Heterozygous cellular glutathione peroxidase deficiency in the mouse: Abnormalities in vascular and cardiac function and structure

Circulation

Volumn 106, Issue 9, 2002, Pages 1154-1158

  Forgione, Marc A ^a   Cap, Andre ^a   Liao, Ronglih ^a   Moldovan, Nicanor I ^a   Eberhardt, Robert T ^a   Lim, Chee Chew ^a   Jones, John ^a   Goldschmidt Clermont, Pascal J ^a   Loscalzo, Joseph ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidants; Endothelium; Nitric oxide; Oxygen; Vasculature

Indexed keywords

ACETYLCHOLINE; GLUTATHIONE PEROXIDASE; ISOPROSTANE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; CONTROLLED STUDY; DIASTOLE; ENZYME DEFICIENCY; FIBROBLAST; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE PERFUSION; HETEROZYGOSITY; HISTOPATHOLOGY; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; VASOCONSTRICTION; WILD TYPE;

ANIMALS; ANTIOXIDANTS; AORTA, THORACIC; BRADYKININ; CORONARY VESSELS; CYCLIC GMP; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE TARGETING; GLUTATHIONE PEROXIDASE; HETEROZYGOTE; MALE; MESENTERY; METABOLISM, INBORN ERRORS; MICE; MICROCIRCULATION; MUSCARINIC AGONISTS; MYOCARDIAL CONTRACTION; MYOCARDIUM; NITRIC OXIDE DONORS; OXIDATIVE STRESS; VASODILATOR AGENTS; VASOMOTOR SYSTEM;

EID: 0037183563     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000026820.87824.6A     Document Type: Article

References (30)

1. Nitric oxide activity in the human coronary circulation: Impact of risk factors for coronary atherosclerosis
2. The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium
3. Inhibition of nitric oxide production: Mechanisms of vascular albumin leakage
4. Nitric oxide regulation of tissue free radical injury
5. Cholesterol reduction in cardiovascular disease: Clinical benefits and possible mechanisms
6. Comparative study of the enzymatic defense systems against oxygen-derived free radicals: The key role of glutathione peroxidase
7. Diversity of glutathione peroxidases
8. Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation: Formation of novel nitrogen-containing oxidized lipid derivatives
9. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase
10. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells
11. Cellular glutathione peroxidase deficiency and endothelial dysfunction
12. Vasodilator response of mesenteric arterioles to histamine in spontaneously hypertensive rats
13. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia
14. 2+-handling proteins and effects of isoproterenol
15. Glutathione-related antioxidant defenses in human atherosclerotic plaques
16. Macrophage glutathione content and glutathione peroxidase activity are inversely related to cell-mediated oxidation of LDL: In vitro and in vivo studies
17. Selenium deficiency reduces the abundance of mRNA for Se-dependent glutathione peroxidase 1 by a UGA-dependent mechanism likely to be nonsense codon-mediated decay of cytoplasmic mRNA
18. Selenium supplementation and diet induced hypercholesterolemia in the rat: Changes in lipid levels, malonyldialdehyde production and the nitric oxide synthase activity
19. Association between cardiovascular death and myocardial infarction and serum selenium in a matched-pair longitudinal study
20. In vivo formation of 8-iso-prostaglandin f2α and platelet activation in diabetes mellitus: Effects of improved metabolic control and vitamin E supplementation
21. Modulation of oxidant stress in vivo in chronic cigarette smokers
22. In vivo formation of 8-Epi-prostaglandin F2 α is increased in hypercholesterolemia
23. 2 isoprostanes in hypercholesterolemia
24. Cyclooxygenase-dependent formation of the isoprostane, 8-epi prostaglandin F2 α
25. Generation of 8-epiprostaglandin F2α by human monocytes: Discriminate production by reactive oxygen species and prostaglandin endoperoxide synthase-2
26. IPF2α-I: An index of lipid peroxidation in humans
27. Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury
28. Buthionine sulfoximide reduces the protective capacity of myocytes to withstand peroxide-derived free radical attack
29. The aging paradox: Free radical theory of aging
30. Oxidative damage in the senescence-accelerated mouse