Design of peptide-based inhibitors for human immunodeficiency virus type 1 strains resistant to T-20

Journal of Biological Chemistry

Volumn 284, Issue 8, 2009, Pages 4914-4920

  Izumi, Kazuki ^a   Kodama, Eiichi ^a   Shimura, Kazuya ^a   Sakagami, Yasuko ^a   Watanabe, Kentaro ^a   Ito, Saori ^a   Watabe, Tsuyoshi ^a   Terakawa, Yukihiro ^a   Nishikawa, Hiroki ^a   Sarafianos, Stefan G ^b   Kitaura, Kazuo ^a   Oishi, Shinya ^a   Fujii, Nobutaka ^a   Matsuoka, Masao ^a  

^a KYOTO UNIVERSITY   (Japan)

^b University of Missouri   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIRCULAR DICHROISM; CONFORMATIONAL CHANGE; DRUG RESISTANCE; FUSION INHIBITORS; HELIX BUNDLE; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS TYPE-1; MULTIDRUG RESISTANCE; N-TERMINAL; PEPTIDE-BASED INHIBITORS; POTENT INHIBITOR; PROTEASE INHIBITOR; RESISTANT STRAINS; REVERSE TRANSCRIPTASE;

DICHROISM; MACHINE DESIGN;

AMINES;

ALANINE; ENFUVIRTIDE; GLYCINE; GLYCOPROTEIN GP 41; ISOLEUCINE; LEUCINE; METHIONINE; PEPTIDE; PEPTIDE C34; PROLINE; SERINE; UNCLASSIFIED DRUG; GP41 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS FUSION INHIBITOR; PEPTIDE FRAGMENT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ANTIVIRAL SUSCEPTIBILITY; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; GENE SEQUENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; THERMOSTABILITY; VIRUS INHIBITION; VIRUS REPLICATION; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; GENETICS; HELA CELL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METABOLISM; MISSENSE MUTATION; MULTIDRUG RESISTANCE; PHYSIOLOGY;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

AMINO ACID SUBSTITUTION; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, VIRAL; HELA CELLS; HIV ENVELOPE PROTEIN GP41; HIV FUSION INHIBITORS; HIV INFECTIONS; HIV-1; HUMANS; MUTATION, MISSENSE; PEPTIDE FRAGMENTS; VIRUS REPLICATION;

EID: 64149109197     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M807169200     Document Type: Article

References (38)

1. Chan, D. C., and Kim, P. S. (1998) Cell 93, 681-684
2. Weiss, C. D. (2003) AIDS Rev. 5, 214-221
3. Jiang, S., Lin, K., Strick, N., and Neurath, A. R. (1993) Nature 365, 113
4. Chan, D. C., Chutkowski, C. T., and Kim, P. S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15613-15617
5. Dwyer, J. J., Wilson, K. L., Davison, D. K., Freel, S. A., Seedorff, J. E., Wring, S. A., Tvermoes, N. A., Matthews, T. J., Greenberg, M. L., and Delmedico, M. K. (2007) Proc. Natl. Acad. Sci. U. S. A. 104, 12772-12777
6. Otaka, A., Nakamura, M., Nameki, D., Kodama, E., Uchiyama, S., Nakamura, S., Nakano, H., Tamamura, H., Kobayashi, Y., Matsuoka, M., and Fujii, N. (2002) Angew. Chem. Int. Ed. Engl. 41, 2937-2940
7. Lalezari, J. P., Henry, K., O'Hearn, M., Montaner, J. S., Piliero, P. J., Trottier, B., Walmsley, S., Cohen, C., Kuritzkes, D. R., Eron, J. J., Jr., Chung, J., DeMasi, R., Donatacci, L., Drobnes, C., Delehanty, J., and Salgo, M. (2003) N. Engl. J. Med. 348, 2175-2185
8. Lazzarin, A., Clotet, B., Cooper, D., Reynes, J., Arasteh, K., Nelson, M., Katlama, C., Stellbrink, H. J., Delfraissy, J. F., Lange, J., Huson, L., DeMasi, R., Wat, C., Delehanty, J., Drobnes, C., and Salgo, M. (2003) N. Engl. J. Med. 348, 2186-2195
9. Baldwin, C. E., and Berkhout, B. (2006) Retrovirology 3, 84
10. Cabrera, C., Marfil, S., Garcia, E., Martinez-Picado, J., Bonjoch, A., Bofill, M., Moreno, S., Ribera, E., Domingo, P., Clotet, B., and Ruiz, L. (2006) AIDS 20, 2075-2080
11. Labrosse, B., Morand-Joubert, L., Goubard, A., Rochas, S., Labernardiere, J. L., Pacanowski, J., Meynard, J. L., Hance, A. J., Clavel, F., and Mammano, F. (2006) J. Virol. 80, 8807-8819
12. Mink, M., Mosier, S. M., Janumpalli, S., Davison, D., Jin, L., Melby, T., Sista, P., Erickson, J., Lambert, D., Stanfield-Oakley, S. A., Salgo, M., Cammack, N., Matthews, T., and Greenberg, M. L. (2005) J. Virol. 79, 12447-12454
13. Nameki, D., Kodama, E., Ikeuchi, M., Mabuchi, N., Otaka, A., Tamamura, H., Ohno, M., Fujii, N., and Matsuoka, M. (2005) J. Virol. 79, 764-770
14. Perez-Alvarez, L., Carmona, R., Ocampo, A., Asorey, A., Miralles, C., Perez de Castro, S., Pinilla, M., Contreras, G., Taboada, J. A., and Najera, R. (2006) J. Med. Virol. 78, 141-147
15. Xu, L., Pozniak, A., Wildfire, A., Stanfield-Oakley, S. A., Mosier, S. M., Ratcliffe, D., Workman, J., Joall, A., Myers, R., Smit, E., Cane, P. A., Greenberg, M. L., and Pillay, D. (2005) Antimicrob. Agents Chemother. 49, 1113-1119
16. Armand-Ugon, M., Gutierrez, A., Clotet, B., and Este, J. A. (2003) Antiviral Res. 59, 137-142
17. Baldwin, C. E., Sanders, R. W., Deng, Y., Jurriaans, S., Lange, J. M., Lu, M., and Berkhout, B. (2004) J. Virol. 78, 12428-12437
18. Baldwin, C., and Berkhout, B. (2008) J. Virol. 82, 7735-7740
19. Kimpton, J., and Emerman, M. (1992) J. Virol. 66, 2232-2239
20. Maeda, Y., Venzon, D. J., and Mitsuya, H. (1998) J. Infect. Dis. 177, 1207-1213
21. Adachi, A., Gendelman, H. E., Koenig, S., Folks, T., Willey, R., Rabson, A., and Martin, M. A. (1986) J. Virol. 59, 284-291
22. Hachiya, A., Kodama, E. N., Sarafianos, S. G., Schuckmann, M. M., Sakagami, Y., Matsuoka, M., Takiguchi, M., Gatanaga, H., and Oka, S. (2008) J. Virol. 82, 3261-3270
23. Chan, D. C., Fass, D., Berger, J. M., and Kim, P. S. (1997) Cell 89, 263-273
24. Case, D. A., Cheatham, T. E., 3rd, Darden, T., Gohlke, H., Luo, R., Merz, K. M., Jr., Onufriev, A., Simmerling, C., Wang, B., and Woods, R. J. (2005) J. Comput. Chem. 26, 1668-1688
25. Nilsson, I., Saaf, A., Whitley, P., Gafvelin, G., Waller, C., and von Heijne, G. (1998) J. Mol. Biol. 284, 1165-1175
26. Eckert, D. M., and Kim, P. S. (2001) Annu. Rev. Biochem. 70, 777-810
27. Bai, X., Wilson, K. L., Seedorff, J. E., Ahrens, D., Green, J., Davison, D. K., Jin, L., Stanfield-Oakley, S. A., Mosier, S. M., Melby, T. E., Cammack, N., Wang, Z., Greenberg, M. L., and Dwyer, J. J. (2008) Biochemistry 47, 6662-6670
28. Watabe, T., Oishi, S., Watanabe, K., Ohno, H., Nakano, H., Nakatsu, T., Kato, H., Izumi, K., Kodama, E., Matsuoka, M., and Fujii, N. (2009) Peptide Science, in press
29. Nishitsuji, H., Kohara, M., Kannagi, M., and Masuda, T. (2006) J. Virol. 80, 7658-7666
30. Nishikawa, H., Nakamura, S., Kodama, E., Ito, S., Kajiwara, K., Izumi, K., Sakagami, Y., Oishi, S., Ohkubo, T., Kobayashi, Y., Otaka, A., Fujii, N., and Matsuoka, M. (September 10, 2008) Int. J. Biochem. Cell Biol. 10.1016/j.biocel.2008.08.039
31. Oishi, S., Ito, S., Nishikawa, H., Watanabe, K., Tanaka, M., Ohno, H., Izumi, K., Sakagami, Y., Kodama, E., Matsuoka, M., and Fujii, N. (2008) J. Med. Chem. 51, 388-391
32. Chinnadurai, R., Rajan, D., Munch, J., and Kirchhoff, F. (2007) J. Virol. 81, 6563-6572
33. Eggink, D., Baldwin, C. E., Deng, Y., Langedijk, J. P., Lu, M., Sanders, R. W., and Berkhout, B. (2008) J. Virol. 82, 6678-6688
34. Futaki, S., Suzuki, T., Ohashi, W., Yagami, T., Tanaka, S., Ueda, K., and Sugiura, Y. (2001) J. Biol. Chem. 276, 5836-5840
35. Nagahara, H., Vocero-Akbani, A. M., Snyder, E. L., Ho, A., Latham, D. G., Lissy, N. A., Becker-Hapak, M., Ezhevsky, S. A., and Dowdy, S. F. (1998) Nat. Med. 4, 1449-1452
36. Takeuchi, T., Kosuge, M., Tadokoro, A., Sugiura, Y., Nishi, M., Kawata, M., Sakai, N., Matile, S., and Futaki, S. (2006) ACS Chem. Biol. 1, 299-303
37. Walensky, L. D., Kung, A. L., Escher, I., Malia, T. J., Barbuto, S., Wright, R. D., Wagner, G., Verdine, G. L., and Korsmeyer, S. J. (2004) Science 305, 1466-1470
38. Walensky, L. D., Pitter, K., Morash, J., Oh, K. J., Barbuto, S., Fisher, J., Smith, E., Verdine, G. L., and Korsmeyer, S. J. (2006) Mol. Cell 24, 199-210