Design and evaluation of sifuvirtide, a novel HIV-1 fusion inhibitor

Journal of Biological Chemistry

Volumn 283, Issue 17, 2008, Pages 11126-11134

  He, Yuxian ^a,e   Xiao, Yonghong ^b   Song, Haifeng ^c   Liang, Qing ^d   Ju, Dan ^d   Chen, Xin ^d   Lu, Hong ^e   Jing, Weiguo ^e   Jiang, Shibo ^e   Zhang, Linqi ^a,f  

^a INSTITUTE OF PATHOGEN BIOLOGY   (China)

^b PEKING UNIVERSITY   (China)

^c BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

^d FusoGen Pharmaceuticals Inc   (China)

^e NEW YORK BLOOD CENTER   (United States)

^f TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; PHARMACOKINETICS; THREE DIMENSIONAL;

ADVERSE EVENTS; CELL FUSIONS; CLINICAL STUDIES; CLINICAL USES; DIFFERENT MECHANISMS; DIMENSIONAL STRUCTURES; DOMINANT NEGATIVES; DRUG RESISTANCES; FUSION INHIBITORS; HEALTHY INDIVIDUALS; HELIX BUNDLES; HIGH POTENCIES; HIV/AIDS; IN VITRO; MECHANISM OF ACTIONS; PHARMACOKINETIC PROFILES; PHARMACOKINETIC STUDIES; RESISTANT STRAINS; SINGLE DOSES;

BIOCHEMISTRY;

GLYCOPROTEIN GP 41; PEPTIDE DERIVATIVE; PROTEIN C34; PROTEIN T 1249; PROTEIN T20; SIFUVIRTIDE; UNCLASSIFIED DRUG; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; PEPTIDE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CELL FUSION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG DESIGN; DRUG EFFICACY; DRUG HALF LIFE; DRUG MECHANISM; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; DRUG TOLERABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENOTYPE; HUMAN; HUMAN EXPERIMENT; HUMAN IMMUNODEFICIENCY VIRUS 1; LIPID MEMBRANE; MALE; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PHENOTYPE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; UNSPECIFIED SIDE EFFECT; VIRUS STRAIN; AMINO ACID SEQUENCE; CHEMISTRY; CHINA; CIRCULAR DICHROISM; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; METHODOLOGY; MOLECULAR GENETICS; SYNTHESIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

ADULT; AMINO ACID SEQUENCE; ANTI-HIV AGENTS; CHEMISTRY, PHARMACEUTICAL; CHINA; CIRCULAR DICHROISM; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GENOTYPE; HIV INFECTIONS; HUMANS; MALE; MOLECULAR SEQUENCE DATA; PEPTIDES; PHENOTYPE;

EID: 45549093277     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800200200     Document Type: Article

References (42)

1. Palella, F. J., Jr., Delaney, K. M., Moorman, A. C., Loveless, M. O., Fuhrer, J., Satten, G. A., Aschman, D. J., and Holmberg, S. D. (1998) N. Engl. J. Med. 338, 853-860
2. Hogg, R. S., Bangsberg, D. R., Lima, V. D., Alexander, C., Bonner, S., Yip, B., Wood, E., Dong, W. W., Montaner, J. S., and Harrigan, P. R. (2006) PLoS. Med. 3, e356
3. Pillay, D., Taylor, S., and Richman, D. D. (2000) Rev. Med. Virol. 10, 231-253
4. Este, J. A., and Telenti, A. (2007) Lancet 370, 81-88
5. Moore, J. P., and Doms, R. W. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 10598-10602
6. Hunter, E., and Swanstrom, R. (1990) Curr. Top. Microbiol. Immunol. 157, 187-253
7. Wyatt, R., and Sodroski, J. (1998) Science 280, 1884-1888
8. Berger, E. A., Murphy, P. M., and Farber, J. M. (1999) Annu. Rev. Immunol. 17, 657-700
9. Doms, R. W., and Moore, J. P. (2000) J. Cell Biol. 151, F9-F14
10. Chan, D. C., Fass, D., Berger, J. M., and Kim, P. S. (1997) Cell 89, 263-273
11. Tan, K., Liu, J., Wang, J., Shen, S., and Lu, M. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 12303-12308
12. Weissenhorn, W., Dessen, A., Harrison, S. C., Skehel, J. J., and Wiley, D. C. (1997) Nature 387, 426-430
13. Eckert, D. M., and Kim, P. S. (2001) Annu. Rev. Biochem. 70, 777-810
14. Leonard, J. T., and Roy, K. (2006) Curr. Med. Chem. 13, 911-934
15. Liu, S., Wu, S., and Jiang, S. (2007) Curr. Pharm. Des. 13, 143-162
16. Bewley, C. A., Louis, J. M., Ghirlando, R., and Clore, G. M. (2002) J. Biol. Chem. 277, 14238-14245
17. Debnath, A. K. (2006) Expert. Opin. Investig. Drugs 15, 465-478
18. Root, M. J., Kay, M. S., and Kim, P. S. (2001) Science 291, 884-888
19. Louis, J. M., Bewley, C. A., and Clore, G. M. (2001) J. Biol. Chem. 276, 29485-29489
20. Gustchina, E., Louis, J. M., Bewley, C. A., and Clore, G. M. (2006) J. Mol. Biol. 364, 283-289
21. He, Y., Liu, S., Jing, W., Lu, H., Cai, D., Chin, D. J., Debnath, A. K., Kirchhoff, F., and Jiang, S. (2007) J. Biol. Chem. 282, 25631-25639
22. Shu, W., Liu, J., Ji, H., Radigen, L., Jiang, S., and Lu, M. (2000) Biochemistry 39, 1634-1642
23. Chen, Y. H., Yang, J. T., and Chau, K. H. (1974) Biochemistry 13, 3350-3359
24. Liu, S., Zhao, Q., and Jiang, S. (2003) Peptides 24, 1303-1313
25. Jiang, S., Lin, K., Zhang, L., and Debnath, A. K. (1999) J. Virol. Methods 80, 85-96
26. Jiang, S. B., Lin, K., and Neurath, A. R. (1991) J. Exp. Med. 174, 1557-1563
27. Liu, S., Jing, W., Cheung, B., Lu, H., Sun, J., Yan, X., Niu, J., Farmar, J., Wu, S., and Jiang, S. (2007) J. Biol. Chem. 282, 9612-9620
28. Jiang, S., Lu, H., Liu, S., Zhao, Q., He, Y., and Debnath, A. K. (2004) Antimicrob. Agents Chemother. 48, 4349-4359
29. Kliger, Y., and Shai, Y. (2000) J. Mol. Biol. 295, 163-168
30. Liu, S., Lu, H., Niu, J., Xu, Y., Wu, S., and Jiang, S. (2005) J. Biol. Chem. 280, 11259-11273
31. Shu, W., Ji, H., and Lu, M. (2000) J. Biol. Chem. 275, 1839-1845
32. Rimsky, L. T., Shugars, D. C., and Matthews, T. J. (1998) J. Virol. 72, 986-993
33. Chan, D. C., and Kim, P. S. (1998) Cell 93, 681-684
34. Chan, D. C., Chutkowski, C. T., and Kim, P. S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 15613-15617
35. Otaka, A., Nakamura, M., Nameki, D., Kodama, E., Uchiyama, S., Nakamura, S., Nakano, H., Tamamura, H., Kobayashi, Y., Matsuoka, M., and Fujii, N. (2002) Angew. Chem. Int. Ed. Engl. 41, 2937-2940
36. Eron, J. J., Gulick, R. M., Bartlett, J. A., Merigan, T., Arduino, R., Kilby, J. M., Yangco, B., Diers, A., Drobnes, C., DeMasi, R., Greenberg, M., Melby, T., Raskino, C., Rusnak, P., Zhang, Y., Spence, R., and Miralles, G. D. (2004) J. Infect. Dis. 189, 1075-1083
37. Kilby, J. M., and Eron, J. J. (2003) N. Engl. J. Med. 348, 2228-2238
38. Spek, E. J., Bui, A. H., Lu, M., and Kallenbach, N. R. (1998) Protein Sci. 7, 2431-2437
39. Kammerer, R. A., Jaravine, V. A., Frank, S., Schulthess, T., Landwehr, R., Lustig, A., Garcia-Echeverria, C., Alexandrescu, A. T., Engel, J., and Steinmetz, M. O. (2001) J. Biol. Chem. 276, 13685-13688
40. Marqusee, S., and Baldwin, R. L. (1987) Proc. Natl. Acad. Sci. U. S. A. 84, 8898-8902
41. Moore, J. P., Kitchen, S. G., Pugach, P., and Zack, J. A. (2004) AIDS Res. Hum. Retroviruses 20, 111-126
42. Moore, J. P., and Stevenson, M. (2000) Nat. Rev. Mol. Cell. Biol. 1, 40-49