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The alcohols and other solvents need to be anhydrous.
-
The alcohols and other solvents need to be anhydrous.
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52
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79952584614
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This reaction was tested only in racemic series with L1 as ligand because of the existence of a fast tautomerization between keto and enol forms and hence a rapid racemization.
-
This reaction was tested only in racemic series with L1 as ligand because of the existence of a fast tautomerization between keto and enol forms and hence a rapid racemization.
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79952585535
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The lower yields seem related to purification issues as absolutely clean reaction mixtures containing only the oxazoles are obtained at full conversion in each case.
-
The lower yields seem related to purification issues as absolutely clean reaction mixtures containing only the oxazoles are obtained at full conversion in each case.
-
-
-
-
66
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0000234509
-
-
For related lactone formations, see: Doyle, M. P.; Westrum, L. J.; Wolthuis, W. N. E.; See, M. M.; Boone, W. P.; Bagheri, V.; Pearson, M. M. J. Am. Chem. Soc. 1993, 115, 958
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79952586794
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The loss of enantiomeric purity might be due to a postreaction racemization involving a cleavage of the O(1)-C(2) bond of the dioxole to form an achiral enolate/oxycarbenium intermediate; the cationic part is stabilized by donating groups on the aryl moiety of the benzaldehyde and hence the result of entry 3, Table 5.
-
The loss of enantiomeric purity might be due to a postreaction racemization involving a cleavage of the O(1)-C(2) bond of the dioxole to form an achiral enolate/oxycarbenium intermediate; the cationic part is stabilized by donating groups on the aryl moiety of the benzaldehyde and hence the result of entry 3, Table 5.
-
-
-
-
69
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79952582263
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3-substituted benzaldehyde.
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3-substituted benzaldehyde.
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-
-
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