Characterization of dihydrofolate reductases from multiple strains of Plasmodium falciparum using mathematical descriptors of their inhibitors

Chemistry and Biodiversity

Volumn 8, Issue 3, 2011, Pages 440-453

  Basak, Subhash C ^a   Mills, Denise ^a   Hawkins, Douglas M ^b  

^a UNIVERSITY OF MINNESOTA DULUTH   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIHYDRO 1,2,3 TRIAZINE DERIVATIVE; 1,2 DIHYDRO 1,3,5 TRIAZINE DERIVATIVE; 1,3,5 DIHYDROTRIAZINE DERIVATIVE; ANTIMALARIAL AGENT; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG TARGETING; GENE MUTATION; INTERMETHOD COMPARISON; KAPPA STATISTICS; MATHEMATICAL COMPUTING; NONHUMAN; PARTIAL LEAST SQUARES REGRESSION; PLASMODIUM FALCIPARUM; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; REGRESSION ANALYSIS; RIDGE REGRESSION; STRAIN DIFFERENCE; WILD TYPE;

ANTIMALARIALS; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; LIGANDS; MALARIA, FALCIPARUM; MOLECULAR STRUCTURE; MUTATION; PLASMODIUM FALCIPARUM; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; REGRESSION ANALYSIS; STEREOISOMERISM; TETRAHYDROFOLATE DEHYDROGENASE;

PLASMODIUM FALCIPARUM;

EID: 79952715472     PISSN: 16121872     EISSN: 16121880     Source Type: Journal    
DOI: 10.1002/cbdv.201000111     Document Type: Article

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