Deletion of the SRS2 gene suppresses elevated recombination and DNA damage sensitivity in rad5 and rad18 mutants of Saccharomyces cerevisiae

Mutation Research - DNA Repair

Volumn 486, Issue 2, 2001, Pages 137-146

  Friedl, Anna A ^a,b   Liefshitz, Batia ^c   Steinlauf, Rivka ^c   Kupiec, Martin ^c  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c TEL AVIV UNIVERSITY   (Israel)

Author keywords

Helicases; Recombination; Replication

Indexed keywords

FUNGAL PROTEIN; MUTANT PROTEIN; RAD18 PROTEIN; RAD5 PROTEIN; SRS2 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; CELL STRAIN; CELL SURVIVAL; CONTROLLED STUDY; DNA DAMAGE; GENE DELETION; GENE INACTIVATION; GENE MUTATION; GENETIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SACCHAROMYCES CEREVISIAE; SISTER CHROMATID; ULTRAVIOLET IRRADIATION;

ADENOSINE TRIPHOSPHATASES; DNA DAMAGE; DNA HELICASES; DNA REPAIR; DNA-BINDING PROTEINS; FUNGAL PROTEINS; GENES, FUNGAL; MODELS, GENETIC; RADIATION, IONIZING; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

SACCHAROMYCES CEREVISIAE;

EID: 0035850252     PISSN: 09218777     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0921-8777(01)00086-6     Document Type: Article

References (60)

1. The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme
2. Specific complex formation between RAD6 and RAD18 proteins: A potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites
3. Yeast DNA repair proteins Rad6 and Rad18 form a heterodimer that has ubiquitin-conjugating, DNA binding, and ATP hydrolytic activities
4. Characterization of postreplication repair in Saccharomyces cerevisiae and effects of rad6, rad18, rev3 and rad52 mutations
5. The RAD6 gene and protein of Saccharomyces cerevisiae
6. Specificity and frequency of UV-induced reversion of an iso-1-cytochrome c-ochre mutants in radiation sensitive strains of yeast
7. Interchromosomal and intrachromosomal recombination in rad18 mutants of Saccharomyces cerevisiae
8. A similar defect in UV-induced mutagenesis conferred by the rad6 and rad18 mutations of Saccharomyces cerevisiae
9. REV3, a Saccharomyces cerevisiae gene whose function is required for induced mutagenesis, is predicted to encode a nonessential DNA polymerase
10. Thymine-thymine dimer bypass by yeast DNA polymerase ξ
11. Distinct roles for Rev1p and Rev7p during translation synthesis in Saccharomyces cerevisiae
12. Analysis of damage tolerance pathways in Saccharomyces cerevisiae: A requirement for Rev3 DNA polymerase in translation synthesis
13. Deoxycytidytransferase activity of yeast REV1 protein
14. Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome
15. The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways
16. Mutants of yeast defective in mutations induced by ultraviolet light
17. Ultraviolet-induced reversion of cyc1 alleles in radiation sensitive strains of yeast. II. rev2 mutant strains
18. Analysis of mutagenic DNA repair in a thermoconditional mutant of Saccharomyces cerevisiae. IV. Influence of DNA replication and excision repair on REV2 dependent UV-mutagenesis and repair
19. Bridge-building between mathematical theory and molecular biology: The REV2 gene as paradigm
20. The RAD5 gene product is involved in the avoidance of non-homologous end-joining of DNA double strand breaks in the yeast Saccharomyces cerevisiae
21. SWI2/SNF2 and related proteins: ATP-driven motors that disrupt protein-DNA interactions?
22. MMS2, encoding a ubiquitin-conjugating enzyme-like protein, is a member of the yeast error-free postreplication repair pathway
23. Genetic interactions between error-prone and error-free postreplication repair pathways in Saccharomyces cerevisiae
24. UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae
25. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assmebly of novel polyubiquitin chains for DNA repair
26. Two ring finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair
27. Purification and characterization of the Srs2 DNA helicase of the yeast Saccharomyces cerevisiae
28. RADH, a gene of Saccharomyces cerevisiae encoding a putative DNA helicase involved in DNA repair. Characteristics of radH mutants and sequence of the gene
29. Semidominant suppressors of Srs2 helicase mutations of Saccharomyces cerevisiae map in the RAD51 gene, whose sequence predicts a protein with similarities to procaryotic RecA protein
30. Semidominant mutations in the yeast Rad51 protein and their relationship with the Srs2 helicase
31. The yeast type I topoisomerase Top3 interacts with Sgs1, a DNA helicase homolog: A potential eukaryotic gyrase
32. Requirement of yeast SGS1 and SRS2 genes for replication and transcription
33. Homologous recombination is responsible for cell death in the absence of the Sgs1 and Srs2 helicases
34. A radical solution to death
35. Metabolic suppressors of trimethoprim and ultraviolet sensitivities of Saccharomyces cerevisiae rad6 mutants
36. The Srs2 suppressor of rad6 mutations of Saccharomyces cerevisiae acts by channeling DNA lesions into the RAD52 DNA repair pathway
37. The hyper-gene conversion hpr5-1 mutation of Saccharomyces cerevisiae is an allele of the SRS2/RADH gene
38. Analysis of mitotic and meiotic defects in Saccharomyces cerevisiae SRS2 DNA helicase mutants
39. The role of DNA repair genes in recombination between repeated sequences in yeast
40. Genetic interactions between mutants of the error prone repair group of Saccharomyces cerevisiae and their effect on recombination and mutagenesis
41. One-step disruption in yeast
42. Sister chromatids are preferred over homologs as substrates for recombinational repair in Saccharomyces cerevisiae
43. Ectopic recombination between Ty elements in Saccharomyces cerevisiae is not induced by DNA damage
44. Cell cycle variation in the induction of lethality and mitotic recombination after treatment with UV and nitrous acid in the yeast, Saccharomyces cerevisiae
45. The relevance of the nuclear division cycle to radiosensitivity in yeast
46. Analysis of mutagenic repair in a thermoconditional repair mutant of Saccharomyces cerevisiae. II. Influence of cycloheximide on UV-irradiated exponentially growing rev2ts cells
47. The complexity of the interactions between RAD52 and SRS2
48. Genetic control of intrachromosomal recombination in Saccharomyces cerevisiae. Isolation and genetic characterization of hyper-recombination mutations
49. An α-control of DNA repair in the yeast Saccharomyces cerevisiae: Genetic and physiological aspects
50. Two pathways for removal of nonhomologous DNA ends during double-strand break repair in Saccharomyces cerevisiae
51. Antipairing and strand transferase activities of E. coli helicase II (UvrD)
52. uvrD mutations enhance tandem repeat deletion in the Escherichia coli chromosome via SOS induction of the RecF recombination pathway
53. RecQ helicase, in concert with RecA and SSB proteins, initiates and disrupts DNA recombination
54. uvrD mutations enhance tandem repeat deletion in the Escherichia coli chromosome via SOS induction of the RecF recombination pathway
55. A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae
56. Associations of UBE21 with RAD52, UBL1, p53, and RAD51 proteins in a yeast two-hybrid system
57. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
58. Requirement of proliferating cell nuclear antigen in RAD6-dependent postreplicational DNA repair
59. Requirement of yeast DNA polymerase δ in post-replicational repair of UV-damaged DNA