Evidence for antibody-catalyzed ozone formation in bacterial killing and inflammation

Science

Volumn 298, Issue 5601, 2002, Pages 2195-2199

  Wentworth Jr , Paul ^a   McDunn, Jonathan E ^a   Wentworth, Anita D ^a   Takeuchi, Cindy ^a   Nieva, Jorge ^a   Jones, Teresa ^a   Bautista, Cristina ^a   Ruedi, Julie M ^a   Gutierrez, Abel ^a   Janda, Kim D ^a   Babior, Bernard M ^a   Eschenmoser, Albert ^a,b   Lerner, Richard A ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGENS; BACTERIA; BIODIVERSITY; CATALYSIS; HYDROGEN PEROXIDE; OXIDATION; OZONE;

BACTERIAL KILLINGS;

ANTIBODIES;

ANTIBODY; HYDROGEN PEROXIDE; OZONE; SINGLET OXYGEN; WATER;

ANTIBODY; BACTERIUM;

ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL INFECTION; BACTERICIDAL ACTIVITY; CONTROLLED STUDY; HUMAN; HUMAN CELL; INFLAMMATION; LEUKOCYTE ACTIVATION; NEUTROPHIL; NONHUMAN; OXIDATION; PRIORITY JOURNAL; RESPIRATORY BURST;

ANIMALS; ANTIBODIES, CATALYTIC; ARTHUS REACTION; BLOOD BACTERICIDAL ACTIVITY; CATALASE; CATALYSIS; ESCHERICHIA COLI; HEMATOPORPHYRINS; HUMANS; HYDROGEN PEROXIDE; INDIGOTINDISULFONATE SODIUM; INFLAMMATION; MICE; NEUTROPHIL ACTIVATION; NEUTROPHILS; OXIDATION-REDUCTION; OZONE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY BURST; SINGLET OXYGEN; ULTRAVIOLET RAYS; WATER;

BACTERIA (MICROORGANISMS);

EID: 0037073888     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1077642     Document Type: Article

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31. We thank members of the TSRI mass-spectroscopy facility, especially G. Suizdak and M. Sonderegger for assistance with the isotope analysis, M. Wood for expert assistance with the electron microscopy experiments, and C. Cochran for supply of the antibody to 85A. Supported by NIH GM43858 (K.D.J.), PO1CA27489 (Program Project Grant to K.D.J. and R.A.L.) and The Skaggs Institute for Chemical Biology. J.E.M. is an Achievement Rewards for College Scientists (ARCS) Foundation graduate fellow; C.T. is supported in part by NIH training grant (ST32AI07606).