Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans

Journal of Nutrition

Volumn 137, Issue 11, 2007, Pages

  Pool Zobel, Beatrice L ^a   Sauer, Julia ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

FRUCTOSE OLIGOSACCHARIDE; INULIN;

CANCER INHIBITION; CANCER RISK; CANCER SURGERY; CLINICAL TRIAL; COLORECTAL CANCER; CONFERENCE PAPER; EXPERIMENTAL STUDY; HIGH RISK PATIENT; HUMAN; IN VITRO STUDY; INTERVENTION STUDY; NONHUMAN; POLYPECTOMY; VOLUNTEER;

ANIMALIA; RODENTIA;

EID: 35848960340     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/137.11.2580s     Document Type: Conference Paper

References (32)

1. Fearon ER, Vogelstein B. A genetic model for colorectal tumorigenesis. Cell. 1990;61:759-67.
2. Fearon ER. Human cancer syndromes: clues to the origin and nature of cancer. Science. 1997;278:1043-50.
3. World Cancer Research Fund, American Institute for Cancer Research. Food, nutrition and the prevention of cancer: a global perspective. Washington, DC: American Institute for Cancer Research; 1997.
4. Berlau J, Glei M, Pool-Zobel BL. Colon cancer risk factors from nutrition. Anal Bioanal Chem. 2004;378:737-43.
5. Cummings JH, Englyst HN. Fermentation in the human large intestine and the available substrates. Am J Clin Nutr. 1987;45:1243-55.
6. McGarr SE, Ridlon JM, Hylemon PB. Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature. J Clin Gastroenterol. 2005;39:98-109.
7. Rieger MA, Parlesak A, Pool-Zobel BL, Rechkemmer G, Bode C. A diet high in fat and meat but low in dietary fibre increases the genotoxic potential of "faecal water." Carcinogenesis. 1999;20:2311-6.
8. Van Tassell RL, Kingston DG, Wilkins TD. Metabolism of dietary genotoxins by the human colonic microflora; the fecapentaenes and heterocyclic amines. Mutat Res. 1990;238:209-21.
9. Knasmüller S, Steinkellner H, Hirschl AM, Rabot S, Nobis EC, Kassie F. Impact of bacteria in dairy products and of the intestinal microflora on the genotoxic and carcinogenic effects of heterocyclic aromatic amines. Mutat Res. 2001;480-482:129-38.
10. Hague A, Paraskeva C. The short-chain fatty acid butyrate induces apoptosis in colorectal tumour cell lines. Eur J Cancer Prev. 1995;4:359-64.
11. Ebert MN, Beyer-Sehlmeyer G, Liegibel UM, Kautenburger T, Becker TW, Pool-Zobel BL. Butyrate-induces glutathione S-transferase in human colon cells and protects from genetic damage by 4-hydroxynonenal. Nutr Cancer. 2001;41:156-64.
12. Klinder A, Gietl E, Hughes R, Jonkers N, Karlsson P, McGlyn H, Pistoli S, Tuohy KM, Rafter J, et al. Gut fermentation products of inulin-derived prebiotics beneficially modulate markers of tumour progression in human colon tumour cells. Int J Cancer Prev. 2004;1:19-32.
13. Probert HM, Apajalahti JH, Rautonen N, Stowell J, Gibson GR. Polydextrose, lactitol, and fructo-oligosaccharide fermentation by colonic bacteria in a three-stage continuous culture system. Appl Environ Microbiol. 2004;70:4505-11.
14. Johnson IT. New approaches to the role of diet in the prevention of cancers of the alimentary tract. Mutat Res. 2004;551:9-28.
15. Wattenberg LW. An overview of chemoprevention: current status and future prospects. Proc Soc Exp Biol Med. 1997;216:133-41.
16. Hinnebusch BF, Meng S, Wu JT, Archer SY, Hodin RA. The effects of short-chain fatty acids on human colon cancer cell phenotype are associated with histone hyperacetylation. J Nutr. 2002;132:1012-7.
17. Marks PA, Rifkind RA, Richon VM, Breslow R, Miller T, Kelly WK. Histone deacetylases and cancer: causes and therapies. Nat Rev Cancer. 2001;1:194-202.
18. Pool-Zobel BL, Leucht U. Induction of DNA damage by risk factors of colon cancer in human colon cells derived from biopsies. Mutat Res. 1997;375:105-15.
19. Pool-Zobel BL, Abrahamse SL, Collins AR, Kark W, Gugler R, Oberreuther D, Siegel EG, Treptow-van Lishaut S, Rechkemmer G. Analysis of DNA strand breaks, oxidized bases, and glutathione S-transferase P1 in human colon cells from biopsies. Cancer Epidemiol Biomarkers Prev. 1999;8:609-14.
20. Pool-Zobel BL, Selvaraju V, Sauer J, Kautenburger T, Kiefer J, Richter KK, Soom M, Wolfl S. Butyrate may enhance toxicological defence in primary, adenoma and tumor human colon cells by favourably modulating expression of glutathione S-transferases genes, an approach in nutrigenomics. Carcinogenesis. 2005;26:1064-76.
21. Schäferhenrich A, Sendt W, Scheele J, Kuechler A, Liehr T, Claussen U, Rapp A, Greulich KO, Pool-Zobel BL. Putative colon cancer risk factors damage global DNA and TP53 in primary human colon cells isolated from surgical samples. Food Chem Toxicol. 2003;41:655-64.
22. Sauer J, Richter KK, Pool-Zobel BL. Products formed during fermentation of the prebiotic inulin with human gut flora enhance expression of biotransformation genes in human primary colon cells. Br J Nutr. 2007;97:928-37.
23. Roediger WEW. Utilization of nutrients by isolated epithelial cells of the rat colon. Gastroenterology. 1982;83:424-9.
24. Sauer J, Richter KK, Pool-Zobel BL. Physiological concentrations of butyrate favorably modulate genes of oxidative and metabolic stress in primary human colon cells. J Nutr Biochem. 2007 Apr 13 [Epub ahead of print].
25. Pool-Zobel B, Veeriah S, Bohmer FD. Modulation of xenobiotic metabolising enzymes by anticarcinogens-focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis 6. Mutat Res. 2005;591:74-92.
26. Rafter J, Govers M, Martel P, Pannemans D, Pool-Zobel B, Rechkemmer G, Rowland I, Tuijtelaars S van LJ. PASSCLAIM-diet-related cancer. Eur J Nutr. 2004;43: Suppl 2:II47-84.
27. Abrahamse SL, Pool-Zobel BL, Rechkemmer G. Potential of short chain fatty acids to modulate the induction of DNA damage and changes in the intracellular calcium concentration by oxidative stress in isolated rat distal colon cells. Carcinogenesis. 1999;20:629-34.
28. Pool-Zobel BL. Inulin-type fructans and reduction in colon cancer risk: review of experimental and human data. Br J Nutr. 2005;93: Suppl 1:S73-90.
29. Femia AP, Luceri C, Dolara P, Giannini A, Biggeri A, Salvadori M, Clune Y, Collins KJ, Paglierani M, Caderni G. Antitumorigenic activity of the prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis on azoxymethane-induced colon carcinogenesis in rats. Carcinogenesis. 2002;23:1953-60.
30. Klinder A, Forster A, Caderni G, Femia AP, Pool-Zobel BL. Fecal water genotoxicity is predictive of tumor-preventive activities by inulin-like oligofructoses, probiotics (Lactobacillus rhamnosus and Bifidobacterium lactis), and their synbiotic combination. Nutr Cancer. 2004;49:144-55.
31. Rafter J, Bennett M, Caderni G, Clune Y, Hughes R, Karlsson PC, Klinder A, O'Riordan M, O'Sullivan GC, et al. Dietary synbiotics reduce cancer risk factors in polypectomized and colon cancer patients. Am J Clin Nutr. 2007;85:488-96.
32. Boutron-Ruault MC, Marteau P, Lavergne-Slove A, Myara A, Gerhardt MF, Franchisseur C, Bornet F, The Eripolyp Study Group. Effects of a 3-mo consumption of short-chain fructo-oligosaccharides on parameters of colorectal carcinogenesis in patients with or without small or large colorectal adenomas. Nutr Cancer. 2005;53:160-8.