosa in vitro. JPEN J Parenter Enteral Nutr 16, 43-48.
34. Munjal U, Glei M, Pool-Zobel BL, et al. (2009) Fermentation products of inulin-type fructans reduce proliferation and induce apoptosis in human colon tumour cells of different stages of carcinogenesis. Br J Nutr 102, 663-671.
35. Amrein TM, Gränicher P, Arrigoni E, et al. (2003) In vitro digestibility and colonic fermentability of aleurone isolated from wheat bran. Lebenssm WissTechnol 36, 451-460.
36. Pool-Zobel BL & Sauer J (2007) Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans. J Nutr 137, 2580S-2584S.
37. Pool-Zobel BL, Selvaraju V, Sauer J, et al. (2005) Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S-transferases genes, an approach in nutrigenomics. Carcinogenesis 26, 1064-1076.
38. Scharlau D, Borowicki A, Habermann N, et al. (2009) Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre. Mutat Res 682, 39-53.
39. Zampa A, Silvi S, Fabiani R, et al. (2004) Effects of different digestible carbohydrates on bile acid metabolism and SCFA production by human gut micro-flora grown in an in vitro semi-continuous culture. Anaerobe 10, 19-26.
40. Ridlon JM, Kang DJ & Hylemon PB (2006) Bile salt biotransformations by human intestinal bacteria. J Lipid Res 47, 241-259.
41. Elhardallou SB (1992) The bile acids binding of the fibre-rich fractions of three starchy legumes. Plant Foods Hum Nutr 42, 207-218.
42. Hofmann T, Weber A, Sauer J, et al. (2008) Formation of tumour promoting and tumour inhibitory products during gut flora mediated fermentation of inulin-type fructans and wheat bran. J Clin Biochem Nutr 43, 1-5.
43. Bonovas S, Tsantes A, Drosos T, et al. (2008) Cancer chemoprevention: a summary of the current evidence. Anticancer Res 28, 1857-1866.
44. Shiraki K, Ito T, Sugimoto K, et al. (2005) Different effects of bile acids, ursodeoxycholic acid and deoxycholic acid, on cell growth and cell death in human colonic adenocarcinoma cells. Int J Mol Med 16, 729-733.
45. Mortensen PB, Holtug K & Rasmussen HS (1988) Shortchain fatty acid production from mono-and disaccharides in a fecal incubation system: implications for colonic fermentation of dietary fiber in humans. J Nutr 118, 321-325.
46. Lebet V, Arrigoni E & Amadò R (1998) Digestion procedure using mammalian enzymes to obtain substrates for in vitro fermentation studies. Lebenssm WissTechnol 31, 509-515.
47. Borowicki A, Stein K, Scharlau D, et al. (2010) Fermentation supernatants of wheat (Triticum aestivum L.) aleurone beneficially modulate cancer progression in human colon cells. J Agric Food Chem 58, 2001-2007.
48. Borowicki A, Michelmann A, Stein K, et al. (2010) Fermented wheat aleurone enriched with probiotic strains LGG and Bb12 modulates markers of tumor progression in human colon cells. Nutr Cancer (In the Press).
49. Stein K, Borowicki A, Scharlau D, et al. (2010) Fermented wheat aleurone induces enzymes involved in detoxification of carcinogens and in antioxidative defence in human colon cells. Br J Nutr 104, 1101-1111.