Cholesterol secosterol adduction inhibits the misfolding of a mutant prion protein fragment that induces neurodegeneration

Angewandte Chemie - International Edition

Volumn 48, Issue 50, 2009, Pages 9469-9472

  Scheinost, Johanna C ^a   Witter, Daniel P ^a   Boldt, Grant E ^a   Offer, John ^a   Wentworth Jr , Paul ^a,b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Atheronal; Cholesterol; Prion proteins; Protein misfolding

Indexed keywords

INDUCED PROTEINS; MISFOLDING; MOLECULAR SCAFFOLDS; NEURODEGENERATION; PRION DISEASE; PRION PROTEIN; PRION PROTEINS; PROTEIN MISFOLDING;

ALDEHYDES; CHOLESTEROL;

PROTEINS;

ALDEHYDE; ATHERONAL B; ATHERONAL-B; CHOLESTEROL; DRUG DERIVATIVE; MUTANT PROTEIN; PEPTIDE FRAGMENT;

ANIMAL; ARTICLE; DEGENERATIVE DISEASE; DRUG EFFECT; GENETICS; KINETICS; MOUSE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRION; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION;

ALDEHYDES; ANIMALS; CHOLESTEROL; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MUTANT PROTEINS; NEURODEGENERATIVE DISEASES; PEPTIDE FRAGMENTS; PRIONS; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN MULTIMERIZATION;

EID: 73249144466     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200904524     Document Type: Article

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