Lithium chloride and staurosporine potentiate the accumulation of phosphorylated glycogen synthase kinase 3β/Tyr216, resulting in glycogen synthase kinase 3β activation in SH-SY5Y human neuroblastoma cell lines

Journal of Neuroscience Research

Volumn 89, Issue 5, 2011, Pages 755-763

  Noël, Anastasia ^a   Barrier, Laurence ^a   Rinaldi, Francois ^a   Hubert, Claire ^a   Fauconneau, Bernard ^a   Ingrand, Sabrina ^a  

^a IBMIG Institut de Biologie Moleculaire et dIngenierie Genetique   (France)

Author keywords

GSK3 inhibition; Neuronal cells; Serine 9 phosphorylation; Tyrosine 216 phosphorylation

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; STAUROSPORINE;

ANIMAL CELL; ARTICLE; CELL STRAIN; CELL STRAIN SH SY5Y; CELL VIABILITY; CONTROLLED STUDY; CYTOLYSIS; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT;

ANTIMANIC AGENTS; CELL LINE, TUMOR; CELLS, CULTURED; GLYCOGEN SYNTHASE KINASE 3; HUMANS; LITHIUM CHLORIDE; NEUROBLASTOMA; NEURONS; PHOSPHORYLATION; STAUROSPORINE;

EID: 79952522220     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22587     Document Type: Article

References (36)

1. Agholme L, Lindström T, Kågedal K, Marcusson J, Hallbeck MJ. 2010. An in vitro model for neuroscience: differentiation of SH-SY5Y cells into cells with morphological and biochemical characteristics of mature neurons. J Alzheimers Dis 20: 1069-1082.
2. Aparicio IM, Garcia-Herreros M, Fair T, Lonergan P. 2010. Identification and regulation of glycogen synthase kinase-3 during bovine embryo development. Reproduction 140: 83-92.
3. Berridge MJ, Downes CP, Hanley MR. 1989. Neural and developmental actions of lithium: a unifying hypothesis. Cell 59: 411-419.
4. Bhat RV, Shanley J, Correll MP, Fieles WE, Keith RA, Scott CW, Lee CM. 2000. Regulation and localization of tyrosine 216 phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration. Proc Natl Acad Sci U S A 97: 11074-11079.
5. Bijur GN, De Sarno P, Jope RS. 2000. Glycogen synthase kinase-3beta facilitates staurosporine- and heat shock-induced apoptosis. Protection by lithium. J Biol Chem 275: 7583-7590.
6. Bilir A, Erguven M, Yazihan N, Aktas E, Oktem G, Sabanci A. 2010. Enhancement of vinorelbine-induced cytotoxicity and apoptosis by clomipramine and lithium chloride in human neuroblastoma cancer cell line SH-SY5Y. J Neurooncol DOI 10.1007/s11060-010-0209-6.
7. Chalecka-Franaszek E, Chuang DM. 1999. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc Natl Acad Sci U S A 96: 8745-8750.
8. Chin PC, Majdzadeh N, D'Mello SR. 2005. Inhibition of GSK3beta is a common event in neuroprotection by different survival factors. Brain Res Mol Brain Res 137: 193-201.
9. Cohen P, Frame S. 2001. The renaissance of GSK3. Nat Rev Mol Cell Biol 2: 769-776.
10. Cole A, Frame S, Cohen P. 2004. Further evidence that the tyrosine phosphorylation of glycogen synthase kinase-3 (GSK3) in mammalian cells is an autophosphorylation event. Biochem J 377: 249-255.
11. D'Mello SR, Anelli R, Calissano P. 1994. Lithium induces apoptosis in immature cerebellar granule cells but promotes survival of mature neurons. Exp Cell Res 211: 332-338.
12. Davies SP, Reddy H, Caivano M, Cohen P. 2000. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105.
13. De Sarno P, Li X, Jope RS. 2002. Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium. Neuropharmacology 43: 1158-1164.
14. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RA, Kaplan DR, Greenberg ME. 1997. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 275: 661-665.
15. Feyt C, Kienlen-Campard P, Leroy K, N'Kuli F, Courtoy PJ, Octave JN. 2005. Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3. J Biol Chem 280: 33220-33227.
16. Hanada M, Saito E, Kambe T, Hagiwara Y, Kubo T. 1998. Effects of genistein and staurosporine on angiotensin II-induced DNA synthesis, protein synthesis and mitogen-activated protein kinase activation in vascular smooth muscle cells. Biol Pharm Bull 21: 1045-1049.
17. Iglesias-Serret D, Piqué M, Gil J, Pons G, López JM. 2003. Transcriptional and translational control of Mcl-1 during apoptosis. Arch Biochem Biophys 417: 141-152.
18. Ingrand S, Barrier L, Lafay-Chebassier C, Fauconneau B, Page G, Hugon J. 2007. The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation. FEBS Lett 58: 4473-4478.
19. Jantas D, Szymanska M, Budziszewska B, Lason W. 2009. An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons. Apoptosis 14: 900-912.
20. Jope RS. 1999. Anti-bipolar therapy: mechanism of action of lithium. Mol Psychiatry 4: 117-128.
21. Klein PS, Melton DA. 1996. A molecular mechanism for the effect of lithium on development. Proc Natl Acad Sci U S A 93: 8455-8459.
22. Li X, Friedman AB, Zhu W, Wang L, Boswell S, May RS, Davis LL, Jope RS. 2007. Lithium regulates glycogen synthase kinase-3beta in human peripheral blood mononuclear cells: implication in the treatment of bipolar disorder. Biol Psychiatry 61: 216-222.
23. Malich G, Markovic B, Winder C. 1997. The sensitivity and specificity of the MTS tetrazolium assay for detecting the in vitro cytotoxicity of 20 elements using human cell lines. Toxicology 124: 179-192.
24. Marmol F. 2008. Lithium: bipolar disorder and neurodegenerative diseases Possible cellular mechanisms of the therapeutic effects of lithium. Prog Neuropsychopharmacol Biol Psychiatry 32: 1761-1771.
25. Morel M, Couturier J, Pontcharraud R, Gil R, Fauconneau B, Paccalin M, Page G. 2009. Evidence of molecular links between PKR and mTOR signalling pathways in Abeta neurotoxicity: role of p53, Redd1 and TSC2. Neurobiol Dis 36: 151-161.
26. O'Brien WT, Harper AD, Jové F, Woodgett JR, Maretto S, Piccolo S, Klein PS. 2004. Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium. J Neurosci 24: 6791-6798.
27. Page G, Rioux Bilan A, Ingrand S, Lafay-Chebassier C, Pain S, Perault Pochat MC, Bouras C, Bayer T, Hugon J. 2006. Activated double-stranded RNA-dependent protein kinase and neuronal death in models of Alzheimer's disease. Neuroscience 139: 1343-1354.
28. Phiel CJ, Wilson CA, Lee VMY, Klein PS. 2003. GSK-3α regulates production of Alzheimer's disease amyloid-β peptides. Nature 423: 435-439.
29. Rametti A, Esclaire F, Yardin C, Terro F. 2004. Linking alterations in tau phosphorylation and cleavage during neuronal apoptosis. J Biol Chem 279: 54518-54528.
30. Ryves WJ, Harwood AJ. 2001. Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem Biophys Res Commun 280: 720-725.
31. Simon D, Benitez MJ, Gimenez-Cassina A, Garrido JJ, Bhat RV, Diaz-Nido J, Wandosell F. 2008. Pharmacological inhibition of GSK3 is not strictly correlated with a decrease in tyrosine phosphorylation of residues 216/279. J Neurosci Res 86: 668-674.
32. Stambolic V, Ruel L, Woodgett JR. 1996. Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol Dec 6: 1664-1668.
33. Vantelon N, Rioux-Bilan A, Ingrand S, Pain S, Page G, Guillard O, Barrier L, Piriou A, Fauconneau B. 2007. Regulation of initiation factors controlling protein synthesis on cultured astrocytes in lactic acid-induced stress. Eur J Neurosci 26: 689-700.
34. Wang X, Janmaat M, Beugnet A, Paulin FE, Proud CG. 2002. Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF)2B is insufficient for the activation of eIF2B by insulin. Biochem J 367: 475-481.
35. Welsh GI, Miller CM, Loughlin AJ, Price NT, Proud CG. 1998. Regulation of eukaryotic initiation factor eIF2B: glycogen synthase kinase-3 phosphorylates a conserved serine which undergoes dephosphorylation in response to insulin. FEBS Lett 421: 125-130.
36. Zhang F, Phiel CJ, Spece L, Gurvich N, Klein PS. 2003. Inhibitory phosphorylation of glycogen synthase kinase-3 (GSK-3) in response to lithium. Evidence for autoregulation of GSK-3. J Biol Chem 278: 33067-33077.