메뉴 건너뛰기




Volumn 129, Issue 2, 2009, Pages 189-194

The efficacy of erythropoietin on acute spinal cord injury. An experimental study on a rat model

Author keywords

Acute spinal cord injury; EPO; Erythropoietin; Neuroprotection

Indexed keywords

RECOMBINANT ERYTHROPOIETIN;

EID: 59749089064     PISSN: 09368051     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00402-008-0594-x     Document Type: Article
Times cited : (20)

References (47)
  • 1
    • 84943442523 scopus 로고
    • Surgery for experimental lesions of spinal cord equivalent to crush injury of fracture dislocation of spinal column. A preliminary report
    • Allen AR (1911) Surgery for experimental lesions of spinal cord equivalent to crush injury of fracture dislocation of spinal column. A preliminary report. JAMA 57:878-880
    • (1911) JAMA , vol.57 , pp. 878-880
    • Allen, A.R.1
  • 2
    • 33749523715 scopus 로고    scopus 로고
    • Preventive effect of erythropoietin on spinal cord cell apoptosis following acute traumatic injury in rats
    • Arishima Y, Takao S, Ichiro Y, Kazunori Y, Setsuro K (2006) Preventive effect of erythropoietin on spinal cord cell apoptosis following acute traumatic injury in rats. Spine 31:2432-2438
    • (2006) Spine , vol.31 , pp. 2432-2438
    • Arishima, Y.1    Takao, S.2    Ichiro, Y.3    Kazunori, Y.4    Setsuro, K.5
  • 3
    • 33646571167 scopus 로고    scopus 로고
    • Pharmacological approaches to repair the injured spinal cord
    • Baptiste D, Fehlings M (2006) Pharmacological approaches to repair the injured spinal cord. J Neurotrauma 23:318-334
    • (2006) J Neurotrauma , vol.23 , pp. 318-334
    • Baptiste, D.1    Fehlings, M.2
  • 4
    • 0028919411 scopus 로고
    • A sensitive and reliable locomotor rating scale for open field testing in rats
    • Basso DM, Beattie MS, Bresnahan JC (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J Neurotrauma 12:1-21
    • (1995) J Neurotrauma , vol.12 , pp. 1-21
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 5
    • 9144237424 scopus 로고    scopus 로고
    • Erythropoietin both protect from and reverses experimental diabetic neuropathy
    • Bianchi R, Buyukakilli B, Brines M et al (2004) Erythropoietin both protect from and reverses experimental diabetic neuropathy. Proc Natl Acad Sci 101:823-828
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 823-828
    • Bianchi, R.1    Buyukakilli, B.2    Brines, M.3
  • 6
    • 0025344617 scopus 로고
    • A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury
    • Bracken MB, Shepard MJ, Collins WF et al (1990) A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal cord injury. N Engl J Med 322(20):1405-1411
    • (1990) N Engl J Med , vol.322 , Issue.20 , pp. 1405-1411
    • Bracken, M.B.1    Shepard, M.J.2    Collins, W.F.3
  • 7
    • 1642422176 scopus 로고    scopus 로고
    • Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the third national acute spinal cord injury randomized controlled trial
    • National Acute Spinal Cord Injury Study
    • Bracken MB, Shepard MJ, Holford TR et al (1997) Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the third national acute spinal cord injury randomized controlled trial. National Acute Spinal Cord Injury Study. JAMA 277:1597-1604
    • (1997) JAMA , vol.277 , pp. 1597-1604
    • Bracken, M.B.1    Shepard, M.J.2    Holford, T.R.3
  • 8
    • 33746137372 scopus 로고    scopus 로고
    • Discovering erythropoietin's extra-hematopoietic functions: Biology and clinical promise
    • Brines M, Cerami A (2006) Discovering erythropoietin's extra-hematopoietic functions: Biology and clinical promise. Kidney Int 70:246-250
    • (2006) Kidney Int , vol.70 , pp. 246-250
    • Brines, M.1    Cerami, A.2
  • 9
    • 0034641710 scopus 로고    scopus 로고
    • Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury
    • Brines ML, Ghezzi P, Keenam S et al (2000) Erythropoietin crosses the blood-brain barrier to protect against experimental brain injury. Proc Natl Acad Sci 97:10526-10531
    • (2000) Proc Natl Acad Sci , vol.97 , pp. 10526-10531
    • Brines, M.L.1    Ghezzi, P.2    Keenam, S.3
  • 10
    • 0037447256 scopus 로고    scopus 로고
    • Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling
    • Calvillo L, Latini R, Kajstura J et al (2003) Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Proc Natl Acad Sci 100:4802-4806
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 4802-4806
    • Calvillo, L.1    Latini, R.2    Kajstura, J.3
  • 11
    • 0037133191 scopus 로고    scopus 로고
    • Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury
    • Celik M, Gökmen N, Erbayraktar S et al (2002) Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury. Proc Natl Acad Sci 99:2258-2263
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 2258-2263
    • Celik, M.1    Gökmen, N.2    Erbayraktar, S.3
  • 12
    • 33750071388 scopus 로고    scopus 로고
    • The effects of systemically administered methylprednisolone and recombinant human erythropoietin after acute spinal cord compressive injury in rats
    • Cetin A, Nas K, Buyukbayram H, Ceviz A, Olmez G (2006) The effects of systemically administered methylprednisolone and recombinant human erythropoietin after acute spinal cord compressive injury in rats. Eur Spine J 15:1539-1544
    • (2006) Eur Spine J , vol.15 , pp. 1539-1544
    • Cetin, A.1    Nas, K.2    Buyukbayram, H.3    Ceviz, A.4    Olmez, G.5
  • 13
    • 0035833541 scopus 로고    scopus 로고
    • Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kB signalling cascades
    • Digicaylioglu M, Lipton SA (2001) Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-kB signalling cascades. Nature 412:641-647
    • (2001) Nature , vol.412 , pp. 641-647
    • Digicaylioglu, M.1    Lipton, S.A.2
  • 14
    • 0028326548 scopus 로고
    • Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord
    • Dusart I, Schwab ME (1994) Secondary cell death and the inflammatory reaction after dorsal hemisection of the rat spinal cord. Eur J Neurosci 6:712-724
    • (1994) Eur J Neurosci , vol.6 , pp. 712-724
    • Dusart, I.1    Schwab, M.E.2
  • 15
    • 0036982647 scopus 로고    scopus 로고
    • Recombinant human erythropoietin for neuroprotection: What is the evidence?
    • Eid T, Brines M (2002) Recombinant human erythropoietin for neuroprotection: What is the evidence? Clin Breast Cancer 3(Suppl 3):109-115
    • (2002) Clin Breast Cancer , vol.3 , Issue.SUPPL. 3 , pp. 109-115
    • Eid, T.1    Brines, M.2
  • 16
    • 0842334686 scopus 로고    scopus 로고
    • Non-erythroid functions of erythropoietin
    • Gassmann M, Heinicke K, Soliz J et al (2003) Non-erythroid functions of erythropoietin. Adv Exp Med Biol 543:323-330
    • (2003) Adv Exp Med Biol , vol.543 , pp. 323-330
    • Gassmann, M.1    Heinicke, K.2    Soliz, J.3
  • 17
    • 0035893918 scopus 로고    scopus 로고
    • The Sygen multi-center acute spinal cord injury study
    • Geisler FH, Coleman WP, Grieco G et al (2001) The Sygen multi-center acute spinal cord injury study. Spine 26(Suppl 24):87-98
    • (2001) Spine , vol.26 , Issue.SUPPL. 24 , pp. 87-98
    • Geisler, F.H.1    Coleman, W.P.2    Grieco, G.3
  • 18
    • 0037047154 scopus 로고    scopus 로고
    • Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma
    • Gorio A, Gokmen N, Erbayraktar S et al (2002) Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma. Proc Natl Acad Sci 99:9450-9455
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 9450-9455
    • Gorio, A.1    Gokmen, N.2    Erbayraktar, S.3
  • 19
    • 28044447674 scopus 로고    scopus 로고
    • Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury
    • Gorio A, Madaschi L, Di Stefano B et al (2005) Methylprednisolone neutralizes the beneficial effects of erythropoietin in experimental spinal cord injury. Proc Natl Acad Sci 102:16379-16384
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 16379-16384
    • Gorio, A.1    Madaschi, L.2    Di Stefano, B.3
  • 20
    • 33646445515 scopus 로고    scopus 로고
    • Amelioration of spinal cord compressive injury by pharmacological preconditioning with erythropoietin and a nonerythropoietic erythropoietin derivative
    • Grasso G, Sfacteria A, Erbayraktar S et al (2006) Amelioration of spinal cord compressive injury by pharmacological preconditioning with erythropoietin and a nonerythropoietic erythropoietin derivative. J Neurosurg Spine 4:310-318
    • (2006) J Neurosurg Spine , vol.4 , pp. 310-318
    • Grasso, G.1    Sfacteria, A.2    Erbayraktar, S.3
  • 21
    • 16844382718 scopus 로고    scopus 로고
    • Erythropoietin and erythropoietin receptor expression after experimental spinal cord injury encourages therapy by exogenous erythropoietin
    • Grasso G, Sfacteria A, Passalacqua M et al (2005) Erythropoietin and erythropoietin receptor expression after experimental spinal cord injury encourages therapy by exogenous erythropoietin. Neurosurgery 56:821-827
    • (2005) Neurosurgery , vol.56 , pp. 821-827
    • Grasso, G.1    Sfacteria, A.2    Passalacqua, M.3
  • 22
    • 33845938843 scopus 로고    scopus 로고
    • Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats
    • Harada N, Taoka Y, Okajima K (2006) Role of prostacyclin in the development of compression trauma-induced spinal cord injury in rats. J Neurotrauma 23:1739-1749
    • (2006) J Neurotrauma , vol.23 , pp. 1739-1749
    • Harada, N.1    Taoka, Y.2    Okajima, K.3
  • 24
    • 0028340331 scopus 로고
    • Biology of erythropoietin
    • Jelkmann W (1994) Biology of erythropoietin. Clin Invest 72(Suppl 6):3-10
    • (1994) Clin Invest , vol.72 , Issue.SUPPL. 6 , pp. 3-10
    • Jelkmann, W.1
  • 25
    • 1642269715 scopus 로고    scopus 로고
    • Erythropoietin exerts neuroprotection after acute spinal cord injury in rats: Effect on lipid peroxidation and early ultrastructural findings
    • Kaptanoglu E, Solaroglu I, Okutan O, Surucu HS, Akbiyik F, Beskonakli E (2004) Erythropoietin exerts neuroprotection after acute spinal cord injury in rats: Effect on lipid peroxidation and early ultrastructural findings. Neurosurg Rev 27:113-120
    • (2004) Neurosurg Rev , vol.27 , pp. 113-120
    • Kaptanoglu, E.1    Solaroglu, I.2    Okutan, O.3    Surucu, H.S.4    Akbiyik, F.5    Beskonakli, E.6
  • 26
    • 0032572918 scopus 로고    scopus 로고
    • Subcutaneous compared with intravenous epoeitin in patients receiving hemodialysis
    • Department of Veterans Affairs Cooperative Study Group on erythropoietin in hemodialysis patients
    • Kaufman JS, Reda DJ, Fye CL et al (1998) Subcutaneous compared with intravenous epoeitin in patients receiving hemodialysis. Department of Veterans Affairs Cooperative Study Group on erythropoietin in hemodialysis patients. N Engl J Med 339:578-583
    • (1998) N Engl J Med , vol.339 , pp. 578-583
    • Kaufman, J.S.1    Reda, D.J.2    Fye, C.L.3
  • 27
    • 0022255258 scopus 로고
    • Hemorrhagic changes in experimental spinal cord injury models
    • Khan M, Griebel R, Rozdilsky B, Politis M (1985) Hemorrhagic changes in experimental spinal cord injury models. Can J Neurol Sci 12:259-262
    • (1985) Can J Neurol Sci , vol.12 , pp. 259-262
    • Khan, M.1    Griebel, R.2    Rozdilsky, B.3    Politis, M.4
  • 28
    • 3042725549 scopus 로고    scopus 로고
    • Derivatives of erythropoietin that are tissue protective but not erythropoietic
    • Leist M, Ghezzi P, Grasso G (2004) Derivatives of erythropoietin that are tissue protective but not erythropoietic. Science 305:239-242
    • (2004) Science , vol.305 , pp. 239-242
    • Leist, M.1    Ghezzi, P.2    Grasso, G.3
  • 29
    • 2942588678 scopus 로고    scopus 로고
    • Erythropoietin for neurologic protection and diabetic neuropathy
    • Lipton S (2004) Erythropoietin for neurologic protection and diabetic neuropathy. N Engl J Med 350(24):2516-2517
    • (2004) N Engl J Med , vol.350 , Issue.24 , pp. 2516-2517
    • Lipton, S.1
  • 30
    • 34250621353 scopus 로고    scopus 로고
    • Axonal regeneration stimulated by erythropoietin: An experimental study in rats
    • Lykissas MG, SAkellariou E, Vekris MD et al (2007) Axonal regeneration stimulated by erythropoietin: An experimental study in rats. J Neurosci Methods 164:107-115
    • (2007) J Neurosci Methods , vol.164 , pp. 107-115
    • Lykissas, M.G.1    SAkellariou, E.2    Vekris, M.D.3
  • 31
    • 0033162506 scopus 로고    scopus 로고
    • Erythropoietic, neurotrophic, and angiogenic functions of erythropoietin and regulation of erythropoietin production
    • Masuda S, Nagao M, Sasaki R (1999) Erythropoietic, neurotrophic, and angiogenic functions of erythropoietin and regulation of erythropoietin production. Int J Hematol 70:1-6
    • (1999) Int J Hematol , vol.70 , pp. 1-6
    • Masuda, S.1    Nagao, M.2    Sasaki, R.3
  • 32
    • 0027956115 scopus 로고
    • A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes
    • Masuda S, Okano M, Yamagishi K, Nagao M, Ueda M, Sasaki R (1994) A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes. J Biol Chem 269:19488-19493
    • (1994) J Biol Chem , vol.269 , pp. 19488-19493
    • Masuda, S.1    Okano, M.2    Yamagishi, K.3    Nagao, M.4    Ueda, M.5    Sasaki, R.6
  • 33
    • 3142740353 scopus 로고    scopus 로고
    • Blood management for patients with hemoglobin level lower than 130 g/l in total knee arthroplasty
    • Minoda Y, Sakawa A, Fukuoka S, Tada K, Takaoka K (2004) Blood management for patients with hemoglobin level lower than 130 g/l in total knee arthroplasty. Arch Orthop Trauma Surg 124(5):317-319
    • (2004) Arch Orthop Trauma Surg , vol.124 , Issue.5 , pp. 317-319
    • Minoda, Y.1    Sakawa, A.2    Fukuoka, S.3    Tada, K.4    Takaoka, K.5
  • 34
    • 0030636320 scopus 로고    scopus 로고
    • Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death
    • Morishita E, Masuda S, Nagao M, Yasuda Y, Sasaki R (1997) Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death. Neuroscience 76:105-116
    • (1997) Neuroscience , vol.76 , pp. 105-116
    • Morishita, E.1    Masuda, S.2    Nagao, M.3    Yasuda, Y.4    Sasaki, R.5
  • 35
    • 0017992470 scopus 로고
    • Effect of duration of acute spinal cord compression in a new acute cord injury in the rat
    • Rivlin AS, Tator CH (1978) Effect of duration of acute spinal cord compression in a new acute cord injury in the rat. Surg Neurol 10:38-43
    • (1978) Surg Neurol , vol.10 , pp. 38-43
    • Rivlin, A.S.1    Tator, C.H.2
  • 36
    • 0034279419 scopus 로고    scopus 로고
    • Erythropoietin: Multiple physiological functions and regulation of biosynthesis
    • Sasaki R, Masuda S, Nagao M (2000) Erythropoietin: Multiple physiological functions and regulation of biosynthesis. Biosci Biotechnol Biochem 64:1775-1793
    • (2000) Biosci Biotechnol Biochem , vol.64 , pp. 1775-1793
    • Sasaki, R.1    Masuda, S.2    Nagao, M.3
  • 37
    • 33646050607 scopus 로고    scopus 로고
    • Methylprednisolone treatment in acute spinal cord injury: The myth challenged through a structured analysis of published literature
    • Sayer FT, Kronvall E, Nilsson OG (2006) Methylprednisolone treatment in acute spinal cord injury: The myth challenged through a structured analysis of published literature. Spine J 6:335-343
    • (2006) Spine J , vol.6 , pp. 335-343
    • Sayer, F.T.1    Kronvall, E.2    Nilsson, O.G.3
  • 38
    • 0034867539 scopus 로고    scopus 로고
    • Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: Improved behavioral and neuroanatomical recovery with riluzole
    • Schwartz G, Fehlings MG (2001) Evaluation of the neuroprotective effects of sodium channel blockers after spinal cord injury: Improved behavioral and neuroanatomical recovery with riluzole. J Neurosurg Spine 94:245-256
    • (2001) J Neurosurg Spine , vol.94 , pp. 245-256
    • Schwartz, G.1    Fehlings, M.G.2
  • 39
    • 0035893632 scopus 로고    scopus 로고
    • Epidemiology, demographics, and pathophysiology of acute spinal cord injury
    • Sekhon LH, Fehlings MG (2001) Epidemiology, demographics, and pathophysiology of acute spinal cord injury. Spine 26(Suppl 24):2-12
    • (2001) Spine , vol.26 , Issue.SUPPL. 24 , pp. 2-12
    • Sekhon, L.H.1    Fehlings, M.G.2
  • 40
    • 0141643691 scopus 로고    scopus 로고
    • Erythropoietin inhibits spinal neuronal apoptosis and pain following nerve root crush
    • Sekiguchi Y, Kikuchi S, Myers RR., Campana WM (2003) Erythropoietin inhibits spinal neuronal apoptosis and pain following nerve root crush. Spine 28:2577-2584
    • (2003) Spine , vol.28 , pp. 2577-2584
    • Sekiguchi, Y.1    Kikuchi, S.2    Myers, R.R.3    Campana, W.M.4
  • 41
    • 0034963564 scopus 로고    scopus 로고
    • Anatomical repair of nerve membranes in crushed mammalian spinal cord with polyethylene glycol
    • Shi R, Borgens RB (2000) Anatomical repair of nerve membranes in crushed mammalian spinal cord with polyethylene glycol. J Neurocytol 29:633-643
    • (2000) J Neurocytol , vol.29 , pp. 633-643
    • Shi, R.1    Borgens, R.B.2
  • 42
    • 0035894847 scopus 로고    scopus 로고
    • Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells
    • Shingo T, Sorokan ST, Shimazaki T, Weiss S (2001) Erythropoietin regulates the in vitro and in vivo production of neuronal progenitors by mammalian forebrain neural stem cells. J Neurosci 21:9733-9743
    • (2001) J Neurosci , vol.21 , pp. 9733-9743
    • Shingo, T.1    Sorokan, S.T.2    Shimazaki, T.3    Weiss, S.4
  • 44
    • 0034192225 scopus 로고    scopus 로고
    • Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans
    • Stohlawetz PJ, Dzirlo L, Hergovich N (2000) Effects of erythropoietin on platelet reactivity and thrombopoiesis in humans. Blood 95:2983-2989
    • (2000) Blood , vol.95 , pp. 2983-2989
    • Stohlawetz, P.J.1    Dzirlo, L.2    Hergovich, N.3
  • 45
    • 0028812680 scopus 로고
    • Update on the pathophysiology and pathology of acute spinal cord injury
    • Tator CH (1995) Update on the pathophysiology and pathology of acute spinal cord injury. Brain Pathol 5:407-413
    • (1995) Brain Pathol , vol.5 , pp. 407-413
    • Tator, C.H.1
  • 46
    • 0037481943 scopus 로고    scopus 로고
    • Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice
    • Wells JE, Hurlbert RJ, Fehlings MG et al (2003) Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice. Brain 126:1628-1637
    • (2003) Brain , vol.126 , pp. 1628-1637
    • Wells, J.E.1    Hurlbert, R.J.2    Fehlings, M.G.3
  • 47
    • 0030669135 scopus 로고    scopus 로고
    • Erythropoietin administration increases production and reactivity of platelets in dogs
    • Wolf RF, Peng J, Friese P, Gilmore LS, Burstein SA, Dale GL (1997) Erythropoietin administration increases production and reactivity of platelets in dogs. Thromb Haemost 78:1505-1509
    • (1997) Thromb Haemost , vol.78 , pp. 1505-1509
    • Wolf, R.F.1    Peng, J.2    Friese, P.3    Gilmore, L.S.4    Burstein, S.A.5    Dale, G.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.