The role of the calcium and the voltage clocks in sinoatrial node dysfunction

Yonsei Medical Journal

Volumn 52, Issue 2, 2011, Pages 211-219

  Joung, Boyoung ^a   Chen, Peng Sheng ^b   Lin, Shien Fong ^b  

^a Yonsei University College of Medicine   (South Korea)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium; Sarcoplasmic reticulum; Sick sinus syndrome; Sinoatrial node

Indexed keywords

CAFFEINE; CALCIUM; ION CHANNEL; ISOPRENALINE; RYANODINE RECEPTOR 2;

BETA ADRENERGIC STIMULATION; BRADYCARDIA; CALCIUM TRANSPORT; DEPOLARIZATION; DOWN REGULATION; EXPERIMENTAL DOG; HEART ATRIUM FIBRILLATION; HEART ATRIUM PACEMAKER; HEART RATE; HUMAN; NONHUMAN; REVIEW; SARCOPLASMIC RETICULUM; SINUS NODE; SYMPATHETIC TONE; TACHYCARDIA;

ANIMALS; ARRHYTHMIA, SINUS; ATRIAL FIBRILLATION; BRADYCARDIA; CALCIUM; CALCIUM CHANNELS; DOGS; HUMANS; SICK SINUS SYNDROME; SINOATRIAL NODE;

EID: 79952800332     PISSN: 05135796     EISSN: None     Source Type: Journal    
DOI: 10.3349/ymj.2011.52.2.211     Document Type: Review

References (51)

1. Adán V, Crown LA. Diagnosis and treatment of sick sinus syndrome. Am Fam Physician 2003;67:1725-32.
2. Brown HF, Difrancesco D, Noble SJ. How does adrenaline accelerate the heart? Nature 1979;280:235-6.
3. Baruscotti M, Bucchi A, DiFrancesco D. Physiology and pharmacology of the cardiac pacemaker ("funny") current. Pharmacol-Ther 2005;107:59-79.
4. DiFrancesco D. Pacemaker mechanisms in cardiac tissue. Annu Rev Physiol 1993;55:455-72.
5. DiFrancesco D. The pacemaker current (I(f) plays an important role in regulating Sa node pacemaker activity. Cardiovasc Res 1995;30:307-8.
6. Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D. Familial sinus bradycardia associated with a mutation in the cardil. Adán V, Crown LA. Diagnosis and treatment of sick sinus syndrome. Am Fam Physician 2003;67:1725-32.
7. Bucchi A, Barbuti A, Baruscotti M, DiFrancesco D. Heart rate reduction via selective 'funny' channel blockers. Curr Opin Pharmacol 2007;7:208-13.
8. Nof E, Luria D, Brass D, Marek D, Lahat H, Reznik-Wolf H, et al. Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia. Circulation 2007;116: 463-70.
9. Rubenstein DS, Lipsius SL. Mechanisms of automaticity in subsidiary pacemakers from cat right atrium. Circ Res 1989;64:648-57.
10. Li J, Qu J, Nathan RD. Ionic basis of ryanodine's negative chronotropic effect on pacemaker cells isolated from the sinoatrial node. Am J Physiol 1997;273:H2481-9.
11. Ju YK, Allen DG. Intracellular calcium and Na+-Ca2+ exchange current in isolated toad pacemaker cells. J Physiol 1998;508:153-66.
12. Hüser J, Blatter LA, Lipsius SL. Intracellular Ca2+ release contributes to automaticity in cat atrial pacemaker cells. J Physiol 2000;524 Pt 2:415-22.
13. Vinogradova TM, Bogdanov KY, Lakatta EG. Novel perspectives on the beating rate of the heart. Circ Res 2002;91:e3.
14. Maltsev VA, Vinogradova TM, Lakatta EG. The emergence of a general theory of the initiation and strength of the heartbeat. J Pharmacol Sci 2006;100:338-69.
15. Vinogradova TM, Lyashkov AE, Zhu W, Ruknudin AM, Sirenko S, Yang D, et al. High basal protein kinase A-dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells. Circ Res 2006;98: 505-14.
16. Bhuiyan ZA, van den Berg MP, van Tintelen JP, Bink-Boelkens MT, Wiesfeld AC, Alders M, et al. Expanding spectrum of human TYR2-related disease: new electrocardiographic, structural, and genetic features. Circulation 2007;116:1569-76.
17. Verheijck EE, van Kempen MJ, Veereschild M, Lurvink J, Jongsma HJ, Bouman LN. Electrophysiological features of the mouse sinoatrial node in relation to connexin distribution. Cardiovasc Res 2001;52:40-50.
18. Lancaster MK, Jones SA, Harrison SM, Boyett MR. Intracellular Ca2+ and pacemaking within the rabbit sinoatrial node: Heterogeneity of role and control. J Physiol 2004;556:481-94.
19. Tellez JO, Dobrzynski H, Greener ID, Graham GM, Laing E, Honjo H, et al. Differential expression of ion channel transcripts in atrial muscle and sinoatrial node in rabbit. Circ Res 2006;99: 1384-93.
20. Boineau JP, Miller CB, Schuessler RB, Roeske WR, Autry LJ, Wylds AC, et al. Activation sequence and potential distribution maps demonstrating multicentric atrial impulse origin in dogs. Circ Res 1984;54:332-47.
21. Boineau JP, Schuessler RB, Mooney CR, Wylds AC, Miller CB, Hudson RD, et al. Multicentric origin of the atrial depolarization wave: the pacemaker complex. Relation to dynamics of atrial conduction, P-wave changes and heart rate control. Circulation 1978;58:1036-48.
22. Schuessler RB, Boineau JP, Wylds AC, Hill DA, Miller CB, Roeske WR. Effect of canine cardiac nerves on heart rate, rhythm, and pacemaker location. Am J Physiol 1986;250:H630-44.
23. Joung B, Tang L, Maruyama M, Han S, Chen Z, Stucky M, et al. Intracellular calcium dynamics and acceleration of sinus rhythm by beta-adrenergic stimulation. Circulation 2009;119:788-96.
24. Vinogradova TM, Bogdanov KY, Lakatta EG. beta-Adrenergic stimulation modulates ryanodine recepr Ca(2+) release during diastolic depolarization to accelerate pacemaker activity in rabbit sinoatrial nodal cells. Circ Res 2002;90:73-9.
25. Dobrzynski H, Boyett MR, Anderson RH. New insights into pacemaker activity: promoting understanding of sick sinus syndrome. Circulation 2007;115:1921-32.
26. Verkerk AO, Wilders R, Coronel R, Ravesloot JH, Verheijck EE. Ionic remodeling of sinoatrial node cells by heart failure. Circulation 2003;108:760-6.
27. Nattel S, Maguy A, Le Bouter S, Yeh YH. Arrhythmogenic ion-channel remodeling in the heart: heart failure, myocardial infarction, and atrial fibrillation. Physiol Rev 2007;87:425-56.
28. Van Wagoner DR, Pond AL, Lamorgese M, Rossie SS, McCarthy PM, Nerbonne JM. Atrial L-type Ca2+ currents and human atrial fibrillation. Circ Res 1999;85:428-36.
29. Workman AJ, Kane KA, Rankin AC. The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovasc Res 2001;52: 226-35.
30. Van Wagoner DR, Pond AL, McCarthy PM, Trimmer JS, Nerbonne JM. Outward K+ current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ Res 1997;80: 772-81.
31. Yeh YH, Burstein B, Qi XY, Sakabe M, Chartier D, Comtois P, et al. Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia: a molecular basis for tachycardia-bradycardia syndrome. Circulation 2009;119:1576-85.
32. Efimov IR, Fedorov VV, Joung B, Lin SF. Mapping cardiac pacemaker circuits: methodological puzzles of the sinoatrial node optical mapping. Circ Res 2010;106:255-71.
33. Joung B, Lin SF, Chen Z, Antoun PS, Maruyama M, Han S, et al. Mechanisms of sinoatrial node dysfunction in a canine model of pacing-induced atrial fibrillation. Heart Rhythm 2010;7:88-95.
34. Sanders P, Kistler PM, Morton JB, Spence SJ, Kalman JM. Remodeling of sinus node function in patients with congestive heart failure: reduction in sinus node reserve. Circulation 2004;110: 897-903.
35. Ogawa M, Zhou S, Tan AY, Song J, Gholmieh G, Fishbein MC, et al. Left stellate ganglion and vagal nerve activity and cardiac arrhythmias in ambulatory dogs with pacing-induced congestive heart failure. J Am Coll Cardiol 2007;50:335-43.
36. Zicha S, Fernández-Velasco M, Lonardo G, L'Heureux N, Nattel S. Sinus node dysfunction and hyperpolarization-activated (HCN) channel subunit remodeling in a canine heart failure model. Cardiovasc Res 2005;66:472-81.
37. Rubart M, Zipes DP. Mechanisms of sudden cardiac death. J Clin-Invest 2005;115:2305-15.
38. Sanders P, Berenfeld O, Hocini M, Jaïs P, Vaidyanathan R, Hsu LF, et al. Spectral analysis identifies sites of high-frequency activity maintaining atrial fibrillation in humans. Circulation 2005;112: 789-97.
39. Joung B, Shinohara T, Zhang H, Kim D, Choi EK, On YK, et al. Tachybradycardia in the isolated canine right atrium induced by chronic sympathetic stimulation and pacemaker current inhibition. Am J Physiol Heart Circ Physiol 2010;299:H634-42.
40. Bers DM. Calcium cycling and signaling in cardiac myocytes. Annu Rev Physiol 2008;70:23-49.
41. ter Keurs HE, Zhang YM, Miura M. Damage-induced arrhythmias: reversal of excitation-contraction coupling. Cardiovasc Res 1998;40:444-55.
42. Boyden PA, ter Keurs HE. Reverse excitation-contraction coupling: Ca2+ ions as initiators of arrhythmias. J Cardiovasc Electrophysiol 2001;12:382-5.
43. Lakatta EG, DiFrancesco D. What keeps us ticking: a funny current, a calcium clock, or both? J Mol Cell Cardiol 2009;47:157-70.
44. Maltsev VA, Lakatta EG. Synergism of coupled subsarcolemmal Ca2+ clocks and sarcolemmal voltage clocks confers robust and flexible pacemaker function in a novel pacemaker cell model. Am J Physiol Heart Circ Physiol 2009;296:H594-615.
45. Lakatta EG, Maltsev VA, Vinogradova TM. A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart's pacemaker. Circ Res 2010;106:659-73.
46. Zhou Z, Lipsius SL. Na(+)-Ca2+ exchange current in latent pacemaker cells isolated from cat right atrium. J Physiol 1993;466: 263-85.
47. Hata T, Noda T, Nishimura M, Watanabe Y. The role of Ca2+ release from sarcoplasmic reticulum in the regulation of sinoatrial node automaticity. Heart Vessels 1996;11:234-41.
48. Rigg L, Terrar DA. Possible role of calcium release from the sarcoplasmic reticulum in pacemaking in guinea-pig sino-atrial node. Exp Physiol 1996;81:877-80.
49. Bogdanov KY, Vinogradova TM, Lakatta EG. Sinoatrial nodal cell ryanodine receptor and Na(+)-Ca(2+) exchanger: molecular partners in pacemaker regulation. Circ Res 2001;88:1254-8.
50. Shinohara T, Joung B, Kim D, Maruyama M, Luk HN, Chen PS, et al. Induction of atrial ectopic beats with calcium release inhibition: Local hierarchy of automaticity in the right atrium. Heart Rhythm 2010;7:110-6.
51. Joung B, Zhang H, Shinohara T, Maruyama M, Han S, Kim D, et al. Delayed Afterdepolarization in intact Canine Sinoatrial Node as a Novel Mechanism for Atrial Arrhythmia. J Cardiovasc Electrophysiol 2010. (In press)