7-Chloro-6-piperidin-1-yl-quinoline-5,8-dione (PT-262), a novel ROCK inhibitor blocks cytoskeleton function and cell migration

Biochemical Pharmacology

Volumn 81, Issue 7, 2011, Pages 856-865

  Tsai, Chih Chien ^a,b   Liu, Huei Fang ^a   Hsu, Kai Cheng ^a   Yang, Jinn Moon ^a   Chen, Chinpiao ^c   Liu, Kuang Kai ^a   Hsu, Tzu Sheng ^b   Chao, Jui I ^a  

^a NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^b TZU CHI UNIVERSITY   (Taiwan)

^c NATIONAL DONG HWA UNIVERSITY   (Taiwan)

Author keywords

Cell migration; Cytoskeleton; Lung cancer; PT 262; ROCK

Indexed keywords

2 METHYL 1 [(4 METHYL 5 ISOQUINOLINE)SULFONYL] HOMOPIPERAZINE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 7 CHLORO 6 PIPERIDIN 1 YL QUINOLINE 5,8 DIONE; COLCHICINE; CYTOCHALASIN B; H 1152; PACLITAXEL; PHALLACIDIN; PT 262; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL; CANCER INHIBITION; CELL MIGRATION; CONTROLLED STUDY; CYTOSKELETON; DRUG ACTIVITY; DRUG EFFICACY; DRUG STRUCTURE; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS FIBER;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL MOVEMENT; CYTOSKELETON; HUMANS; MICROSCOPY, ATOMIC FORCE; PROTEIN KINASE INHIBITORS; QUINOLONES; QUINONES; RHO-ASSOCIATED KINASES; RNA, SMALL INTERFERING;

EID: 79952573259     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2011.01.009     Document Type: Article

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