Hypolipidemic effects of chitosan nanoparticles in hyperlipidemia rats induced by high fat diet

International Immunopharmacology

Volumn 11, Issue 4, 2011, Pages 457-461

  Zhang, Hong Liang ^a,b   Tao, Yi ^a   Guo, Jiao ^a   Hu, Yin Ming ^a   Su, Zheng Quan ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b South China Center for Innovative Pharmaceuticals   (China)

Author keywords

Chitosan; Nanoparticles; Plasma viscosity; Serum lipid; Spray drying

Indexed keywords

ANTILIPEMIC AGENT; CHITOSAN; CHITOSAN NANPARTICLE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LIPID EMULSION; LOW DENSITY LIPOPROTEIN CHOLESTEROL; NANOCARRIER; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG MEGADOSE; DRUG SYNTHESIS; EVAPORATION; FOOD INTAKE; GELATION; HYPERLIPIDEMIA; LIPID DIET; LIPOPROTEIN BLOOD LEVEL; LIVER WEIGHT; LOW DRUG DOSE; MALE; NONHUMAN; PARTICLE SIZE; PLASMA VISCOSITY; PRIORITY JOURNAL; RAT; SPRAY DRYING;

ACUTE TOXICITY TESTS; ANIMALS; BLOOD VISCOSITY; CHITOSAN; DIETARY FATS; DISEASE MODELS, ANIMAL; HYPERLIPIDEMIAS; HYPOLIPIDEMIC AGENTS; LIPIDS; MALE; NANOPARTICLES; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 79952740135     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2010.12.015     Document Type: Article

References (38)

1. Prasad K, Kalra J. Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E. Am Heart J 1993;125:958-73. (Pubitemid 23117326)
2. Deepa PR, Varalakshmi P. Atheroprotective effect of exogenous heparin-derivative treatment on the aortic disturbances and lipoprotein oxidation in hypercholesterolemic diet fed rats. Clin Chim Acta 2005;355:119-30.
3. Zhang J, Liu J, Li L, Xia W. Dietary chitosan improves hypercholesterolemia in rats fed high-fat diets. Nutr Res 2008;28:383-90. (Pubitemid 351718471)
4. Woo CJ, Park HD. An extracellular Bacillus sp. chitinase for the production of chitotriose as a major chitinolytic product. Biotechnol Lett 2003;25:409-12.
5. Rockway S, Menard M. A scientific review of chitosan: ef.cacy, applications and safety. Innov Food Technol 2000;9:61-4.
6. Razdan A, Pettersson D. Hypolipidaemic, gastrointestinal and related responses of broiler chickens to chitosans of different viscosity. Br J Nutr 1996;76:387-97. (Pubitemid 26333983)
7. Miura T, Usami M, Tsuura Y, Ishida H, Seino Y. Hypoglycemic and hypolipidemic effect of chitosan in normal and neonatal streptozotocin-induced diabetic mice. Biol Pharm Bull 1995;18:1623-5.
8. Deuchi K, Kanauchi O, Imasato Y, Kobayashi E. Effect of the viscosity or deacetylation degree of chitosan on fecal fat excreted from rats fed on a high-fat diet. Biosci Biotechnol Biochem 1995;59:781-5.
9. Ormrod DJ, Holmes CC, Miller TE. Dietary chitosan inhibits hypercholesterolaemia and atherogenesis in the apolipoprotein E-deficient mouse model of atherosclerosis. Atherosclerosis 1998;138:329-34. (Pubitemid 28313517)
10. Rebecca N, Schiller MS, Eleanor Barrager RD. A randomized, double-blind, placebo-controlled study examining the effects of a rapidly soluble chitosan dietary supplement on weight loss and body composition in overweight and mildly obese individuals. J Am Nutraceutical Assoc 2001;4:42-9.
11. Pittler E, Ernst M. Chitosan as a treatment for body weight reduction? Ameta-analysis. Perfusion 1998;11:461-5.
12. Pittler MH, Abbot NC, Harkness EF, Ernst E. Randomized, double-blind trial of chitosan for body weight reduction. Eur J Clin Nutr 1999;53:379-81. (Pubitemid 29243433)
13. Veneroni G, Veneroni F, Contos S, Tripod S, De Bernardi M, Guarino C, et al. Effect of a new chitosan dietary integrator and hypocaloric diet on hyperlipidemia and overweight in obese patients. Acta Toxicol Ther 1996;17:53-70.
14. Zhang H, et al. Hypolipidemic effects of chitosan nanoparticles in hyperlipidemia rats induced by high fat diet. Int Immunopharmacol 2011, doi:10.1016/j.intimp.2010.12.015.
15. Sarmento B, Ferreira DC, Jorgensen L, van de Weert M. Probing insulin's secondary structure after entrapment into alginate/chitosan nanoparticles. Eur J Pharm Biopharm 2007;65:10-7. (Pubitemid 44827699)
16. Chen F, Zhang ZR, Huang Y. Evaluation and modification of N-trimethyl chitosan chloride nanoparticles as protein carriers. Int J Pharm 2007;336:166-73. (Pubitemid 46551555)
17. Calvo P, Remuñán-López C, Vila-Jato JL, Alonso MJ. Novel hydrophilic chitosanpolyethylene oxide nanoparticles as protein carriers. J Appl Polym Sci 1997;63: 125-32. (Pubitemid 127613982)
18. Lee KY, Kim JH, Kwon IC, Jeong SY. Self-aggregates of deoxycholic acid-modified chitosan as a novel carrier of adriamycin. Colloid Polym Sci 2000;278:1216-9.
19. Berthold A, Cremer K, Kreuter J. Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs. J Control Release 1996;39:17-25. (Pubitemid 26139808)
20. Liang H, Shinohara K, Minoshima H, Matsushima K. Analysis of constant rate period of spray drying of slurry. Chem Eng Sci 2001;56:2205-13. (Pubitemid 32325118)
21. Broadhead J, Rouan SKE, Rhodes CT. The spray drying of pharmaceuticals. Drug Dev Ind Pharm 1992;18:1169-206.
22. Elversson J, Millqvist-Fureby A. Particle size and density in spray drying-effects of carbohydrate properties. J Pharm Sci 2005;94:2049-60. (Pubitemid 41551488)
23. Iskandar F, Gradon L, Okuyama K. Control of the morphology of nanostructured particles prepared by the spray drying of a nanoparticle sol. J Colloid Interface Sci 2003;265:296-303. (Pubitemid 37072070)
24. Lenggoro IW, Hata T, Iskandar F, Lunden MM, Okuyama K. An experimental and modeling investigation of particle production by spray pyrolysis using a laminar Jow aerosol reactor. J Mater Res 2000;15:733-43. (Pubitemid 34566994)
25. Bodmeier R, Chen HG, Paeratakul O. A novel approach to the oral delivery of micro- or nanoparticles. Pharm Res 1989;6:413-7. (Pubitemid 19176086)
26. Calvo P, Remunan-Lopez C, Vila-Jato JL, Alonso MJ. Chitosan and chitosan/ethylene oxide-propylene oxide block copolymer nanoparticles as novel carriers for proteins and vaccines. Pharm Res 1997;14:1431-6. (Pubitemid 27481075)
27. Wang WN, Lenggoro IW, Okuyama K. Dispersion and aggregation of nanoparticles derived from colloidal droplets under low-pressure conditions. J Colloid Interface Sci 2005;288:423-31. (Pubitemid 40779542)
28. Castelli WP. Epidemiology of coronary heart disease: the Framingham study. Am J Med 1984;76:4-12. (Pubitemid 14151605)
29. Sugano M, Fujisaki Y. Effect of the type of diet on the distribution of 3-hydroxy-3- methylglutaryl coenzyme A (HMG-CoA) reductase in rat small intestine. Experientia 1980;36:1399-400. (Pubitemid 11185263)
30. Ausar SF, Morcillo M, Leon AE, Ribotta PD, Masih R, Vilaro Mainero M, et al. Improvement of HDL- and LDL-cholesterol levels in diabetic subjects by feeding bread containing chitosan. J Med Food 2003;6:397-9. (Pubitemid 38114334)
31. Ming M, Guanhua L, Zhanhai Y, Guang C, Xuan Z. Effect of the Lycium barbarum polysaccharides administration on blood lipid metabolism and oxidative stress of mice fed high-fat diet in vivo. Food Chem 2009;113:872-7.
32. Kimura F, Hasegawa G, Obayashi H, Adachi T, Hara H, Ohta M, et al. Serum extracellular superoxide dismutase in patients with type 2 diabetes: relationship to the development of micro- and macrovascular complications. Diab Care 2003;26:1246-50. (Pubitemid 36929280)
33. Xu C, Haiyan Z, Hua Z, Jianhong Z, Pin D. Effect of Curcuma kwangsiensis polysaccharides on blood lipid profiles and oxidative stress in high-fat rats. Int J Biol Macromol 2009;44:138-42.
34. Hong YK, Wu HT, Ma T, Liu WJ, He XJ. Effects of Glycyrrhiza glabra polysaccharides on immune and antioxidant activities in high-fat mice. Int J Biol Macromol 2009;45:61-4.
35. Diaz MN, Frei B, Vita JA, Keaney Jr JF. Antioxidants and atherosclerotic heart disease. N Engl J Med 1997;337:408-16. (Pubitemid 27328371)
36. Chung MJ, Sung NJ, Park CS, Kweon DK, Mantovani A, Moon TW, et al. Antioxidative and hypocholesterolemic activities of water-soluble puerarin glycosides in HepG2 cells and in C57 BL/6J mice. Eur J Pharmacol 2008;578: 159-70. (Pubitemid 350309595)
37. Windberger U, Bartholovitsch A, Plasenzotti R, Korak KJ, Heinze G. Whole blood viscosity, plasma viscosity and erythrocyte aggregation in nine mammalian species: reference values and comparison of data. Exp Physiol 2003;88:431-40. (Pubitemid 36626390)
38. Fowkes FG, Pell JP, Donnan PT, Housley E, Lowe GD, Riemersma RA, et al. Sex differences in susceptibility to etiologic factors for peripheral atherosclerosis. Importance of plasma fibrinogen and blood viscosity. Arterioscler Thromb 1994;14:862-8.