메뉴 건너뛰기




Volumn 16, Issue 5-6, 2011, Pages 181-187

Exploiting personalized information for reagent selection in drug design

Author keywords

[No Author keywords available]

Indexed keywords

ANILINE; ATORVASTATIN; CHLORPROMAZINE; IMIPRAMINE; REAGENT; SILDENAFIL;

EID: 79952452599     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2011.01.006     Document Type: Short Survey
Times cited : (15)

References (35)
  • 1
    • 67349164247 scopus 로고    scopus 로고
    • Making medicinal chemistry more effective: Application of lean sigma to improve processes, speed and quality
    • S. Andersson Making medicinal chemistry more effective: application of lean sigma to improve processes, speed and quality Drug Discov. Today 14 2009 598 604
    • (2009) Drug Discov. Today , vol.14 , pp. 598-604
    • Andersson, S.1
  • 2
    • 34247498643 scopus 로고    scopus 로고
    • Lean thinking for drug discovery - Better productivity for pharma
    • E. Petrillo Lean thinking for drug discovery - better productivity for pharma Drug Discov. World 8 2007 9 16
    • (2007) Drug Discov. World , vol.8 , pp. 9-16
    • Petrillo, E.1
  • 3
    • 0031024171 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • DOI 10.1016/S0169-409X(96)00423-1, PII S0169409X96004231
    • C. Lipinski Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings Adv. Drug Deliv. Rev. 23 1997 3 25 (Pubitemid 27046991)
    • (1997) Advanced Drug Delivery Reviews , vol.23 , Issue.1-3 , pp. 3-25
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 4
    • 0034461768 scopus 로고    scopus 로고
    • Drug-like properties and the causes of poor solubility and poor permeability
    • DOI 10.1016/S1056-8719(00)00107-6, PII S1056871900001076
    • C. Lipinski Drug-like properties and the causes of poor solubility and poor permeability J. Pharmacol. Toxicol. Methods 44 2000 235 249 (Pubitemid 32239479)
    • (2000) Journal of Pharmacological and Toxicological Methods , vol.44 , Issue.1 , pp. 235-249
    • Lipinski, C.A.1
  • 5
    • 11144320699 scopus 로고    scopus 로고
    • Navigating chemical space for biology and medicine
    • DOI 10.1038/nature03193
    • C. Lipinski, and A. Hopkins Navigating chemical space for biology and medicine Nature 432 2004 855 861 (Pubitemid 40037141)
    • (2004) Nature , vol.432 , Issue.7019 , pp. 855-861
    • Lipinski, C.1    Hopkins, A.2
  • 8
    • 69949109727 scopus 로고    scopus 로고
    • Using the golden triangle to optimize clearance and oral absorption
    • T.W. Johnson Using the golden triangle to optimize clearance and oral absorption Bioorg. Med. Chem. Lett. 19 2009 5560 5564
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 5560-5564
    • Johnson, T.W.1
  • 9
    • 35748934487 scopus 로고    scopus 로고
    • The influence of drug-like concepts on decision-making in medicinal chemistry
    • DOI 10.1038/nrd2445, PII NRD2445
    • P.D. Leeson, and B. Springthorpe The influence of drug-like concepts on decision-making in medicinal chemistry Nat. Rev. Drug Discov. 6 2007 881 890 (Pubitemid 350042396)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.11 , pp. 881-890
    • Leeson, P.D.1    Springthorpe, B.2
  • 12
    • 34548147556 scopus 로고    scopus 로고
    • The rule of five revisited: Applying log D in place of log P in drug-likeness filters
    • DOI 10.1021/mp0700209
    • S.K. Bhal The rule of five revisited: applying log D in place of log P in drug-likeness filters Mol. Pharm. 4 2007 556 560 (Pubitemid 47310166)
    • (2007) Molecular Pharmaceutics , vol.4 , Issue.4 , pp. 556-560
    • Bhal, S.K.1    Kassam, K.2    Peirson, I.G.3    Pearl, G.M.4
  • 13
    • 65449179589 scopus 로고    scopus 로고
    • Defining optimum lipophilicity and molecular weight ranges for drug candidates; Molecular weight dependent lower log D limits based on permeability
    • M.J. Waring Defining optimum lipophilicity and molecular weight ranges for drug candidates; molecular weight dependent lower log D limits based on permeability Bioorg. Med. Chem. Lett. 19 2009 2844 2851
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2844-2851
    • Waring, M.J.1
  • 14
    • 71049126548 scopus 로고    scopus 로고
    • Escape from flatland: Increasing saturation as an approach to improving clinical success
    • F. Lovering Escape from flatland: increasing saturation as an approach to improving clinical success J. Med. Chem. 52 2009 6752 6756
    • (2009) J. Med. Chem. , vol.52 , pp. 6752-6756
    • Lovering, F.1
  • 15
    • 70350409235 scopus 로고    scopus 로고
    • The impact of aromatic ring count on compound developability: Are too many aromatic rings a liability in drug design?
    • T.J. Ritchie, and S.J. Macdonald The impact of aromatic ring count on compound developability: are too many aromatic rings a liability in drug design? Drug Discov. Today 14 2009 1011 1020
    • (2009) Drug Discov. Today , vol.14 , pp. 1011-1020
    • Ritchie, T.J.1    MacDonald, S.J.2
  • 16
    • 33847336843 scopus 로고    scopus 로고
    • A quantitative assessment of hERG liability as a function of lipophilicity
    • M.J. Waring, and C. Johnstone A quantitative assessment of hERG liability as a function of lipophilicity Bioorg. Med. Chem. Lett. 17 2007 1759 1764
    • (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 1759-1764
    • Waring, M.J.1    Johnstone, C.2
  • 17
    • 49849094738 scopus 로고    scopus 로고
    • Physiochemical drug properties associated with in vivo toxicological outcomes
    • J.D. Hughes Physiochemical drug properties associated with in vivo toxicological outcomes Bioorg. Med. Chem. Lett. 18 2008 4872 4875
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 4872-4875
    • Hughes, J.D.1
  • 18
    • 39749181550 scopus 로고    scopus 로고
    • Generation of a set of simple, interpretable ADMET rules of thumb
    • DOI 10.1021/jm701122q
    • M.P. Gleeson Generation of a set of simple, interpretable ADMET rules of thumb J. Med. Chem. 51 2008 817 834 (Pubitemid 351304691)
    • (2008) Journal of Medicinal Chemistry , vol.51 , Issue.4 , pp. 817-834
    • Gleeson, M.P.1
  • 19
    • 37549071045 scopus 로고    scopus 로고
    • Drug discovery beyond the 'rule-of-five'
    • M.Q. Zhang, and B. Wilkinson Drug discovery beyond the 'rule-of-five' Curr. Opin. Biotechnol. 18 2007 478 488
    • (2007) Curr. Opin. Biotechnol. , vol.18 , pp. 478-488
    • Zhang, M.Q.1    Wilkinson, B.2
  • 21
    • 58349114259 scopus 로고    scopus 로고
    • Atypical antipsychotic drugs and the risk of sudden cardiac death
    • W.A. Ray Atypical antipsychotic drugs and the risk of sudden cardiac death N. Engl. J. Med. 360 2009 225 235
    • (2009) N. Engl. J. Med. , vol.360 , pp. 225-235
    • Ray, W.A.1
  • 22
    • 0033025637 scopus 로고    scopus 로고
    • Chance favors the prepared mind - From serendipity to rational drug design
    • H. Kubinyi Chance favors the prepared mind. From serendipity to rational drug design J. Recept. Signal Transduct. Res. 19 1999 15 39 (Pubitemid 29152173)
    • (1999) Journal of Receptor and Signal Transduction Research , vol.19 , Issue.1-4 , pp. 15-39
    • Kubinyi, H.1
  • 23
    • 33750576990 scopus 로고    scopus 로고
    • The role of serendipity in drug discovery
    • T.A. Ban The role of serendipity in drug discovery Dialogues Clin. Neurosci. 8 2006 335 344 (Pubitemid 44682750)
    • (2006) Dialogues in Clinical Neuroscience , vol.8 , Issue.3 , pp. 335-344
    • Ban, T.A.1
  • 24
    • 0030572496 scopus 로고    scopus 로고
    • Sildenafil (Viagra(TM)), a potent and selective inhibitor of type 5 CGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
    • DOI 10.1016/0960-894X(96)00323-X
    • N.K. Terrett Sildenafil (VIAGRA™), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction Bioorg. Med. Chem. Lett. 6 1996 1819 1824 (Pubitemid 26253884)
    • (1996) Bioorganic and Medicinal Chemistry Letters , vol.6 , Issue.15 , pp. 1819-1824
    • Terrett, N.K.1    Bell, A.S.2    Brown, D.3    Ellis, P.4
  • 25
    • 20844435854 scopus 로고    scopus 로고
    • Toward the next generation of recommender systems: A survey of the state-of-the-art and possible extensions
    • DOI 10.1109/TKDE.2005.99
    • G. Adomavicius, and A. Tuzhilin Toward the next generation of recommender systems: a survey of the state-of-the-art and possible extensions IEEE Trans. Knowl. Data Eng. 17 2005 734 749 (Pubitemid 40860454)
    • (2005) IEEE Transactions on Knowledge and Data Engineering , vol.17 , Issue.6 , pp. 734-749
    • Adomavicius, G.1    Tuzhilin, A.2
  • 26
    • 0037252945 scopus 로고    scopus 로고
    • Amazon.com recommendations: Item-to-item collaborative filtering
    • G. Linden Amazon.com recommendations: item-to-item collaborative filtering IEEE Internet Comput. 7 2003 76 80
    • (2003) IEEE Internet Comput. , vol.7 , pp. 76-80
    • Linden, G.1
  • 27
    • 84976668719 scopus 로고
    • Using collaborative filtering to weave an information tapestry
    • D. Goldberg Using collaborative filtering to weave an information tapestry Commun. ACM 35 1992 61 70
    • (1992) Commun. ACM , vol.35 , pp. 61-70
    • Goldberg, D.1
  • 28
    • 0015061168 scopus 로고
    • Geometry for the selfish herd
    • W.D. Hamilton Geometry for the selfish herd Theor. Biol. 31 1971 295 311
    • (1971) Theor. Biol. , vol.31 , pp. 295-311
    • Hamilton, W.D.1
  • 29
    • 0034693731 scopus 로고    scopus 로고
    • The Ames Salmonella/microsome mutagenicity assay
    • K. Mortelmans, and E. Zeiger The Ames Salmonella/microsome mutagenicity assay Mutat. Res. 455 2000 29 60
    • (2000) Mutat. Res. , vol.455 , pp. 29-60
    • Mortelmans, K.1    Zeiger, E.2
  • 30
    • 0015591140 scopus 로고
    • An improved bacterial test system for the detection and classification of mutagens and carcinogens
    • B.N. Ames An improved bacterial test system for the detection and classification of mutagens and carcinogens Proc. Natl. Acad. Sci. U.S.A. 70 1973 782 786
    • (1973) Proc. Natl. Acad. Sci. U.S.A. , vol.70 , pp. 782-786
    • Ames, B.N.1
  • 31
    • 77952772341 scopus 로고    scopus 로고
    • Extended-connectivity fingerprints
    • D. Rogers, and M. Hahn Extended-connectivity fingerprints J. Chem. Inf. Model. 50 2010 742 754
    • (2010) J. Chem. Inf. Model. , vol.50 , pp. 742-754
    • Rogers, D.1    Hahn, M.2
  • 32
    • 0036827075 scopus 로고    scopus 로고
    • Reoptimization of MDL keys for use in drug discovery
    • J.L. Durant Reoptimization of MDL keys for use in drug discovery J. Chem. Inf. Comp. Sci. 42 2003 1273 1280
    • (2003) J. Chem. Inf. Comp. Sci. , vol.42 , pp. 1273-1280
    • Durant, J.L.1
  • 33
    • 77954344350 scopus 로고    scopus 로고
    • Cheminformatic tools for medicinal chemists
    • S.W. Muchmore Cheminformatic tools for medicinal chemists J. Med. Chem. 53 2010 4830 4841
    • (2010) J. Med. Chem. , vol.53 , pp. 4830-4841
    • Muchmore, S.W.1
  • 35
    • 0036740917 scopus 로고    scopus 로고
    • Why do we need so many chemical similarity search methods?
    • R.P. Sheridan, and S.K. Kearsley Why do we need so many chemical similarity search methods? Drug Discov. Today 7 2002 903 911
    • (2002) Drug Discov. Today , vol.7 , pp. 903-911
    • Sheridan, R.P.1    Kearsley, S.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.