Extracellular heat shock protein 60 (Hsp60) levels in children with septic shock

Inflammation Research

Volumn 56, Issue 5, 2007, Pages 216-219

  Wheeler, D S ^a,b   Lahni, P ^b   Odoms, K ^b   Jacobs, B R ^a,b   Carcillo, J A ^c   Doughty, L A ^a,b   Wong, H R ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN S HOSPITAL RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

Children; Danger signal; Extracellular; Heat shock proteins; Hsp60; Pediatrics; Sepsis; Septic shock; SIRS

Indexed keywords

HEAT SHOCK PROTEIN 60;

ANALYSIS OF VARIANCE; ARTICLE; BLOOD SAMPLING; CHILD HOSPITALIZATION; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; CRITICALLY ILL PATIENT; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR SPACE; FEMALE; HOSPITAL ADMISSION; HOST; HUMAN; IMMUNOMODULATION; INNATE IMMUNITY; KRUSKAL WALLIS TEST; MAJOR CLINICAL STUDY; MALE; NEWBORN; PATHOGENESIS; PLASMA; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; SEPTIC SHOCK; TERTIARY HEALTH CARE; UPREGULATION;

ADOLESCENT; ADULT; CASE-CONTROL STUDIES; CHAPERONIN 60; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INFANT; INFANT, NEWBORN; INFLAMMATION; MALE; PILOT PROJECTS; RETROSPECTIVE STUDIES; SHOCK, SEPTIC;

EID: 34250899756     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-007-6108-4     Document Type: Article

References (38)

1. Wong HR, Wispe JR. The stress response and the lung. Am J Physiol 1997; 273: L1-9.
2. Wong HR. Potential protective role of the heat shock response in sepsis. New Horiz 1998; 6: 194-200.
3. Wheeler DS, Wong HR. The Heat Shock Response and Transplantation Immunology. In: Wilkes DS, Burlingham WJ, editors. Immunobiology of Organ Transplantation. New York: Kluwer Academic/Plenum Publishers; 2004. p. 525-43.
4. Bukau B, Horwich AL. The Hsp70 and Hsp60 chaperone machines. Cell 1998; 92(351-66).
5. Levy-Rimler G, Bell RE, Ben-Tal N, Azem A. Type I chaperonins: Not all are created equal. FEBS Lett 2002; 529: 1-5.
6. Richardson A, Landry SJ, Georgopoulos C. The ins and outs of a molecular chaperone machine. Trends Biochem Sci 1998; 23: 138-43.
7. Fink AL. Chaperone-mediated protein folding. Physiol Rev 1999; 79: 425-49.
8. Gao YL, Brosnan CF, Raine CS. Experimental autoimmune encephalomyelitis. Qualitative and semiquantitative differences in heat shock protein 60 expression in the central nervous system. J Immunol 1995; 154: 3548-56.
9. Soltys BJ, Gupta RS. Cell surface localization of the 60 kDa heat shock chaperonin protein (hsp60) in mammalian cells. Cell Biol Int 1997; 5: 315-20.
10. Belles C, Kuhl A, Nosheny R, Carding SR. Plasma membrane expression of heat shock protein 60 in vivo in response to infection. Infect Immun 1999; 67: 4191-200.
11. Todryk S, Melcher AA, Hardwick N, al e. Heat shock protein 70 induced during tumor cell killing induces Th1 cytokines and targets immature dendritic cell precursors to enhance antigen uptake. J Immunol 1999; 163: 1398-408.
12. Hantschel M, Pfister K, Jordan A, Scholz R, Andreesen R, Scmitz G, et al. HSP 70 plasma membrane expression on primary tumor biopsy material and bone marrow of leukemic patients. Cell Stress Chaperones 2000; 5: 438-42.
13. Guzhova I, Kislyakova K, Moskaliova O, Fridlanskaya I, Tytell M, Cheetham M, et al. In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance. Brain Res 2001; 914(1-2): 66-73.
14. Feng H, Zeng Y, Whitesell L, Katsanis E. Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity. Blood 2001; 97: 3505-12.
15. Barreto A, Gonzalez JM, Kabingu E, Asea A, Fiorentino S. Stress-induced release of HSC70 from human tumors. Cell Immunol 2003; 222: 97-104.
16. Martin CA, Carsons SE, Kowalewski R, Bernstein D, Valentino M, Santiago-Schwarz F. Aberrant extracellular and dendritic cell (DC) surface expression of heat shock protein (hsp)70 in the rheumatoid joint: possible mechanisms of hsp/DC-mediated cross-priming. J Immunol 2003; 171(11): 5736-42.
17. Gastpar R, Gross C, Rossbacher L, Ellwart J, Riegger J, Multhoff G. The cell surface-localized heat shock protein 70 epitope TKD induces migration and cytolytic activity selectively in human NK cells. J Immunol 2004; 172: 972-80.
18. Bausero MA, Page DT, Osinaga E, Asea A. Surface expression of Hsp25 and Hsp72 differentially regulates tumour growth and metastasis. Tumour Biol 2004; 25: 243-51.
19. Korbelik M, Sun J, Cecic I. Photodynamic therapy-induced cell surface expression and release of heat shock proteins: Relevance for tumor response. Cancer Res 2005; 65: 1018-26.
20. Lang A, Benke, Eitner F, Engel D, Ehrlich S, Breloer M, et al. Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: In vivo evidence for an immunologic danger signal. J Am Soc Nephrol 2005; 16: 383-91.
21. Johnson JD, Fleshner M. Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72. J Leukoc Biol 2006; 79: 425-34.
22. Matzinger P. An innate sense of danger. Semin Immunol 1998; 10: 399-415.
23. Wheeler DS, Zingarelli B, Wong HR. The Role of Extracellular Heat Shock Proteins in Cellular Inflammation and Injury. In: Vincent J-L, editor. 2006 Yearbook of Intensive Care and Emergency Medicine. Berlin, Germany: Springer; 2006. p. 45-51.
24. Hashiguchi N, Ogura H, Tanaka H, Koh T, Nakamori Y, Noborio M, et al. Enhanced expression of heat shock proteins in activated polymorphonuclear leukocytes in patients with sepsis. J Trauma 2001; 51(6): 1104-9.
25. Wheeler DS, Fisher LEJ, Catravas JD, Jacobs BR, Carcillo JA, Wong HR. Extracellular Hsp70 levels in children with septic shock. Pediatr Crit Care Med 2005; 6: 308-11.
26. Wong HR, Doughty LA, Wedel N, White M, Nelson BJ, Havrilla N, et al. Plasma bactericidal/permeability-increasing protein concentrations in critically ill children with the sepsis syndrome. Pediatr Infect Dis J 1995; 14: 1087-91.
27. Krafte-Jacobs B, Brilli RB. Increased circulating thrombomodulin in children with septic shock. Crit Care Med 1998; 26: 933-8.
28. Proulx F, Fayon M, Farrell CA, Lacroix J, Gauthier M. Epidemiology of sepsis and multiple organ dysfunction syndrome in children. Chest 1996; 109: 1033-7.
29. Watson RS, Carcillo JA, Linde-Zwirble WT, Clermont G, Lidicker J, Angus DC. The epidemiology of severe sepsis in children in the United States. Am J Respir Crit Care Med 2003; 167: 695-701.
30. Asea A, Kraeft SK, Kurt-Jones EA, Stevenson MA, Chen LB, Finberg RW, et al. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine. Nat Med 2000; 6(4): 435-42.
31. Asea A. Chaperokine-induced signal transduction pathways. Exerc Immunol Rev 2003; 9: 25-33.
32. Vabulas RM, Ahmad-Nejad P, da Costa C, Miethke T, Kirschning CJ, Hacker H, et al. Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 2001; 276(33): 31332-9.
33. Pockley AG, Wu R, Lemne C, Kiessling R, de Faire U, Frostegard J. Circulating heat shock protein 60 is associated with early cardiovascular disease. Hypertension 2000; 36(2): 303-7.
34. Xu Q, Schett G, Perschinka H, Mayr M, Egger G, Oberhollenzer F, et al. Serum soluble heat shock protein 60 is elevated in subjects with atherosclerosis in a general population. Circulation 2000; 102(1): 14-20.
35. Zhu J, Katz RJ, Quyyumi AA, Canos DA, Rott D, Csako G, et al. Association of serum antibodies to heat-shock protein 65 with coronary calcification levels: suggestion of pathogen-triggered autoimmunity in early atherosclerosis. Circulation 2004; 109(1): 36-41.
36. Lewthwaite J, Owen N, Coates A, Henderson B, Steptoe A. Circulating human heat shock protein 60 in the plasma of British civil servants: Relationship to physiological and psychosocial stress. Circulation 2002; 106: 196-201.
37. Pespeni M, Mackersie RC, Lee H, Morabito D, Hodnett M, Howard M, et al. Serum levels of hsp60 correlate with the development of acute lung injury after trauma. J Surg Res 2005; 126: 41-7.
38. Pittet J-F, Lee H, Morabito D, Howard MB, Welch WJ, Mackersie RC. Serum levels of Hsp72 measured early after trauma correlate with survival. J Trauma 2002; 52: 611-7.