A single instillation of amorphous silica nanoparticles induced inflammatory responses and tissue damage until day 28 after exposure

Journal of Health Science

Volumn 57, Issue 1, 2011, Pages 60-71

  Park, Eun Jung ^a   Roh, Jinkyu ^b   Kim, Younghun ^b   Choi, Kyunghee ^a  

^a National Institute of Environmental Research   (South Korea)

^b Kwangwoon University   (South Korea)

Author keywords

Amorphous silica nanoparticle; Cytokine; Gene expression; Inflammation

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; NANOPARTICLE; SILICON DIOXIDE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CHRONIC INFLAMMATION; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOTOXIC T LYMPHOCYTE; DNA SEQUENCE; DOWN REGULATION; GENE EXPRESSION REGULATION; HISTOPATHOLOGY; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; MICROARRAY ANALYSIS; MOUSE; NATURAL KILLER T CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PARTICLE SIZE; PHYSICAL CHEMISTRY; TISSUE INJURY; UPREGULATION; WEIGHT CHANGE; WEIGHT GAIN;

MUS;

EID: 79952587647     PISSN: 13449702     EISSN: 13475207     Source Type: Journal    
DOI: 10.1248/jhs.57.60     Document Type: Article

References (42)

1. Arts, J. H., Muijser, H., Duistermaat, E., Junker, K. and Kuper, C. F. (2007) Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months. Food Chem. Toxicol., 45, 1856-1867.
2. Fubini, B. and Hubbard, A. (2003) Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radic. Biol. Med., 34, 1507-1516.
3. McLaughlin, J. K., Chow, W. H. and Levy, L. S. (1997) Amorphous silica: a review of health effects from inhalation exposure with particular reference to cancer. J. Toxicol. Environ. Health, 50, 553-566.
4. Barik, T.K., Sahu, B., and Swain, V., (2008) Nanosilica-from medicine to pest control. Parasitol. Res., 103, 253-258.
5. Rahman, A., Seth, D., Mukhopadhyaya, S. K., Brahmachary, R. L., Ulrichs, C. and Goswami, A. (2009) Surface functionalized amorphous nanosilica and microsilica with nanopores as promising tools in biomedicine. Naturwissenschaften, 96, 31-38.
6. Van Hoecke, K., De Schamphelaere, K. A., Van der Meeren, P., Lucas, S. and Janssen, C. R. (2008) Ecotoxicity of silica nanoparticles to the green alga Pseudokirchneriella subcapitata: importance of surface area. Environ. Toxicol. Chem., 27, 1948-1957.
7. Chang, J. S., Chang, K. L., Hwang, D. F. and Kong, Z. L. (2007) In vitro cytotoxicity of silica nanoparti- cles at high concentrations strongly depends on the metabolic activity type of the cell line. Environ. Sci. Technol., 41, 2064-2068.
8. Eom, H. J. and Choi, J. (2009) Oxidative stress of silica nanoparticles in human bronchial epithelial cell, Beas-2B. Toxicol. In Vitro, 23, 1326-1332.
9. Jin, Y., Kannan, S., Wu, M. and Zhao, J. X. (2007) Toxicity of luminescent silica nanoparticles to living cells. Chem. Res. Toxicol., 20, 1126-1133.
10. Lin, W., Huang, Y., Zhou, X. D. and Ma, Y. (2006) In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol. Appl. Pharmacol., 217, 252-259.
11. DiMatteo, M., Antonini, J. M., Van Dyke, K. and Reasor, M. J. (1996) Characteristics of the acutephase pulmonary response to silica in rats. J. Tox- icol. Environ. Health, 47, 93-108.
12. Kaewamatawong, T., Shimada, A., Okajima, M., Inoue, H., Morita, T., Inoue, K. and Takano, H. (2006) Acute and subacute pulmonary toxicity of low dose of ultrafine colloidal silica particles in mice after intratracheal instillation. Toxicol. Pathol., 34, 958-965.
13. Park, E. J., Cho, W. S., Jeong, J., Yi, J., Choi, K. and Park, K. (2009) Pro-inflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation. Toxicology, 259, 113-121.
14. Choi, M., Cho, W. S., Han, B. S., Cho, M., Kim, S. Y., Yi, J. Y., Ahn, B., Kim, S. H. and Jeong, J. (2008) Transient pulmonary fibrogenic effect induced by intratracheal instillation of ultrafine amorphous silica in A/J mice. Toxicol. Lett., 182, 97-101.
15. Hauck, T. S., Ghazani, A. A. and Chan, W. C. (2008) Assessing the effect of surface chemistry on gold nanorod uptake, toxicity, and gene expression in mammalian cells. Small, 4, 153-159.
16. Park, E. J., Kim, H., Kim, Y., Yi, J., Choi, K. and Park, K. (2010) Inflammatory responses may be in- duced by a single intratracheal instillation of iron nanoparticlesd in mice. Toxicology, 275, 65-71.
17. Vendrame, M., Gemma, C., Pennypacker, K. R., Bickford, P. C., Davis, S. C., Sanberg, P. R. and Willing, A. E. (2006) Cord blood rescues stroke- induced changes in splenocyte phenotype and function. Exp. Neurol., 199, 191-200.
18. Brown, T. (2009) Silica exposure, smoking, silicosis and lung cancer-complex interactions. Occup. Med. (Lond.), 59, 89-95.
19. Hamiton, R. F., Jr., Thakur, S. A. and Holian, A. (2008) Silica binding and toxicity in alveolar macrophages. Free Radic. Biol. Med., 44, 1246-1258.
20. Merget, R., Bauer, T., Küpper, H. U., Philippou, S., Bauer, H. D., Breitstadt, R. and Bruening, T. (2002) Health hazards due to the inhalation of amorphous silica. Arch. Toxicol., 75, 625-634.
21. Castranova, V., Porter, D., Millecchia, L., Ma, J. Y., Hubbs, A. F. and Teass, A. (2002) Effect of inhaled crystalline silica in a rat model: time course of pulmonary reactions. Mol. Cell. Biochem., 234-235, 177-184.
22. Kneuer, C., Sameti, M., Bakowsky, U., Schiestel, T., Schirra, H., Schmidt, H. and Lehr, C. M. (2000) A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro. Bioconjug. Chem., 11, 926-932.
23. Ravi Kumar, M. N., Sameti, M., Mohapatra, S. S., Kong, X., Lockey, R. F., Bakowsky, U., Lindenblatt, G.,Schmidt H. Lehr C.M. (2004) Cationic silica nanoparticles as gene carriers: synthesis, characterization and transfection efficiency in vitro and in vivo. J. Nanosci. Nanotechnol., 4, 876-881.
24. Kozłowska, E., Krzystyniak, K., Drela, N., Grabarczyk, P. and Izdebska-Szymona, K. (1996) Thymus-directed immunotoxicity of airborne dust particles from upper Silesia (Poland) under acute extrapulmonary studies in mice. J. Toxicol. Environ. Health, 49, 563-579.
25. Richters, A. and Damji, K. S. (1988) Changes in T- lymphocyte subpopulations and natural killer cells following exposure to ambient levels of nitrogen dioxide. J. Toxicol. Environ. Health, 25, 247-256.
26. Smialowicz, R. J., Luebke, R. W., Riddle, M.M. Rogers R.R. and Rowe D. G., (1985) Evaluation of the immunotoxic potential of chlordecone with comparison to cyclophosphamide. J. Toxicol. Environ. Health, 15, 561-574.
27. Park, E. J., Yoon, J., Choi, K., Yi, J. and Park, K. (2009) Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intra-tracheal instillation. Toxicology, 260, 37-46.
28. Hulikova, K., Benson, V., Svoboda, J., Sima, P. and Fiserova, A. (2009) N-Acetyl-D-glucosamine- coated polyamidoamine dendrimer modulates anti- body formation via natural killer cell activation. Int. Immunopharmacol., 9, 792-799.
29. Thapa, P., Zhang, G., Xia, C., Gelbard, A., Overwijk, W. W., Liu, C., Hwu, P., Chang, D. Z., Courtney, A., Sastry, J. K., Wang, P. G., Li, C.and Zhou, D. (2009) Nanoparticle formulated alpha-galactosylceramide activates NKT cells without inducing anergy. Vaccine, 27, 3484-3488.
30. Pan, X., Chen, L., Liu, S., Yang, X., Gao, J. X. and Lee, R. J. (2009) Antitumor activity of G3139 lipid nanoparticles (LNPs). Mol. Pharm., 6, 211-220.
31. Park, E. J. and Park, K. (2009) Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol. Lett., 184, 18-25.
32. Mayeux, P. R. (1997) Pathobiology of lipopolysac-charide. J. Toxicol. Environ. Health, 51, 415-435.
33. Reinhart, P. G. and Gairola, C. G. (1997) Amiodarone-induced pulmonary toxicity in Fischer rats: release of tumor necrosis factor alpha and transforming growth factor beta by pulmonary alve-olar macrophage. J. Toxicol. Environ. Health, 52, 353-365.
34. Wilson, T. C., Bachurski, C. J., Ikegami, M., Jobe, A. H. and Kallapur, S. G. (2005) Pulmonary and sys- temic induction of SAA3 after ventilation and en-dotoxin in preterm lambs. Pediatr. Res., 58, 1204-1209.
35. Lawrence, D. A. (1996) Transforming growth factor-beta: a general review. Eur. Cytokine Netw., 7,363-374.
36. Gauldie, J., Kolb, M., Ask, K., Martin, G., Bonniaud, P. and Warburton, D. (2006) Smad3 sig- naling involved in pulmonary fibrosis and emphysema. Proc. Am. Thorac. Soc., 3, 696-702.
37. Cawston, T., Carrere, S., Catterall, J., Duggleby, R., Elliott, S., Shingleton, B. and Rowan, A. (2001) Matrix metalloproteinases and TIMPs: properties and implications for the treatment of chronic obstructive pulmonary disease. Novartis Foundation Symposium, 234, 205-218.
38. Clark, I. M., Swingler, T. E., Sampieri, C. L. and Edwards, D. R. (2008) The regulation of matrix metalloproteinases and their inhibitors. Int. J. Biochem. Cell. Biol., 40, 1362-1378.
39. Demedts, I. K., Brusselle, G. G., Bracke, K. R., Vermaelen, K. Y. and Pauwels, R. A. (2005) Matrix metalloproteinases in asthma and COPD. Curr. Opin. Pharmacol., 5, 257-263.
40. Gueders, M. M., Foidart, J. M., Noel, A. and Cataldo, D. D. (2006) Matrix metalloproeinases (MMPs) and tissue inhibitors of MMPs in the res- piratory tract: potential implications in asthma and other lung diseases. Eur. J. Pharmacol., 533, 133- 144.
41. Lagente, V., Manoury, B., Nénan, S., Le Quémen, C., Martin-Chouly, C. and Boichot, E. (2005) Role of marix metalloproteinases in the development of airway inflammation and remodeling. Braz. J. Med. Biol. Res., 38, 1521-1530.
42. Ohbayashi, H. (2002) Matrix metalloproteinases in lung diseases. Curr. Protein Pept. Sci., 3, 409-421.