Postsynaptic alteration of NR2A subunit and defective autophosphorylation of alpha CaMKII at Threonine-286 contribute to abnormal plasticity and morphology of upper motor neurons in presymptomatic SOD1 G93A mice, a murine model for amyotrophic lateral sclerosis

Cerebral Cortex

Volumn 21, Issue 4, 2011, Pages 796-805

  Spalloni, A ^a   Origlia, N ^b   Sgobio, C ^a   Trabalza, A ^a,c   Nutini, M ^a,d   Berretta, N ^a   Bernardi, G ^a,d   Domenici, L ^b,e   Ammassari Teule, M ^a,b   Longone, P ^a  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b CNR Consiglio Nazionale delle Ricerche   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

AMPA and NMDA receptors; cortical synaptic plasticity; dendrite outgrowth; familial amyotrophic lateral sclerosis (fALS); SOD1G93A mutation; upper motor neurons

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; SUPEROXIDE DISMUTASE; THREONINE; THREONINE 286; TYLOXAPOL; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASYMPTOMATIC DISEASE; AUTOPHOSPHORYLATION; BRAIN ELECTROPHYSIOLOGY; CONTROLLED STUDY; DENDRITE; ENZYME PHOSPHORYLATION; GENE MUTATION; MALE; MOTONEURON; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIMARY MOTOR CORTEX; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYNAPSE; WILD TYPE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BLOTTING, WESTERN; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; DISEASE MODELS, ANIMAL; EVOKED POTENTIALS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MICE; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; MOTOR NEURONS; MUTATION; NEURONAL PLASTICITY; PHOSPHORYLATION; RECEPTORS, N-METHYL-D-ASPARTATE; SUPEROXIDE DISMUTASE; THREONINE;

EID: 79952823474     PISSN: 10473211     EISSN: 14602199     Source Type: Journal    
DOI: 10.1093/cercor/bhq152     Document Type: Article

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