Inflammatory responses may be induced by a single intratracheal instillation of iron nanoparticles in mice

Toxicology

Volumn 275, Issue 1-3, 2010, Pages 65-71

  Park, Eun Jung ^a   Kim, Hero ^b   Kim, Younghun ^b   Yi, Jongheop ^c   Choi, Kyunghee ^d   Park, Kwangsik ^a  

^a Dongduk Women's University   (South Korea)

^b Kwangwoon University   (South Korea)

^c Seoul National University   (South Korea)

^d National Institute of Environmental Research   (South Korea)

Author keywords

Cytokines; Inflammation; Intratracheal instillation; Iron oxide nanoparticles; Mice

Indexed keywords

FERROUS CHLORIDE; GLUTATHIONE; HEAT SHOCK PROTEIN; IMMUNOGLOBULIN E; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; IRON OXIDE; MATRIX METALLOPROTEINASE; NANOPARTICLE; PHOSPHATE BUFFERED SALINE; SERUM AMYLOID A; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; BLOOD ANALYSIS; CD8+ T LYMPHOCYTE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; GENE EXPRESSION; GRANULOMA; INFLAMMATION; LUNG ALVEOLUS; LUNG LAVAGE; LYMPHOCYTE COUNT; MALE; MOLECULAR SIZE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TH0 CELL; TH1 CELL; TH2 CELL; TISSUE INJURY;

ANIMALS; FERRIC COMPOUNDS; INFLAMMATION MEDIATORS; INTUBATION, INTRATRACHEAL; LUNG; MALE; MICE; MICE, INBRED ICR; NANOPARTICLES; TRACHEA;

MUS;

EID: 77954818793     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.06.002     Document Type: Article

References (24)

1. Apopa P.L., Qian Y., Shao R., Guo N.L., Schwegler-Berry D., Pacurari M., Porter D., Shi X., Vallyathan V., Castranova V., Flynn D.C. Iron oxide nanoparticles induce human microvascular endothelial cell permeability through reactive oxygen species production and microtubule remodeling. Part Fibre Toxicol. 2009, 6:1.
2. Cho W.S., Cho M., Kim S.R., Choi M., Lee J.Y., Han B.S., Park S.N., Yu M.K., Jon S., Jeong J. Pulmonary toxicity and kinetic study of Cy5.5-conjugated superparamagnetic iron oxide nanoparticles by optical imaging. Toxicol. Appl. Pharmacol. 2009, 239(1):106-115.
3. Epstein W.L., Fukuyama K. Mechanisms of granulomatous inflammation. Immunol. Ser. 1989, 46:687-721.
4. Hussain S.M., Hess K.L., Gearhart J.M., Geiss K.T., Schlager J.J. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol. In Vitro 2005, 19(7):975-983.
5. Jain T.K., Reddy M.K., Morales M.A., Leslie-Pelecky D.L., Labhasetwar V. Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. Mol. Pharm. 2008, 5(2.):316-327.
6. Jeng H.A., Swanson J. Toxicity of metal oxide nanoparticles in mammalian cells. J. Environ. Sci. Health A: Tox. Hazard. Subst. Environ. Eng. 2006, 4(12):2699-2711.
7. Johansson N., Kähän V.M. Matrix metalloproteinases in squamous cell carcinoma. Histol. Histopathol. 2000, 15(1):225-237.
8. 3 particles. Chem. Mater. 1996, 8:2209-2211.
9. Karlsson H.L., Cronholm P., Gustafsson J., Möller L. Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes. Chem. Res. Toxicol. 2008, 21(9):1726-1732.
10. Lawrence D.A. Transforming growth factor-beta: a general review. Eur. Cytokine Netw. 1996, 7(3):363-374.
11. Möller W., Barth W., Kohlhäufl M., Häussinger K., Stahlhofen W., Heyder J. Human alveolar long-term clearance of ferromagnetic iron oxide microparticles in healthy and diseased subjects. Exp. Lung Res. 2001, 27(7):547-568.
12. Oberdorster G. Significance of particle parameters in the evaluation of exposure-dose-response relationships of inhaled particles. Inhal. Toxicol. 1996, 8:73-89.
13. Park E.J., Choi J., Park Y.K., Park K. Oxidative stress induced by cerium oxide nanoparticles in cultured BEAS-2B cells. Toxicology 2008, 245(1-2):90-100.
14. Park E.J., Cho W.S., Jeong J., Yi J., Choi K., Park K. Pro-inflammatory and potential allergic responses resulting from B cell activation in mice treated with multi-walled carbon nanotubes by intratracheal instillation. Toxicology 2009, 259:113-121.
15. Park E.J., Yoon J., Choi K., Yi J., Park K. Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation. Toxicology 2009, 260:37-46.
16. Rahman I., MacNee W. Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches. Free Radic. Biol. Med. 2000, 28(9):1405-1420.
17. Rahman I., Biswas S.K., Jimenez L.A., Torres M., Forman H.J. Glutathione, stress responses, and redox signaling in lung inflammation. Antioxid. Redox Signal. 2005, 7(1-2):42-59.
18. Ravi Kumar M.N., Sameti M., Mohapatra S.S., Kong X., Lockey R.F., Bakowsky U., Lindenblatt G., Schmidt H., Lehr C.M. Cationic silica nanoparticles as gene carriers: synthesis, characterization and transfection efficiency in vitro and in vivo. J. Nanosci. Nanotechnol. 2004, 4(7):876-881.
19. Raynal I., Prigent P., Peyramaure S., Najid A., Rebuzzi C., Corot C. Macrophage endocytosis of superparamagnetic iron oxide nanoparticles: mechanisms and comparison of ferumoxides and ferumoxtran-10. Invest. Radiol. 2004, 39(1):56-63.
20. 4 magnetic nanoparticles on HeLa cells. J. Nanosci. Nanotechnol. 2009, 9(5):2866-2871.
21. Stone V., Johnston H., Clift M.J. Air pollution, ultrafine and nanoparticle toxicology: cellular and molecular interactions. IEEE Trans. Nanobiosci. 2007, 6(4):331-340.
22. Weinstein J.S., Varallyay C.G., Dosa E., Gahramanov S., Hamilton B., Rooney W.D., Muldoon L.L., Neuwelt E.A. Superparamagnetic iron oxide nanoparticles:diagnostic magnetic resonance imagind and potential therapeutic applications in neurooncology and central nervous system inflammatory paathologies, a review. J. Cereb. Blood Flow Metab. 2010, 30(1):15-35.
23. Williams G.T., Williams W.J. Granulomatous inflammation-a review. J. Clin. Pathol. 1983, 36(7):723-733.
24. Woodard B.H., Rsoenberg S.I., Farnham R., Adams D.O. Incidence and nature of primary granulomatous inflammation in surgically removed material. Am. J. Surg. Pathol. 1982, 6(2):119-129.