Synthesis and biological evaluation of febrifugine analogues as potential antimalarial agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 13, 2009, Pages 4496-4502

  Zhu, Shuren ^a   Zhang, Quan ^a   Gudise, Chandrashekar ^b   Wei, Lai ^a   Smith, Erika ^a   Zeng, Yuling ^c  

^a Radix Pharmaceuticals Inc   (United States)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Antimalarial; Febrifugine

Indexed keywords

3 [3 (3 BENZYLOXYPYRROLIDIN 2 YL) 2 OXOPROPYL] 3H PYRIDO[3,2 D]PYRIMIDIN 4 ONE; 3 [3 (3 BENZYLOXYPYRROLIDIN 2 YL) 2 OXOPROPYL] 5 TRIFLUOROMETHYL 3H QUINAZOLIN 4 ONE; 3 [3 (3 HYDROXYPYRROLIDIN 2 YL) 2 OXOPROPYL] 3H PYRIDO[3,2 D]PYRIMIDIN 4 ONE; 3 [3 (3 HYDROXYPYRROLIDIN 2 YL) 2 OXOPROPYL] 3H PYRIDO[4,3 D]PYRIMIDIN 4 ONE; ANTIMALARIAL AGENT; CHLOROQUINE; FEBRIFUGINE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; MALARIA; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; TOXICITY TESTING;

ANIMALS; ANTIMALARIALS; DRUG EVALUATION, PRECLINICAL; HYDRANGEACEAE; MALARIA; MICE; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PIPERIDINES; PLASMODIUM FALCIPARUM; QUINAZOLINES; STRUCTURE-ACTIVITY RELATIONSHIP;

DICHROA FEBRIFUGA; PLASMODIUM FALCIPARUM;

EID: 66749087558     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.05.011     Document Type: Article

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