-
1
-
-
67049159857
-
Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: A multicentre prospective registration study
-
Patterson CC, Dahlquist GG, Gyurus E, Green A, Soltesz G. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009; 373: 2027-2033.
-
(2009)
Lancet
, vol.373
, pp. 2027-2033
-
-
Patterson, C.C.1
Dahlquist, G.G.2
Gyurus, E.3
Green, A.4
Soltesz, G.5
-
2
-
-
24944444760
-
Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism
-
DOI 10.1038/ni1234, PII N1234
-
Ciofani M, Zuniga-Pflucker JC. Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. Nat Immunol 2005; 6: 881-888. (Pubitemid 43090442)
-
(2005)
Nature Immunology
, vol.6
, Issue.9
, pp. 881-888
-
-
Ciofani, M.1
Zuniga-Pflucker, J.C.2
-
3
-
-
33846505022
-
Key factors in the organized chaos of early T cell development
-
DOI 10.1038/ni1436, PII NI1436
-
Hayday AC, Pennington DJ. Key factors in the organized chaos of early T cell development. Nat Immunol 2007; 8: 137-144. (Pubitemid 46152644)
-
(2007)
Nature Immunology
, vol.8
, Issue.2
, pp. 137-144
-
-
Hayday, A.C.1
Pennington, D.J.2
-
4
-
-
27844539406
-
The role of apoptosis in the development and function of T lymphocytes
-
DOI 10.1038/sj.cr.7290345
-
Zhang N, Hartig H, Dzhagalov I, Draper D, He YW. The role of apoptosis in the development and function of T lymphocytes. Cell Res 2005; 15: 749-769. (Pubitemid 41653913)
-
(2005)
Cell Research
, vol.15
, Issue.10
, pp. 749-769
-
-
Zhang, N.1
Hartig, H.2
Dzhagalov, I.3
Draper, D.4
He, Y.W.5
-
5
-
-
0027960973
-
Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production
-
Greiner EF, Guppy M, Brand K. Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production. J Biol Chem 1994; 269: 31484-31490. (Pubitemid 24379505)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.50
, pp. 31484-31490
-
-
Greiner, E.F.1
Guppy, M.2
Brand, K.3
-
6
-
-
30544442651
-
Lymphocyte selection by starvation: Glucose metabolism and cell death
-
DOI 10.1016/j.it.2005.11.002, PII S1471490605002838
-
Jacobs SR, Rathmell JC. Lymphocyte selection by starvation: glucose metabolism and cell death. Trends Immunol 2006; 27: 4-7. (Pubitemid 43083557)
-
(2006)
Trends in Immunology
, vol.27
, Issue.1
, pp. 4-7
-
-
Jacobs, S.R.1
Rathmell, J.C.2
-
7
-
-
0037450683
-
In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells
-
Yu Q, Erman B, Bhandoola A, Sharrow SO, Singer A. In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells. J Exp Med 2003; 197: 475-487.
-
(2003)
J Exp Med
, vol.197
, pp. 475-487
-
-
Yu, Q.1
Erman, B.2
Bhandoola, A.3
Sharrow, S.O.4
Singer, A.5
-
9
-
-
0141863388
-
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
-
DOI 10.1128/MCB.23.20.7315-7328.2003
-
Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, Thompson CB. Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol 2003; 23: 7315-7328. (Pubitemid 37211011)
-
(2003)
Molecular and Cellular Biology
, vol.23
, Issue.20
, pp. 7315-7328
-
-
Rathmell, J.C.1
Fox, C.J.2
Plas, D.R.3
Hammerman, P.S.4
Cinalli, R.M.5
Thompson, C.B.6
-
10
-
-
26244453715
-
Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2
-
DOI 10.1016/j.cell.2005.07.032, PII S0092867405008020
-
Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC et al. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell 2005; 123: 89-103. (Pubitemid 41414531)
-
(2005)
Cell
, vol.123
, Issue.1
, pp. 89-103
-
-
Nutt, L.K.1
Margolis, S.S.2
Jensen, M.3
Herman, C.E.4
Dunphy, W.G.5
Rathmell, J.C.6
Kornbluth, S.7
-
11
-
-
0031238860
-
Structural determinants for the intracellular localization of the isozymes of mammalian hexokinase: Intracellular localization of fusion constructs incorporating structural elements from the hexokinase isozymes and the green fluorescent protein
-
DOI 10.1006/abbi.1997.0241
-
Sui D, Wilson JE. Structural determinants for the intracellular localization of the isozymes of mammalian hexokinase: intracellular localization of fusion constructs incorporating structural elements from the hexokinase isozymes and the green fluorescent protein. Arch Biochem Biophys 1997; 345: 111-125. (Pubitemid 27374215)
-
(1997)
Archives of Biochemistry and Biophysics
, vol.345
, Issue.1
, pp. 111-125
-
-
Sui, D.1
Wilson, J.E.2
-
12
-
-
67650724069
-
Regulation and function of NF-kappaB transcription factors in the immune system
-
Vallabhapurapu S, Karin M. Regulation and function of NF-kappaB transcription factors in the immune system. Ann Rev Immunol 2009; 27: 693-733.
-
(2009)
Ann Rev Immunol
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
Karin, M.2
-
13
-
-
0033637216
-
NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development
-
Voll RE, Jimi E, Phillips RJ, Barber DF, Rincon M, Hayday AC et al. NF-kappa B activation by the pre-T cell receptor serves as a selective survival signal in T lymphocyte development. Immunity 2000; 13: 677-689.
-
(2000)
Immunity
, vol.13
, pp. 677-689
-
-
Voll, R.E.1
Jimi, E.2
Phillips, R.J.3
Barber, D.F.4
Rincon, M.5
Hayday, A.C.6
-
14
-
-
42749093061
-
High glucose induction of DNA-binding activity of the transcription factor NFkappaB in patients with diabetic nephropathy
-
Yang B, Hodgkinson A, Oates PJ, Millward BA, Demaine AG. High glucose induction of DNA-binding activity of the transcription factor NFkappaB in patients with diabetic nephropathy. Biochimica et Biophysica Acta 2008; 1782: 295-302.
-
(2008)
Biochimica et Biophysica Acta
, vol.1782
, pp. 295-302
-
-
Yang, B.1
Hodgkinson, A.2
Oates, P.J.3
Millward, B.A.4
Demaine, A.G.5
-
15
-
-
12744279316
-
High glucose inhibits apoptosis induced by serum deprivation in vascular smooth muscle cells via upregulation of Bcl-2 and Bcl-xl
-
Li H, Telemaque S, Miller RE, Marsh JD. High glucose inhibits apoptosis induced by serum deprivation in vascular smooth muscle cells via upregulation of Bcl-2 and Bcl-xl. Diabetes 2005; 54: 540-545.
-
(2005)
Diabetes
, vol.54
, pp. 540-545
-
-
Li, H.1
Telemaque, S.2
Miller, R.E.3
Marsh, J.D.4
-
16
-
-
0036231781
-
Flux through the hexosamine pathway is a determinant of nuclear factor kappaB-dependent promoter activation
-
James LR, Tang D, Ingram A, Ly H, Thai K, Cai L et al. Flux through the hexosamine pathway is a determinant of nuclear factor kappaB- dependent promoter activation. Diabetes 2002; 51: 1146-1156. (Pubitemid 34438362)
-
(2002)
Diabetes
, vol.51
, Issue.4
, pp. 1146-1156
-
-
James, L.R.1
Tang, D.2
Ingram, A.3
Ly, H.4
Thai, K.5
Cai, L.6
Seholey, J.W.7
-
17
-
-
33845663688
-
High glucose alone, as well as in combination with proinflammatory cytokines, stimulates nuclear factor kappa-B-mediated transcription in hepatocytes in vitro
-
DOI 10.1016/j.jdiacomp.2006.02.001, PII S1056872706000110
-
Iwasaki Y, Kambayashi M, Asai M, Yoshida M, Nigawara T, Hashimoto K. High glucose alone, as well as in combination with proinflammatory cytokines, stimulates nuclear factor kappa-B-mediated transcription in hepatocytes in vitro. J Diabetes Complications 2007; 21: 56-62. (Pubitemid 44960844)
-
(2007)
Journal of Diabetes and Its Complications
, vol.21
, Issue.1
, pp. 56-62
-
-
Iwasaki, Y.1
Kambayashi, M.2
Asai, M.3
Yoshida, M.4
Nigawara, T.5
Hashimoto, K.6
-
18
-
-
44449114703
-
Increased glucose availability activates chicken thymocyte metabolism and survival
-
Humphrey BD, Rudrappa SG. Increased glucose availability activates chicken thymocyte metabolism and survival. J Nutr 2008; 138: 1153-1157. (Pubitemid 351769144)
-
(2008)
Journal of Nutrition
, vol.138
, Issue.6
, pp. 1153-1157
-
-
Humphrey, B.D.1
Rudrappa, S.G.2
-
19
-
-
0000685691
-
Studies in antibody response of mice to tumour inoculation
-
Gorer PA. Studies in antibody response of mice to tumour inoculation. Br J Cancer 1950; 4: 372-379.
-
(1950)
Br J Cancer
, vol.4
, pp. 372-379
-
-
Gorer, P.A.1
-
20
-
-
0035942178
-
Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation
-
DOI 10.1073/pnas.081547998
-
Conte D, Liston P, Wong JW, Wright KE, Korneluk RG. Thymocyte-targeted overexpression of xiap transgene disrupts T lymphoid apoptosis and maturation. Proc Natl Acad Sci USA 2001; 98: 5049-5054. (Pubitemid 32397080)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.9
, pp. 5049-5054
-
-
Conte, D.1
Liston, P.2
Wong, J.W.3
Wright, K.E.4
Korneluk, R.G.5
-
21
-
-
0037148840
-
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
-
DOI 10.1038/415922a
-
Bouillet P, Purton JF, Godfrey DI, Zhang LC, Coultas L, Puthalakath H et al. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 2002; 415: 922-926. (Pubitemid 34174755)
-
(2002)
Nature
, vol.415
, Issue.6874
, pp. 922-926
-
-
Bouillet, P.1
Purton, J.F.2
Godfrey, D.I.3
Zhang, L.-C.4
Coultas, L.5
Puthalakath, H.6
Pellegrini, M.7
Cory, S.8
Adams, J.M.9
Strasser, A.10
-
22
-
-
0036849781
-
Bax deficiency partially corrects interleukin-7 receptor alpha deficiency
-
DOI 10.1016/S1074-7613(02)00450-8
-
Khaled AR, Li WQ, Huang J, Fry TJ, Khaled AS, Mackall CL et al. Bax deficiency partially corrects interleukin-7 receptor alpha deficiency. Immunity 2002; 17: 561-573. (Pubitemid 35351502)
-
(2002)
Immunity
, vol.17
, Issue.5
, pp. 561-573
-
-
Khaled, A.R.1
Li, W.Q.2
Huang, J.3
Fry, T.J.4
Khaled, A.S.5
Mackall, C.L.6
Muegge, K.7
Young, H.A.8
Durum, S.K.9
-
23
-
-
0033215040
-
Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases
-
DOI 10.1093/emboj/18.19.5242
-
Deveraux QL, Leo E, Stennicke HR, Welsh K, Salvesen GS, Reed JC. Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases. EMBO J 1999; 18: 5242-5251. (Pubitemid 29465575)
-
(1999)
EMBO Journal
, vol.18
, Issue.19
, pp. 5242-5251
-
-
Deveraux, Q.L.1
Leo, E.2
Stennicke, H.R.3
Welsh, K.4
Salvesen, G.S.5
Reed, J.C.6
-
24
-
-
1642553460
-
To be, or not to be: NF-kappaB is the answer - Role of Rel/NF-kappaB in the regulation of apoptosis
-
DOI 10.1038/sj.onc.1207230, Apoptosis - Part 2
-
Kucharczak J, Simmons MJ, Fan Y, Gelinas C. To be, or not to be: NF-kappaB is the answer - role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene 2003; 22: 8961-8982. (Pubitemid 38121698)
-
(2003)
Oncogene
, vol.22
, Issue.56 REV. ISS. 8
, pp. 8961-8982
-
-
Kucharczak, J.1
Simmons, M.J.2
Fan, Y.3
Gelinas, C.4
-
25
-
-
0141992937
-
Regulation of developing B cell survival by RelA-containing NF-kappaB complexes
-
Prendes M, Zheng Y, Beg AA. Regulation of developing B cell survival by RelA-containing NF-kappa B complexes. J Immunol 2003; 171: 3963-3969. (Pubitemid 37238669)
-
(2003)
Journal of Immunology
, vol.171
, Issue.8
, pp. 3963-3969
-
-
Prendes, M.1
Zheng, Y.2
Beg, A.A.3
-
26
-
-
0037111664
-
Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: Analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis
-
DOI 10.1182/blood.V100.10.3749
-
Munzert G, Kirchner D, Stobbe H, Bergmann L, Schmid RM, Dohner H et al. Tumor necrosis factor receptor-associated factor 1 gene overexpression in B-cell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis. Blood 2002; 100: 3749-3756. (Pubitemid 35303947)
-
(2002)
Blood
, vol.100
, Issue.10
, pp. 3749-3756
-
-
Munzert, G.1
Kirchner, D.2
Stobbe, H.3
Bergmann, L.4
Schmid, R.M.5
Dohner, H.6
Heimpel, H.7
-
27
-
-
0035424999
-
Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment
-
Alcamo E, Mizgerd JP, Horwitz BH, Bronson R, Beg AA, Scott M et al. Targeted mutation of TNF receptor I rescues the RelA-deficient mouse and reveals a critical role for NF-kappa B in leukocyte recruitment. J Immunol 2001; 167: 1592-1600. (Pubitemid 32703160)
-
(2001)
Journal of Immunology
, vol.167
, Issue.3
, pp. 1592-1600
-
-
Alcamo, E.1
Mizgerd, J.P.2
Horwitz, B.H.3
Bronson, R.4
Beg, A.A.5
Scott, M.6
Doerschuk, C.M.7
Hynes, R.O.8
Baltimore, D.9
-
28
-
-
0033023431
-
C-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function
-
Liou HC, Jin Z, Tumang J, Andjelic S, Smith KA, Liou ML. c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function. Int Immunol 1999; 11: 361-371. (Pubitemid 29121623)
-
(1999)
International Immunology
, vol.11
, Issue.3
, pp. 361-371
-
-
Liou, H.-C.1
Jin, Z.2
Tumang, J.3
Andjelic, S.4
Smith, K.A.5
Liou, M.-L.6
-
29
-
-
77449142258
-
Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands
-
Yao D, Brownlee M. Hyperglycemia-induced reactive oxygen species increase expression of the receptor for advanced glycation end products (RAGE) and RAGE ligands. Diabetes 2010; 59: 249-255.
-
(2010)
Diabetes
, vol.59
, pp. 249-255
-
-
Yao, D.1
Brownlee, M.2
-
30
-
-
75949121425
-
Advanced glycation endproducts alter functions and promote apoptosis in endothelial progenitor cells through receptor for advanced glycation endproducts mediate overpression of cell oxidant stress
-
Chen J, Song M, Yu S, Gao P, Yu Y, Wang H et al. Advanced glycation endproducts alter functions and promote apoptosis in endothelial progenitor cells through receptor for advanced glycation endproducts mediate overpression of cell oxidant stress. Mol Cell Biochem 2010; 335: 137-146.
-
(2010)
Mol Cell Biochem
, vol.335
, pp. 137-146
-
-
Chen, J.1
Song, M.2
Yu, S.3
Gao, P.4
Yu, Y.5
Wang, H.6
-
31
-
-
67449083455
-
Increased secretion of IP-10 from monocytes under hyperglycemia is via the TLR2 and TLR4 pathway
-
Devaraj S, Jialal I. Increased secretion of IP-10 from monocytes under hyperglycemia is via the TLR2 and TLR4 pathway. Cytokine 2009; 47: 6-10.
-
(2009)
Cytokine
, vol.47
, pp. 6-10
-
-
Devaraj, S.1
Jialal, I.2
-
32
-
-
75149138278
-
Control of central self-tolerance induction by autoreactive CD4+ thymocytes
-
Irla M, Hollander G, Reith W. Control of central self-tolerance induction by autoreactive CD4+ thymocytes. Trends Immunol 2010; 31: 71-79.
-
(2010)
Trends Immunol
, vol.31
, pp. 71-79
-
-
Irla, M.1
Hollander, G.2
Reith, W.3
-
33
-
-
33748866909
-
Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus
-
DOI 10.1038/ni1385, PII NI1385
-
Bonasio R, Scimone ML, Schaerli P, Grabie N, Lichtman AH, von Andrian UH. Clonal deletion of thymocytes by circulating dendritic cells homing to the thymus. Nat Immunol 2006; 7: 1092-1100. (Pubitemid 44420654)
-
(2006)
Nature Immunology
, vol.7
, Issue.10
, pp. 1092-1100
-
-
Bonasio, R.1
Scimone, M.L.2
Schaerli, P.3
Grabie, N.4
Lichtman, A.H.5
Von, A.U.H.6
-
34
-
-
15244338878
-
Defective central tolerance induction in NOD mice: Genomics and genetics
-
DOI 10.1016/j.immuni.2005.01.015
-
Zucchelli S, Holler P, Yamagata T, Roy M, Benoist C, Mathis D. Defective central tolerance induction in NOD mice: genomics and genetics. Immunity 2005; 22: 385-396. (Pubitemid 40387479)
-
(2005)
Immunity
, vol.22
, Issue.3
, pp. 385-396
-
-
Zucchelli, S.1
Holler, P.2
Yamagata, T.3
Roy, M.4
Benoist, C.5
Mathis, D.6
-
35
-
-
0028448483
-
Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points
-
Linette GP, Grusby MJ, Hedrick SM, Hansen TH, Glimcher LH, Korsmeyer SJ. Bcl-2 is upregulated at the CD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1994; 1: 197-205.
-
(1994)
Immunity
, vol.1
, pp. 197-205
-
-
Linette, G.P.1
Grusby, M.J.2
Hedrick, S.M.3
Hansen, T.H.4
Glimcher, L.H.5
Korsmeyer, S.J.6
-
36
-
-
56249095514
-
NFkappaB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions
-
Yang WH, Park SY, Nam HW, Kim do H, Kang JG, Kang ES et al. NFkappaB activation is associated with its O-GlcNAcylation state under hyperglycemic conditions. Proc Natl Acad Sci USA 2008; 105: 17345-17350.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17345-17350
-
-
Yang, W.H.1
Park, S.Y.2
Nam, H.W.3
Kim Do, H.4
Kang, J.G.5
Kang, E.S.6
-
38
-
-
0035896366
-
Protein kinase B (PKB/Akt) - A key regulator of glucose transport?
-
Hajduch E, Litherland GJ, Hundal HS. Protein kinase B (PKB/Akt) - a key regulator of glucose transport? FEBS Lett 2001; 492: 199-203.
-
(2001)
FEBS Lett
, vol.492
, pp. 199-203
-
-
Hajduch, E.1
Litherland, G.J.2
Hundal, H.S.3
-
39
-
-
0035432491
-
Glucose Induces beta-Cell Apoptosis Via Upregulation of the Fas Receptor in Human Islets
-
Maedler K, Spinas GA, Lehmann R, Sergeev P, Weber M, Fontana A et al. Glucose induces beta-cell apoptosis via upregulation of the Fas receptor in human islets. Diabetes 2001; 50: 1683-1690. (Pubitemid 33641583)
-
(2001)
Diabetes
, vol.50
, Issue.8
, pp. 1683-1690
-
-
Maedler, K.1
Spinas, G.A.2
Lehmann, R.3
Sergeev, P.4
Weber, M.5
Fontana, A.6
Kaiser, N.7
Donath, M.Y.8
-
40
-
-
57349184120
-
Streptozotocin-induced diabetic models in mice and rats
-
Wu KK, Huan Y. Streptozotocin-induced diabetic models in mice and rats. Curr Protocols Pharmacol 2008; 40: 5.47.1-5.47.14.
-
(2008)
Curr Protocols Pharmacol
, vol.40
-
-
Wu, K.K.1
Huan, Y.2
|