Discovery of Very Late Antigen-4 (VLA-4, α4β 1 integrin) allosteric antagonists

Journal of Biological Chemistry

Volumn 286, Issue 7, 2011, Pages 5455-5463

  Chigaev, Alexandre ^a   Wu, Yang ^a   Williams, D Bart ^a   Smagley, Yelena ^a   Sklar, Larry A ^a  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION ASSAYS; ADHESION RECEPTORS; CELL-BASED; CELLULAR AGGREGATES; CHEMICAL LIBRARIES; COLONY FORMING UNITS; EXTRACELLULAR MATRICES; IN-VITRO; IN-VIVO; INTEGRIN LIGANDS; INTEGRINS; LIGAND BINDING AFFINITY; LIGAND-RECEPTOR INTERACTIONS; LOW TEMPERATURES; ORDERS OF MAGNITUDE; PERIPHERAL BLOOD; SMALL MOLECULES;

ANTIGENS; ASSAYS; BINDING ENERGY; CELL ADHESION; CHEMICAL DETECTION; DISEASES; LIGANDS;

ADHESION;

METITEPINE; METIXENE; PERPHENAZINE; PLERIXAFOR; THIORIDAZINE; TRIFLUOPERAZINE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 4; VERY LATE ACTIVATION ANTIGEN 4 ANTAGONIST;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL ADHESION; CELL ASSAY; CELL DISRUPTION; COLONY FORMING UNIT; COMPETITIVE INHIBITION; CONTROLLED STUDY; DOSE RESPONSE; HEAT SENSITIVITY; HUMAN; HUMAN CELL; IMMUNOMODULATION; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; LIGAND BINDING; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL MOBILIZATION; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; ANIMALS; HEMATOPOIETIC STEM CELL MOBILIZATION; HEMATOPOIETIC STEM CELLS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; INTEGRIN ALPHA4BETA1; MICE; U937 CELLS;

MUS;

EID: 79953127478     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.162636     Document Type: Article

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