Structure-activity studies of ground- and transition-state analogue inhibitors of cyclophilin

Journal of Medicinal Chemistry

Volumn 44, Issue 16, 2001, Pages 2593-2600

  Wang, H C ^a   Kim, K ^a   Bakhtiar, R ^b   Germanas, J P ^a  

^a SOUTHERN METHODIST UNIVERSITY   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 (2 METHYLNAPHTHYL) N ACETYL 6 AMINO 8A CARBOXYINDOLIZIDIN 5 ONE METHYL ESTER; 6 (2 METHYLNAPHTHYL) N BENZYLOXYCARBONYL 6 AMINO 8A CARBOXYINDOLIZIDIN 5 ONE METHYL ESTER; 6 (2 METHYLNAPHTHYL) N TERT BUTOXYCARBONYL 6 AMINO 8A CARBOXYINDOLIZIDIN 5 ONE METHYL ESTER; 6 (2 METHYLNAPHTHYL) N TERT BUTOXYCARBONYL 6 AMINO 8A INDOLIZIDIN METHYL ESTER; 6 BENZYL N BENZYLOXYCARBONYL 6 AMINO 8A CARBOXYINDOLIZIDIN 5 ONE METHYL ESTER; 6 BENZYL N TERT BUTOXYCARBONYLAMINO 8A CARBOXYINDOLIZIDIN 5 ONE METHYL ESTER; 6 N TERT BUTOXYCARBONYLAMINO 8A CARBOXYINDOLIZIDINE METHYL ESTER; CYCLOPHILIN; CYCLOPHILIN A; CYCLOSPORIN A; PROTEIN INHIBITOR; TACROLIMUS; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG PROTEIN BINDING; ENANTIOMER; ENZYME ACTIVE SITE; MOLECULAR WEIGHT; NONHUMAN; PROTEIN FOLDING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CYCLOPHILINS; ENZYME INHIBITORS; INDOLIZINES; LACTAMS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PROLINE; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035797373     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010009r     Document Type: Article

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