Caspase-3 activation as a key factor for HBx-transformed cell death

Cell Proliferation

Volumn 41, Issue 5, 2008, Pages 755-774

  Kim, A ^b,e   Kwon, O S ^a   Kim, S O ^a   He, L ^a   Bae, E Y ^a   Lee, M S ^a   Jeong, S J ^a   Shim, J H ^b   Yoon, D Y ^b   Kim, C H ^c   Moon, A ^d   Kim, K E ^e   Ahn, J S ^a   Kim, B Y ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Konkuk University   (South Korea)

^c Sungkyunkwan University   (South Korea)

^d Duksung Women's University   (South Korea)

^e Chungnam National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CAMPTOTHECIN; CASPASE 12; CASPASE 3; CASPASE 9; DNA TOPOISOMERASE; GLYCOGEN SYNTHASE KINASE; HEPATITIS B VIRUS X PROTEIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEASOME INHIBITOR; PROTEIN KINASE B; PYRROLIDINE DERIVATIVE; SALAZOSULFAPYRIDINE; WORTMANNIN;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CELL GROWTH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; NONHUMAN; TUMOR GROWTH;

CAMPTOTHECIN; CASPASE 3; CELL DEATH; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CELL SURVIVAL; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LEUPEPTINS; NF-KAPPA B; OLIGOPEPTIDES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS;

HEPATITIS B VIRUS;

EID: 51649117144     PISSN: 09607722     EISSN: 13652184     Source Type: Journal    
DOI: 10.1111/j.1365-2184.2008.00550.x     Document Type: Article

References (42)

1. Adams J (2004) The development of proteasome inhibitors as anticancer drugs. Cancer Cell 5, 417 421.
2. Benn J, Schneider RJ (1994) Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc. Natl. Acad. Sci. USA 91, 10350 10354.
3. Brazil DP, Hemmings BA (2001) Ten years of protein kinase B signalling: a hard Akt to follow. Trends Biochem. Sci. 26, 657 664.
4. Chung TW, Lee YC, Kim CH (2004) Hepatitis B viral HBx induces matrix metalloproteinase-9 gene expression through activation of ERK and PI-3K/AKT pathways: involvement of invasive potential. FASEB J. 18, 1123 1125.
5. Ciechanover A, Brundin P (2003) The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Neuron 40, 427 446.
6. Cui F, Wang Y, Wang J, Wei K, Hu J, Liu F, Wang H, Zhao X, Zhang X, Yang X (2006) The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice. Proteomics 6, 498 504.
7. Cusack JC Jr., Liu R, Houston M, Abendroth K, Elliott PJ, Adams J, Baldwin AS Jr. (2001) Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res. 61, 3535 3540.
8. Feitelson M (1992) Hepatitis B virus infection and primary hepatocellular carcinoma. Clin. Microbiol. Rev. 5, 275 301.
9. Fernandez Y, Verhaegen M, Miller TP, Rush JL, Steiner P, Opipari AW Jr., Lowe SW, Soengas MS (2005) Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications. Cancer Res. 65, 6294 6304.
10. Frame S, Cohen P (2001) GSK3 takes centre stage more than 20 years after its discovery. Biochem. J. 359, 1 16.
11. Gottlob K, Fulco M, Levrero M, Graessmann A (1998) The hepatitis B virus HBx protein inhibits caspase-3 activity. J. Biol. Chem. 273, 33347 33353.
12. Grilli M, Chiu JJ, Lenardo MJ (1993) NF-kappa B and Rel: participants in a multiform transcriptional regulatory system. Int. Rev. Cytol. 143, 1 62.
13. Hayashi T, Faustman D (2000) Essential role of human leukocyte antigen-encoded proteasome subunits in NF-kappaB activation and prevention of tumor necrosis factor-alpha-induced apoptosis. J. Biol. Chem. 275, 5238 5247.
14. Hochstrasser M (1996) Ubiquitin-dependent protein degradation. Annu. Rev. Genet. 30, 405 439.
15. Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406, 86 90.
16. Hu Z, Zhang Z, Doo E, Coux O, Goldberg AL, Liang TJ (1999) Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex. J. Virol. 73, 7231 7240.
17. Kaufman RJ (2002) Orchestrating the unfolded protein response in health and disease. J. Clin. Invest. 110, 1389 1398.
18. Kaufman RJ, Scheuner D, Schroder M, Shen X, Lee K, Liu CY, Arnold SM (2002) The unfolded protein response in nutrient sensing and differentiation. Nat. Rev. Mol. Cell Biol. 3, 411 421.
19. Kwon O, Kim KA, Kim SO, Ha R, Oh WK, Kim MS, Kim HS, Kim GD, Kim JW, Jung M, Ahn JS, Kim BY (2006) NF-kappaB inhibition increases chemosensitivity to trichostatin A-induced cell death of Ki-Ras-transformed human prostate epithelial cells. Carcinogenesis 27, 2258 2268.
20. Lenz HJ (2003) Clinical update: proteasome inhibitors in solid tumors. Cancer Treat. Rev. 29 (Suppl. 1 41 48.
21. Lin Y, Tang H, Nomura T, Dorjsuren D, Hayashi N, Wei W, Ohta T, Roeder R, Murakami S (1998) The hepatitis B virus X protein is a co-activator of activated transcription that modulates the transcription machinery and distal binding activators. J. Biol. Chem. 273, 27097 27103.
22. Mayo MW, Baldwin AS (2000) The transcription factor NF-kappaB: control of oncogenesis and cancer therapy resistance. Biochim. Biophys. Acta. 1470, M55 M62.
23. Menendez-Benito V, Verhoef LG, Masucci MG, Dantuma NP (2005) Endoplasmic reticulum stress compromises the ubiquitin-proteasome system. Hum. Mol. Genet. 14, 2787 2799.
24. Miao J, Chen GG, Chun SY, Lai PP (2006) Hepatitis B virus X protein induces apoptosis in hepatoma cells through inhibiting Bcl-xL expression. Cancer Lett. 236, 115 124.
25. Mitchell BS (2003) The proteasome - an emerging therapeutic target in cancer. N. Engl. J. Med. 348, 2597 2598.
26. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J (2000) Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403, 98 103.
27. Robinson WS (1994) Molecular events in the pathogenesis of hepadnavirus-associated hepatocellular carcinoma. Annu. Rev. Med. 45, 297 323.
28. Sato T, Odagiri H, Ikenaga SK, Maruyama M, Sasaki M (2003) Chemosensitivity of human pancreatic carcinoma cells is enhanced by IkappaBalpha super-repressor. Cancer Sci. 94, 467 472.
29. Schwabe RF, Brenner DA (2002) Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Am. J. Physiol. Gastrointest. Liver Physiol. 283, G204 G211.
30. Sherman MY, Goldberg AL (2001) Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases. Neuron 29, 15 32.
31. Shih WL, Kuo ML, Chuang SE, Cheng AL, Doong SL (2000) Hepatitis B virus X protein inhibits transforming growth factor-beta-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway. J. Biol. Chem. 275, 25858 25864.
32. Shuda M, Kondoh N, Imazeki N, Tanaka K, Okada T, Mori K, Hada A, Arai M, Wakatsuki T, Matsubara O, Yamamoto N, Yamamoto M (2003) Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis. J. Hepatol. 38, 605 614.
33. Song L, De Sarno P, Jope RS (2002) Central role of glycogen synthase kinase-3beta in endoplasmic reticulum stress-induced caspase-3 activation. J. Biol. Chem. 277, 44701 44708.
34. Su F, Schneider RJ (1996) Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of rel-related proteins. J. Virol. 70, 4558 4566.
35. Tirasophon W, Lee K, Callaghan B, Welihinda A, Kaufman RJ (2000) The endoribonuclease activity of mammalian IRE1 autoregulates its mRNA and is required for the unfolded protein response. Genes Dev. 14, 2725 2736.
36. Wang CY, Cusack JC Jr., Liu R, Baldwin AS Jr. (1999) Control of inducible chemoresistance: enhanced anti-tumor therapy through increased apoptosis by inhibition of NF-kappaB. Nat. Med. 5, 412 417.
37. Wang T, Wang Y, Wu MC, Guan XY, Yin ZF (2004) Activating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma. World J. Gastroenterol. 10, 356 360.
38. Welihinda AA, Tirasophon W, Kaufman RJ (1999) The cellular response to protein misfolding in the endoplasmic reticulum. Gene Expr. 7, 293 300.
39. Yoshida H, Haze K, Yanagi H, Yura T, Mori K (1998) Identification of the cis-acting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J. Biol. Chem. 273, 33741 33749.
40. Zavrski I, Jakob C, Schmid P, Krebbel H, Kaiser M, Fleissner C, Rosche M, Possinger K, Sezer O (2005) Proteasome: an emerging target for cancer therapy. Anticancer Drugs 16, 475 481.
41. Zhang K, Kaufman RJ (2004) Signaling the unfolded protein response from the endoplasmic reticulum. J. Biol. Chem. 279, 25935 25938.
42. Zhang Z, Torii N, Furusaka A, Malayaman N, Hu Z, Liang TJ (2000) Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex. J. Biol. Chem. 275, 15157 15165.