Whole plant extracts versus single compounds for the treatment of malaria: Synergy and positive interactions

Malaria Journal

Volumn 10, Issue SUPPL. 1, 2011, Pages

  Rasoanaivo, Philippe ^a   Wright, Colin W ^b   Willcox, Merlin L ^c,d   Gilbert, Ben ^e  

^a IMRA ^*  (Madagascar)

^b UNIVERSITY OF BRADFORD   (United Kingdom)

^c RITAM   (United Kingdom)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMETIN; ARTEMISIA ANNUA EXTRACT; ARTEMISININ; ATOVAQUONE; ATOVAQUONE PLUS PROGUANIL; CASTICIN; CHLOROQUINE; CHRYSOSPLENETIN; CHRYSOSPLENOL D; CINCHONA ALKALOID; CINCHONINE; CIRSILINEOL; CURCUMIN; DIHYDROQUINIDINE; EPIGALLOCATECHIN GALLATE; EUPATORIN; FERETIA APODANTHERA EXTRACT; FLAVONOID; GUIERA SENEGALENSIS EXTRACT; NAUCLEA LATIFOLIA EXTRACT; PIPERINE; PLANT EXTRACT; PROGUANIL; QUERCETIN 3,3' DIMETHYLETHER RHAMNOGLUCOSIDE; QUINIDINE; QUINIMAX; QUININE; TROLOX C; UNCLASSIFIED DRUG; UNINDEXED DRUG; URSOLIC ACID;

ABSENCE OF SIDE EFFECTS; ANDROGRAPHIS PANICULATA; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ANTIOXIDANT ACTIVITY; ARTEMISIA; ARTEMISIA ANNUA; BOSCIA SALICIFOLIA; BRAIN MALARIA; CINCHONA; CLINICAL RESEARCH; COMPETITIVE INHIBITION; CURCUMA LONGA; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG EXCRETION; DRUG FATALITY; DRUG HALF LIFE; DRUG HYPERSENSITIVITY; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENTIATION; DRUG STRUCTURE; DRUG TOLERABILITY; FERETIA APODANTHERA; GINGER; GLYCYRRHIZA GLABRA; GUIERA SENEGALENSIS; HEDYOTIS CORYMBOSA; HERBAL MEDICINE; HERNANDIA VOYRONII; HUMAN; IC 50; IMMUNOMODULATION; IN VITRO STUDY; LANNEA SCHWEINFURTHII; LIPID PEROXIDATION; MALARIA; MALARIA FALCIPARUM; MEDICINAL PLANT; MONOTHERAPY; MULTIDRUG RESISTANCE; NAUCLEA LATIFOLIA; NONHUMAN; PHARMACODYNAMICS; PHYTOCHEMISTRY; PICRORHIZA KURROA; PLANT LEAF; PLANT ROOT; PLASMODIUM BERGHEI INFECTION; RECOMMENDED DRUG DOSE; REVIEW; SCLEROCARYA BIRREA; SINGLE DRUG DOSE; SPIROSPERMUM PENDULIFLORUM; STRYCHNOPSIS THOUARSII; STRYCHNOS MYRTOIDES; ZIZIPHUS JUJUBE;

ANTIMALARIALS; DRUG DISCOVERY; DRUG SYNERGISM; HUMANS; MALARIA; PLANT EXTRACTS; PLANTS; PLANTS, MEDICINAL; PLASMODIUM;

EID: 79952758442     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-S1-S4     Document Type: Review

References (115)

1. An overview of ethnobotanical studies on plants used for the treatment of malaria. M Willcox G Burford G Bodeker, Traditional Medicinal Plants and Malaria Boca Raton: CRC Press, Willcox M, Bodeker G, Rasoanaivo P, 2004 187 197
2. Plant-derived antimalarial agents: new leads and efficient phytomedicines. Part II. Non-alkaloidal natural products. R Batista AdJ Silva Jr. AB de Oliveira, Molecules 2009 14 3037 3072 10.3390/molecules14083037 19701144
3. Antimalarials from nature. K Kaur M Jain T Kaur R Jain, Bioorganic & Medicinal Chemistry 2009 17 3229 3256 10.1016/j.bmc.2009.02.050 19299148
4. Plant-derived antimalarial agents: new leads and efficient phythomedicines. Part I. Alkaloids. AB Oliveira MF Dolabela FC Braga RLRP Jacome FP Varotti MM Povoa, Anais da Academia Brasileira de Ciencias 2009 81 715 740 19893898
5. Synergy in plant medicines. B Gilbert LF Alves, Curr Med Chem 2003 10 13 20 10.2174/0929867033368583 12570718 (Pubitemid 36131646)
6. The synergy principle at work in plants, pathogens, insects, herbivores and humans. JA Duke MJ Bogenschutz-Godwin, Natural Products from Plants Boca Raton: CRC Press, Kaufmann PB, Cseke LJ, Warbler S, Duke JA, Brielmann HL, 1999 183 205
7. Modified fixed-ratio isobologram method for studying in vitro interactions between atovaquone and proguanil or dihydroartemisinin against drug-resistant strains of Plasmodium falciparum. QL Fivelman IS Adagu DC Warhurst, Antimicrob Agents Chemother 2004 48 4097 4102 10.1128/AAC.48.11.4097- 4102.2004 15504827 (Pubitemid 39434861)
8. Combination of quinine, quinidine and cinchonine for the treatment of acute falciparum malaria: correlation with the susceptibility of Plasmodium falciparum to the cinchona alkaloids in vitro. A Sowunmi LA Salako OJ Laoye AF Aderounmu, Trans R Soc Trop Med Hyg 1990 84 626 629 10.1016/0035-9203(90)90127-Z 2278056 (Pubitemid 20358565)
9. A combination of quinine, quinidine and cinchonine (LA 40221) in the treatment of chloroquine resistant falciparum malaria in Thailand: two double-blind trials. D Bunnag T Harinasuta S Looareesuwan S Chittamas W Pannavut J Berthe JM Mondesir, Trans R Soc Trop Med Hyg 1989 83 66 10.1016/0035-9203(89) 90707-4 2690417 (Pubitemid 19265523)
10. Synergy research: approaching a new generation of phytopharmaceuticals. H Wagner G Ulrich-Merzenich, Phytomedicine 2009 16 97 110 10.1016/j.phymed.2008. 12.018 19211237
11. Natural Medicine in the Tropics I: Foundation Text. H Hirt B M'Pia, Winnenden: Anamed 2008
12. Introduction to Ecological Biochemistry. JB Harborne, London: Academic Press Ltd 1988
13. Multidrug pump inhibitors uncover remarkable activity of plant antimicrobials. G Tegos FR Stermitz O Lomovskaya K Lewis, Antimicrob Agents Chemother 2002 46 3133 3141 10.1128/AAC.46.10.3133-3141.2002 12234835
14. Artemisia Species: From Traditional Medicines to Modern Antimalarials-and Back Again. M Willcox, Journal of Alternative & Complementary Medicine 2009 15 101 109 10.1089/acm.2008.0327
15. Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity. CW Wright PA Linley R Brun S Wittlin E Hsu, Molecules 2010 15 804 812 10.3390/molecules15020804 20335947
16. Studies on the antimalarial action of gelatin capsule of Artemisia annua. YD Wan YD Zang JS Wang, Zongguo ji sheng chong xue yu ji sheng chong bing za shi (Chinese Journal of Parasitology and Parasitic Diseases) 1992 10 290 294
17. Synergy and other interactions in phytomedicines. EM Williamson, Phytomedicine 2001 8 401 409 10.1078/0944-7113-00060 11695885 (Pubitemid 32983062)
18. Synergy and polyvalence: paradigms to explain the activity of herbal products. PJ Houghton, Evaluation of Herbal Medicinal Products London: Pharmaceutical Press, Houghton PJ, Mukherjee PK, 2009 85 94
19. A mechanism for the synergistic antimalarial action of atovaquone and proguanil. IK Srivastava AB Vaidya, Antimicrob Agents Chemother 1999 43 1334 1339 10348748 (Pubitemid 29259321)
20. Pharmacopée Africaine. OUA, Lagos: Organisation de l'Unité Africaine 1985
21. Stereoelectronic features of the cinchona alkaloids determine their differential antimalarial activity. JM Karle AK Bhattacharjee, Bioorg Med Chem 1999 7 1769 1774 10.1016/S0968-0896(99)00120-0 10530923 (Pubitemid 29457672)
22. Wartime Cinchona Procurement in Latin America. WH Hodge, Economic Botany 1948 2 229 257 10.1007/BF02859067
23. Activity of a combination of three cinchona bark alkaloids against Plasmodium falciparum in vitro. P Druilhe O Brandicourt T Chongsuphajaisiddhi J Berthe, Antimicrob Agents Chemother 1988 32 250 254 3284455 (Pubitemid 18061384)
24. The herbal tea approach for artemisinin as a therapy for malaria? FH Jansen, Trans R Soc Trop Med Hyg 2006 100 285 286 10.1016/j.trstmh.2005.08.004 16274712 (Pubitemid 43091829)
25. Artemisia annua as a self-reliant treatment for malaria in developing countries. S De Ridder F Van der Kooy R Verpoorte, Journal of Ethnopharmacology 2008 120 302 314 10.1016/j.jep.2008.09.017 18977424 (Pubitemid 50328629)
26. Letter To The Editor : Artemisia annua as a herbal tea for malaria. ML Willcox J Falquet JFS Ferreira B Gilbert E Hsu PM Magalhes J Plaizier-Vercammen VP Sharma CW Wright W Yaode, African Journal of Traditional, Complementary and Alternative Medicines 2007 4 121 123 (Pubitemid 351565813)
27. Antimalarial activity of Artemisia annua flavonoids from whole plants and cell cultures. K-S Liu S-L Yang M Roberts B Elford J Phillipson, Plant Cell Reports 1992 11 637 640 10.1007/BF00236389
28. Potentiation of the antimalarial activity of qinghaosu by methoxylated flavones. BC Elford MF Roberts JD Phillipson RJ Wilson, Trans R Soc Trop Med Hyg 1987 81 434 436 10.1016/0035-9203(87)90161-1 3318019
29. The contribution of flavonoids to the antimalarial activity of Artemisia annua. KC-S Liu S-L Yang MF Roberts BC Elford JD Phillipson, Planta Medica 1989 55 654 655 10.1055/s-2006-962242
30. Antioxidant and antiradical activities of flavonoids. S Burda W Oleszek, J Agric Food Chem 2001 49 2774 2779 10.1021/jf001413m 11409965 (Pubitemid 32826067)
31. Mode of action of artemisinin. CW Wright DC Warhurst, Artemisia London: Taylor and Francis, Wright CW, 2002 18 [Hardmann R (Series Editor): Medinal and Aromatic Plants - Industrial Profiles]
32. Flavonoids as antioxidants. P-G Pietta, Journal of Natural Products 2000 63 1035 1042 10.1021/np9904509 10924197 (Pubitemid 30624503)
33. Evaluation of the total peroxyl radical-scavenging capacity of flavonoids: structure-activity relationships. AJ Dugas J Castaneda-Acosta GC Bonin KL Price NH Fischer GW Winston, Journal of Natural Products 2000 63 327 331 10.1021/np990352n 10757712 (Pubitemid 30173687)
34. Diterpenoids and flavonoids from the fruits of Vitex agnus-castus and antioxidant activity of the fruit extracts and their constituents. Z Hadju J Hohmann P Forgo T Martinek M Dervarics I Zupko G Falkay D Cossuta I Mathe, Phytotherapy Research 2007 21 391 394 10.1002/ptr.2021 17262892 (Pubitemid 46595988)
35. Flavonoids from Artemisia annua L. as antioxidants and their potential synergism with artemisinin against malaria and cancer. JFS Ferreira DL Luthria T Sasaki A Hyerick, Molecules 2010 15 3135 3170 10.3390/molecules15053135 20657468
36. Curcumin for malaria therapy. RC Reddy PG Vatsala VG Keshamouni G Padmanaban PN Rangarajan, Biochem Biophys Res Commun 2005 326 472 474 10.1016/j.bbrc.2004.11.051 15582601 (Pubitemid 39593570)
37. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. L Cui J Miao, Antimicrob Agents Chemother 2007 51 488 494 10.1128/AAC.01238-06 17145789 (Pubitemid 46185265)
38. Medicinal Plants of Samoa. G Uhe, Economic Botany 1974 28 1 30 10.1007/BF02861375
39. Understanding of Malaria in Ayurveda and Strategies for Local Production of Herbal Anti-malarials. D Shankar S Venugopal, First International Meeting of the Research Initiative on Traditional Antimalarials Moshi, Tanzania 1999
40. Curcumin-artemisinin combination therapy for malaria. DN Nandakumar VA Nagaraj PG Vathsala P Rangarajan G Padmanaban, Antimicrob Agents Chemother 2006 50 1859 1860 10.1128/AAC.50.5.1859-1860.2006 16641461
41. Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin. K Mishra AP Dash BK Swain N Dey, Malaria Journal 2009 8 26 10.1186/1475-2875-8-26 19216765
42. Synergistic in vitro antimalarial activity of plant extracts used as traditional herbal remedies in Mali. N Azas N Laurencin F Delmas C Di Giorgio M Gasquet M Laget P Timon-David, Parasitol Res 2002 88 165 171 10.1007/s004360100454 11936507 (Pubitemid 34151146)
43. The in vitro anti-plasmodial and in vivo anti-malarial efficacy of combinations of some medicinal plants used traditionally for treatment of malaria by the Meru community in Kenya. JW Gathirwa GM Rukunga EN Njagi SA Omar PG Mwitari AN Guantai FM Tolo CW Kimani CN Muthaura PG Kirira, et al. J Ethnopharmacol 2008 115 223 231 10.1016/j.jep.2007.09.021 18065175 (Pubitemid 50008982)
44. In vitro anti-plasmodial and in vivo anti-malarial activity of some plants traditionally used for the treatment of malaria by the Meru community in Kenya. J Gathirwa G Rukunga E Njagi S Omar A Guantai C Muthaura P Mwitari C Kimani P Kirira F Tolo, et al. Journal of Natural Medicines 2007 61 261 268 10.1007/s11418-007-0140-0 (Pubitemid 47440755)
45. The importance of pharmacological synergy in psychoactive herbal medicines. M Spinella, Altern Med Rev 2002 7 130 137 11991792 (Pubitemid 34461524)
46. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. G Shoba D Joy T Joseph M Majeed R Rajendran PS Srinivas, Planta Med 1998 64 353 356 10.1055/s-2006-957450 9619120 (Pubitemid 28234275)
47. Antipyretic activity of some Indian plants used in traditional medicine. M Anis M Iqbal, Fitoterapia 1986 57 52 54
48. Herbal Folk Medicine of Tirumala and Tirupati Region of Chittor District, Andhra Pradesh. S Vedavathy DN Rao, Fitoterapia 1995 66 167 171
49. Treatment of malaria through herbal drugs from Orissa, India. RDG Aminuddin A Subhan Khan, Fitoterapia 1993 64 545 548 (Pubitemid 24034804)
50. Piperine enhances the bioavailability of the tea polyphenol (-)-epigallocatechin-3-gallate in mice. JD Lambert J Hong DH Kim VM Mishin CS Yang, J Nutr 2004 134 1948 1952 15284381 (Pubitemid 39031322)
51. Drug Interactions: Cytochrome P450 Drug Interaction Table. http://medicine.iupui.edu/clinpharm/ddis/table.asp
52. Drug-grapefruit juice interactions. GC Kane JJ Lipsky, Mayo Clinic Proceedings 2000 75 933 942 10.4065/75.9.933 10994829
53. Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products. R Appiah-Opong JNM Commandeur B van Vugt-Lussenburg NPE Vermeulen, Toxicology 2007 235 83 91 10.1016/j.tox.2007.03.007 17433521 (Pubitemid 46669770)
54. An in vitro evaluation of human cytochrome P450 3A4 and P-glycoprotein inhibition by garlic. BC Foster MS Foster S Vandenhoek A Krantis JW Budzinski JT Arnason KD Gallicano S Choudri, J Pharm Pharm Sci 2001 4 176 184 11466175 (Pubitemid 34305609)
55. Ethnobotany of the Garífuna of Eastern Nicaragua. FG Coe GJ Anderson, Economic Botany 1996 50 71 107 10.1007/BF02862114
56. Identification of the human cytochrome P450 enzymes involved in the in vitro metabolism of artemisinin. USH Svensson M Ashton, British Journal of Clinical Pharmacology 1999 48 528 535 10.1046/j.1365-2125.1999.00044.x 10583023 (Pubitemid 29454233)
57. In vitro evidence for auto-induction of artemisinin metabolism in the rat. S Gupta USH Svensson M Ashton, European Journal of Drug Metabolism and Pharmacokinetics 2001 26 173 176 10.1007/BF03190393 11695717
58. Why is it that antimalarial drug treatments do not always work? NJ White, Annals of Tropical Medicine and Parasitology 1998 92 449 458 10.1080/00034989859429 9683896 (Pubitemid 28312560)
59. Grapefruit juice increases the bioavailability of artemether. MA van Agtmael V Gupta TH van der Wösten JPB Rutten CJ van Boxtel, European Journal of Clinical Pharmacology 1999 55 405 410 10.1007/s002280050648 10456492 (Pubitemid 29344086)
60. Pharmacokinetic study of artemisinin after oral intake of a traditional preparation of Artemisia annua L. (annual wormwood). K Rath K Taxis G Walz CH Gleiter SM Li L Heide, Am J Trop Med Hyg 2004 70 128 132 14993622 (Pubitemid 38200515)
61. Innate immunity to malaria. MM Stevenson EM Riley, Nature Rev Immunol 2004 4 169 180 10.1038/nri1311 (Pubitemid 38339083)
62. Immunomodulatory agents for prophylaxis and therapy of infections. KN Masihi, Int J Antimicrob Agents 2000 14 181 191 10.1016/S0924-8579(99)00161-2 10773486 (Pubitemid 30201542)
63. Immunomodulatory therapy associated to anti-parasite drugs as a way to prevent severe forms of malaria. MI Muniz-Junqueira, Curr Clin Pharmacol 2007 2 59 73 10.2174/157488407779422285 18690855
64. Immunomodulator effect of picroliv and its potential in treatment against resistant Plasmodium yoelii (MDR) infection in mice. V Dwivedi A Khan A Vasco N Fatima VK Soni A Dangi S Misra-Bhattacharya M Owais, Pharm Res 2008 25 2312 2319 10.1007/s11095-008-9631-2 18551251
65. A Traditional Oriental Herbal Medicine, Juzen-taiho-to has Suppressive Effect on Non-lethal Rodent Malaria by Means of Stimulation of Host Immunity. H Yamaura F Kobayashi Y Komatsu M Tsuji H Sato F Shirota R Shirasaka S Waki, Japanese Journal of Parasitology 1996 45 6 11
66. Immunopathogenesis of cerebral malaria. NH Hunt J Golenser T Chan-Ling S Parekh C Rae S Potter IM Medana J Miu HJ Ball, International Journal for Parasitology 2006 36 569 582 10.1016/j.ijpara.2006.02.016 16678181 (Pubitemid 43674512)
67. Modulation of cerebral malaria by fasudil and other immune-modifying compounds. JH Waknine-Grinberg JA McQuillan N Hunt H Ginsburg J Golenser, Experimental Parasitology 2010 125 141 146 10.1016/j.exppara.2010.01.005 20093114
68. Qinghaosu resistance in rodent malaria. AN Chawira DC Warhurst W Peters, Transactions of the Royal Society of Tropical Medicine & Hygiene 1986 80 477 480 10.1016/0035-9203(86)90351-2
69. Artemisinin resistance: current status and scenarios for containment. AM Dondorp S Yeung L White C Nguon NPJ Day D Socheat L von Seidlein, Nature Reviews Microbiology 2010 8 272 280 10.1038/nrmicro2385 20208550
70. Reversing agents in the treatment of drug-resistant malaria. P Rasoanaivo S Ratsimamanga-Urverg F Frappier, Curr Med Chem 1996 3 1 10 (Pubitemid 26127553)
71. Structural analysis of chloroquine resistance reversal by imipramine analogs. AK Bhattacharjee DE Kyle JL Vennerstrom, Antimicrob Agents Chemother 2001 45 2655 2657 10.1128/AAC.45.9.2655-2657.2001 11502547 (Pubitemid 32801928)
72. Reversal of chloroquine resistance in Plasmodium falciparum by verapamil. SK Martin AM Oduola WK Milhous, Science 1987 235 899 901 10.1126/science. 3544220 3544220 (Pubitemid 17019130)
73. Two flavonols from Artemisia annua which potentiate the activity of berberine and norfloxacin against a resistant strain of Staphylococcus aureus. FR Stermitz LN Scriven G Tegos K Lewis, Planta Medica 2002 68 1140 1141 10.1055/s-2002-36347 12494348 (Pubitemid 36140326)
74. Antimalarial activity of extracts and fractions from Bidens pilosa and other Bidens species (Asteraceae) correlated with the presence of acetylene and flavonoid compounds. MG Brandao AU Krettli LS Soares CG Nery HC Marinuzzi, Journal of Ethnopharmacology 1997 57 131 138 10.1016/S0378-8741(97)00060-3 9254115 (Pubitemid 27344803)
75. New evidences of antimalarial activity of Bidens pilosa roots extract correlated with polyacetylene and flavonoids. FQ Oliveira V Andrade-Neto AU Krettli MG Brandao, Journal of Ethnopharmacology 2004 93 39 42 10.1016/j.jep.2004.03.026 15182902 (Pubitemid 38739267)
76. Synergistic effects in vitro with chloroquine, of methanol extract of Bidens pilosa leaves on resistant Plasmodium falciparum isolate. W Mbacham M Evehe D Bilanda T Dimo V Ndikum O Ogundahunsi N Njifutie J Ouedraogo, 4th MIM Pan-African Malaria Conference; Yaounde, Cameroon 2005 365B
77. Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. J Hong JD Lambert SH Lee PJ Sinko CS Yang, Biochem Biophys Res Commun 2003 310 222 227 10.1016/j.bbrc.2003.09.007 14511674 (Pubitemid 37162786)
78. Antimalarial properties of green tea. AR Sannella L Messori A Casini F Francesco Vincieri AR Bilia G Majori C Severini, Biochem Biophys Res Commun 2007 353 177 181 10.1016/j.bbrc.2006.12.005 17174271 (Pubitemid 44970448)
79. Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. S Anuchapreeda P Leechanachai MM Smith SV Ambudkar PN Limtrakul, Biochem Pharmacol 2002 64 573 582 10.1016/S0006-2952(02) 01224-8 12167476
80. Potential synergism of natural products in the treatment of cancer. S HemaIswarya M Doble, Phytother Res 2006 20 239 249 10.1002/ptr.1841 16557604
81. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. AL Cheng CH Hsu JK Lin MM Hsu YF Ho TS Shen JY Ko JT Lin BR Lin W Ming-Shiang, et al. Anticancer Res 2001 21 2895 2900 11712783
82. Cinchonine, a potent efflux inhibitor to circumvent anthracycline resistance in vivo. P Genne MT Dimanche-Boitrel RY Mauvernay G Gutierrez O Duchamp JM Petit F Martin B Chauffert, Cancer Res 1992 52 2797 2801 1581892
83. Apoptosis induced by doxorubicin and cinchonine in P388 multidrug-resistant cells. S Furusawa S Nakano J Wu S Sakaguchi M Takayanagi KI Sasaki S Satoh, J Pharm Pharmacol 2001 53 1029 1039 10.1211/0022357011776289 11480538 (Pubitemid 32640287)
84. The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids. DC Warhurst JC Craig IS Adagu DJ Meyer SY Lee, Malaria Journal 2003 2 26 10.1186/1475-2875-2-26 14505493
85. Phase I study of cinchonine, a multidrug resistance reversing agent, combined with the CHVP regimen in relapsed and refractory lymphoproliferative syndromes. E Solary L Mannone D Moreau D Caillot RO Casasnovas H Guy M Grandjean JE Wolf F Andre P Fenaux, et al. Leukemia 2000 14 2085 2094 10.1038/sj.leu.2401945 11187897 (Pubitemid 32042247)
86. Bisbenzylisoquinolines as modulators of chloroquine resistance in Plasmodium falciparum and multidrug resistance in tumor cells. F Frappier A Jossang J Soudon F Calvo P Rasoanaivo S Ratsimamanga-Urverg J Saez J Schrevel P Grellier, Antimicrob Agents Chemother 1996 40 1476 1481 8726022 (Pubitemid 26170003)
87. In vitro antimalarial activity and chloroquine potentiating action of two bisbenzylisoquinoline enantiomer alkaloids isolated from Strychnopsis thouarsii and Spirospermum penduliflorum. S Ratsimamanga-Urverg P Rasoanaivo L Ramiaramanana R Milijaona H Rafatro F Verdier A Rakoto-Ratsimamanga J Le Bras, Planta Med 1992 58 540 543 10.1055/s-2006-961545 1484894 (Pubitemid 23074545)
88. In vitro antiplasmodial activity and chloroquine-potentiating action of three new isoquinoline alkaloid dimers isolated from Hernandia voyronii Jumelle. S Ratsimamanga-Urverg P Rasoanaivo H Rafatro B Robijaona A Rakoto-Ratsimamanga, Ann Trop Med Parasitol 1994 88 271 277 7944672 (Pubitemid 24231919)
89. In vitro and in vivo chloroquine-potentiating action of Strychnos myrtoides alkaloids against chloroquine-resistant strains of Plasmodium malaria. P Rasoanaivo S Ratsimamanga-Urverg R Milijaona H Rafatro A Rakoto-Ratsimamanga C Galeffi M Nicoletti, Planta Medica 1994 60 13 16 10.1055/s-2006-959398 8134408 (Pubitemid 24082596)
90. Reversal of chloroquine and mefloquine resistance in Plasmodium falciparum by the two monoindole alkaloids, icajine and isoretuline. M Frederich MP Hayette M Tits P De Mol L Angenot, Planta Medica 2001 67 523 527 10.1055/s-2001-16476 11509972 (Pubitemid 32800417)
91. Enhancement of the antimalarial effect of chloroquine by chloropheniramine in vivo. A Sowunmi AM Oduola OA Ogundahunsi LA Salako, Tropical Medicine & International Health 1998 3 177 183 10.1046/j.1365-3156. 1998.00212.x (Pubitemid 28208274)
92. A Multicenter Study of Azithromycin, Alone and in Combination with Chloroquine, for the Treatment of Acute Uncomplicated Plasmodium falciparum Malaria in India. W Dunne Michael N Singh M Shukla N Valecha PC Bhattacharyya V Dev K Patel K Mohapatra Manoj J Lakhani R Benner, et al. The Journal of Infectious Diseases 2005 191 1582 1588 10.1086/429343 15838784 (Pubitemid 40656745)
93. Blood schizontocidal activity of azithromycin and its combination with a/b arteether against multi-drug resistant Plasmodium yoelii nigeriensis, a novel MDR parasite model for antimalarial screening. R Tripathi S Dhawan GP Dutta, Parasitology 2005 131 295 301 10.1017/S003118200500778X 16178350 (Pubitemid 41277728)
94. Randomised controlled clinical trial of strychnos myrtoides extract for reversal of chloroquine resistance. (Comment on: Potential antimalarial activity of indole alkaloids).[comment]. ML Willcox P Rasoanaivo, Transactions of the Royal Society of Tropical Medicine & Hygiene 2008 102 1165 1166 10.1016/j.trstmh.2008.04.030
95. The relative therapeutic value in malaria of the cinchona alkaloids quinine, cinchonine, quinidine, cinchonidine and quinoidine, and the two derivatives - hydroquinine and ethylhydrocupreine. A MacGilchrist, Indian Journal of Medical Research 1915 III 1 53
96. Toxbase. http://www.toxbase.org
97. Changshan (Dichroa febrifuga). Ancient Febrifuge And Modern Antimalarial: Lessons For Research From A Forgotten Tale. SH-l Lei G Bodeker, Traditional Medicinal Plants and Malaria Boca Raton: CRC Press, Willcox M, Bodeker G, Rasoanaivo P, 2004
98. Synthesis and biological evaluation of febrifugine analogues as potential antimalarial agents. S Zhu Q Zhang C Gudise L Wei E Smith Y Zeng, Bioorganic & Medicinal Chemistry 2009 17 4496 4502 10.1016/j.bmc.2009.05.011 19467876
99. Hepatoprotective effects of 18[beta]-glycyrrhetinic acid on carbon tetrachloride-induced liver injury. Inhibition of cytochrome P450 2E1 expression. HG Jeong HJ You SJ Park AR Moon YC Chung SK Kang HK Chun, Pharmacological Research 2002 46 221 227 10.1016/S1043-6618(02)00121-4 12220964 (Pubitemid 35300760)
100. Protective effect of Zizyphus jujuba fruit extract against paracetamol and thioacetamide induced hepatic damage in rats. SP Kumar SMB Asdaq NP Kumar M Asad DK Khajuria, The Internet Journal of Pharmacology 2009 7
101. Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status. TA Ajith U Hema MS Aswathy, Food and Chemical Toxicology 2007 45 2267 2272 10.1016/j.fct.2007.06. 001 17637489 (Pubitemid 47451580)
102. Zingiberis rhizoma: a comprehensive review on the ginger effect and efficacy profiles. S Chrubasik MH Pittler BD Roufogalis, Phytomedicine 2005 12 684 701 10.1016/j.phymed.2004.07.009 16194058 (Pubitemid 41169818)
103. Folk Medicines in primary health care: common plants used for the treatment of fevers in India. VK Singh ZA Ali, Fitoterapia 1994 65 68 74 (Pubitemid 24119722)
104. Ethnobotanical Value and Conservation of Sacred Groves of the Kpaa Mende in Sierra Leone. AR Lebbie RP Guries, Economic Botany 1995 49 297 308 10.1007/BF02862349
105. The role of traditional medicine on antimalarials in Zambia. R Vongo, First International Meeting of the Research Initiative on Traditional Antimalarials Moshi, Tanzania 1999
106. Antimalarial drug discovery: efficacy models for compound screening. DA Fidock PJ Rosenthal SL Croft R Brun S Nwaka, Nat Rev Drug Discov 2004 3 509 520 10.1038/nrd1416 15173840 (Pubitemid 38807533)
107. Quassia amara L. (Simaroubaceae) leaf tea: Effect of the growing stage and desiccation status on the antimalarial activity of a traditional preparation. S Bertani E Houl G Bourdy D Stien V Jullian I Landau E Deharo, Journal of Ethnopharmacology 2007 111 40 42 10.1016/j.jep.2006.10.028 17157466 (Pubitemid 46553697)
108. Improved Traditional Phytomedicines in current use for the clinical treatment of malaria. ML Willcox, Planta Med Epub ahead of print 21204042
109. Ayush-64. V Sharma, Traditional Medicinal Plants and Malaria Boca Raton: CRC Press, Willcox M, Bodeker G, Rasoanaivo P, 2004 83 89
110. Malarial-5: Development of an antimalarial phytomedicine in Mali. D Diallo A Maiga C Diakite M Willcox, Traditional Medicinal Plants and Malaria Boca Raton: CRC Press, Willcox M, Bodeker G, Rasoanaivo P, 2004
111. Clinical tests carried out under the Auspices of the Malaria Commission. E Pampana, League of Nations: Quarterly Bulletin of the Health Organisation 1934 III 328 343
112. Critical Analysis of the Results achieved. W Fletcher, League of Nations: Quarterly Bulletin of the Health Organisation 1934 III 344 358
113. The Relative Clinical Efficacy of Totaquina and Quinine. EP Hicks S Diwan Chand, Records of the Malaria Survey of India 1935 5 39 50
114. The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria. PN Mimche D Taramelli L Vivas, Malaria Journal 2011 10 Suppl 1 10
115. How can natural products serve as a viable source of lead compounds for the development of new/novel anti-malarials. E Guantai K Chibale, Malaria Journal 2011 10 Suppl 1 2