In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs

Science Signaling

Volumn 4, Issue 165, 2011, Pages

  Lau, Ken S ^a,b,c   Juchheim, Alwin M ^a,b   Cavaliere, Kimberly R ^a   Philips, Sarah R ^a   Lauffenburger, Douglas A ^c   Haigis, Kevin M ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Massachusetts Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; TUMOR NECROSIS FACTOR ALPHA; BENZAMIDE DERIVATIVE; DIPHENYLAMINE; DRUG DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOPROTEIN; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR 2;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; IN VIVO STUDY; INTESTINE EPITHELIUM CELL; MALE; MOUSE; NONHUMAN; PARTIAL LEAST SQUARES REGRESSION; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYSTEM ANALYSIS; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CLUSTER ANALYSIS; DISCRIMINANT ANALYSIS; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DUODENUM; GENETICS; ILEUM; METABOLISM; MOUSE MUTANT; REGRESSION ANALYSIS; TIME; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BENZAMIDES; BLOTTING, WESTERN; CELL PROLIFERATION; CLUSTER ANALYSIS; DIPHENYLAMINE; DISCRIMINANT ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DUODENUM; ILEUM; LEAST-SQUARES ANALYSIS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; PHOSPHOPROTEINS; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE II; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79953102845     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001338     Document Type: Article

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37. Acknowledgments: We thank J. Pritchard, L. Kleiman, D. Clarke, and B. Cosgrove for comments on the manuscript. Funding: This work was supported by grants from the National Institute of General Medical Sciences (R01-GM088827 to K.M.H. and D.A.L.) and the National Cancer Institute (U54-CA112967 to D.A.L.). K.S.L. is a Robert Black Fellow of the Damon Runyon Cancer Research Foundation. Author contributions: K.S.L., D.A.L., and K.M.H. designed the experiments; K.S.L., A.M.J., K.R.C., and S.R.P. conducted the experiments; K.S.L. performed computational analyses; K.S.L., D.A.L., and K.M.H. wrote the manuscript; all of the authors discussed the results and edited the manuscript; and K.M.H. coordinated all aspects of the project. Competing interests: The authors declare that they have no competing financial interests.