In vitro selection and characterization of HIV-1 variants with increased resistance to sifuvirtide, a novel HIV-1 fusion inhibitor

Journal of Biological Chemistry

Volumn 286, Issue 5, 2011, Pages 3277-3287

  Liu, Zhonghua ^a   Shan, Mei ^a   Li, Li ^a   Lu, Lu ^b   Meng, Shu ^a   Chen, Cheng ^c   He, Yuxian ^a   Jiang, Shibo ^b   Zhang, Linqi ^a,c  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b NEW YORK BLOOD CENTER   (United States)

^c Tsinghua University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL DEVELOPMENT; CLINICAL INVESTIGATION; CRITICAL AMINO ACIDS; FUSION INHIBITORS; HEPTAD REPEAT REGIONS; HIV-1 INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS; IN-VITRO; IN-VIVO; N-TERMINALS; SITE DIRECTED MUTAGENESIS;

AMINO ACIDS; ANIMAL CELL CULTURE; CELL CULTURE; DISEASES;

VIRUSES;

GLYCOPROTEIN GP 41; SIFUVIRTIDE; ENFUVIRTIDE; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; PEPTIDE; PEPTIDE FRAGMENT;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIVIRAL RESISTANCE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CROSS RESISTANCE; CYTOPATHOGENIC EFFECT; GENETIC TRANSFECTION; GENOTYPE; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO SELECTION; NONHUMAN; PHENOTYPIC VARIATION; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; VIRUS CELL INTERACTION; VIRUS CHARACTERIZATION; VIRUS INFECTIVITY; VIRUS MUTANT; VIRUS MUTATION; CROSS REACTION; GENETIC VARIABILITY; GENETICS; HUMAN; MUTATION; PHYSIOLOGY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SUBSTITUTION; CROSS REACTIONS; DRUG RESISTANCE, VIRAL; GENETIC VARIATION; HIV ENVELOPE PROTEIN GP41; HIV FUSION INHIBITORS; HIV-1; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE FRAGMENTS; PEPTIDES;

EID: 79952781156     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.199323     Document Type: Article

References (48)

1. Melikyan, G. B. (2008) Retrovirology 5, 111
2. Chan, D. C., and Kim, P. S. (1998) Cell 93, 681-684
3. Root, M. J., Kay, M. S., and Kim, P. S. (2001) Science 291, 884-888
4. Jiang, S., and Debnath, A. K. (2000) Biochem. Biophys. Res. Commun. 269, 641-646
5. Chan, D. C., Fass, D., Berger, J. M., and Kim, P. S. (1997) Cell 89, 263-273
6. Weissenhorn, W., Dessen, A., Harrison, S. C., Skehel, J. J., and Wiley, D. C. (1997) Nature 387, 426-430
7. Tan, K., Liu, J., Wang, J., Shen, S., and Lu, M. (1997) Proc. Natl. Acad. Sci. U.S.A. 94, 12303-12308
8. Rapaport, D., Ovadia, M., and Shai, Y. (1995) EMBO J. 14, 5524-5531
9. Blacklow, S. C., Lu, M., and Kim, P. S. (1995) Biochemistry 34, 14955-14962
10. Lombardi, S., Massi, C., Indino, E., La Rosa, C., Mazzetti, P., Falcone, M. L., Rovero, P., Fissi, A., Pieroni, O., Bandecchi, P., Esposito, F., Tozzini, F., Bendinelli, M., and Garzelli, C. (1996) Virology 220, 274-284
11. Wang, E., Sun, X., Qian, Y., Zhao, L., Tien, P., and Gao, G. F. (2003) Biochem. Biophys. Res. Commun. 302, 469-475
12. Lambert, D. M., Barney, S., Lambert, A. L., Guthrie, K., Medinas, R., Davis, D. E., Bucy, T., Erickson, J., Merutka, G., and Petteway, S. R., Jr. (1996) Proc. Natl. Acad. Sci. U.S.A. 93, 2186-2191
13. Weissenhorn, W., Carfí, A., Lee, K. H., Skehel, J. J., and Wiley, D. C. (1998) Mol. Cell 2, 605-616
14. Xu, Y., Gao, S., Cole, D. K., Zhu, J., Su, N., Wang, H., Gao, G. F., and Rao, Z. (2004) Biochem. Biophys. Res. Commun. 315, 664-670
15. Liu, S., Xiao, G., Chen, Y., He, Y., Niu, J., Escalante, C. R., Xiong, H., Farmar, J., Debnath, A. K., Tien, P., and Jiang, S. (2004) Lancet 363, 938-947
16. Tripet, B., Howard, M. W., Jobling, M., Holmes, R. K., Holmes, K. V., and Hodges, R. S. (2004) J. Biol. Chem. 279, 20836-20849
17. Xu, Y., Lou, Z., Liu, Y., Pang, H., Tien, P., Gao, G. F., and Rao, Z. (2004) J. Biol. Chem. 279, 49414-49419
18. Dorr, P., Westby, M., Dobbs, S., Griffin, P., Irvine, B., Macartney, M., Mori, J., Rickett, G., Smith-Burchnell, C., Napier, C., Webster, R., Armour, D., Price, D., Stammen, B., Wood, A., and Perros, M. (2005) Antimicrob. Agents Chemother. 49, 4721-4732
19. Fätkenheuer, G., Pozniak, A. L., Johnson, M. A., Plettenberg, A., Staszewski, S., Hoepelman, A. I., Saag, M. S., Goebel, F. D., Rockstroh, J. K., Dezube, B. J., Jenkins, T. M., Medhurst, C., Sullivan, J. F., Ridgway, C., Abel, S., James, I. T., Youle, M., and van der Ryst, E. (2005) Nat. Med. 11, 1170-1172
20. Kromdijk, W., Huitema, A. D., and Mulder, J. W. (2010) Expert Opin. Pharmacother. 11, 1215-1223
21. Trkola, A., Ketas, T. J., Nagashima, K. A., Zhao, L., Cilliers, T., Morris, L., Moore, J. P., Maddon, P. J., and Olson, W. C. (2001) J. Virol. 75, 579-588
22. Jacobson, J. M., Saag, M. S., Thompson, M. A., Fischl, M. A., Liporace, R., Reichman, R. C., Redfield, R. R., Fichtenbaum, C. J., Zingman, B. S., Patel, M. C., Murga, J. D., Pemrick, S. M., D'Ambrosio, P., Michael, M., Kroger, H., Ly, H., Rotshteyn, Y., Buice, R., Morris, S. A., Stavola, J. J., Maddon, P. J., Kremer, A. B., and Olson, W. C. (2008) J. Infect. Dis. 198, 1345-1352
23. Kuritzkes, D. R., Jacobson, J., Powderly, W. G., Godofsky, E., DeJesus, E., Haas, F., Reimann, K. A., Larson, J. L., Yarbough, P. O., Curt, V., and Shanahan, W. R., Jr. (2004) J. Infect. Dis. 189, 286-291
24. Dwyer, J. J., Wilson, K. L., Davison, D. K., Freel, S. A., Seedorff, J. E., Wring, S. A., Tvermoes, N. A., Matthews, T. J., Greenberg, M. L., and Delmedico, M. K. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 12772-12777
25. Liu, K., Lu, H., Hou, L., Qi, Z., Teixeira, C., Barbault, F., Fan, B. T., Liu, S., Jiang, S., and Xie, L. (2008) J. Med. Chem. 51, 7843-7854
26. Katritzky, A. R., Tala, S. R., Lu, H., Vakulenko, A. V., Chen, Q. Y., Sivapackiam, J., Pandya, K., Jiang, S., and Debnath, A. K. (2009) J. Med. Chem. 52, 7631-7639
27. Pan, C., Cai, L., Lu, H., Qi, Z., and Jiang, S. (2009) J. Virol. 83, 7862-7872
28. Chen, X., Lu, L., Qi, Z., Lu, H., Wang, J., Yu, X., Chen, Y., and Jiang, S. (2010) J. Biol. Chem. 285, 25506-25515
29. He, Y., Xiao, Y., Song, H., Liang, Q., Ju, D., Chen, X., Lu, H., Jing, W., Jiang, S., and Zhang, L. (2008) J. Biol. Chem. 283, 11126-11134
30. Liu, S., Zhao, Q., and Jiang, S. (2003) Peptides 24, 1303-1313
31. Jiang, S., Lin, K., Zhang, L., and Debnath, A. K. (1999) J. Virol. Methods 80, 85-96
32. Liu, S., Jing, W., Cheung, B., Lu, H., Sun, J., Yan, X., Niu, J., Farmar, J., Wu, S., and Jiang, S. (2007) J. Biol. Chem. 282, 9612-9620
33. Zhu, Y., Lu, L., Xu, L., Yang, H., Jiang, S., and Chen, Y. H. (2010) J. Virol. 84, 9359-9368
34. Buzon, V., Natrajan, G., Schibli, D., Campelo, F., Kozlov, M. M., and Weissenhorn, W. (2010) PLoS Pathog. 6, e1000880
35. Peitsch, M. C. (1996) Biochem. Soc. Trans. 24, 274-279
36. Izumi, K., Kodama, E., Shimura, K., Sakagami, Y., Watanabe, K., Ito, S., Watabe, T., Terakawa, Y., Nishikawa, H., Sarafianos, S. G., Kitaura, K., Oishi, S., Fujii, N., and Matsuoka, M. (2009) J. Biol. Chem. 284, 4914-4920
37. Shimura, K., Nameki, D., Kajiwara, K., Watanabe, K., Sakagami, Y., Oishi, S., Fujii, N., Matsuoka, M., Sarafianos, S. G., and Kodama, E. N. (2010) J. Biol. Chem. 285, 39471-39480
38. Jiang, S., Lu, H., Liu, S., Zhao, Q., He, Y., and Debnath, A. K. (2004) Antimicrob. Agents Chemother. 48, 4349-4359
39. Liu, S., Lu, H., Niu, J., Xu, Y., Wu, S., and Jiang, S. (2005) J. Biol. Chem. 280, 11259-11273
40. Jiang, S., Lin, K., and Lu, M. (1998) J. Virol. 72, 10213-10217
41. Rimsky, L. T., Shugars, D. C., and Matthews, T. J. (1998) J. Virol. 72, 986-993
42. Wei, X., Decker, J. M., Liu, H., Zhang, Z., Arani, R. B., Kilby, J. M., Saag, M. S., Wu, X., Shaw, G. M., and Kappes, J. C. (2002) Antimicrob. Agents Chemother. 46, 1896-1905
43. Bewley, C. A., Louis, J. M., Ghirlando, R., and Clore, G. M. (2002) J. Biol. Chem. 277, 14238-14245
44. Baldwin, C. E., Sanders, R. W., Deng, Y., Jurriaans, S., Lange, J. M., Lu, M., and Berkhout, B. (2004) J. Virol. 78, 12428-12437
45. Lu, J., Sista, P., Giguel, F., Greenberg, M., and Kuritzkes, D. R. (2004) J. Virol. 78, 4628-4637
46. Eggink, D., Baldwin, C. E., Deng, Y., Langedijk, J. P., Lu, M., Sanders, R. W., and Berkhout, B. (2008) J. Virol. 82, 6678-6688
47. Baldwin, C., and Berkhout, B. (2008) J. Virol. 82, 7735-7740
48. Eggink, D., Langedijk, J. P., Bonvin, A. M., Deng, Y., Lu, M., Berkhout, B., and Sanders, R. W. (2009) J. Biol. Chem. 284, 26941-26950