Interactions between the chemotherapeutic agent eribulin mesylate (E7389) and P-glycoprotein in CF-1 abcb1a-deficient mice and Caco-2 cells

Xenobiotica

Volumn 41, Issue 4, 2011, Pages 320-326

  Taur, Jan Shiang ^a   Desjardins, Christopher S ^a   Schuck, Edgar L ^a   Wong, Y Nancy ^a  

^a EISAI INC   (United States)

Author keywords

Caco 2 cells; CF 1 abcb1a deficient mice; drug drug interactions; eribulin; P glycoprotein

Indexed keywords

DIGOXIN; ERIBULIN; GLYCOPROTEIN P;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG PENETRATION; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MOUSE; NONHUMAN; SINGLE DRUG DOSE;

ANIMALS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CACO-2 CELLS; DRUG INTERACTIONS; FURANS; HUMANS; KETONES; MALE; MESYLATES; MICE; P-GLYCOPROTEIN;

MUS;

EID: 79952936148     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2010.542256     Document Type: Article

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