Up-regulation of cytolytic functions of human Vδ2- γδ T lymphocytes through engagement of ILT2 expressed by tumor target cells

Blood

Volumn 117, Issue 10, 2011, Pages 2864-2873

  Harly, Christelle ^a   Peyrat, Marie Alix ^a   Netzer, Sonia ^b   Déchanet Merville, Julie ^b   Bonneville, Marc ^a   Scotet, Emmanuel ^a  

^a Team 12   (France)

^b CNRS Bordeaux Segalen University   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 256; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR ILT2; T LYMPHOCYTE RECEPTOR DELTA CHAIN; UNCLASSIFIED DRUG;

ANTIBODY SPECIFICITY; ANTIGENICITY; ARTICLE; B LYMPHOCYTE; CELL ACTIVATION; CELL CLONE; CELL INTERACTION; CELL SPECIFICITY; CELL TRANSFORMATION; CONTROLLED STUDY; CYTOTOXICITY; EFFECTOR CELL; GAMMA DELTA T LYMPHOCYTE; HUMAN; HUMAN CELL; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TARGET CELL; UPREGULATION;

EID: 79953121252     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-09-309781     Document Type: Article

References (50)

1. Haas W, Pereira P, Tonegawa S. Gamma/delta cells. Annu Rev Immunol. 1993;11:637-685. (Pubitemid 23115020)
2. Hayday AC. [gamma][delta] cells: a right time and a right place for a conserved third way of protection. Annu Rev Immunol. 2000;18:975-1026.
3. Hayday AC. Gammadelta T cells and the lymphoid stress-surveillance response. Immunity. 2009;31(2):184-196.
4. Bonneville M, O'Brien RL, Born WK. Gammadelta T cell effector functions: a blend of innate programming and acquired plasticity. Nat Rev Immunol. 2010;10(7):467-478.
5. Bonneville M, Fournie JJ. Sensing cell stress and transformation through Vgamma9Vdelta2 T cell-mediated recognition of the isoprenoid pathway metabolites. Microbes Infect. 2005;7(3):503-509. (Pubitemid 40603450)
6. Bonneville M, Scotet E. Human Vgamma9Vdelta2 T cells: promising new leads for immunotherapy of infections and tumors. Curr Opin Immunol. 2006;18(5):539-546. (Pubitemid 44311448)
7. Thedrez A, Sabourin C, Gertner J, et al. Self/non-self discrimination by human gammadelta T cells: simple solutions for a complex issue? Immunol Rev. 2007;215:123-135.
8. Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH, Spies T. Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc Natl Acad Sci U S A. 1999;96(12):6879-6884. (Pubitemid 29274978)
9. Groh V, Steinle A, Bauer S, Spies T. Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. Science. 1998;279(5357):1737-1740. (Pubitemid 28164472)
10. Spada FM, Grant EP, Peters PJ, et al. Self-recognition of CD1 by gamma/delta T cells: implications for innate immunity. J Exp Med. 2000;191(6):937-948.
11. Flament C, Benmerah A, Bonneville M, Triebel F, Mami-Chouaib F. Human TCR-gamma/delta alloreactive response to HLA-DR molecules: comparison with response of TCR-alpha/beta. J Immunol. 1994;153(7):2890-2904.
12. Kato Y, Tanaka Y, Tanaka H, Yamashita S, Minato N. Requirement of species-specific interactions for the activation of human gamma delta T cells by pamidronate. J Immunol. 2003;170(7):3608-3613. (Pubitemid 36359229)
13. Kato Y, Tanaka Y, Hayashi M, Okawa K, Minato N. Involvement of CD166 in the activation of human γδT cells by tumor cells sensitized with nonpeptide antigens. J Immunol. 2006;177(2):877-884. (Pubitemid 44036588)
14. Pietschmann K, Beetz S, Welte S, et al. Toll-like receptor expression and function in subsets of human gammadelta T lymphocytes. Scand J Immunol. 2009;70(3):245-255.
15. Angelini DF, Borsellino G, Poupot M, et al. FcgammaRIII discriminates between 2 subsets of Vgamma9Vdelta2 effector cells with different responses and activation pathways. Blood. 2004;104(6):1801-1807. (Pubitemid 39202290)
16. Halary F, Peyrat MA, Champagne E, et al. Control of self-reactive cytotoxic T lymphocytes expressing gamma delta T cell receptors by natural killer inhibitory receptors. Eur J Immunol. 1997;27(11):2812-2821. (Pubitemid 27478348)
17. Das H, Groh V, Kuijl C, et al. MICA engagement by human Vgamma2Vdelta2 T cells enhances their antigen-dependent effector function. Immunity. 2001;15(1):83-93. (Pubitemid 32728322)
18. Nedellec S, Sabourin C, Bonneville M, Scotet E. NKG2D costimulates human Vgamma9Vdelta2 T cell antitumor cytotoxicity through protein kinase Ctheta-dependent modulation of early TCR-induced calcium and transduction signals. J Immunol. 2010;185(1):55-63.
19. Trichet V, Benezech C, Dousset C, Gesnel MC, Bonneville M, Breathnach R. Complex interplay of activating and inhibitory signals received by Vgamma9Vdelta2 T cells revealed by target cell beta2-microglobulin knockdown. J Immunol. 2006;177(9):6129-6136. (Pubitemid 44628829)
20. Colonna M, Navarro F, Bellon T, et al. A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells. J Exp Med. 1997;186(11):1809-1818. (Pubitemid 27524591)
21. Cosman D, Fanger N, Borges L, et al. A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules. Immunity. 1997;7(2):273-282. (Pubitemid 27392018)
22. Vitale M, Castriconi R, Parolini S, et al. The leukocyte Ig-like receptor (LIR)-1 for the cytomegalovirus UL18 protein displays a broad specificity for different HLA class I alleles: analysis of LIR-1 + NK cell clones. Int Immunol. 1999;11(1):29-35. (Pubitemid 29037586)
23. Saverino D, Fabbi M, Ghiotto F, et al. The CD85/LIR-1/ILT2 inhibitory receptor is expressed by all human T lymphocytes and down-regulates their functions. J Immunol. 2000;165(7):3742-3755. (Pubitemid 32057280)
24. Lamar DL, Weyand CM, Goronzy JJ. Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineages. Blood. 2010;115(16):3278-3286.
25. Geronimi F, Richard E, Redonnet-Vernhet I, et al. Highly efficient lentiviral gene transfer in CD34+ and CD34+/38-/lin- cells from mobilized peripheral blood after cytokine prestimulation. Stem Cells. 2003;21(4):472-480. (Pubitemid 36793489)
26. Shimizu Y, Geraghty DE, Koller BH, Orr HT, DeMars R. Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibility complex genes in mutant lymphoblastoid cells. Proc Natl Acad Sci U S A. 1988;85(1):227-231.
27. Colonna M, Samaridis J, Cella M, et al. Human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J Immunol. 1998;160(7):3096-3100. (Pubitemid 28164696)
28. Davodeau F, Peyrat MA, Hallet MM, et al. Close correlation between Daudi and mycobacterial antigen recognition by human gamma delta T cells and expression of V9JPC1 gamma/V2DJC delta-encoded T cell receptors. J Immunol. 1993;151(3):1214-1223. (Pubitemid 23219257)
29. Soderstrom K, Bucht A, Halapi E, et al. High expression of V gamma 8 is a shared feature of human gamma delta T cells in the epithelium of the gut and in the inflamed synovial tissue. J Immunol. 1994;152(12):6017-6027.
30. Soderstrom K, Bucht A, Halapi E, et al. Human gamma delta T-cells in the epithelium of the gut and in the inflamed synovial tissue preferentially express the V gamma 8 T-cell receptor chain. Ann N Y Acad Sci. 1995;756:406-409.
31. Robak E, Blonski JZ, Bartkowiak J, Niewiadomska H, Sysa-Jedrzejowska A, Robak T. Circulating TCR gammadelta cells in the patients with systemic lupus erythematosus. Mediators Inflamm. 1999;8(6):305-312. (Pubitemid 30232876)
32. Robak E, Niewiadomska H, Robak T, et al. Lymphocyctes Tgammadelta in clinically normal skin and peripheral blood of patients with systemic lupus erythematosus and their correlation with disease activity. Mediators Inflamm. 2001;10(4):179-189. (Pubitemid 32846107)
33. Taupin JL, Halary F, Dechanet J, et al. An enlarged subpopulation of T lymphocytes bearing two distinct gammadelta TCR in an HIV-positive patient. Int Immunol. 1999;11(4):545-552. (Pubitemid 29179002)
34. Dechanet J, Merville P, Lim A, et al. Implication of gammadelta T cells in the human immune response to cytomegalovirus. J Clin Invest. 1999;103(10):1437-1449. (Pubitemid 29535500)
35. Halary F, Pitard V, Dlubek D, et al. Shared reactivity of Vδ2(neg) γδ T cells against cytomegalovirus- infected cells and tumor intestinal epithelial cells. J Exp Med. 2005;201(10):1567-1578. (Pubitemid 40721002)
36. Knight A, Madrigal AJ, Grace S, et al. The role of Vdelta2-negative gamma-delta T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplants. Blood. 2010;116(12):2164-2172.
37. Vermijlen D, Brouwer M, Donner C, et al. Human cytomegalovirus elicits fetal gammadelta T cell responses in utero. J Exp Med. 2010;207(4):807-821.
38. De Rosa SC, Mitra DK, Watanabe N, Herzenberg LA, Roederer M. Vdelta1 and Vdelta2 gammadelta T cells express distinct surface markers and might be developmentally distinct lineages. J Leukoc Biol. 2001;70(4):518-526. (Pubitemid 32954762)
39. Hacker G, Kromer S, Falk M, Heeg K, Wagner H, Pfeffer K. V delta 1+ subset of human gamma delta T cells responds to ligands expressed by EBV-infected Burkitt lymphoma cells and transformed B lymphocytes. J Immunol. 1992;149(12):3984-3989. (Pubitemid 23068881)
40. Bartkowiak J, Kulczyck-Wojdala D, Blonski JZ, Robak T. Molecular diversity of gammadelta T cells in peripheral blood from patients with B-cell chronic lymphocytic leukaemia. Neoplasma. 2002;49(2):86-90. (Pubitemid 34493666)
41. Brown D, Trowsdale J, Allen R. The LILR family: modulators of innate and adaptive immune pathways in health and disease. Tissue Antigens. 2004;64(3):215-225. (Pubitemid 39120446)
42. Vivier E, Anfossi N. Inhibitory NK-cell receptors on T cells: witness of the past, actors of the future. Nat Rev Immunol. 2004;4(3):190-198. (Pubitemid 38339085)
43. Dietrich J, Cella M, Colonna M. Ig-like transcript 2 (ILT2)/leukocyte Ig-like receptor 1 (LIR1) inhibits TCR signaling and actin cytoskeleton reorganization. J Immunol. 2001;166(4):2514-2521. (Pubitemid 32173488)
44. Young NT, Waller EC, Patel R, Roghanian A, Austyn JM, Trowsdale J. The inhibitory receptor LILRB1 modulates the differentiation and regulatory potential of human dendritic cells. Blood. 2008;111(6):3090-3096.
45. Merlo A, Tenca C, Fais F, et al. Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes. Clin Diagn Lab Immunol. 2005;12(6):705-712.
46. Geppert TD, Wacholtz MC, Patel SS, Lightfoot E, Lipsky PE. Activation of human T-cell clones and Jurkat cells by cross-linking class I MHC molecules. J Immunol. 1989;142(11):3763-3772. (Pubitemid 19164401)
47. Sambhara SR, Miller RG. Programmed cell death of T cells signaled by the T cell receptor and the alpha 3 domain of class I MHC. Science. 1991;252(5011):1424-1427. (Pubitemid 21917060)
48. Amirayan N, Machy P. MHC class I molecules are implicated in costimulatory signals during TCR/CD3-induced activation. Cell Immunol. 1996;168(1):1-12. (Pubitemid 26083195)
49. Agrawal S, Marquet J, Freeman GJ, et al. Cutting edge: MHC class I triggering by a novel cell surface ligand costimulates proliferation of activated human T cells. J Immunol. 1999;162(3):1223-1226. (Pubitemid 29306988)
50. Anfossi N, Doisne JM, Peyrat MA, et al. Coordinated expression of Ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells. J Immunol. 2004;173(12):7223-7229. (Pubitemid 39628158)