Analysis of heterotropic cooperativity in cytochrome P450 3A4 using α-Naphthoflavone and testosterone

Journal of Biological Chemistry

Volumn 286, Issue 7, 2011, Pages 5540-5545

  Frank, Daniel J ^a   Denisov, Ilia G ^a   Sligar, Stephen G ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADDITIVE ACTION; ALLOSTERIC EFFECT; COOPERATIVITY; CYTOCHROME P450-3A4; GLOBAL ANALYSIS; HETEROTROPIC COOPERATIVITY; LINEAR COMBINATIONS; METABOLIC PROFILES; MOLAR RATIO; NANODISCS; NON-COOPERATIVE; NON-MICHAELIS-MENTEN KINETICS; PRODUCT FORMATION; SPIN STATE;

KINETIC THEORY; METABOLISM; PORPHYRINS;

SUBSTRATES;

ALPHA NAPHTHOFLAVONE; CYTOCHROME P450 3A4; NANODISC; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TESTOSTERONE;

ALLOSTERISM; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME METABOLISM; ENZYME SUBSTRATE COMPLEX; HETEROTROPHY; HORMONE BINDING; HORMONE METABOLISM; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALLOSTERIC REGULATION; BENZOFLAVONES; CYTOCHROME P-450 CYP3A; HUMANS; KINETICS; MODELS, CHEMICAL; NANOSTRUCTURES; TESTOSTERONE;

EID: 79953154250     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.182055     Document Type: Article

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