Gadd45a protects against cell death in dorsal root ganglion neurons following peripheral nerve injury

Journal of Neuroscience Research

Volumn 89, Issue 5, 2011, Pages 689-699

  Lin, Chung Ren ^a,b   Yang, Chien Hui ^a   Huang, Chiu En ^a   Wu, Chih Hsien ^a,c   Chen, Yi Shen ^a,c   Sheen Chen, Shyr Ming ^a   Huang, Hui Wen ^a,c   Chen, Kuan Hung ^a,c  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Axotomy; Small hairpin RNA; Viral vector

Indexed keywords

CYTOCHROME C; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45ALPHA; NERVE GROWTH FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; EMBRYO; ENZYME RELEASE; MALE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SPINAL GANGLION; UPREGULATION;

ANIMALS; ANIMALS, NEWBORN; AXOTOMY; CELL CYCLE PROTEINS; CELL DEATH; DISEASE MODELS, ANIMAL; GANGLIA, SPINAL; LIGANDS; MALE; NERVE DEGENERATION; NERVE GROWTH FACTOR; NUCLEAR PROTEINS; PERIPHERAL NERVOUS SYSTEM DISEASES; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NEUROPATHY; SENSORY RECEPTOR CELLS; UP-REGULATION;

EID: 79952499915     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22589     Document Type: Article

References (51)

1. Allen RT, Hunter WJ, 3rd, Agrawal DK. 1997. Morphological and biochemical characterization and analysis of apoptosis. J Pharmacol Toxicol Methods 37: 215-228.
2. Beadling C, Johnson KW, Smith KA. 1993. Isolation of interleukin 2-induced immediate-early genes. Proc Natl Acad Sci U S A 90: 2719-2723.
3. Befort K, Karchewski L, Lanoue C, Woolf CJ. 2003. Selective up-regulation of the growth arrest DNA damage-inducible gene Gadd45 alpha in sensory and motor neurons after peripheral nerve injury. Eur J Neurosci 18: 911-922.
4. Carrier F, Smith ML, Bae I, Kilpatrick KE, Lansing TJ, Chen CY, Engelstein M, Friend SH, Henner WD, Gilmer TM, et al. 1994. Characterization of human Gadd45, a p53-regulated protein. J Biol Chem 269: 32672-32677.
5. Charriaut-Marlangue C, Richard E, Ben-Ari Y. 1999. DNA damage and DNA damage-inducible protein Gadd45 following ischemia in the P7 neonatal rat. Brain Res Dev Brain Res 116: 133-140.
6. Chen J, Uchimura K, Stetler RA, Zhu RL, Nakayama M, Jin K, Graham SH, Simon RP. 1998. Transient global ischemia triggers expression of the DNA damage-inducible gene GADD45 in the rat brain. J Cereb Blood Flow Metab 18: 646-657.
7. Costigan M, Befort K, Karchewski L, Griffin RS, D'Urso D, Allchorne A, Sitarski J, Mannion JW, Pratt RE, Woolf CJ. 2002. Replicate high-density rat genome oligonucleotide microarrays reveal hundreds of regulated genes in the dorsal root ganglion after peripheral nerve injury. BMC Neurosci 3: 16.
8. Fayolle C, Pourchet J, de Fromentel CC, Puisieux A, Dore JF, Voeltzel T. 2008. Gadd45a activation protects melanoma cells from ultraviolet B-induced apoptosis. J Invest Dermatol 128: 196-202.
9. Fornace AJJr, Alamo IJr, Hollander MC. 1988. DNA damage-inducible transcripts in mammalian cells. Proc Natl Acad Sci U S A 85: 8800-8804.
10. Fornace AJJr, Jackman J, Hollander MC, Hoffman-Liebermann B, Liebermann DA. 1992. Genotoxic-stress-response genes and growth-arrest genes. gadd, MyD, and other genes induced by treatments eliciting growth arrest. Ann N Y Acad Sci 663: 139-153.
11. Gupta M, Gupta SK, Balliet AG, Hollander MC, Fornace AJ, Hoffman B, Liebermann DA. 2005. Hematopoietic cells from Gadd45a- and Gadd45b-deficient mice are sensitized to genotoxic-stress-induced apoptosis. Oncogene.
12. Hart AM, Wiberg M, Youle M, Terenghi G. 2002. Systemic acetyl-L-carnitine eliminates sensory neuronal loss after peripheral axotomy: a new clinical approach in the management of peripheral nerve trauma. Exp Brain Res 145: 182-189.
13. Henshall DC, Sinclair J, Simon RP. 1999. Relationship between seizure-induced transcription of the DNA damage-inducible gene GADD45, DNA fragmentation, and neuronal death in focally evoked limbic epilepsy. J Neurochem 73: 1573-1583.
14. Hildesheim J, Bulavin DV, Anver MR, Alvord WG, Hollander MC, Vardanian L, Fornace AJJr. 2002. Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53. Cancer Res 62: 7305-7315.
15. Hokfelt T, Zhang X, Wiesenfeld-Hallin Z. 1994. Messenger plasticity in primary sensory neurons following axotomy and its functional implications. Trends Neurosci 17: 22-30.
16. Hollander MC, Alamo I, Jackman J, Wang MG, McBride OW, Fornace AJJr. 1993. Analysis of the mammalian gadd45 gene and its response to DNA damage. J Biol Chem 268: 24385-24393.
17. Hollander MC, Sheikh MS, Bulavin DV, Lundgren K, Augeri-Henmueller L, Shehee R, Molinaro TA, Kim KE, Tolosa E, Ashwell JD, Rosenberg MP, Zhan Q, Fernandez-Salguero PM, Morgan WF, Deng CX, Fornace AJJr. 1999. Genomic instability in Gadd45a-deficient mice. Nat Genet 23: 176-184.
18. Hollander MC, Kovalsky O, Salvador JM, Kim KE, Patterson AD, Haines DC, Fornace AJJr. 2001. Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency. Cancer Res 61: 2487-2491.
19. Hughes PE, Alexi T, Yoshida T, Schreiber SS, Knusel B. 1996. Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation. Neuroscience 74: 1143-1160.
20. Jin K, Chen J, Kawaguchi K, Zhu RL, Stetler RA, Simon RP, Graham SH. 1996. Focal ischemia induces expression of the DNA damage-induciblegene GADD45 in the rat brain. Neuroreport 7: 1797-1802.
21. Kastan MB, Zhan Q, el-Deiry WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJJr. 1992. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597.
22. Kim SH, Chung JM. 1992. An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50: 355-363.
23. Kovalsky O, Lung FD, Roller PP, Fornace AJJr. 2001. Oligomerization of human Gadd45a protein. J Biol Chem 276: 39330-39339.
24. Lekan HA, Chung K, Yoon YW, Chung JM, Coggeshall RE. 1997. Loss of dorsal root ganglion cells concomitant with dorsal root axon sprouting following segmental nerve lesions. Neuroscience 81: 527-534.
25. Lin CR, Amaya F, Barrett L, Wang H, Takada J, Samad TA, Woolf CJ. 2006. Prostaglandin E2 receptor EP4 contributes to inflammatory pain hypersensitivity. J Pharmacol Exp Ther 319: 1096-1103.
26. McKay Hart A, Brannstrom T, Wiberg M, Terenghi G. 2002. Primary sensory neurons and satellite cells after peripheral axotomy in the adult rat: timecourse of cell death and elimination. Exp Brain Res 142: 308-318.
27. Papathanasiou MA, Fornace AJJr. 1991. DNA-damage inducible genes. Cancer Treat Res 57: 13-36.
28. Papathanasiou MA, Kerr NC, Robbins JH, McBride OW, Alamo IJr, Barrett SF, Hickson ID, Fornace AJJr. 1991. Induction by ionizing radiation of the gadd45 gene in cultured human cells: lack of mediation by protein kinase C. Mol Cell Biol 11: 1009-1016.
29. Parsadanian AS, Cheng Y, Keller-Peck CR, Holtzman DM, Snider WD. 1998. Bcl-xL is an antiapoptotic regulator for postnatal CNS neurons. J Neurosci 18: 1009-1019.
30. Plunet W, Kwon BK, Tetzlaff W. 2002. Promoting axonal regeneration in the central nervous system by enhancing the cell body response to axotomy. J Neurosci Res 68: 1-6.
31. Rishi AK, Sun RJ, Gao Y, Hsu CK, Gerald TM, Sheikh MS, Dawson MI, Reichert U, Shroot B, Fornace AJJr, Brewer G, Fontana JA. 1999. Post-transcriptional regulation of the DNA damage-inducible gadd45 gene in human breast carcinoma cells exposed to a novel retinoid CD437. Nucleic Acids Res 27: 3111-3119.
32. Saeki Y, Ichikawa T, Saeki A, Chiocca EA, Tobler K, Ackermann M, Breakefield XO, Fraefel C. 1998. Herpes simplex virus type 1 DNA amplified as bacterial artificial chromosome in Escherichia coli: rescue of replication-competent virus progeny and packaging of amplicon vectors. Hum Gene Ther 9: 2787-2794.
33. Saeki Y, Breakefield XO, Chiocca EA. 2003. Improved HSV-1 amplicon packaging system using ICP27-deleted, oversized HSV-1 BAC DNA. Methods Mol Med 76: 51-60.
34. Sakaue M, Adachi H, Jetten AM. 1999. Post-transcriptional regulation of MyD118 and GADD45 in human lung carcinoma cells during 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid-induced apoptosis. Mol Pharmacol 55: 668-676.
35. Salvador JM, Hollander MC, Nguyen AT, Kopp JB, Barisoni L, Moore JK, Ashwell JD, Fornace AJJr. 2002. Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome. Immunity 16: 499-508.
36. Schmidt-Kastner R, Zhao W, Truettner J, Belayev L, Busto R, Ginsberg MD. 1998. Pixel-based image analysis of HSP70, GADD45 and MAP2 mRNA expression after focal cerebral ischemia: hemodynamic and histological correlates. Brain Res Mol Brain Res 63: 79-97.
37. Sheen K, Chung JM. 1993. Signs of neuropathic pain depend on signals from injured nerve fibers in a rat model. Brain Res 610: 62-68.
38. Smith GB, Mocarski ES. 2005. Contribution of GADD45 family members to cell death suppression by cellular Bcl-xL and cytomegalovirus vMIA. J Virol 79: 14923-14932.
39. Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O'Connor PM, Fornace AJJr. 1994. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science 266: 1376-1380.
40. Smith ML, Kontny HU, Zhan Q, Sreenath A, O'Connor PM, Fornace AJJr. 1996. Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to u.v.-irradiation or cisplatin. Oncogene 13: 2255-2263.
41. Takekawa M, Saito H. 1998. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95: 521-530.
42. Torp R, Su JH, Deng G, Cotman CW. 1998. GADD45 is induced in Alzheimer's disease, and protects against apoptosis in vitro. Neurobiol Dis 5: 245-252.
43. Uberti D, Carsana T, Bernardi E, Rodella L, Grigolato P, Lanni C, Racchi M, Govoni S, Memo M. 2002. Selective impairment of p53-mediated cell death in fibroblasts from sporadic Alzheimer's disease patients. J Cell Sci 115: 3131-3138.
44. Vairapandi M, Balliet AG, Fornace AJJr, Hoffman B, Liebermann DA. 1996. The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1. Oncogene 12: 2579-2594.
45. Winter J, Forbes CA, Sternberg J, Lindsay RM. 1988. Nerve growth factor (NGF) regulates adult rat cultured dorsal root ganglion neuron responses to the excitotoxin capsaicin. Neuron 1: 973-981.
46. Xiao HS, Huang QH, Zhang FX, Bao L, Lu YJ, Guo C, Yang L, Huang WJ, Fu G, Xu SH, Cheng XP, Yan Q, Zhu ZD, Zhang X, Chen Z, Han ZG, Zhang X. 2002. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Proc Natl Acad Sci U S A 99: 8360-8365.
47. Yang Q, Manicone A, Coursen JD, Linke SP, Nagashima M, Forgues M, Wang XW. 2000. Identification of a functional domain in a GADD45-mediated G2/M checkpoint. J Biol Chem 275: 36892-36898.
48. Zerbini LF, Wang Y, Czibere A, Correa RG, Cho JY, Ijiri K, Wei W, Joseph M, Gu X, Grall F, Goldring MB, Zhou JR, Libermann TA. 2004. NF-kappa B-mediated repression of growth arrest- and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival. Proc Natl Acad Sci U S A 101: 13618-13623.
49. Zhang W, Bae I, Krishnaraju K, Azam N, Fan W, Smith K, Hoffman B, Liebermann DA. 1999. CR6: a third member in the MyD118 and Gadd45 gene family which functions in negative growth control. Oncogene 18: 4899-4907.
50. Zhang W, Hoffman B, Liebermann DA. 2001. Ectopic expression of MyD118/Gadd45/CR6 (Gadd45beta/alpha/gamma) sensitizes neoplastic cells to genotoxic stress-induced apoptosis. Int J Oncol 18: 749-757.
51. Zhu RL, Graham SH, Jin J, Stetler RA, Simon RP, Chen J. 1997. Kainate induces the expression of the DNA damage-inducible gene, GADD45, in the rat brain. Neuroscience 81: 707-720.