Monoaminergic and catecholaminergic activation of the central pattern generator for locomotion following spinal cord injury: Innovative therapeutic approaches

Neural Regeneration Research

Volumn 4, Issue 10, 2009, Pages 796-800

  Guertin, Pierre A ^a,b  

^a UNIVERSITÉ LAVAL   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Central pattern generator; Locomotion; Mice; Spinal cord injury

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; 4 AMINO 1 (6 CHLORO 2 PYRIDYL)PIPERIDINE; 6 CHLORO 2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; BUSPIRONE; CATECHOLAMINE; CLONIDINE; DOPAMINE RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA; N METHYL DEXTRO ASPARTIC ACID; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; QUIPAZINE; SEROTONIN 2 AGONIST; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SKF 81293; UNCLASSIFIED DRUG;

ARTICLE; BRADYCARDIA; CATECHOLAMINE NERVE CELL; EVIDENCE BASED MEDICINE; HUMAN; HYPOTENSION; IN VITRO STUDY; LOCOMOTION; MEDICAL LITERATURE; MONOAMINE NERVE CELL; NONHUMAN; SEDATION; SIDE EFFECT; SPINAL CORD INJURY; TRAINING; TREADMILL EXERCISE; WHEELCHAIR;

EID: 70449813300     PISSN: 16735374     EISSN: None     Source Type: Journal    
DOI: 10.3969/j.issn.1673-5374.2009.10.013     Document Type: Article

References (59)

1. Barbeau H, Chau C, Rossignol S. Noradrenergic agonists and locomotor training affect locomotor recovery after cord transection in adult cats. Brain Res Bull. 1993;30(3-4):387-393. (Pubitemid 23072748)
2. Chau C, Barbeau H, Rossignol S. Effects of intrathecal alpha1- and alpha 2-noradrenergic agonists and norepinephrine on locomotion in chronic spinal cats. J Neurophysiol. 1998;79(6):2941-2963. (Pubitemid 28317025)
3. Barbeau H, Chau C, Rossignol S. Noradrenergic agonists and locomotor training affect locomotor recovery after cord transection in adult cats. Brain Res Bull. 1993;30(3-4):387-393. (Pubitemid 23072748)
4. Fung J, Stewart JE, Barbeau H. The combined effects of clonidine and cyproheptadine with interactive training on the modulation of locomotion in spinal cord injured subjects. J Neurol Sci. 1990;100(1-2):85-93.
5. Barbeau H, Pépin A, Norman KE, et al. Walking after spinal cord injury: control and recovery. The Neuroscientist. 1998;4(1):14-24. (Pubitemid 28303602)
6. Rémy-Néris O, Barbeau H, Daniel O, et al. Effects of intrathecal Clonidine injection on spinal reflexes and human locomotion in incomplete paraplegic subjects. Exp Brain Res. 1999;129(3):433-440. (Pubitemid 29537614)
7. Weinberg M, Barbeau H, Gauthier S. The effects of cyproheptadine on locomotion and on spasticity in patients with spinal cord injuries. J Neurol Neurosurg Psychiatry. 1990;53(9):754-763. (Pubitemid 20296517)
8. Kawamata T, Omote K, Yamamoto H, et al. Antihyperalgesic and side effects of intrathecal Clonidine and tizanidine in a rat model of neuropathic pain. Anesthesiology. 2003;98(6):1480-1483. (Pubitemid 36622485)
9. Rémy-Néris O, Denys P, Daniel O, et al. Effect of intrathecal Clonidine on group I and group II oligosynaptic excitation in paraplegics. Exp Brain Res. 2003;148(4):509-514. (Pubitemid 36259462)
10. Denys P, Even-Schneider A, Rémy-Néris O, et al. Intrathecal therapy for bladder hyperreflexia. Neurochirurgie. 2003;49(2-3 Pt 2):395-398.
11. Grillner S, Zangger P. On the central generation of locomotion in the low spinal cat. Exp Brain Res. 1979;34(2):241-261. (Pubitemid 9249372)
12. Sherrington CS. Flexion-reflex of the limb, crossed extension-reflex, and reflex stepping and standing. J Physiol. 1910;40(1-2):28-121.
13. Brown GT. The intrinsic factors in the act of progression in the mammal. Proc R Soc Lond Ser B. 1911;84:308-319.
14. Viala D, Buser P. Modalités d'obtention de rythmes locomoteurs chez le lapin spinal par traitements pharmacologiques (DOPA, 5-HTP, D-amphetamine). Brain Res. 1971;35:151-165.
15. Barbeau H, Rossignol S. The effects of serotonergic drugs on the locomotor pattern and on cutaneous reflexes of the adult chronic spinal cat. Brain Res. 1990;514(1):55-67. (Pubitemid 20147587)
16. Barbeau H, Rossignol S. Initiation and modulation of the locomotor pattern in the adult chronic spinal cat by noradrenergic, serotonergic and dopaminergic drugs. Brain Res. 1991;546(2):250-260.
17. Edgerton VR, de Leon RD, Tillakaratne N, et al. Use-dependent plasticity in spinal stepping and standing. Adv Neurol. 1997;72:233-247.
18. Cina C, Hochman S. Diffuse distribution of sulforhodamine-labeled neurons during serotonin-evoked locomotion in the neonatal rat thoracolumbar spinal cord. J Comp Neurol. 2000;423(4):590-602. (Pubitemid 30452623)
19. Bonnot A, Whelan PJ, Mentis GZ, et al. Locomotor-like activity generated by the neonatal mouse spinal cord. Brain Res Brain Res Rev. 2002;40(1-3):141- 151. (Pubitemid 36183165)
20. Nishimaru H, Takizawa H, Kudo N. 5-Hydroxytryptamine-induced locomotor rhythm in the neonatal mouse spinal cord in vitro. Neurosci Lett. 2000;280(3):187-190 (Pubitemid 30089832)
21. Calancie B, Needham-Shropshire B, Jacobs P, et al. Involuntary steeping after chronic spinal cord injury: evidence for a central pattern generator for locomotion in man. Brain. 1994;117(5):1143-1159. (Pubitemid 24350546)
22. Dimitrijevic MR, Gerasimenko Y, Pinter MM. Evidence for a spinal central pattern generator in humans. Ann N Y Acad Sci. 1998;860:377-392. (Pubitemid 29045983)
23. Rossignol S, Dubuc R. Spinal pattern generation. Curr Opin Neurobiol. 1994;4(6):894-902.
24. Schmidt BJ, Jordan LM. The role of serotonin in reflex modulation and locomotor rhythm production in the mammalian spinal cord. Brain Res Bull. 2000;53:689-710.
25. Grillner S. Control of locomotion in bipeds, tetrapods and fish. In: Handbook of Physiology. Bethesda, MD: American Physiological Society. 1981:1179-1236.
26. Poon MLT. Induction of fictive swimming in lamprey by L-DOPA and amino acids. J Comp Physiol. 1980;136:337-344.
27. Branchereau P, Morin D, Bonnot A, et al. Development of lumbar rhythmic networks: from embryonic to neonate locomotor-like patterns in the mouse. Brain Res Bull. 2000;53(5):711-718. (Pubitemid 32114322)
28. Cazalets JR, Gardette M, Hilaire G. Locomotor network maturation is transiently delayed in the MAOA-deficient mouse. J Neurophysiol. 2000;83(4):2468-2670. (Pubitemid 30198694)
29. Bonnot A, Morin D, Viala D. Genesis of spontaneous rhythmic motor patterns in the lumbosacral spinal cord of neonate mouse. Brain Res Dev Brain Res. 1998;108(1-2):89-99. (Pubitemid 28332822)
30. Whelan P, Bonnot A, O'Donovan MJ. Properties of rhythmic activity generated by the isolated spinal cord of the neonatal mouse. J Neurophysiol. 2000;84(6):2821-2833.
31. Cowley KC, Schmidt BJ. A comparison of motor patterns induced by N-methyl-D-aspartate, acetylcholine and serotonin in the in vitro neonatal rat spinal cord. Neurosci Lett. 1994;171(1-2):147-150. (Pubitemid 24142111)
32. Cazalets JR, Sqalli-houssaini Y, Clarac F. Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. J Physiol. 1992;455:187-204.
33. Beato M, Nistri A. Serotonin-induced inhibition of locomotor rhythm of the rat isolated spinal cord is mediated by the 5-HT1 receptor class. Proc R Soc Lond B Biol Sci. 1998;265(1410):2073-2080. (Pubitemid 28502543)
34. Sqalli-Houssaini Y, Cazalets JR, Clarac F. Oscillatory properties of the central pattern generator for locomotion in neonatal rats. J Neurophysiol. 1993;70(2):803-813. (Pubitemid 23239207)
35. Kjaerulff O, Kiehn O. Sulphorhodamine-labelled cells in the neonatal rat spinal cord following chemically induced locomotor activity in vitro. J Physiol. 1994;478(Pt 2):265-273. (Pubitemid 24232198)
36. Kiehn O, Kjaerulff O. Spatiotemporal characteristics of 5-HT and dopamine-induced rhythmic hindlimb activity in the in vitro neonatal rat. J Neurophysiol. 1996;75(4):1472-1482. (Pubitemid 26114058)
37. Hochman S, Garraway SM, Machacek DW, et al. 5-HT receptors and the neuromodulatory control of spinal cord function. In: Cope TC, ed. Motor Neurobiology of the Spinal Cord. London: CRC Press. 2001:47-87.
38. Molineaux SM, Jessell TM, Axel R, et al. 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Natl Acad Sci U S A. 1989;86(17):6793-6797.
39. Pompeiano M, Palacios JM, Mengod G. Distribution of the serotonin 5-HT2 receptor family mRNAs: comparison between 5-HT2A and 5-HT2C receptors. Brain Res Mol Brain Res. 1994;23(1-2):163-178. (Pubitemid 24090994)
40. Marlier L, Teilhac JR, Cerruti C, et al. Autoradiographic mapping of 5-HT1, 5-HT1A, 5-HT1B and 5-HT2 receptors in the rat spinal cord. Brain Res. 1991;550:15-23.
41. Guertin PA. Role of NMDA receptor activation in serotonin agonist-induced air-stepping in paraplegic mice. Spinal Cord. 2004;42(3):185-190.
42. Landry ES, Guertin PA. Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28(6):1053-1060.
43. Ung RV, Landry ES, Rouleau P, et al. Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection. Eur J Neurosci. 2008;28(11):2231-2242.
44. Kim D, Murray M, Simansky KJ. The serotonergic 5-HT(2C) agonist m-chlorophenylpiperazine increases weight-supported locomotion without development of tolerance in rats with spinal transections. Exp Neurol. 2001;169(2):496-500. (Pubitemid 32524443)
45. Yi DK, Adipudi V, Shibayama M, et al. Transplant-mediated locomotion is improved by selective serotonergic agonists. Ann N Y Acad Sci. 1998;860:524-527 (Pubitemid 29046015)
46. Kim D, Adipudi V, Giszter S, et al. Direct agonists for serotonin (5-HT 2) receptors enhance locomotor function in rats that received neural transplants after neonatal spinal transection. J Neurosci. 1999;19:6213-6224. (Pubitemid 29327953)
47. Guertin PA, Leblond H, L'Espérance M, et al. Restoration of hindlimb locomotor movements induced by serotonergic and noradrenergic agonists in a novel paraplegic mouse model. Human Frontier Science Program Organization 2nd Invitational Annual Meeting, Ottawa, Canada, 2002- Abstract. (manuscript in preparation).
48. Landry ES, Lapointe NP, Rouillard C, et al. Contribution of spinal 5-HT1A and 5-HT7 receptors to locomotor-like movement induced by 8-OH-DPAT in spinal cord transected mice. Eur J Neurosci. 2006;24:535-546. (Pubitemid 44100345)
49. Guertin PA, Steuer I. Ionotropic 5-HT3 receptor agonist-induced motor responses in the hindlimbs of paraplegic mice. J Neurophysiol. 2005;94(5):3397-3405. (Pubitemid 41504776)
50. Holstege JC, Van Dijken H, Buijs RM, et al. Distribution of dopamine immunoreactivity in the rat, cat and monkey spinal cord. J Comp Neurol. 1996;376(4):631-652. (Pubitemid 27009845)
51. Demenge P, Mouchet P, Guerin B, et al. Identification and distribution of neuroleptic binding sites in the rat spinal cord. J Neurochem. 1981;37(1):53-59. (Pubitemid 11003475)
52. Commissiong JW, Sedgwick EM. Letter: Dopamine and noradrenaline in human spinal cord. Lancet.1975;1(7902):347.
53. Zhu H, Clemens S, Sawchuk M, et al. Unaltered D1, D2, D4, and D5 dopamine receptor mRNA expression and distribution in the spinal cord of the D3 receptor knockout mouse. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2008;194(11):957-962.
54. Zhu H, Clemens S, Sawchuk M, et al. Expression and distribution of all dopamine receptor subtypes (D(1)-D(5)) in the mouse lumbar spinal cord: a real-time polymerase chain reaction and non-autoradiographic in situ hybridization study. Neuroscience. 2007;149(4):885-897.
55. Guertin PA. Synergistic activation of the central pattern generator for locomotion by I-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice. Neurosci Lett. 2004;358(2):71-74.
56. McCrea AE, Stehouwer DJ, Van Hartesveldt C. Dopamine D1 and D2 antagonists block L-DOPA-induced air-stepping in decerebrate neonatal rats. Brain Res Dev Brain Res. 1997;100(1):130-132. (Pubitemid 27241503)
57. Lapointe NP, Rouleau P, Ung RV, et al. Specific role of dopamine D1 receptors in spinal network activation and rhythmic movement induction in vertebrates. J Physiol. 2009; 587(7):1499-1511
58. Lapointe NP, Guertin PA. Synergistic effects of D1/5 and 5-HT1A/7 receptor agonists on locomotor movement induction in complete spinal cord-transected mice. J Neurophysiol. 2008;100(1):160-168.
59. Guertin PA, Brochu C.Preliminary evidence of safety following administration of L-DOPA and buspirone in an incomplete monoplegic patient. Spinal Cord. 2009;47(1):91-92.