An Arg/Lys → Gln mutant of recombinant murine myelin basic protein as a mimic of the deiminated form implicated in multiple sclerosis

Protein Expression and Purification

Volumn 25, Issue 2, 2002, Pages 330-341

  Bates, Ian R ^a   Libich, David S ^a   Wood, D Denise ^b   Moscarello, Mario A ^b   Harauz, George ^a  

^a UNIVERSITY OF GUELPH   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Cathepsin D; Circular dichroism; Citrulline; Deimination; Lipid vesicle aggregation; Multiple sclerosis; Myelin basic protein

Indexed keywords

MURINAE;

ARGININE; CATHEPSIN D; GLUTAMINE; ISOPROTEIN; LYSINE; MYELIN BASIC PROTEIN; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; ELECTROSPRAY MASS SPECTROMETRY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MISSENSE MUTATION; MOLECULAR GENETICS; MOLECULAR MIMICRY; MOLECULAR WEIGHT; MOUSE; MULTIPLE SCLEROSIS; PROTEIN BINDING; SEQUENCE ALIGNMENT; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ARGININE; BLOTTING, WESTERN; CATHEPSIN D; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; GLUTAMINE; KINETICS; LYSINE; MICE; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MULTIPLE SCLEROSIS; MUTATION, MISSENSE; MYELIN BASIC PROTEINS; PROTEIN BINDING; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 0036025305     PISSN: 10465928     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1046-5928(02)00017-7     Document Type: Article

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