Targeting MOG expression to dendritic cells delays onset of experimental autoimmune disease

Autoimmunity

Volumn 44, Issue 3, 2011, Pages 177-187

  Ko, Hyun Ja ^a   Chung, Jie Yu ^a   Nasa, Zeyad ^a   Chan, James ^a   Siatskas, Christopher ^b   Toh, Ban Hock ^a   Alderuccio, Frank ^a  

^a MONASH UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

bone marrow transduction; dendritic cells; Experimental autoimmune encephalomyelitis; gene therapy; myelin oligodendrocyte glycoprotein; tolerance

Indexed keywords

AUTOANTIGEN; MYELIN OLIGODENDROCYTE GLYCOPROTEIN; RETROVIRUS VECTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; BONE MARROW CELL; CELL TRANSPLANTATION; CONTROLLED STUDY; DENDRITIC CELL; DNA MODIFICATION; GENE EXPRESSION; GENETIC TRANSDUCTION; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN TARGETING; TRANSGENE;

ANIMALS; ANTIGENS, CD11C; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; CELL LINE; DENDRITIC CELLS; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENE ORDER; GENE THERAPY; GENETIC VECTORS; MICE; MICE, INBRED C57BL; MYELIN-ASSOCIATED GLYCOPROTEIN; NIH 3T3 CELLS; PROMOTER REGIONS, GENETIC; RETROVIRIDAE;

EID: 79953102525     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.3109/08916934.2010.515274     Document Type: Article

References (46)

1. Davidson A, Diamond B. Autoimmune diseases. N EnglJ Med 2001;345:340-350.
2. Rose NR, Mackay IR. The autoimmune diseases. 4th ed. San Diego, CA: Elsevier Academic Press; 2006.
3. Casetta I, Iuliano G, Filippini G. Azathioprine for multiple sclerosis. Cochrane Database Syst Rev 2007;(4):CD003982.
4. Schacke H, Docke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 2002;96: 23-43. (Pubitemid 35346616)
5. Alaez C, Loyola M, Murguia A, Flores H, Rodriguez A, Ovilla R, Ignacio G, Amador R, Salinas V, Perez F, Rodriguez D, Morales Z, Llinguin G, Vazquez A, Altamirano A, Gorodezky C Hematopoietic stem cell transplantation (HSCT): An approach to autoimmunity Autoimmun Rev 2006;5:167-179. (Pubitemid 43234181)
6. Mancardi G, Saccardi R. Autologous haematopoietic stem-cell transplantation in multiple sclerosis. Lancet Neurol 2008;7: 626-636.
7. Nash RA, McSweeney PA, Crofford LJ, Abidi M, Chen CS, Godwin JD, Gooley TA, Holmberg L, Henstorf G, LeMaistre CF, Mayes MD, McDonagh KT, McLaughlin B, Molitor JA, Nelson JL, Shulman H, Storb R, Viganego F, Wener MH, Seibold JR, Sullivan KM, Furst DE. High-dose immunosuppressive therapy and autologous hematopoietic cell transplantation for severe systemic sclerosis: Long-term follow-up of the US multicenter pilot study. Blood 2007;110: 1388-1396. (Pubitemid 47281441)
8. Dazzi F, Tyndall A. Cell therapy for autoimmune diseases. Arthritis Res Ther 2007;9:206.
9. Marmont AM, Burt RK. Hematopoietic stem cell transplan-tation for systemic lupus erythematosus, the antiphospholipid syndrome and bullous skin diseases. Autoimmunity 2008;41: 639-647.
10. Blanco Y, Saiz A, Carreras E, Graus F. Autologous haematopoietic-stem- cell transplantation for multiple scler-osis. Lancet Neurol 2005;4:54-63. (Pubitemid 40023236)
11. Tyndall A, Saccardi R. Haematopoietic stem cell transplan-tation in treatment of severe autoimmune disease: Results from phase I/II studies, prospective randomized trials and future directions. Clin Exp Immunol 2005;141:1-9. (Pubitemid 40904634)
12. Couzin J. Immunology. Gently soothing a savage immune system. Science 2002;296:456-458. (Pubitemid 34408644)
13. Hacein-Bey-Abina S, Le Deist F, Carlier F, Bouneaud C, Hue C, De Villartay JP, Thrasher AJ, Wulffraat N, Sorensen R, Dupuis-Girod S, Fischer A, Davies EG, Kuis W, Leiva L, Cavazzana-Calvo M. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N EnglJ Med 2002;346:1185-1193. (Pubitemid 34984579)
14. Aiuti A, Cattaneo F, Galimberti S, Benninghoff U, Cassani B, Callegaro L, Scaramuzza S, Andolfi G, Mirolo M, Brigida I, Tabucchi A, Carlucci F, Eibl M, Aker M, Slavin S, Al-Mousa H, Al Ghonaium A, Ferster A, Duppenthaler A, Notarangelo L, Wintergerst U, Buckley RH, Bregni M, Marktel S, Valsecchi MG, Rossi P, Ciceri F, Miniero R, Bordignon C, Roncarolo MG. Gene therapy for immunodeficiency due to adenosinen deaminase deficiency. N Engl J Med 2009;360: 447-458.
15. Chan J, Ban EJ, Chun KH, Wang B, Backstrom BT, Bernard C, Toh BH, Alderuccio F. Transplantation of bone marrow transduced to express self-antigen establishes dele-tional tolerance and permanently remits autoimmune disease. J Immmunol 2008;181:7571-7580.
16. Xu B, Haviernik P, Wolfraim LA, Bunting KD, Scott DW. Bone marrow transplantation combined with gene therapy to induce antigen-specific tolerance and ameliorate EAE. Mol Ther 2006;13:42-48. (Pubitemid 41763481)
17. Hacein-Bey-Abina S, Garrigue A, Wang GP, Soulier J, Lim A, Morillon E, Clappier E, Caccavelli L, Delabesse E, Beldjord K, Asnafi V, MacIntyre E, Dal Cortivo L, Radford I, Brousse N, Sigaux F, Moshous D, Hauer J, Borkhardt A, Belohradsky BH, Wintergerst U, Velez MC, Leiva L, Sorensen R, Wulffraat N, Blanche S, Bushman FD, Fischer A, Cavazzana-Calvo M. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy ofSCID-X1. J Clin Invest 2008;118:3132-3142.
18. Kohn DB, Candotti F Gene therapy fulfilling its promise. N EnglJ Med 2009;360:518-521.
19. Gallegos AM, Bevan MJ. Central tolerance: Good but imperfect. Immunol Rev 2006;209:290-296.
20. Proietto AI, van Dommelen S, Wu L. The impact of circulating dendritic cells on the development and differen-tiation of thymocytes. Immunol Cell Biol 2009;87:39-45.
21. Brocker T, Riedinger M, Karjalainen K Targeted expression of majorhistocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J Exp Med 1997;185: 541-550. (Pubitemid 27078372)
22. Dresch C, Edelmann SL, Marconi P, Brocker T Lentiviral-mediated transcriptional targeting of dendritic cells for induction of T cell tolerance in vivo. J Immunol 2008;181: 4495-4506.
23. Kitamura T, Koshino Y, Shibata F, Oki T, Nakajima H, Nosaka T, Kumagai H. Retrovirus-mediated gene transfer and expression cloning: Powerful tools in functional genomics. Exp Hematol 2003;31:1007-1014. (Pubitemid 37329742)
24. Yu SF, von Ruden T, Kantoff PW, Garber C, Seiberg M, Ruther U, Anderson WF, Wagner EF, Gilboa E. Self-inactivating retroviral vectors designed for transfer of whole genes into mammalian cells. ProcNatl Acad Sci USA 1986;83: 3194-3198. (Pubitemid 16043003)
25. Luckashenak N, Schroeder S, Endt K, Schmidt D, Mahnke K, Bachmann MF, Marconi P, Deeg CA, Brocker T Constitutive crosspresentation of tissue antigens by dendritic cells controls CD8+ T cell tolerance in vivo. Immunity 2008;28:521-532.
26. Pear WS, Nolan GP, Scott ML, Baltimore D. Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci USA 1993;90:8392-8396. (Pubitemid 23277674)
27. Chan J, Clements W, Field J, Lock P, Yap F, Toh BH, Alderuccio F. Transplantation of bone marrow genetically engineered to express proinsulin II protects against auto-immune insulitis in NOD mice. J Gene Med 2006;8: 1281-1290. (Pubitemid 44782507)
28. Limon A, Briones J, Puig T, Carmona M, Fornas O, Cancelas JA, Nadal M, Garcia J, Rueda F, Barquinero J. High-titer retroviral vectors containing the enhanced green fluorescent protein gene for efficient expression in hemato-poietic cells. Blood 1997;90:3316-3321. (Pubitemid 27473399)
29. Alderuccio F, Chan J, Toh BH. Tweaking the immune system: Gene therapy-assisted autologous haematopoietic stem cell transplantation as a treatment for autoimmune disease. Autoimmunity 2008;41:679-685.
30. Karnezis T, Mandemakers W, McQualter JL, Zheng B, Ho PP, Jordan KA, Murray BM, Barres B, Tessier-Lavigne M, Bernard CC. The neurite outgrowth inhibitor Nogo A is involved in autoimmune-mediated demyelination. Nat Neuro-sci 2004;7:736-744. (Pubitemid 38859058)
31. Marmont A. Will heamatopoietic stem cell transplantation cure human autoimmune diseases? J Autoimmun 2008;30: 145-150.
32. Alderuccio F, Chan J, Scott DW, Toh BH. Gene therapy and bone marrow stem-cell transfer to treat autoimmune disease. Trends Mol Med 2009;15:344-351.
33. Gallegos AM, Bevan MJ. Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med 2004;200:1039-1049. (Pubitemid 39431128)
34. Stripecke R. Lentiviral vector-mediated genetic programming of mouse and human dendritic cells. Methods Mol Biol 2009; 506:139-158.
35. Mukhopadhaya A, Hanafusa T, Jarchum I, Chen YG, Iwai Y Serreze DV, Steinman RM, Tarbell KV, DiLorenzo TP. Selective delivery of beta cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8 + T cells in NOD mice. Proc Natl Acad Sci USA 2008;105: 6374-6379. (Pubitemid 351758353)
36. Dhodapkar MV, Steinman RM, Krasovsky J, Munz C, Bhardwaj N. Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells. J Exp Med 2001;193:233-238. (Pubitemid 32524454)
37. Hogquist KA, Baldwin TA, Jameson SC. Central tolerance: Learning self-control in the thymus. Nat Rev Immunol 2005; 5:772-782. (Pubitemid 41400851)
38. Liston A, Lesage S, Wilson J, Peltonen L, Goodnow CC. Aire regulates negative selection of organ-specific T cells. Nat Immunol 2003;4:350-354. (Pubitemid 36432317)
39. Zehn D, Bevan MJ. T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity 2006;25: 261-270. (Pubitemid 44224142)
40. Bailey SL, Schreiner B, McMahon EJ, Miller SD. CNS myeloid DCs presenting endogenous myelin peptides "preferentially" polarize CD4 + T(H)-17 cells in relapsing EAE. Nat Immunol 2007;8:172-180. (Pubitemid 46152648)
41. Werner-Klein M, Dresch C, Marconi P, Brocker T. Transcriptional targeting of B cells for induction ofperipheral CD8 T cell tolerance. J Immunol 2007;178:7738-7746. (Pubitemid 46898045)
42. Song L, Wang J, Wang R, Yu M, Sun Y, Han G, Li Y, Qian J, Scott DW, Kang Y, Soukhareva N, Shen B. Retroviral delivery of GAD-IgG fusion construct induces tolerance and modu-lates diabetes: A role for CD4+ regulatory T cells and TGF-beta? Gene Ther 2004;11:1487-1496. (Pubitemid 39359456)
43. Melo ME, Qian J, El-Amine M, Agarwal RK, Soukhareva N, Scott DW Gene transfer of Ig-fusion proteins into B cells prevents and treats autoimmune diseases. J Immunol 2002; 168:4788-4795. (Pubitemid 34441388)
44. Agarwal RK, Kang Y, Zambidis E, Scott DW, Chan CC, Caspi RR Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental auto-immune uveitis. J Clin Invest 2000;106:245-252. (Pubitemid 30483128)
45. Perchellet A, Brabb T, Goverman JM. Crosspresentation by nonhematopoietic and direct presentation by hematopoietic cells induce central tolerance to myelin basic protein. Proc Natl Acad Sci USA 2008;105:14040-14045.
46. Tian C, Bagley J, Iacomini J. Expression of antigen on mature lymphocytes is required to induce T cell tolerance by gene therapy. J Immunol 2002;169:3771-3776.