Adduction of cholesterol 5,6-secosterol aldehyde to membrane-bound myelin basic protein exposes an immunodominant epitope

Biochemistry

Volumn 50, Issue 12, 2011, Pages 2092-2100

  Cygan, Natalie K ^a   Scheinost, Johanna C ^a   Butters, Terry D ^a   Wentworth, Paul ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE MOIETY; ANTIBODY BINDING; ANTIBODY LIGHT CHAIN; APOLIPOPROTEIN B; CATHEPSIN D; CENTRAL NERVOUS SYSTEMS; CITRULLINE; CONCENTRATION-DEPENDENT; CYTOSOLIC; DISEASE SEVERITY; IMMUNODOMINANT EPITOPES; LARGE UNILAMELLAR VESICLES; LIPID COMPOSITION; LYSINE SIDE CHAINS; MEMBRANE-BOUND; MISFOLDING; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEIN; NEURODEGENERATION; POSITIVE CHARGES; STRUCTURAL CHANGE; STRUCTURE ACTIVITY RELATIONSHIPS; SURFACE EXPOSURE; SYNUCLEIN;

AMINO ACIDS; ANTIBODIES; ANTIGENS; CELL MEMBRANES; CHOLESTEROL; FLUORESCENCE MICROSCOPY; NEURODEGENERATIVE DISEASES; ORGANIC COMPOUNDS;

ALDEHYDES;

ALDEHYDE DERIVATIVE; ATHERONAL A; ATHERONAL B; CATHEPSIN D; EPITOPE; MYELIN BASIC PROTEIN; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

ADDUCTION; ANTIGEN BINDING; ARTICLE; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; LIGHT SCATTERING; LIPID COMPOSITION; MULTIPLE SCLEROSIS; MYELIN SHEATH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE;

ALDEHYDES; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATHEPSIN D; CATTLE; CELL MEMBRANE; CHOLESTEROL; HUMANS; IMMUNODOMINANT EPITOPES; MOLECULAR SEQUENCE DATA; MYELIN BASIC PROTEINS; PROTEIN STABILITY; PROTEIN STRUCTURE, TERTIARY; SURFACE PROPERTIES; UNILAMELLAR LIPOSOMES;

BOVINAE;

EID: 79952963272     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200109q     Document Type: Article

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