Funny current downregulation and sinus node dysfunction associated with atrial tachyarrhythmia a molecular basis for tachycardia-bradycardia syndrome

Circulation

Volumn 119, Issue 12, 2009, Pages 1576-1585

  Yung Hsin Yeh, ^a,c   Burstein, Brett ^a,b   Qi, Xiao Yan ^a   Sakabe, Masao ^a   Chartier, Denis ^a   Comtois, Philippe ^a   Wang, Zhiguo ^a   Kuo, Chi Tai ^c   Nattel, Stanley ^a,d  

^a MONTREAL HEART INSTITUTE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d Chang Gung University Tao Yuan ^*  (Canada)

Author keywords

arrhythmia; electrophysiology; ion channels; pacing; Sinoatrial node

Indexed keywords

CONNEXIN 43; CYCLIC NUCLEOTIDE GATED CHANNEL; ION CHANNEL; MESSENGER RNA; TRANSCRIPTION FACTOR ERG; VOLTAGE GATED CALCIUM CHANNEL; CALCIUM CHANNEL; POTASSIUM CHANNEL;

ACTION POTENTIAL; ALPHA CHAIN; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA CHAIN; BRADYCARDIA; CONTROLLED STUDY; DISEASE ASSOCIATION; DOG; DOWN REGULATION; GAP JUNCTION; HEART FUNCTION; HEART MUSCLE CELL; HEART PACING; HEART VENTRICLE REMODELING; HYPERPOLARIZATION; IN VIVO STUDY; ION CURRENT; KINETICS; NONHUMAN; PATCH CLAMP; PERIODICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINUS NODE; SINUS NODE DYSFUNCTION; SUPRAVENTRICULAR TACHYCARDIA; TACHYCARDIA; WHOLE CELL; ANIMAL; GENETICS; HEART ATRIUM; HEART FUNCTION TEST; HEART MUSCLE CONDUCTION SYSTEM; ION TRANSPORT; METABOLISM; PATHOPHYSIOLOGY; SYNDROME;

ANIMALS; BRADYCARDIA; CALCIUM CHANNELS; DOGS; DOWN-REGULATION; ELECTROPHYSIOLOGIC TECHNIQUES, CARDIAC; HEART ATRIA; HEART CONDUCTION SYSTEM; ION CHANNELS; ION TRANSPORT; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; RNA, MESSENGER; SINOATRIAL NODE; SYNDROME; TACHYCARDIA;

EID: 65249189288     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.108.789677     Document Type: Article

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