Effect of emodin on neuropathic pain transmission mediated by P2X2/3 receptor of primary sensory neurons

Brain Research Bulletin

Volumn 84, Issue 6, 2011, Pages 406-413

  Gao, Yun ^a   Liu, Han ^a   Deng, Libin ^a   Zhu, Gaochun ^a   Xu, Changshui ^a   Li, Guilin ^a   Liu, Shuangmei ^a   Xie, Jinyan ^a   Liu, Jun ^a   Kong, Fanjun ^a   Wu, Raoping ^a   Li, Guodong ^a   Liang, Shangdong ^a  

^a NANCHANG UNIVERSITY   (China)

Author keywords

ATP; Emodin; Neuropathic pain; P2X2 3 receptor; Primary sensory neuron

Indexed keywords

CARBOXYMETHYLCELLULOSE; EMODIN; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2X3 RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC CONSTRICTION INJURY; CONTROLLED STUDY; DRUG EFFECT; INJURY; MALE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE CELL; SPINAL GANGLION;

ANALGESICS; ANIMALS; EMODIN; GANGLIA, SPINAL; MALE; NEURALGIA; PAIN MEASUREMENT; PROTEIN KINASE INHIBITORS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2X2; RECEPTORS, PURINERGIC P2X3; SENSORY RECEPTOR CELLS;

EID: 79953046095     PISSN: 03619230     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2011.01.017     Document Type: Article

References (52)

1. Andó R.D., Méhész B., Gyires K., Illes P., Sperlágh B. A comparative analysis of the activity of ligands acting at P2X and P2Y receptor subtypes in models of neuropathic, acute and inflammatory pain. Br. J. Pharmacol. 2010, 159:1106-1117.
2. Bennett G.J., Xie Y.K. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988, 33:87-107.
3. Bethea J.R., Dietrich W.D. Targeting the host inflammatory response in traumatic spinal cord injury. Curr. Opin. Neurol. 2002, 15:355-360.
4. Burgard E.C., Niforatos W., van Biesen T., Lynch K.J., Touma E., Metzger R.E., Kowaluk E.A., Jarvis M.F. P2X receptor-mediated ionic currents in dorsal root ganglion neurons. J. Neurophysiol. 1999, 82:1590-1598.
5. Burnstock G. P2X receptors in sensory neurones. Br. J. Anaesth. 2000, 84:476-488.
6. Burnstock G. Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol. Rev. 2006, 58:58-86.
7. Burnstock G. Purinergic P2 receptors as targets for novel analgesics. Pharmacol. Ther. 2006, 110:433-454.
8. Burnstock G. Physiology and pathophysiology of purinergic neurotransmission. Physiol. Rev. 2007, 87:659-797.
9. Chan T.C., Chang C.J., Koonchanok N.M., Geahlen R.L. Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor. Biochem. Biophys. Res. Commun. 1993, 193:1152-1158.
10. Chen Y., Shu Y., Zhao Z. Ectopic purinergic sensitivity develops at sites of chronic nerve constriction injury in rat. Neuroreport 1999, 10:2779-2782.
11. Chen H.C., Hsieh W.T., Chang W.C., Chung J.G. Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. Food Chem. Toxicol. 2004, 42:1251-1257.
12. Chizh B.A., Illes P. P2X receptors and nociception. Pharmacol. Rev. 2001, 53:553-568.
13. Cobacho N., De la Calle J.L., González-Escalada J.R., Paíno C.L. Levodopa analgesia in experimental neuropathic pain. Brain Res. Bull. 2010, 83:304-309.
14. Cockayne D.A., Hamilton S.G., Zhu Q.M., Dunn P.M., Zhong Y., Novakovic S., Malmberg A.B., Cain G., Berson A., Kassotakis L., Hedley L., Lachnit W.G., Burnstock G., McMahon S.B., Ford A.P. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 2000, 407:1011-1015.
15. Du Y., Ko K.M. Effects of emodin treatment on mitochondrial ATP generation capacity and antioxidant components as well as susceptibility to ischemia-reperfusion injury in rat hearts: single versus multiple doses and gender difference. Life Sci. 2005, 77:2770-2782.
16. Dunn P.M., Zhong Y., Bunstock G. P2X receptors in peripheral neurons. Prog. Neurobiol. 2001, 65:107-134.
17. Erlinge D., Burnstock G. P2 receptors in cardiovascular regulation and disease. Purinergic Signal. 2008, 4:1-20.
18. Gao Y., Xu C.S., Liang S.D., Zhang A.X., Mu S.N., Wang Y.X., Wan F. Effect of tetramethylpyrazine on primary afferent transmission mediated receptor in neuropathic pain states by P2X. Brain Res. Bull. 2008, 77:27-32.
19. Gao Y., Xu C.S., Yu K.H., Li G.L., Wana F., Liu S.M., Lin J.R., Liu H., Zhang J., Li X., Liang S.D. Effect of tetramethylpyrazine on DRG neuron P2X3 receptor involved in transmitting pain after burn. Burn 2010, 36:127-134.
20. Guedes R.P., Dal Bosco L., Araújo A.S., Belló-Klein A., Ribeiro M.F., Partata W.A. Sciatic nerve transection increases glutathione antioxidant system activity and neuronal nitric oxide synthase expression in the spinal cord. Brain Res. Bull. 2009, 80:422-427.
21. Jarvis M.F., Kowaluk E.A. Pharmacological characterization of P2X3 homomeric and heteromeric channels in nociceptive signaling and behavior. Drug Dev. Res. 2001, 220-231.
22. Jarvis M.F., Burgard E.C., Garaughty S.Mc., Honore P., Lynch K., Brennan T.J., Subieta A., Van Biesen T., Cartmell J., Bianchi B., Niforatos W., Kage K., Yu H., Mikusa J., Wismer C.T., Zhu C.Z., Chu K., Lee C.H., Stewart A.O., Polakowski J., Cox B.F., Kowaluk E., Williams M., Sullivan J., Caltynek F. A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:17179-17184.
23. Kennedy C., Assis T.S., Currie A.J., Rowan E.G. Crossing the pain barrier: P2 receptors as targets for novel analgesics. J. Physiol. 2003, 553:683-694.
24. Koyama M., Kelly T.R., Watanabe K.A. Novel type of potential anticancer agents derived from chrysophanol and emodin. Some structure-activity relationship studies. J. Med. Chem. 1988, 31:283-284.
25. Li C., Peoples R.W., Lanthorn T.H., Li Z.W., Weight F.F. Distinct ATP-activated currents in different types of neurons dissociated from rat dorsal root ganglion. Neurosci. Lett. 1999, 263:57-60.
26. Li G.L., Liu S.M., Zhang J., Yu K.H., Xu C.S., Lin J.R., Li X., Liang S.D. Increased sympathoexcitatory reflex induced by myocardial ischemic nociceptive signaling via P2X2/3 receptor in rat superior cervical ganglia. Neurochem. Int. 2010, 56:984-990.
27. Li H.L., Chen H.L., Li H., Zhang K.L., Chen X.Y., Wang X.W., Kong Q.Y., Liu J. Regulatory effects of emodin on NF-kappaB activation and inflammatory cytokine expression in RAW 264.7 macrophages. Int. J. Mol. Med. 2005, 16:41-47.
28. Liang S.D., Gao Y., Xu C.S., Xu B.H., Mu S.N. Effect of tetramethylpyrazine on acute nociception mediated by signaling of P2X receptor activation in rat. Brain Res. 2004, 995:247-252.
29. Liang S.D., Xu C.S., Zhou T., Liu H.Q., Gao Y., Li G.L. Tetramethylpyrazine inhibits ATP-activated currents in rat dorsal root ganglion neurons. Brain Res. 2005, 1040:92-97.
30. Liang S.D., Xu C.S., Li G.L., Gao Y. P2X receptors and modulation of pain transmission: focus on effects of drugs and compounds used in traditional Chinese medicine. Neurochem. Int. 2010, 57:705-712.
31. Lin J.R., Li G.L., Den X.R., Xu C.S., Liu S.M., Gao Y., Liu H., Zhang J., Li X., Liang S.D. VEGF and its receptor-2 involved in neuropathic pain transmission mediated by P2X2/3 receptor of primary sensory neurons. Brain Res. Bull. 2010, 83:284-291.
32. Lu J.S., Liu J.X., Zhang W.Y., Liang S.W., Wang D., Fang J. Preventive effects of emodin on cerebral ischemia injury and expression of the inflammatory factors in rats with cerebral ischemia. China J. Chin. Mater. Med. 2005, 1939-1943.
33. Merskey H., Bogduk N. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. Classification of Chronic Pain 1994, IASP Press, Seattle, pp. 180-181.
34. Merskey H. Logic, truth and language in concepts of pain. Qual. Life Res. 1994, 3:69-76.
35. Myers R.R., Campana W.M., Shubayev V.I. The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets. Drug Discov. Today 2006, 11:8-20.
36. North R.A. Molecular physiology of P2X receptors. Physiol. Rev. 2002, 82:1013-1067.
37. Novakovic S.D., Kassotakis L.C., Oglesby I.B., Smith J.A., Eglen R.M., Ford A.P., Hunter J.C. Immunocytochemical localization of P2X3 purinoceptors in sensory neurons in naive rats and following neuropathic injury. Pain 1999, 80:273-282.
38. Souslova V., Cesare P., Ding Y., Akopian A.N., Stanfa L., Suzuki R., Carpenter K., Dickenson A., Boyce S., Hill R., Nebenuis-Oosthuizen D., Smith A.J., Kidd E.J. J.N. currents in different types of neurons dissociated from rat dorsal root ganglion. Neurosci. Lett. 1999, 263:57-60.
39. Sperlagh B., Vizi E.S. Neuronal synthesis, storage and release of ATP. Semin. Neurosci. 1996, 8:175-186.
40. Su H.Y, Cherng S.H., Chen C.C., Lee H. Emodin inhibits the mutagenicity and DNA adducts induced by 1-nitropyrene. Mutat. Res. 1995, 329:205-212.
41. Ueno S., Tsuda M., Iwanaga T., Inoue K. Cell type-specific ATP activated responses in rat dorsal root ganglion neurons. Br. J. Pharmacol. 1999, 126:429-436.
42. Vizi E.S., Fekete A., Karoly R., Mike A. Non-synaptic receptors and transporters involved in brain functions and targets of drug treatment. Br. J. Pharmacol. 2010, 160:785-809.
43. Vizi E.S., Sperlagh B. Receptor- and carrier-mediated release of ATP of postsynaptic origin: cascade transmission. Prog. Brain Res. 1999, 120:159-169.
44. Vizi E.S., Sperlagh B., Baranyi M. Evidence that ATP released from the postsynaptic site by noradrenaline, is involved in mechanical responses of guinea-pig vas deferens: cascade transmission. Neuroscience 1992, 50:455-465.
45. Vizi E.S., Liang S.D., Sperlágh B., Kittel A., Jurányi Z. Studies on the release and extracellular metabolism of endogenous ATP in rat superior cervical ganglion: support for neurotransmitter role of ATP. Neuroscience 1997, 79:893-903.
46. Vulchanova L., Olson T.H., Stone L.S., Riedl M.S., Elde R., Honda C.N. Cytotoxic targeting of isolectin IB4-binding sensory neurons. Neuroscience 2001, 108:143-155.
47. Wan F., Li G.L., Liu S.M., Zhu G.C., Xu C.S., Lin J.R., Zhang J., Li X., Liang S.D. P2X2/3 receptor activity of rat nodose ganglion neurons contributing to myocardial ischemic nociceptive signaling. Auton. Neurosci.: Basic Clin. 2010, 158:58-64.
48. Wang C., Zhang D., Ma H., Liu J. Neuroprotective effects of emodin-8-O-beta-d-glucoside in vivo and in vitro. Eur. J. Pharmacol. 2007, 577:58-63.
49. Wu Y., Tu X., Lin G., Xia H., Huang H., Wan J., Cheng Z., Liu M., Chen G., Zhang H., Fu J., Liu Q., Liu D.X. Emodin-mediated protection from acute myocardial infarction via inhibition of inflammation and apoptosis in local ischemic myocardium. Life Sci. 2007, 81:1332-1338.
50. Xu C.S., Li G.L., Gao Y., Liu S.M., Lin J.R., Zhang J., Li X., Liu H., Liang S.D. Effect of puerarin on P2X3 receptor involved in hyperalgesia after burn injury in the rat. Brain Res. Bull. 2009, 80:341-346.
51. Zhang A.X., Xu C.S., Liang S.D., Gao Y., Li G.L., Wei J., Wan F., Liu S.M., Lin J.R. Role of sodium ferulate in the nociceptive sensory facilitation of neuropathic pain injury mediated by P2X(3) receptor. Neurochem. Int. 2008, 53(6-8):278-282.
52. Zhang A.X., Gao Y., Zhong X.Q., Xu C.S., Li G.L., Liu S.M., Lin J.R., Li X., Zhang J., Liu H., Linag S.D. Effect of sodium ferulate on the hyperalgesia mediated by P2X3 receptor in the neuropathic pain rats. Brain Res. 2010, 1313:215-221.