메뉴 건너뛰기




Volumn 11, Issue 3, 2011, Pages 373-386

Development of targeted therapy for squamous cell carcinomas of the head and neck

Author keywords

bevacizumab; cetuximab; erlotinib; gefitinib; head and neck squamous cell carcinoma; human papilloma virus; pemetrexed; targeted therapy

Indexed keywords

AMG 479; ANTINEOPLASTIC AGENT; BEVACIZUMAB; BORTEZOMIB; CAPECITABINE; CARBOPLATIN; CEDIRANIB; CELECOXIB; CETUXIMAB; CISPLATIN; CIXUTUMUMAB; CONTUSUGENE LADENOVEC; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FIGITUMUMAB; FLUOROURACIL; GEFITINIB; GEMCITABINE; HYDROXYUREA; IMC A 12; IMC C 225; LAPATINIB; METHOTREXATE; OXALIPLATIN; PANITUMUMAB; PEMETREXED; PLACEBO; PLATINUM COMPLEX; SUNITINIB; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN INHIBITOR;

EID: 79952961101     PISSN: 14737140     EISSN: 17448328     Source Type: Journal    
DOI: 10.1586/era.10.193     Document Type: Review
Times cited : (10)

References (103)
  • 2
    • 0041629450 scopus 로고    scopus 로고
    • Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer
    • DOI 10.1200/JCO.2003.01.504
    • Mendelsohn J, Baselga J. Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J. Clin. Oncol. 21(14), 2787-2799 (2003) (Pubitemid 46606324)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.14 , pp. 2787-2799
    • Mendelsohn, J.1    Baselga, J.2
  • 3
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19(3), 183-232 (1995)
    • (1995) Crit. Rev. Oncol. Hematol. , vol.19 , Issue.3 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 4
    • 33745828702 scopus 로고    scopus 로고
    • EGF-ERBB signalling: Towards the systems level
    • DOI 10.1038/nrm1962, PII NRM1962
    • Citri A, Yarden Y. EGF-ErbB signaling: towards the systems level. Nat. Rev. Mol. Biol. 7(7), 505-516 (2006) (Pubitemid 44036456)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.7 , pp. 505-516
    • Citri, A.1    Yarden, Y.2
  • 5
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • DOI 10.1038/nrc1609
    • Hynes NE, Lane HA. ErbB receptors and cancer: the complexity of targeted inhibitors. Nat. Rev. Cancer 5(5), 341-354 (2005) (Pubitemid 40637826)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 6
    • 1642421130 scopus 로고    scopus 로고
    • Target-based agents against ErbB receptors and their ligands: A novel approach to cancer treatment
    • DOI 10.1677/erc.0.0100001
    • Normanno N, Bianco C, De Luca A, Maiello MR, Salomon DS. Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment. Endocr. Relat. Cancer 10(1), 1-21 (2003) (Pubitemid 36457237)
    • (2003) Endocrine-Related Cancer , vol.10 , Issue.1 , pp. 1-21
    • Normanno, N.1    Bianco, C.2    De Luca, A.3    Maiello, M.R.4    Salomon, D.S.5
  • 7
    • 17444403242 scopus 로고    scopus 로고
    • Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
    • DOI 10.1016/j.ccr.2005.03.003
    • Li S, Schmitz KR, Jeffrey PD, Wiltzius JJ, Kussie P, Ferguson KM. Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. Cancer Cell 7(4), 301-311 (2005) (Pubitemid 40544648)
    • (2005) Cancer Cell , vol.7 , Issue.4 , pp. 301-311
    • Li, S.1    Schmitz, K.R.2    Jeffrey, P.D.3    Wiltzius, J.J.W.4    Kussie, P.5    Ferguson, K.M.6
  • 8
    • 0028116305 scopus 로고
    • Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells
    • Fan Z, Lu Y, Wu X, Mendelsohn J. Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamous carcinoma cells. J. Biol. Chem. 269(44), 27595-27602 (1994) (Pubitemid 24346592)
    • (1994) Journal of Biological Chemistry , vol.269 , Issue.44 , pp. 27595-27602
    • Fan, Z.1    Lu, Y.2    Wu, X.3    Mendelsohn, J.4
  • 9
    • 0028819660 scopus 로고
    • Biological efficacy of a chimeric antibody to the epidermal growth factor in a human tumor xenograft model
    • Goldstein NI, Prewett M, Zuklys K, Rockwell P, Mendelsohn J. Biological efficacy of a chimeric antibody to the epidermal growth factor in a human tumor xenograft model. Clin. Cancer Res. 1, 1311-1318 (1995)
    • (1995) Clin. Cancer Res. , vol.1 , pp. 1311-1318
    • Goldstein, N.I.1    Prewett, M.2    Zuklys, K.3    Rockwell, P.4    Mendelsohn, J.5
  • 10
    • 0030324626 scopus 로고    scopus 로고
    • The biologic effects of C225, a chimeric monoclonal antibody to the EGFR, on human prostate carcinoma
    • Prewett M, Rockwell P, Rockwell RF, et al. The biologic effects of C225, a chimeric monoclonal antibody to the EGFR, on human prostate carcinoma. J. Immunother. Emphasis Tumor Immunol. 19(6), 419-427 (1996)
    • (1996) J. Immunother. Emphasis Tumor Immunol. , vol.19 , Issue.6 , pp. 419-427
    • Prewett, M.1    Rockwell, P.2    Rockwell, R.F.3
  • 11
    • 0031054990 scopus 로고    scopus 로고
    • Epidermal growth factor receptor family and chemosensitization
    • Mendelsohn J, Fan Z. Epidermal growth factor receptor family and chemosensitization. J. Natl Cancer Inst. 89(5), 341-343 (1997) (Pubitemid 27102599)
    • (1997) Journal of the National Cancer Institute , vol.89 , Issue.5 , pp. 341-343
    • Mendelsohn, J.1    Fan, Z.2
  • 15
    • 33144461661 scopus 로고    scopus 로고
    • Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: An Eastern Cooperative Oncology Group Study
    • DOI 10.1200/JCO.2005.02.4646
    • Burtness B, Goldwasser MA, Flood W, Mattar B, Forastiere AA. Phase III randomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern Cooperative Oncology Group study. J. Clin. Oncol. 23(34), 8646-8654 (2005) (Pubitemid 46211507)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.34 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3    Mattar, B.4    Forastiere, A.A.5
  • 16
    • 34250180582 scopus 로고    scopus 로고
    • Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
    • DOI 10.1200/JCO.2006.06.7447
    • Vermorken JB, Trigo J, Hitt R, et al. Open-label, uncontrolled, multicenter Phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinumbased therapy. J. Clin. Oncol. 25(16), 2171-2177 (2007) (Pubitemid 46954639)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.16 , pp. 2171-2177
    • Vermorken, J.B.1    Trigo, J.2    Hitt, R.3    Koralewski, P.4    Diaz-Rubio, E.5    Rolland, F.6    Knecht, R.7    Amellal, N.8    Schueler, A.9    Baselga, J.10
  • 17
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • Vermorken JB, Mesia R, Rivera F, et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N. Engl. J. Med. 359, 1116-1127 (2008)
    • (2008) N. Engl. J. Med. , vol.359 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 19
    • 73249143536 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a Phase 3 randomised trial, and relation between cetuximab-induced rash and survival
    • Bonner J, Harari P, Giralt J, et al. Radiotherapy plus cetuximab for locoregionally advanced head and neck cancer: 5-year survival data from a Phase 3 randomised trial, and relation between cetuximab-induced rash and survival. Lancet Oncol. 11, 21-27 (2010)
    • (2010) Lancet Oncol. , vol.11 , pp. 21-27
    • Bonner, J.1    Harari, P.2    Giralt, J.3
  • 20
    • 77949478008 scopus 로고    scopus 로고
    • Phase II randomized trial of postoperative chemoradiation plus cetuximab for high-risk squamous cell carcinoma of the head and neck (RTOG 0234)
    • Kies MS, Harris J, Rotman MZ, et al. Phase II randomized trial of postoperative chemoradiation plus cetuximab for high-risk squamous cell carcinoma of the head and neck (RTOG 0234). Int. J. Radiat. Oncol. Biol. Phys. 75(3), S15 (2009)
    • (2009) Int. J. Radiat. Oncol. Biol. Phys. , vol.75 , Issue.3
    • Kies, M.S.1    Harris, J.2    Rotman, M.Z.3
  • 21
    • 74949111286 scopus 로고    scopus 로고
    • Surgery for laryngopharyngeal SCC in the era of organ preservation
    • Lefebvre JL. Surgery for laryngopharyngeal SCC in the era of organ preservation. Clin. Exp. Otorhinolaryngol. 2(4), 159-163 (2009)
    • (2009) Clin. Exp. Otorhinolaryngol. , vol.2 , Issue.4 , pp. 159-163
    • Lefebvre, J.L.1
  • 22
    • 79952982858 scopus 로고    scopus 로고
    • Groupe Oncologie Radiotherapie Tete et Cou (GORTEC). Sequential chemoradiotherapy (SCRT) for larynx preservation (LP), preliminary results of the randomized Phase II TREMPLIN study
    • Orlando, FL, USA, May-2 June 2009
    • Lefebvre JL, Pointreau Y, Rolland F, et al. Groupe Oncologie Radiotherapie Tete Et Cou (GORTEC). Sequential chemoradiotherapy (SCRT) for larynx preservation (LP), preliminary results of the randomized Phase II TREMPLIN study. Presented at: American Society of Clinical Oncology. Orlando, FL, USA, May-2 June 2009
    • American Society of Clinical Oncology
    • Lefebvre, J.L.1    Pointreau, Y.2    Rolland, F.3
  • 23
    • 23844523253 scopus 로고    scopus 로고
    • Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinumrefractory metastatic and/or recurrent squamous cell carcinoma of the head and neck
    • Baselga J, Trigo JM, Bourhis J, et al. Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinumrefractory metastatic and/or recurrent squamous cell carcinoma of the head and neck. J. Clin. Oncol. 23(24), 5568-5577 (2005)
    • (2005) J. Clin. Oncol. , vol.23 , Issue.24 , pp. 5568-5577
    • Baselga, J.1    Trigo, J.M.2    Bourhis, J.3
  • 25
    • 34347395051 scopus 로고    scopus 로고
    • A Phase III randomized parallel-group study of gefitinib (IRESSA) versus methotrexate (IMEX) in patients with recurrent squamous cell carcinoma of the head and neck
    • Los Angeles, CA, USA, 14-18 April
    • Stewart JS, Cohen E, Licitra L, et al. A Phase III randomized parallel-group study of gefitinib (IRESSA) versus methotrexate (IMEX) in patients with recurrent squamous cell carcinoma of the head and neck. Presented at: 98th Annual Meeting of the American Association for Cancer Research. Los Angeles, CA, USA, 14-18 April 2007
    • (2007) 98th Annual Meeting of the American Association for Cancer Research
    • Stewart, J.S.1    Cohen, E.2    Licitra, L.3
  • 26
    • 29144471675 scopus 로고    scopus 로고
    • Clinical and molecular Phase II study of gefitinib in patients (pts) with recurrent squamous cell cancer of the head and neck (H&N Ca)
    • Abstract 5531
    • Wheeler RH, Jones D, Sharma P, et al. Clinical and molecular Phase II study of gefitinib in patients (pts) with recurrent squamous cell cancer of the head and neck (H&N Ca). J. Clin. Oncol. 23(16S), 507s (2005) (Abstract 5531)
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16
    • Wheeler, R.H.1    Jones, D.2    Sharma, P.3
  • 27
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • DOI 10.1200/JCO.2004.06.075
    • Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL. Multicenter Phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J. Clin. Oncol. 22(1), 77-85 (2004) (Pubitemid 41095117)
    • (2004) Journal of Clinical Oncology , vol.22 , Issue.1 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3    Hidalgo, M.4    Agarvala, S.S.5    Siu, L.L.6
  • 29
    • 70350637945 scopus 로고    scopus 로고
    • A Phase III randomized, placebo-controlled trial of docetaxel (D) with or without gefitinib (G) in recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN), a trial of the Eastern Cooperative Oncology Group (ECOG)
    • Argiris, Ghebremichael M, Gilbert J, Burtness B, Forastiere A. A Phase III randomized, placebo-controlled trial of docetaxel (D) with or without gefitinib (G) in recurrent or metastatic (R/M) squamous cell carcinoma of the head and neck (SCCHN), a trial of the Eastern Cooperative Oncology Group (ECOG). J. Clin. Oncol. 27 (15S), 6011 (2009)
    • (2009) J. Clin. Oncol. , vol.27 , Issue.15 , pp. 6011
    • Argiris Ghebremichael, M.1    Gilbert, J.2    Burtness, B.3    Forastiere, A.4
  • 30
    • 64649097892 scopus 로고    scopus 로고
    • Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck
    • Simon J, Stewart W, Vokes E, et al. Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck. J. Clin. Oncol. 27, 1864-1871 (2009)
    • (2009) J. Clin. Oncol. , vol.27 , pp. 1864-1871
    • Simon, J.1    Stewart, W.2    Vokes, E.3
  • 33
    • 61449122062 scopus 로고    scopus 로고
    • Phase i study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck
    • Harrington K, El-Hariry I, Bourhis J, et al. Phase I study of lapatinib in combination with chemoradiation in patients with locally advanced squamous cell carcinoma of the head and neck. J. Clin. Oncol. 27(7), 1100-1107 (2009)
    • (2009) J. Clin. Oncol. , vol.27 , Issue.7 , pp. 1100-1107
    • Harrington, K.1    El-Hariry, I.2    Bourhis, J.3
  • 34
    • 0035704913 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor in angiogenesis
    • DOI 10.1159/000046610
    • Ferrara N, Gerber HP. The role of vascular endothelial growth factor in angiogenesis. Acta Haematol. 106(4), 148-156 (2001) (Pubitemid 34124153)
    • (2001) Acta Haematologica , vol.106 , Issue.4 , pp. 148-156
    • Ferrara, N.1    Gerber, H.-P.2
  • 35
    • 63149136088 scopus 로고    scopus 로고
    • Cetuximab (C) and bevacizumab (B) in patients with recurrent or metastatic head and neck squamous cell carcinoma (SCCHN). An interim analysis
    • Kies M, Gibson M, Kim S, et al. Cetuximab (C) and bevacizumab (B) in patients with recurrent or metastatic head and neck squamous cell carcinoma (SCCHN). An interim analysis. J. Clin. Oncol. 26(15S), 6072 (2008)
    • (2008) J. Clin. Oncol. , vol.26 , Issue.15 , pp. 6072
    • Kies, M.1    Gibson, M.2    Kim, S.3
  • 36
    • 68049109938 scopus 로고    scopus 로고
    • Pemetrexed (P) and bevacizumab (B) in patients (pts) with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), updated results of a Phase II trial
    • Feinstein T, Raez L, Rajasenan K, et al. Pemetrexed (P) and bevacizumab (B) in patients (pts) with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), updated results of a Phase II trial. J. Clin. Oncol. 26(15S), 6069 (2008)
    • (2008) J. Clin. Oncol. , vol.26 , Issue.15 , pp. 6069
    • Feinstein, T.1    Raez, L.2    Rajasenan, K.3
  • 37
    • 67649668649 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN)
    • Choong W, Cohen E, Kozloff M, et al. Phase II trial of sunitinib in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN). J. Clin. Oncol. 26(15S), 6064 (2008)
    • (2008) J. Clin. Oncol. , vol.26 , Issue.15 , pp. 6064
    • Choong, W.1    Cohen, E.2    Kozloff, M.3
  • 38
    • 0033899157 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) expression is a prognostic faster for radiotherapy outcome in advanced carcinoma of the cervix
    • Loncaster JA, Cooper RA, Logue JP, et al. Vascular endothelial growth factor (VEGF) expression is a prognostic factor for radiotherapy outcome in advanced carcinoma of the cervix. Br. J. Cancer 83(5), 620-625 (2000) (Pubitemid 30636303)
    • (2000) British Journal of Cancer , vol.83 , Issue.5 , pp. 620-625
    • Loncaster, J.A.1    Cooper, R.A.2    Logue, J.P.3    Davidson, S.E.4    Hunter, R.D.5    West, C.M.L.6
  • 39
    • 0034989311 scopus 로고    scopus 로고
    • Biological consequences of tumor hypoxia
    • Hockel M, Vaupel P. Biological consequences of tumor hypoxia. Semin. Oncol. 28(2 Suppl. 8), 36-41 (2001) (Pubitemid 32522236)
    • (2001) Seminars in Oncology , vol.28 , Issue.2 SUPPL. 8 , pp. 36-41
    • Hockel, M.1    Vaupel, P.2
  • 41
    • 0033990664 scopus 로고    scopus 로고
    • Head and neck squamous cell carcinoma lines produce biologically active angiogenic factors
    • Shemirani B, Crowe DL. Head and neck squamous cell carcinoma lines produce biologically active angiogenic factors. Oral Oncol. 36(1), 61-66 (2000)
    • (2000) Oral Oncol. , vol.36 , Issue.1 , pp. 61-66
    • Shemirani, B.1    Crowe, D.L.2
  • 43
    • 0034111116 scopus 로고    scopus 로고
    • Prognostic significance of Vascular Endothelial Growth Factor protein levels in oral and oropharyngeal squamous cell carcinoma
    • Smith BD, Smith GL, Carter D, Sasaki CT, Haffty BG. Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma. J. Clin. Oncol. 18(10), 2046-2052 (2000) (Pubitemid 30324357)
    • (2000) Journal of Clinical Oncology , vol.18 , Issue.10 , pp. 2046-2052
    • Smith, B.D.1    Smith, G.L.2    Carter, D.3    Sasaki, C.T.4    Haffty, B.G.5
  • 44
    • 0025141337 scopus 로고
    • What is the evidence that tumors are angiogenesis dependent?
    • Folkman J. What is the evidence that tumors are angiogenesis dependent? J. Natl Cancer Inst. 82(1), 4-6 (1990) (Pubitemid 20020880)
    • (1990) Journal of the National Cancer Institute , vol.82 , Issue.1 , pp. 4-6
    • Folkman, J.1
  • 45
    • 0038176480 scopus 로고    scopus 로고
    • Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: Exploring mechanisms of interaction
    • Wachsberger P, Burd R, Dicker AP. Tumor response to ionizing radiation combined with antiangiogenesis or vascular targeting agents: exploring mechanisms of interaction. Clin. Cancer Res. 9(6), 1957-1971 (2003) (Pubitemid 36687614)
    • (2003) Clinical Cancer Research , vol.9 , Issue.6 , pp. 1957-1971
    • Wachsberger, P.1    Burd, R.2    Dicker, A.P.3
  • 47
    • 0035116241 scopus 로고    scopus 로고
    • Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells
    • DOI 10.1023/A:1006764100867
    • O-Charoenrat P, Rhys-Evans P, Modjtahedi H, Eccles SA. Vascular endothelial growth factor family members aredifferentially regulated by c-ErbB signaling in head and neck squamous carcinoma cells. Clin. Exp. Metastasis 18(2), 155-161 (2000) (Pubitemid 32165249)
    • (2000) Clinical and Experimental Metastasis , vol.18 , Issue.2 , pp. 155-161
    • O-charoenrat, P.1    Rhys-Evans, P.2    Modjtahedi, H.3    Eccles, S.4
  • 48
    • 23844527898 scopus 로고    scopus 로고
    • A Phase i study of erlotinib and bevacizumab for recurrent or metastatic squamous cell carcinoma of the head and neck (HNC)
    • Abstract 5504
    • Vokes EE, Cohen EE, Mauer AM, et al. A Phase I study of erlotinib and bevacizumab for recurrent or metastatic squamous cell carcinoma of the head and neck (HNC). J. Clin. Oncol. 23(16S), 501s (2005) (Abstract 5504)
    • (2005) J. Clin. Oncol. , vol.23 , Issue.16
    • Vokes, E.E.1    Cohen, E.E.2    Mauer, A.M.3
  • 49
    • 62349097073 scopus 로고    scopus 로고
    • Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: A Phase I/II study
    • Cohen EE, Davis DW, Karrison TG, et al. Erlotinib and bevacizumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck: a Phase I/II study. Lancet Oncol. 10(3), 204-205 (2009)
    • (2009) Lancet Oncol. , vol.10 , Issue.3 , pp. 204-205
    • Cohen, E.E.1    Davis, D.W.2    Karrison, T.G.3
  • 50
    • 68049109938 scopus 로고    scopus 로고
    • Pemetrexed (P) and bevacizumab (B) in patients (pts) with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), updated results of a Phase II trial
    • Feinstein T, Raez L, Rajasenan K, et al. Pemetrexed (P) and bevacizumab (B) in patients (pts) with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC), updated results of a Phase II trial. J. Clin. Oncol. 26(15S), 6069 (2008)
    • (2008) J. Clin. Oncol. , vol.26 , Issue.15 , pp. 6069
    • Feinstein, T.1    Raez, L.2    Rajasenan, K.3
  • 52
    • 36048982710 scopus 로고    scopus 로고
    • Phase II study of bevacizumab in combination with docetaxel and radiation in locally advanced squamous cell cancer of the head and neck (SCCHN)
    • Abstract 6068
    • Savvides P, Greskovich J, Bokar J, et al. Phase II study of bevacizumab in combination with docetaxel and radiation in locally advanced squamous cell cancer of the head and neck (SCCHN). J. Clin. Oncol. 25(18S), 302s (2007) (Abstract 6068)
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18
    • Savvides, P.1    Greskovich, J.2    Bokar, J.3
  • 53
    • 44649195401 scopus 로고    scopus 로고
    • Randomized Phase II study of concomitant chemoradiotherapy with 5-fluorouracil-hydroxyurea (FHX) compared to FHX and bevacizumab (FHXB) in intermediate stage head and neck cancer (HNC)
    • Abstract 6034
    • Choong NW, Haraf DJ, Cohen EE, et al. Randomized Phase II study of concomitant chemoradiotherapy with 5-fluorouracil-hydroxyurea (FHX) compared to FHX and bevacizumab (FHXB) in intermediate stage head and neck cancer (HNC). J. Clin. Oncol. 25(18S), 302s (2007) (Abstract 6034)
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18
    • Choong, N.W.1    Haraf, D.J.2    Cohen, E.E.3
  • 54
    • 43249128897 scopus 로고    scopus 로고
    • Phase i study of bevacizumab added to fluorouracil and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer
    • Seiwert TY, Haraf DJ, Cohen E, et al. Phase I study of bevacizumab added to fluorouracil and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer. J. Clin. Oncol. 26(10), 1732-1741 (2008)
    • (2008) J. Clin. Oncol. , vol.26 , Issue.10 , pp. 1732-1741
    • Seiwert, T.Y.1    Haraf, D.J.2    Cohen, E.3
  • 55
    • 67649668649 scopus 로고    scopus 로고
    • Phase II trial of sunitinib in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN)
    • Abstract 6064
    • Choong NW, Cohen EE, Kozloff MF, et al. Phase II trial of sunitinib in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck (SCCHN). J. Clin. Oncol. 26(15S), 332s (2008) (Abstract 6064)
    • (2008) J. Clin. Oncol. , vol.26 , Issue.15
    • Choong, N.W.1    Cohen, E.E.2    Kozloff, M.F.3
  • 56
    • 85017053271 scopus 로고    scopus 로고
    • Phase II Study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01
    • Machiels H, Henry S, Zanetta S, et al. Phase II Study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01. J. Clin. Oncol. 27(15S), 6024 (2009)
    • (2009) J. Clin. Oncol. , vol.27 , Issue.15 , pp. 6024
    • MacHiels, H.1    Henry, S.2    Zanetta, S.3
  • 57
    • 68049094591 scopus 로고    scopus 로고
    • Antitumor activity of cediranib in patients with metastatic or recurrent head and neck cancer (HNC) or recurrent non-small cell lung cancer (NSCLC). An open-label exploratory study
    • Saura C, Baselga J, Herbst R, et al. Antitumor activity of cediranib in patients with metastatic or recurrent head and neck cancer (HNC) or recurrent non-small cell lung cancer (NSCLC). An open-label exploratory study. J. Clin. Oncol. 27(15S), 6023 (2009)
    • (2009) J. Clin. Oncol. , vol.27 , Issue.15 , pp. 6023
    • Saura, C.1    Baselga, J.2    Herbst, R.3
  • 59
    • 34247125164 scopus 로고    scopus 로고
    • The proteasome: A worthwhile target for the treatment of solid tumours?
    • DOI 10.1016/j.ejca.2007.01.038, PII S0959804907001220
    • Milano A, Iaffaioli RV, Caponigro F. The proteasome: a worthwhile target for the treatment of solid tumours? Eur. J. Cancer 43(7), 1125-1133 (2007) (Pubitemid 46592015)
    • (2007) European Journal of Cancer , vol.43 , Issue.7 , pp. 1125-1133
    • Milano, A.1    Iaffaioli, R.V.2    Caponigro, F.3
  • 60
    • 33646951017 scopus 로고    scopus 로고
    • Proteasome inhibitors in the lung cancer
    • Scagliotti G. Proteasome inhibitors in the lung cancer. Crit. Rev. Oncol. Hematol. 58(3), 177-189 (2006)
    • (2006) Crit. Rev. Oncol. Hematol. , vol.58 , Issue.3 , pp. 177-189
    • Scagliotti, G.1
  • 61
    • 0036181371 scopus 로고    scopus 로고
    • Development of the proteasome inhibitor PS-341
    • DOI 10.1634/theoncologist.7-1-9
    • Adams J. Development of the proteasome inhibitor PS-341. Oncologist 7, 9-16 (2002) (Pubitemid 34151104)
    • (2002) Oncologist , vol.7 , Issue.1 , pp. 9-16
    • Adams, J.1
  • 62
    • 23844442112 scopus 로고    scopus 로고
    • Nuclear factor-kappaB pathway as a therapeutic target in head and neck squamous cell carcinoma: Pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NF-κB
    • Lun M, Zhang PL, Pellitteri PK, Law A. Kennedy TL, Brown RE. Nuclear factor-kB pathway as a therapeutic target in head and neck squamous cell carcinoma: pharmaceutical and molecular validation in human cell lines using Velcade and siRNA/NFkB. Ann. Clin. Lab. Sci. 35, 251-258 (2005) (Pubitemid 41176783)
    • (2005) Annals of Clinical and Laboratory Science , vol.35 , Issue.3 , pp. 251-258
    • Lun, M.1    Zhang, P.L.2    Pellitteri, P.K.3    Law, A.4    Kennedy, T.L.5    Brown, R.E.6
  • 64
    • 39049096264 scopus 로고    scopus 로고
    • Bortezomib in combination with celecoxib in patients with advanced solid tumors: A Phase i trial
    • Hayslip J, Chaudhary U, Green M, et al. Bortezomib in combination with celecoxib in patients with advanced solid tumors: a Phase I trial. BMC Cancer 7(221), 1-6 (2007)
    • (2007) BMC Cancer , vol.7 , Issue.221 , pp. 1-6
    • Hayslip, J.1    Chaudhary, U.2    Green, M.3
  • 66
    • 42449094627 scopus 로고    scopus 로고
    • Phase i study of capecitabine and oxaliplatin in combination with the proteasome inhibitor bortezomib in patients with advanced solid tumors
    • Cohen SJ, Engstrom PF, Lewis NL, et al. Phase I study of capecitabine and oxaliplatin in combination with the proteasome inhibitor bortezomib in patients with advanced solid tumors. Am. J. Clin. Oncol. 31, 1-5 (2008)
    • (2008) Am. J. Clin. Oncol. , vol.31 , pp. 1-5
    • Cohen, S.J.1    Engstrom, P.F.2    Lewis, N.L.3
  • 67
    • 70350152291 scopus 로고    scopus 로고
    • Phase i trial of bortezomib (VELCADE), cisplatin and radiotherapy for advanced head and neck cancer
    • Kubicek GJ, Machtay M, Axelrod RA, et al. Phase I trial of bortezomib (VELCADE), cisplatin and radiotherapy for advanced head and neck cancer. J. Clin. Oncol. 26(15 Suppl.), S323 (2008)
    • (2008) J. Clin. Oncol. , vol.26 , Issue.15 SUPPL.
    • Kubicek, G.J.1    MacHtay, M.2    Axelrod, R.A.3
  • 68
    • 33846685893 scopus 로고    scopus 로고
    • Bortezomib inhibits cell-cell adhesion and cell migration and enhances epidermal growth factor receptor inhibitor-induced cell death in squamous cell cancer
    • DOI 10.1158/0008-5472.CAN-06-2162
    • Lorch JH, Thomas TO, Schmoll HJ. Bortezomib inhibits cell-cell adhesion and cell migration and enhances epidermal growth factor receptor inhibitor-induced cell death in squamous cell cancer. Cancer Res. 67, 727-734 (2007) (Pubitemid 46192213)
    • (2007) Cancer Research , vol.67 , Issue.2 , pp. 727-734
    • Lorch, J.H.1    Thomas, T.O.2    Schmoll, H.-J.3
  • 69
    • 65549125308 scopus 로고    scopus 로고
    • Phase i study of bortezomib and cetuximab in patients with solid tumours expressing epidermal growth factor receptor
    • Dudek AZ, Lesniewski-Kmak K, Shehadeh NJ, et al. Phase I study of bortezomib and cetuximab in patients with solid tumours expressing epidermal growth factor receptor. Br. J. Cancer 100, 1379-1384 (2009)
    • (2009) Br. J. Cancer , vol.100 , pp. 1379-1384
    • Dudek, A.Z.1    Lesniewski-Kmak, K.2    Shehadeh, N.J.3
  • 70
    • 77951964186 scopus 로고    scopus 로고
    • Nuclear factor-kB pathway and response in a Phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma
    • Chung CH, Aulino J, Muldowney NJ, et al. Nuclear factor-kB pathway and response in a Phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann. Oncol. 21, 864-870 (2010)
    • (2010) Ann. Oncol. , vol.21 , pp. 864-870
    • Chung, C.H.1    Aulino, J.2    Muldowney, N.J.3
  • 71
    • 34547107855 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor as a therapeutic target in head and neck cancer
    • DOI 10.1158/1078-0432.CCR-06-2040
    • Barnes CJ, Ohshiro K, Rayala SK, El-Naggar AK, Kumar R. Insulin-like growth factor receptor as a therapeutic target in head and neck cancer. Clin. Cancer Res. 13(14), 4291-4299 (2007) (Pubitemid 47105993)
    • (2007) Clinical Cancer Research , vol.13 , Issue.14 , pp. 4291-4299
    • Barnes, C.J.1    Ohshiro, K.2    Rayala, S.K.3    El-Naggar, A.K.4    Kumar, R.5
  • 72
    • 33847271170 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma
    • DOI 10.1016/j.canlet.2006.08.004, PII S0304383506004976
    • Slomainy MG, Black LA, Kibbey MM, Tingler MA, Day TA, Rosenzweig SA. Insulin-like growth factor-1 receptor and ligand targeting in head and neck squamous cell carcinoma. Cancer Lett. 248(2), 269-279 (2007) (Pubitemid 46330562)
    • (2007) Cancer Letters , vol.248 , Issue.2 , pp. 269-279
    • Slomiany, M.G.1    Black, L.A.2    Kibbey, M.M.3    Tingler, M.A.4    Day, T.A.5    Rosenzweig, S.A.6
  • 74
    • 33847041527 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 receptor signaling blockade combined with radiation
    • Allen GW, Saba C, Armstrong EA, et al. Insulin-like growth factor-1 receptor signaling blockade combined with radiation. Cancer Res. 67(3), 1155-1162 (2007)
    • (2007) Cancer Res. , vol.67 , Issue.3 , pp. 1155-1162
    • Allen, G.W.1    Saba, C.2    Armstrong, E.A.3
  • 76
    • 26844487041 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling in tamoxifen-resistant breast cancer: A supporting role to the epidermal growth factor receptor
    • DOI 10.1210/en.2005-0247
    • Knowlden JM, Hutchenson IR, Barrow, et al. Insulin-like growth factor-1 receptor signaling in tamoxifen-resistant breast cancer: a supporting role of the epidermal growth factor receptor. Endocrinology 146(11), 4609-4618 (2005) (Pubitemid 41446598)
    • (2005) Endocrinology , vol.146 , Issue.11 , pp. 4609-4618
    • Knowlden, J.M.1    Hutcheson, I.R.2    Barrow, D.3    Gee, J.M.W.4    Nicholson, R.I.5
  • 77
    • 0036708503 scopus 로고    scopus 로고
    • Effect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway
    • DOI 10.1038/sj.neo.7900242
    • Wan X, Helman LJ. Effect of insulin-like growth factor II on protecting myoblast cells against cisplatin-induced apoptosis through p70 S6 kinase pathway. Neoplasia 4(5), 400-408 (2002) (Pubitemid 34976955)
    • (2002) Neoplasia , vol.4 , Issue.5 , pp. 400-408
    • Wan, X.1    Helman, L.J.2
  • 78
    • 13244251090 scopus 로고    scopus 로고
    • Insulin-like growth factor-I decreased etoposide-induced apoptosis in glioma cells by increasing bcl-2 expression and decreasing CPP32 activity
    • DOI 10.1179/016164105X18151
    • Yin D, Tamaki N, Parent AD, et al. Insulinlike growth factor-1 decreased etoposideinduced apoptosis in glioma cells by increasing bcl-2 expression and decreasing CPP32 activity. Neurol. Res. 27(1), 27-35 (2005) (Pubitemid 40189601)
    • (2005) Neurological Research , vol.27 , Issue.1 , pp. 27-35
    • Yin, D.1    Tamaki, N.2    Parent, A.D.3    Zhang, J.H.4
  • 79
    • 49249125421 scopus 로고    scopus 로고
    • Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulin like growth factor type 1 receptor monoclonal antibody CP-751871 in patients with multiple myeloma
    • Lacy MQ, Alsina M, Fonseca R, et al. Phase I, pharmacokinetic and pharmacodynamic study of the anti-insulin like growth factor type 1 receptor monoclonal antibody CP-751871 in patients with multiple myeloma. J. Clin. Oncol. 26(19), 3196-3203 (2008)
    • (2008) J. Clin. Oncol. , vol.26 , Issue.19 , pp. 3196-3203
    • Lacy, M.Q.1    Alsina, M.2    Fonseca, R.3
  • 81
    • 36348954086 scopus 로고    scopus 로고
    • Efficacy of the anti-insulin like growth factor 1 receptor antibody CP-751871 in combination with paclitaxel and carboplatin as first line treatment for advanced non-small cell lung cancer (NSCLC)
    • Karp DD, Paz-Ares LG, Blakely LJ, et al. Efficacy of the anti-insulin like growth factor 1 receptor antibody CP-751871 in combination with paclitaxel and carboplatin as first line treatment for advanced non-small cell lung cancer (NSCLC). J. Clin. Oncol. 25(18S), 7506 (2007)
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 , pp. 7506
    • Karp, D.D.1    Paz-Ares, L.G.2    Blakely, L.J.3
  • 82
    • 74749085657 scopus 로고    scopus 로고
    • Continued high activity of figitumumab (CP-751, 871) combination therapy in squamous lung cancer
    • Karp DD, Novello S, Cardenal F, et al. Continued high activity of figitumumab (CP-751, 871) combination therapy in squamous lung cancer. J. Clin. Oncol. 27(15S) (2009)
    • (2009) J. Clin. Oncol. , Issue.15 , pp. 27
    • Karp, D.D.1    Novello, S.2    Cardenal, F.3
  • 83
    • 79952958466 scopus 로고    scopus 로고
    • Safety, pharmacokinetics and preliminary activity of the anti-IGF-1R antibody CP-751, 871 in patients with sarcoma
    • Postel-Vinay S, Okuno S, Schuetze S, et al. Safety, pharmacokinetics and preliminary activity of the anti-IGF-1R antibody CP-751, 871 in patients with sarcoma. Proc. Eur. J. Cancer 6(12), 388 (2008)
    • (2008) Proc. Eur. J. Cancer , vol.6 , Issue.12 , pp. 388
    • Postel-Vinay, S.1    Okuno, S.2    Schuetze, S.3
  • 84
    • 35148889523 scopus 로고    scopus 로고
    • A Phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-1 receptor IgG1 monoclonal antibody, in patients with advanced solid tumors
    • Higano CS, Yu EY, Whiting SH, et al. A Phase I, first in man study of weekly IMC-A12, a fully human insulin like growth factor-1 receptor IgG1 monoclonal antibody, in patients with advanced solid tumors. J. Clin. Oncol. 25(18S), 3505 (2007)
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 , pp. 3505
    • Higano, C.S.1    Yu, E.Y.2    Whiting, S.H.3
  • 85
    • 77954700291 scopus 로고    scopus 로고
    • Phase i dose-escalation study of the anti-IGF-1R recombinant human IgG1 monoclonal antibody (Mab) IMC-A12, administered every other week to patients with advanced solid tumors
    • Rothenberg ML. Phase I dose-escalation study of the anti-IGF-1R recombinant human IgG1 monoclonal antibody (Mab) IMC-A12, administered every other week to patients with advanced solid tumors. Mol. Target Cancer Ther. 12, 84 (2007)
    • (2007) Mol. Target Cancer Ther. , vol.12 , pp. 84
    • Rothenberg, M.L.1
  • 86
    • 36148976199 scopus 로고    scopus 로고
    • A Phase i pharmacokinetic and pharmacodynamic study of AMG-479, a fully human monoclonal antibody against insulin-like growth factor type 1 receptor (IGF-1R), in advanced solid tumors
    • Tolcher AW, Rothenberg ML, Rodon J, et al. A Phase I pharmacokinetic and pharmacodynamic study of AMG-479, a fully human monoclonal antibody against insulin-like growth factor type 1 receptor (IGF-1R), in advanced solid tumors. J. Clin. Oncol. 25(18S), 3002 (2007)
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 , pp. 3002
    • Tolcher, A.W.1    Rothenberg, M.L.2    Rodon, J.3
  • 87
    • 56149094007 scopus 로고    scopus 로고
    • A Phase IB study of AMG-479, a type 1 insulin-like growth factor receptor (IGF-1R) antibody, in combination with panitumumab (P) or gemcitabine (G)
    • Sarantopoulus J, Mita AC, Mulay M, et al. A Phase IB study of AMG-479, a type 1 insulin-like growth factor receptor (IGF-1R) antibody, in combination with panitumumab (P) or gemcitabine (G). J. Clin. Oncol. 26(15S), 3583 (2008)
    • (2008) J. Clin. Oncol. , vol.26 , Issue.15 , pp. 3583
    • Sarantopoulus, J.1    Mita, A.C.2    Mulay, M.3
  • 88
    • 0032809839 scopus 로고    scopus 로고
    • Adenovirus-mediated wild-type p53 gene transfer as a surgical adjuvant in advanced head and neck cancers
    • Clayman GL, Frank DK, Bruso PA, Goepfert H. Adenovirus-mediated wild-type p53 gene transfer as a surgicaladjuvant in head and neck cancers. Clin. Cancer Res. 5, 1715-1722 (1999) (Pubitemid 29334451)
    • (1999) Clinical Cancer Research , vol.5 , Issue.7 , pp. 1715-1722
    • Clayman, G.L.1    Frank, D.K.2    Bruso, P.A.3    Goepfert, H.4
  • 90
    • 70349326223 scopus 로고    scopus 로고
    • Tumor response and biomarkers associated with increased survival following adenoviral p53 gene therapy (ADVEXIN) in patients with recurrent squamous cell carcinoma of the head and neck
    • Abstract 6057
    • Nemunaitis J, Hamm J, Clayman GL, et al. Tumor response and biomarkers associated with increased survival following adenoviral p53 gene therapy (ADVEXIN) in patients with recurrent squamous cell carcinoma of the head and neck. J. Clin. Oncol. 25(18S), 313 (2007) (Abstract 6057)
    • (2007) J. Clin. Oncol. , vol.25 , Issue.18 , pp. 313
    • Nemunaitis, J.1    Hamm, J.2    Clayman, G.L.3
  • 91
    • 0006596907 scopus 로고    scopus 로고
    • Randomized Phase II study of intratumoral injections of two dosing schedules using a replication-deficient adenovirus carrying p53 gene (Ad5CMV-p53) in patients with recurrent/refractory head and neck cancer
    • Abstract 1717
    • Goodwin WJ, Esser D, Clayman GL, Nemunaitis J, Yver A. Dreiling L. Randomized Phase II study of intratumoral injections of two dosing schedules using a replication-deficient adenovirus carrying p53 gene (Ad5CMV-p53) in patients with recurrent/refractory head and neck cancer. Proc. Am. Soc. Clin. Oncol. 18, 445a (1999) (Abstract 1717)
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.18
    • Goodwin, W.J.1    Esser, D.2    Clayman, G.L.3    Nemunaitis, J.4    Yver, A.5    Dreiling, L.6
  • 92
    • 0001458965 scopus 로고    scopus 로고
    • A Phase II multi-center study of AdCMV-p53 administered intratumorally to patients with recurrent head and neck cancer
    • Abstract 1712
    • Bier-Laning CM, VanEcho D, Yver A. A Phase II multi-center study of AdCMV-p53 administered intratumorally to patients with recurrent head and neck cancer. Proc. Am. Soc. Clin. Oncol. 18, 431a (1999) (Abstract 1712)
    • (1999) Proc. Am. Soc. Clin. Oncol. , vol.18
    • Bier-Laning, C.M.1    Vanecho, D.2    Yver, A.3
  • 93
    • 70349348934 scopus 로고    scopus 로고
    • A Phase II trail of surgery with perioperative INGN 201 (Ad5CMV-p53) gene therapy followed by chemoradiotherapy for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx
    • Yoo GH, Moon J, LeBlanc M, et al. A Phase II trail of surgery with perioperative INGN 201 (Ad5CMV-p53) gene therapy followed by chemoradiotherapy for advanced, resectable squamous cell carcinoma of the oral cavity, oropharynx, hypopharynx, and larynx. Report of the Southwest oncology group. Arch. Otolaryngol. Head Neck Surg. 135(9), 869-874 (2009)
    • (2009) Report of the Southwest Oncology Group. Arch. Otolaryngol. Head Neck Surg. , vol.135 , Issue.9 , pp. 869-874
    • Yoo, G.H.1    Moon, J.2    Leblanc, M.3
  • 95
    • 0033693231 scopus 로고    scopus 로고
    • Selective replication and oncolysis in p53 mutant tumors with Onyx-015, an E1B55Kd gene-deleted adenovirus, in patients with advanced head and neck cancer: A Phase II trial
    • Nemunaitis J, Ganly I, Khuri F, et al. Selective replication and oncolysis in p53 mutant tumors with Onyx-015, an E1B55Kd gene-deleted adenovirus, in patients with advanced head and neck cancer: a Phase II trial. Cancer Res. 60, 6359-6366 (2000)
    • (2000) Cancer Res. , vol.60 , pp. 6359-6366
    • Nemunaitis, J.1    Ganly, I.2    Khuri, F.3
  • 98
    • 70350656518 scopus 로고    scopus 로고
    • Survival outcomes by tumor human papillomavirus (HPV) status in stage. III-IV oropharyngeal cancer (OPC) in RTOG 0129
    • Abstract 6003
    • Gillison ML, Harris J, Westra W, et al. Survival outcomes by tumor human papillomavirus (HPV) status in stage III-IV oropharyngeal cancer (OPC) in RTOG 0129. J. Clin. Oncol. 27(15 Suppl.) (2009) (Abstract 6003)
    • (2009) J. Clin. Oncol. , vol.27 , Issue.15 SUPPL.
    • Gillison, M.L.1    Harris, J.2    Westra, W.3
  • 99
    • 77649207406 scopus 로고    scopus 로고
    • TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma
    • Perrone F, Bossi P, Cortelazzi B, et al. TP53 mutations and pathologic complete response to neoadjuvant cisplatin and fluorouracil chemotherapy in resected oral cavity squamous cell carcinoma. J. Clin. Oncol. 28(5), 761-766 (2010)
    • (2010) J. Clin. Oncol. , vol.28 , Issue.5 , pp. 761-766
    • Perrone, F.1    Bossi, P.2    Cortelazzi, B.3
  • 100
    • 77949625967 scopus 로고    scopus 로고
    • Molecular profiling using tissue microarrays as a tool to identify predictive biomarkers in laryngeal cancer treated with radiotherapy
    • Holgersson G, Ekman S, Reizenstein J, et al. Molecular profiling using tissue microarrays as a tool to identify predictive biomarkers in laryngeal cancer treated with radiotherapy. Cancer Genomics Proteomics 7(1), 1-7 (2010)
    • (2010) Cancer Genomics Proteomics , vol.7 , Issue.1 , pp. 1-7
    • Holgersson, G.1    Ekman, S.2    Reizenstein, J.3
  • 101
    • 79952958774 scopus 로고    scopus 로고
    • Use of multiple biological markers in radiotherapy-treated head and neck cancer
    • Silva P, Slevin NJ, Sloan P, et al. Use of multiple biological markers in radiotherapy-treated head and neck cancer. J. Laryngol. Otol. 14, 1-9 (2010)
    • (2010) J. Laryngol. Otol. , vol.14 , pp. 1-9
    • Silva, P.1    Slevin, N.J.2    Sloan, P.3
  • 102
    • 77953820020 scopus 로고    scopus 로고
    • The role of human papillomavirus in head and neck cancer
    • Lajer CB, von Buchwald C. The role of human papillomavirus in head and neck cancer. APMIS 118(6-7), 510-519 (2010)
    • (2010) APMIS , vol.118 , Issue.6-7 , pp. 510-519
    • Lajer, C.B.1    Von Buchwald, C.2
  • 103
    • 37249013214 scopus 로고    scopus 로고
    • 24 February 2011
    • Clinicaltrials.gov http://clinicaltrials.gov/ct2/results?term=NCT00412217 (Accessed 24 February 2011)
    • Clinicaltrials.gov


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.