Site-directed mutagenesis of CCR2 identified amino acid residues in transmembrane helices 1, 2, and 7 important for MCP-1 binding and biological functions

Biochemical and Biophysical Research Communications

Volumn 327, Issue 2, 2005, Pages 533-540

  Gavrilin, Mikhail A ^a   Gulina, Irina V ^b   Kawano, Tomonori ^b   Dragan, Sofya ^b   Chakravarti, Leena ^b   Kolattukudy, Pappachan E ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

Chemokines; Chemotaxis; Monocytes macrophages; Signal transduction

Indexed keywords

ADENYLATE CYCLASE; CHEMOKINE RECEPTOR CCR2; MONOCYTE CHEMOTACTIC PROTEIN 1;

AMINO ACID ANALYSIS; ARTICLE; CALCIUM TRANSPORT; CELL INFILTRATION; CHEMOTAXIS; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; GENE MUTATION; HUMAN; HUMAN CELL; ION TRANSPORT; MACROPHAGE; MEMBRANE POTENTIAL; MONOCYTE; PRIORITY JOURNAL; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; SUBSTITUTION REACTION;

ADENYLATE CYCLASE; AMINO ACID SEQUENCE; AMINO ACIDS; CALCIUM; CELL LINE; CELL MEMBRANE; CHEMOKINE CCL2; CHEMOTAXIS; CYTOSKELETON; GENE EXPRESSION REGULATION; HUMANS; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PSEUDOPODIA; RECEPTORS, CHEMOKINE; SIGNAL TRANSDUCTION;

EID: 11144292658     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.12.037     Document Type: Article

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