Non-core region modulates interleukin-11 signaling activity: Generation of agonist and antagonist variants

Journal of Biological Chemistry

Volumn 286, Issue 10, 2011, Pages 8085-8093

  Yanaka, Saeko ^a   Sano, Emiko ^a   Naruse, Norio ^b   Miura, Kin Ichiro ^a   Futatsumori Sugai, Mutsumi ^a   Caaveiro, Jose M M ^a   Tsumoto, Kouhei ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b Proteios Research Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BELONG TO; BIOLOGICAL ACTIVITIES; CORE REGION; CYTOKINES; HELICAL BUNDLE; HUMAN INTERLEUKIN-11; IN-CELL; MUTEINS; PRIMARY SEQUENCES; SIGNALING ACTIVITY; STRUCTURAL ELEMENTS; STRUCTURAL POINT;

ESTERIFICATION;

GLYCOSYLATION;

GLYCAN; GLYCOPROTEIN GP 130; INTERLEUKIN 11; INTERLEUKIN 11 RECEPTOR;

ALPHA HELIX; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; GLYCOSYLATION; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN STRUCTURE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STRUCTURAL HOMOLOGY;

AMINO ACID MOTIFS; ANIMALS; CELL LINE, TUMOR; CYTOKINE RECEPTOR GP130; GLYCOSYLATION; HUMANS; INTERLEUKIN-11; MICE; PROTEIN MODIFICATION, TRANSLATIONAL; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953127652     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.152561     Document Type: Article

References (55)

1. Paul, S. R., Bennett, F., Calvetti, J. A., Kelleher, K., Wood, C. R., O'Hara, R. M., Jr., Leary, A. C., Sibley, B., Clark, S. C., and Williams, D. A. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 7512-7516
2. Du, X., and Williams, D. A. (1997) Blood 89, 3897-3908
3. Trepicchio, W. L., and Dorner, A. J. (1998) Ann. N.Y. Acad. Sci. 856, 12-21
4. Sands, B. E., Winston, B. D., Salzberg, B., Safdi, M., Barish, C., Wruble, L., Wilkins, R., Shapiro, M., Schwertschlag, U. S., and RHIL-11 Crohn's Study group (2002) Aliment. Pharmacol. Ther. 16, 399-406
5. Du, X., Liu, Q., Yang, Z., Orazi, A., Rescorla, F. J., Grosfeld, J. L., and Williams, D. A. (1997) Am. J. Physiol. Gastroentest. Liver Physiol. 272, G545-552
6. Obana, M., Maeda, M., Takeda, K., Hayama, A., Mohri, T., Yamashita, T., Nakaoka, Y., Komuro, I., Takeda, K., Matsumiya, G., Azuma, J., and Fujio, Y. (2010) Circulation 121, 684-691
7. Bhatia, M., Davenport, V., and Cairo, M. S. (2007) Leuk. Lymphoma 48, 9-15
8. Peeters, K., Stassen, J. M., Collen, D., Van Geet, C., and Freson, K. (2008) Drug Discov. Today 13, 798-806
9. Kaye, J. A. (1998) Stem Cells 16, Suppl. 2, 207-223
10. Hansen, G., Hercus, T. R., McClure, B. J., Stomski, F. C., Dottore, M., Powell, J., Ramshaw, H., Woodcock, J. M., Xu, Y., Guthridge, M., McKinstry, W. J., Lopez, A. F., and Parker, M. W. (2008) Cell 134, 496-507
11. Nicola, N. A., and Hilton, D. J. (1998) Adv. Protein Chem. 52, 1-65
12. Bravo, J., and Heath, J. K. (2000) EMBO J. 19, 2399-2411
13. Wang, X., Lupardus, P., Laporte, S. L., and Garcia, K. C. (2009) Annu. Rev. Immunol. 27, 29-60
14. McDonald, N. Q., Panayotatos, N., and Hendrickson, W. A. (1995) EMBO J. 14, 2689-2699
15. Somers, W., Stahl, M., and Seehra, J. S. (1997) EMBO J. 16, 989-997
16. Aritomi, M., Kunishima, N., Okamoto, T., Kuroki, R., Ota, Y., and Morikawa, K. (1999) Nature 401, 713-717
17. Boulanger, M. J., Chow, D. C., Brevnova, E. E., and Garcia, K. C. (2003) Science 300, 2101-2104
18. Heinrich, P. C., Behrmann, I., Haan, S., Hermanns, H. M., Müller-Newen, G., and Schaper, F. (2003) Biochem. J. 374, 1-20
19. Hilton, D. J., Hilton, A. A., Raicevic, A., Rakar, S., Harrison-Smith, M., Gough, N. M., Begley, C. G., Metcalf, D., Nicola, N. A., and Willson, T. A. (1994) EMBO J. 13, 4765-4775
20. Schleinkofer, K., Dingley, A., Tacken, I., Federwisch, M., Müller-Newen, G., Heinrich, P. C., Vusio, P., Jacques, Y., and Grötzinger, J. (2001) J. Mol. Biol. 306, 263-274
21. Barton, V. A., Hall, M. A., Hudson, K. R., and Heath, J. K. (2000) J. Biol. Chem. 275, 36197-36203
22. Matadeen, R., Hon, W. C., Heath, J. K., Jones, E. Y., and Fuller, S. (2007) Structure 15, 441-448
23. Boulanger, M. J., and Garcia, K. C. (2004) Adv. Protein Chem. 68, 107-146
24. Taga, T., and Kishimoto, T. (1997) Annu. Rev. Immunol. 15, 797-819
25. Skiniotis, G., Boulanger, M. J., Garcia, K. C., and Walz, T. (2005) Nat. Struct. Mol. Biol. 12, 545-551
26. Ozaki, K., and Leonard, W. J. (2002) J. Biol. Chem. 277, 29355-29358
27. Barton, V. A., Hudson, K. R., and Heath, J. K. (1999) J. Biol. Chem. 274, 5755-5761
28. Boulanger, M. J., Bankovich, A. J., Kortemme, T., Baker, D., and Garcia, K. C. (2003) Mol. Cell 12, 577-589
29. Scahill, S. J., Devos, R., Van der Heyden, J., and Fiers, W. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 4654-4658
30. Sano, E., Iizuka, M., and Kobayashi, S. (1987) Cell Struct. Funct. 12, 509-517
31. Futatsumori-Sugai, M., and Tsumoto, K. (2010) Biochem. Biophys. Res. Commun. 391, 931-935
32. Underhill-Day, N., McGovern, L. A., Karpovich, N., Mardon, H. J., Barton, V. A., and Heath, J. K. (2003) Endocrinology 144, 3406-3414
33. Karow, J., Hudson, K. R., Hall, M. A., Vernallis, A. B., Taylor, J. A., Gossler, A., and Heath, J. K. (1996) Biochem. J. 318, 489-495
34. Sakamoto, S., Caaveiro, J. M., Sano, E., Tanaka, Y., Kudou, M., and Tsumoto, K. (2009) J. Mol. Biol. 389, 880-894
35. Pieper, U., Eswar, N., Webb, B. M., Eramian, D., Kelly, L., Barkan, D. T., Carter, H., Mankoo, P., Karchin, R., Marti-Renom, M. A., Davis, F. P., and Sali, A. (2009) Nucleic Acids Res. 37, D347-354
36. Davis, I. W., Leaver-Fay, A., Chen, V. B., Block, J. N., Kapral, G. J., Wang, X., Murray, L. W., Arendall, W. B., 3rd, Snoeyink, J., Richardson, J. S., and Richardson, D. C. (2007) Nucleic Acids Res. 35, W375-383
37. Bhatia, P. K., and Mukhopadhyay, A. (1999) Adv. Biochem. Eng. Biotechnol. 64, 155-201
38. Jenkins, N., and Curling, E. M. (1994) Enzyme Microb. Technol. 16, 354-364
39. Czupryn, M., Bennett, F., Dube, J., Grant, K., Scoble, H., Sookdeo, H., and McCoy, J. M. (1995) Ann. N.Y. Acad. Sci. 762, 152-164
40. Tacken, I., Dahmen, H., Boisteau, O., Minvielle, S., Jacques, Y., Grötzinger, J., Küster, A., Horsten, U., Blanc, C., Montero-Julian, F. A., Heinrich, P. C., and Müller-Newen, G. (1999) Eur. J. Biochem. 265, 645-655
41. Czupryn, M. J., McCoy, J. M., and Scoble, H. A. (1995) J. Biol. Chem. 270, 978-985
42. Feng, Y., Minnerly, J. C., Zurfluh, L. L., Joy, W. D., Hood, W. F., Abegg, A. L., Grabbe, E. S., Shieh, J. J., Thurman, T. L., McKearn, J. P., and McWherter, C. A. (1999) Biochemistry 38, 4553-4563
43. Lee, C. G., Hartl, D., Matsuura, H., Dunlop, F. M., Scotney, P. D., Fabri, L. J., Nash, A. D., Chen, N. Y., Tang, C. Y., Chen, Q., Homer, R. J., Baca, M., and Elias, J. A. (2008) Am. J. Respir. Cell Mol. Biol. 39, 739-746
44. Lewis, V. O., Ozawa, M. G., Deavers, M. T., Wang, G., Shintani, T., Arap, W., and Pasqualini, R. (2009) Cancer Res. 69, 1995-1999
45. Dela Cruz, C. S., Lee, Y., Viswanathan, S. R., El-Guindy, A. S., Gerlach, J., Nikiforow, S., Shedd, D., Gradoville, L., and Miller, G. (2004) J. Exp. Med. 199, 503-514
46. Oh-eda, M., Hasegawa, M., Hattori, K., Kuboniwa, H., Kojima, T., Orita, T., Tomonou, K., Yamazaki, T., and Ochi, N. (1990) J. Biol. Chem. 265, 11432-11435
47. Tan, H., Dan, G., Gong, H., and Cao, L. (2005) Biotechnol. Lett. 27, 905-910
48. Solá, R. J., Rodríguez-Martínez, J. A., and Griebenow, K. (2007) Cell Mol. Life Sci. 64, 2133-2152
49. Solá, R. J., and Griebenow, K. (2009) J. Pharm. Sci. 98, 1223-1245
50. Sinclair, A. M., and Elliott, S. (2005) J. Pharm. Sci. 94, 1626-1635
51. Takagi, A., Yamashita, N., Yoshioka, T., Takaishi, Y., Sano, K., Yamaguchi, H., Maeda, A., Saito, K., Takakura, Y., and Hashida, M. (2007) J. Control. Release 119, 271-278
52. Pflanz, S., Tacken, I., Grötzinger, J., Jacques, Y., Minvielle, S., Dahmen, H., Heinrich, P. C., and Müller-Newen, G. (1999) FEBS Lett. 450, 117-122
53. Harmegnies, D., Wang, X. M., Vandenbussche, P., Leon, A., Vusio, P., Grötzinger, J., Jacques, Y., Goormaghtigh, E., Devreese, B., and Content, J. (2003) Biochem. J. 375, 23-32
54. Pettersen, E. F., Goddard, T. D., Huang, C. C., Couch, G. S., Greenblatt, D. M., Meng, E. C., and Ferrin, T. E. (2004) J. Comput. Chem. 25, 1605-1612
55. Varki, A., Cummings, R. D., Esko, J. D., Freeze, H. H., Stanley, P., Marth, J. D., Bertozzi, C. R., Hart, G. W., and Etzler, M. E. (2009) Proteomics 9, 5398-5399