RAD51-independent inverted-repeat recombination by a strand-annealing mechanism

DNA Repair

Volumn 10, Issue 4, 2011, Pages 408-415

  Mott, Christina ^a   Symington, Lorraine S ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

RAD51; RAD52; RAD59; Recombination; Template switching

Indexed keywords

RAD52 PROTEIN;

ARTICLE; GENE; GENE MUTATION; GENE REPRESSION; GENETIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; RAD18 GENE; RAD5 GENE; RAD51 GENE; RAD52 GENE; RAD59 GENE;

ALLELES; DNA REPAIR; DNA, SINGLE-STRANDED; GENE ORDER; GENES, FUNGAL; INVERTED REPEAT SEQUENCES; MUTATION; RAD51 RECOMBINASE; RAD52 DNA REPAIR AND RECOMBINATION PROTEIN; RECOMBINATION, GENETIC; YEASTS;

EID: 79952694801     PISSN: 15687864     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dnarep.2011.01.007     Document Type: Article

References (50)

1. Symington L.S. Role of RAD52 epistasis group genes in homologous recombination and double-strand break repair. Microbiol. Mol. Biol. Rev. 2002, 66:630-670. table of contents.
2. Benson F.E., Baumann P., West S.C. Synergistic actions of Rad51 and Rad52 in recombination and DNA repair. Nature 1998, 391:401-404.
3. Gasior S.L., Wong A.K., Kora Y., Shinohara A., Bishop D.K. Rad52 associates with RPA and functions with rad55 and rad57 to assemble meiotic recombination complexes. Genes Dev. 1998, 12:2208-2221.
4. New J.H., Sugiyama T., Zaitseva E., Kowalczykowski S.C. Rad52 protein stimulates DNA strand exchange by Rad51 and replication protein A. Nature 1998, 391:407-410.
5. Shinohara A., Ogawa T. Stimulation by Rad52 of yeast Rad51-mediated recombination. Nature 1998, 391:404-407.
6. Sung P. Function of yeast Rad52 protein as a mediator between replication protein A and the Rad51 recombinase. J. Biol. Chem. 1997, 272:28194-28197.
7. Mortensen U.H., Bendixen C., Sunjevaric I., Rothstein R. DNA strand annealing is promoted by the yeast Rad52 protein. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:10729-10734.
8. Sugiyama T., New J.H., Kowalczykowski S.C. DNA annealing by RAD52 protein is stimulated by specific interaction with the complex of replication protein A and single-stranded DNA. Proc. Natl. Acad. Sci. U.S.A. 1998, 95:6049-6054.
9. Ivanov E.L., Sugawara N., Fishman-Lobell J., Haber J.E. Genetic requirements for the single-strand annealing pathway of double-strand break repair in Saccharomyces cerevisiae. Genetics 1996, 142:693-704.
10. Kang L.E., Symington L.S. Aberrant double-strand break repair in rad51 mutants of Saccharomyces cerevisiae. Mol. Cell. Biol. 2000, 20:9162-9172.
11. McDonald J.P., Rothstein R. Unrepaired heteroduplex DNA in Saccharomyces cerevisiae is decreased in RAD1 RAD52-independent recombination. Genetics 1994, 137:393-405.
12. Mozlin A.M., Fung C.W., Symington L.S. Role of the Saccharomyces cerevisiae Rad51 paralogs in sister chromatid recombination. Genetics 2008, 178:113-126.
13. Smith J., Rothstein R. A mutation in the gene encoding the Saccharomyces cerevisiae single-stranded DNA-binding protein Rfa1 stimulates a RAD52-independent pathway for direct-repeat recombination. Mol. Cell. Biol. 1995, 15:1632-1641.
14. Smith J., Rothstein R. An allele of RFA1 suppresses RAD52-dependent double-strand break repair in Saccharomyces cerevisiae. Genetics 1999, 151:447-458.
15. Dornfeld K.J., Livingston D.M. Plasmid recombination in a rad52 mutant of Saccharomyces cerevisiae. Genetics 1992, 131:261-276.
16. Malagón F., Aguilera A. Yeast spt6-140 mutation, affecting chromatin and transcription, preferentially increases recombination in which Rad51p-mediated strand exchange is dispensable. Genetics 2001, 158:597-611.
17. Rattray A.J., Shafer B.K., McGill C.B., Strathern J.N. The roles of REV3 and RAD57 in double-strand-break-repair-induced mutagenesis of Saccharomyces cerevisiae. Genetics 2002, 162:1063-1077.
18. Rattray A.J., Symington L.S. Use of a chromosomal inverted repeat to demonstrate that the RAD51 and RAD52 genes of Saccharomyces cerevisiae have different roles in mitotic recombination. Genetics 1994, 138:587-595.
19. Bai Y., Symington L.S. A Rad52 homolog is required for RAD51-independent mitotic recombination in Saccharomyces cerevisiae. Genes Dev. 1996, 10:2025-2037.
20. Davis A.P., Symington L.S. The yeast recombinational repair protein Rad59 interacts with Rad52 and stimulates single-strand annealing. Genetics 2001, 159:515-525.
21. Davis A.P., Symington L.S. The Rad52-Rad59 complex interacts with Rad51 and replication protein A. DNA Repair (Amst.) 2003, 2:1127-1134.
22. Petukhova G., Stratton S.A., Sung P. Single strand DNA binding and annealing activities in the yeast recombination factor Rad59. J. Biol. Chem. 1999, 274:33839-33842.
23. Wu Y., Sugiyama T., Kowalczykowski S.C. DNA annealing mediated by Rad52 and Rad59 proteins. J. Biol. Chem. 2006, 281:15441-15449.
24. Pannunzio N.R., Manthey G.M., Bailis A.M. RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae. DNA Repair (Amst.) 2008, 7:788-800.
25. Sugawara N., Ira G., Haber J.E. DNA length dependence of the single-strand annealing pathway and the role of Saccharomyces cerevisiae RAD59 in double-strand break repair. Mol. Cell. Biol. 2000, 20:5300-5309.
26. Manthey G.M., Bailis A.M. Rad51 inhibits translocation formation by non-conservative homologous recombination in Saccharomyces cerevisiae. PLoS ONE 2010, 5:e11889.
27. Wu Y., Kantake N., Sugiyama T., Kowalczykowski S.C. Rad51 protein controls Rad52-mediated DNA annealing. J. Biol. Chem. 2008, 283:14883-14892.
28. Zou H., Rothstein R. Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism. Cell 1997, 90:87-96.
29. Goldstein A.L., McCusker J.H. Three new dominant drug resistance cassettes for gene disruption in Saccharomyces cerevisiae. Yeast 1999, 15:1541-1553.
30. Longtine M.S., McKenzie A., Demarini D.J., Shah N.G., Wach A., Brachat A., Philippsen P., Pringle J.R. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 1998, 14:953-961.
31. Lea D.E., Coulson C. The distribution of the numbers of mutants in bacterial populations. J. Genet. 1949, 49:264-285.
32. Walter J., Newport J. Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alpha. Mol. Cell 2000, 5:617-627.
33. Bailly V., Lamb J., Sung P., Prakash S., Prakash L. Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites. Genes Dev. 1994, 8:811-820.
34. Bailly V., Lauder S., Prakash S., Prakash L. Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin conjugating, DNA binding, and ATP hydrolytic activities. J. Biol. Chem. 1997, 272:23360-23365.
35. Hofmann R.M., Pickart C.M. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 1999, 96:645-653.
36. Jentsch S., McGrath J.P., Varshavsky A. The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme. Nature 1987, 329:131-134.
37. Ulrich H.D., Jentsch S. Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair. EMBO J. 2000, 19:3388-3397.
38. Branzei D., Vanoli F., Foiani M. SUMOylation regulates Rad18-mediated template switch. Nature 2008, 456:915-920.
39. Carlile C.C., Pickart C.M., Matunis M.J., Cohen R.E. Synthesis of free and PCNA-bound polyubiquitin chains by the RING E3 ligase, Rad5. J. Biol. Chem. 2009, 284:29326-29334.
40. Goldfless S., Morag A., Belisle K., Suterajr V., Lovett S. DNA repeat rearrangements mediated by DnaK-dependent replication fork repair. Mol. Cell 2006, 21:595-604.
41. Hoege C., Pfander B., Moldovan G.-L., Pyrowolakis G., Jentsch S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 2002, 419:135-141.
42. Ulrich H.D. Regulating post-translational modifications of the eukaryotic replication clamp PCNA. DNA Repair (Amst.) 2009, 8:461-469.
43. Sugawara N., Haber J.E. Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation. Mol. Cell. Biol. 1992, 12:563-575.
44. Mizuno K.I., Lambert S., Baldacci G., Murray J.M., Carr A.M. Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism. Genes Dev. 2009, 23:2876-2886.
45. Paek A.L., Kaochar S., Jones H., Elezaby A., Shanks L., Weinert T. Fusion of nearby inverted repeats by a replication-based mechanism leads to formation of dicentric and acentric chromosomes that cause genome instability in budding yeast. Genes Dev. 2009, 23:2861-2875.
46. Sugiyama T., Zaitseva E.M., Kowalczykowski S.C. A single-stranded DNA-binding protein is needed for efficient presynaptic complex formation by the Saccharomyces cerevisiae Rad51 protein. J. Biol. Chem. 1997, 272:7940-7945.
47. Liefshitz B., Steinlauf R., Friedl A., Eckardt-Schupp F., Kupiec M. Genetic interactions between mutants of the 'error-prone' repair group of Saccharomyces cerevisiae and their effect on recombination and mutagenesis. Mutat. Res. 1998, 407:135-145.
48. Friedl A.A., Liefshitz B., Steinlauf R., Kupiec M. Deletion of the SRS2 gene suppresses elevated recombination and DNA damage sensitivity in rad5 and rad18 mutants of Saccharomyces cerevisiae. Mutat. Res. 2001, 486:137-146.
49. Papouli E., Chen S., Davies A.A., Huttner D., Krejci L., Sung P., Ulrich H.D. Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p. Mol. Cell 2005, 19:123-133.
50. Pfander B., Moldovan G.-L., Sacher M., Hoege C., Jentsch S. SUMO-modified PCNA recruits Srs2 to prevent recombination during S phase. Nature 2005, 6.