Design and Synthesis of Conformationally Constrained Cyclophilin Inhibitors Showing a Cyclosporin-A Phenotype in C. elegans

ChemBioChem

Volumn 12, Issue 5, 2011, Pages 802-810

  Dunsmore, Colin J ^a,c   Malone, Kirk J ^a,d   Bailey, Kevin R ^a,e   Wear, Martin A ^a   Florance, Hannah ^a   Shirran, Sally ^a,f   Barran, Perdita E ^a   Page, Antony P ^b   Walkinshaw, Malcolm D ^a   Turner, Nicholas J ^a,d  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c Almac Sciences   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e CHARLES RIVER LABORATORIES   (United Kingdom)

^f UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN INHIBITOR; CYCLOSPORIN A DERIVATIVE;

ARTICLE; BINDING AFFINITY; CAENORHABDITIS ELEGANS; CIS TRANS ISOMERISM; DRUG CONFORMATION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVE SITE; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CYCLOPHILIN A; CYCLOSPORINE; DRUG DESIGN; ENZYME INHIBITORS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; SMALL MOLECULE LIBRARIES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

CAENORHABDITIS ELEGANS;

EID: 79952688066     PISSN: 14394227     EISSN: 14397633     Source Type: Journal    
DOI: 10.1002/cbic.201000413     Document Type: Article

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