Procalcitonin to guide duration of antibiotic therapy in intensive care patients: A randomized prospective controlled trial

Critical Care

Volumn 13, Issue 3, 2009, Pages

  Hochreiter, Marcel ^a   Köhler, Thomas ^a   Schweiger, Anna Maria ^a   Keck, Fritz Sixtus ^a   Bein, Berthold ^b   von Spiegel, Tilman ^a   Schroeder, Stefan ^a  

^a West Coast Hospital   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPENICILLIN; AMPICILLIN; ANTIBIOTIC AGENT; BETA LACTAMASE INHIBITOR; C REACTIVE PROTEIN; CARBAPENEM; CEPHALOSPORIN DERIVATIVE; INTERLEUKIN 6; NITROIMIDAZOLE; PROCALCITONIN; QUINOLINE DERIVED ANTIINFECTIVE AGENT; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; CALCITONIN; PROTEIN PRECURSOR;

AGED; ANTIBIOTIC THERAPY; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; HOSPITAL PATIENT; HUMAN; INTENSIVE CARE UNIT; LEUKOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PATIENT MONITORING; PERITONITIS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SOFT TISSUE INFECTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TREATMENT DURATION; UROSEPSIS; BLOOD; DIFFERENTIAL DIAGNOSIS; DRUG MONITORING; POSTOPERATIVE COMPLICATION; PROSPECTIVE STUDY; SEPSIS;

AGED; ANTI-BACTERIAL AGENTS; BIOLOGICAL MARKERS; CALCITONIN; DIAGNOSIS, DIFFERENTIAL; DRUG MONITORING; FEMALE; HUMANS; MALE; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; PROTEIN PRECURSORS; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 67650917117     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc7903     Document Type: Article

References (23)

1. Kumar A Roberts D Wood KE Light B Parrillo JE Sharma S Suppes R Feinstein D Zanotti S Taiberg L Gurka D Cheang M Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock Crit Care Med 2006, 34:1589-1596. 16625125
2. ACCP/SCCM Consensus Conference Committee Definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis Crit Care Med 1992, 20:864-874. 1597042
3. Oberhoffer M Vogelsang H Russwurm S Hartung T Reinkart K Outcome prediction by traditional and new markers of inflammation in patients with sepsis Clin Chem Lab Med 1999, 37:363-368. 10353484
4. Peres Bota D Lopes Ferreira F Mélot C Vincent JL Body temperature alterations in the critically ill Intensive Care Med 2004, 30:811-816. 15127194
5. Bossink A Groeneveld A Hack C Thijs L The clinical host response to microbial infection in medical patients with fever Clin Infect Dis 1999, 29:398-407. 10476749
6. Christ-Crain M Müller B Procalcitonin in bacterial infections - hype, hope, more or less? Swiss Medical Weekly 2005, 135:451-460. 16208582
7. Harbarth S Holeckova K Froidevaux C Pittet D Ricou B Grau GE Vadas L Pugin J Geneva Sepsis Network Diagnostic value of procalcitonin, interleukin 6 and interleukin 8 in critically ill patiens admitted with suspected sepsis Am J Respir Crit Care Med 2001, 164:396-402. 11500339
8. Christ-Crain M Stolz D Bingisser R Müller C Miedinger D Huber PR Zimmerli W Harbarth S Tamm M Müller B Procalcitonin guidance of antibiotic therapy in community - acquired pneumonia Am J Respir Crit Care Med 2006, 174:84-93. 16603606
9. Nobre V Harbarth S Graf JD Rohner P Pugin J Use of procalcitonin to shorten antibiotic treatment duration in septic patients. A randomized trial Am J Respir Crit Care Med 2008, 177:498-505. 18096708
10. Welte T Antibiotikatherapie bei Sepsis Dtsch Med Wochenschr 2004, 129:2609-2613. 15558411
11. Chastre J Wolff M Fagon JY Chevret S Thomas F Wermert D Clementi E Gonzalez J Jusserand D Asfar P Perrin D Fieux F Aubas S PneumA Trial Group Comparison of 8 vs 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: A randomized trial JAMA 2003, 290:2588-2598. 14625336.
12. Singh N Rogers P Atwood CW Wagener MM Yu VL Short-course empiric antibiotic therapy for patients with pulmonary infiltrates in the intensive care unit. A proposed solution for indiscriminate antibiotic prescription Am J Respir Crit Care Med 2000, 162:505-511. 10934078
13. Yu V Singh N Excessive antimicrobial usage cause measurable harm to patients with suspected ventilator - associated pneumonia Intensive Care Med 2004, 30:735-738. 14991088
14. Harbarth S Antibiotikatherapie - Einfluss des Antibiotikaverbrauchs auf Resistenzbildung und - selektion Anästhesiol Intensivmed Schmerzther 2007, 2:130-135.
15. Marchetti O Bille J Fluckiger U Eggimann P Ruef C Garbino J Caladra T Glauser MP Tauber MG Pittet D Fungal Infection Network of Switzerland. Epidermiology of candidemia in Swiss tertiary care hospitals: Seculare trends, 1991-2000 Clin Infect Dis 2004, 38:311-320. 14727199
16. Vincent JL Moreno R Takala J Willatts S De Mendonca A Bruining H Reinhart CK Suter PM Thijs LG The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine Intensive Care Med 1996, 22:707-710. 8844239
17. Engelmann L Die Diagnose der Sepsis Diagnostik und Intensivtherapie bei Sepsis und Multiorganversagen Darmstadt: Steinkopff Engelmann L, Schuster H-P 1 2006:2-10.
18. Meisner M Tschaikowsky K Palmaers T Schmidt J Comparison of Procalcitonin (PCT) and C-reactive protein (CRP) plasma concentrations at different SOFA scores during the course of Sepsis and MODS Critical Care 1999, 3:45-50. 29013 11056723
19. Engel C Brunkhorst FM Bone HG Brunkhorst R Gerlach H Grond S Gruendling M Huhle G Jaschinski U John S Mayer K Oppert M Olthoff D Quintel M Ragaller M Rossaint R Stuber F Weiler N Welte T Bogatsch H Hartog C Loeffler M Reinhart K Epidemiology of sepsis in Germany: Results from a national prospective multicenter study Intensive Care Med 2007, 33:606-618. 17323051
20. Micek S Heuring TJ Hollands JM Shah RA Kollef MH Optimizing antibiotic treatment for ventilator-associated pneumonia Pharmacotherapy 2006, 26:204-213. 16466325
21. Iregui M Ward S Sherman G Fraser VJ Kollef MH Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia Chest 2002, 122:262-268. 12114368
22. Meyer E, Jonas D, Schwab F, Gastmeier P, Rüden H, Daschner FD: SARI: Surveillance of antibiotic use and bacterial resistance in German intensive care units. Correlation between antibiotic use and the emergence of resistance. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2004, 47:345-351.
23. Welte T Die nosokomiale Pneumonie Intensivmed 2006, 43:301-309.