Structure-based discovery of a family of synthetic cyclophilin inhibitors showing a cyclosporin-A phenotype in Caenorhabditis elegans

Biochemical and Biophysical Research Communications

Volumn 363, Issue 4, 2007, Pages 1013-1019

  Yang, Yuande ^a   Moir, Elizabeth ^a   Kontopidis, George ^b   Taylor, Paul ^a,b   Wear, Martin A ^a   Malone, Kirk ^a   Dunsmore, Colin J ^a   Page, Antony P ^c   Turner, Nicholas J ^a   Walkinshaw, Malcolm D ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b CYCLACEL LTD   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

C. elegans; Cyclophilin A; Structure based lead discovery; Virtual screening

Indexed keywords

5,5 DIMETHYL 1,3 CYCLOHEXANEDIONE; CYCLOPHILIN; CYCLOPHILIN INHIBITOR; CYCLOSPORIN A; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; COMPUTER MODEL; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; MALARIA; NONHUMAN; PARASITOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

ANIMALS; CAENORHABDITIS ELEGANS; CRYSTALLOGRAPHY, X-RAY; CYCLOHEXANONES; CYCLOPHILIN A; CYCLOSPORINE; ENZYME INHIBITORS; HUMANS; HYDROPHOBICITY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHENOTYPE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

CAENORHABDITIS ELEGANS; VERMES;

EID: 35248894334     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2007.09.079     Document Type: Article

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