Chitosan oligosaccharides inhibit LPS-induced over-expression of IL-6 and TNF-α in RAW264.7 macrophage cells through blockade of mitogen-activated protein kinase (MAPK) and PI3K/Akt signaling pathways

Carbohydrate Polymers

Volumn 84, Issue 4, 2011, Pages 1391-1398

  Ma, Pan ^a,b   Liu, Hong Tao ^a   Wei, Peng ^a,b   Xu, Qing Song ^a   Bai, Xue Fang ^a   Du, Yu Guang ^a   Yu, Chao ^c  

^a DALIAN INSTITUTE OF CHEMICAL PHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Chitosan oligomers; Inflammation; Macrophage cells; Mitogen activated protein kinase; Phosphatidylinositol 3 kinase

Indexed keywords

CHITOSAN OLIGOMER; INFLAMMATION; MACROPHAGE CELLS; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3-KINASE;

CHEMICAL ACTIVATION; CHITOSAN; ENZYMES; MACROPHAGES; OLIGOMERS; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

CHITIN;

EID: 79952448639     PISSN: 01448617     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carbpol.2011.01.045     Document Type: Article

References (40)

1. J.L. Dou, C.Y. Tan, Y.G. Du, X.F. Bai, K.Y. Wang, and X.J. Ma Effects of chitooligosaccharides on rabbit neutrophils in vitro Carbohydrate Polymers 69 2007 209 213
2. R. Ettinger, R. Mebius, J.L. Browning, S.A. Michie, S. van Tuijl, and G. Kraal Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development International Immunology 10 1998 727 741 (Pubitemid 28279475)
3. M. Guha, and N. Mackman The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells The Journal of Biological Chemistry 277 35 2002 32124 32132 (Pubitemid 34969025)
4. Y. Han, L. Zhao, Z. Yu, J. Feng, and Q. Yu. Role of mannose receptor in oligochitosan-mediated stimulation International Immunopharmacology 5 2005 1533 1542 (Pubitemid 40967911)
5. R. Huang, E. Mendis, N. Rajapakse, and S.K. Kim Strong electronic charge as an important factor for anticancer activity of chitooligosaccharides (COS) Life Sciences 78 2006 2399 2408
6. J.W. Hartley, L.H. Evans, K.Y. Green, Z. Naghashfar, A.R. Macias, and P.M. Zerfas Expression of infectious murine leukemia viruses by RAW264.7 cells, a potential complication for studies with a widely used mouse macrophage cell line Retrovirology 5 2008 1 6
7. M. Karin The regulation of AP-1 activity by mitogen-activated protein kinases The Journal of Biological Chemistry 270 28 1995 16483 16486
8. M. Karin, Z. Liu, and E. Zandi AP-1 function and regulation Current Opinion in Cell Biology 9 1997 240 246 (Pubitemid 27135992)
9. J.B. Kim, A.R. Han, E.Y. Park, J.Y. Kim, W. Cho, and J. Lee Inhibition of LPS-induced iNOS, COX-2 and cytokines expression by poncirin through the NF-κB inactivation in RAW264.7 macrophage cells Biological Pharmaceutical Bulletin 30 12 2007 2345 2351 (Pubitemid 350223740)
10. 2 in NF-κB activation Free Radical Biology & Medicine 45 2008 885 896
11. K.T. Ku, Y.L. Huang, Y.J. Huang, and W.F. Chiou Miyabenol A inhibits LPS-induced NO production via IKK/IkappaB inactivation in RAW 264.7 macrophages: Possible involvement of the p38 and PI3K pathways Journal of agricultural and Food Chemistry 56 19 2008 8911 8918
12. I. Kukavica-IbruIj, M.E. Hamelin, G.A. Prince, C. Gagnon, Y. Bergeron, and M.G. Bergeron Infection with human metapneumovirus predisposes mice to severe pneumococcal puneumonia Journal of Virology 83 2009 1341 1349
13. J. Liu, X. Li, Y. Yue, J. Li, T. He, and Y. He The inhibitory effect of quercetin on IL-6 production by LPS-stimulated neutrophils Cellular & Molecular Immunology 2 6 2005 455 460
14. Y.G. Lee, W.M. Lee, J.Y. Kim, J.Y. Lee, I.K. Lee, and B.S. Yun Src kinase-targeted anti-inflammatory activity of davallialactone from Inonotus xeranticus in lipopolysaccharide-activated RAW264.7 cells British Journal of Pharmacology 154 2008 852 863 (Pubitemid 351821587)
15. H.C. Lee, R. Vinodhkumar, J.W. Yoon, S.K. Park, C.W. Lee, and H.Y. Kim Enhanced inhibitory effect of ultra-fine granules of red ginseng on LPS-induced cytokine expression in the monocyte-derived macrophage THP-1 cells International Journal of Molecular Sciences 9 2008 1379 1392
16. J.P. Luyendyk, G.A. Schabbauer, M. Tencati, T. Holscher, R. Pawlinski, and N. Mackman Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages The Journal of Immunology 180 2008 4218 4226
17. C.S. Lai, J.H. Lee, C.T. Ho, C.B. Liu, J.M. Wang, and Y.J. Wang Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-κB, STAT3 and C/EBP signaling pathways Journal of Agricultural and Food Chemistry 57 2009 10990 10998
18. S.J. Lee, and K.T. Lim Inhibitory effect of ZPDC glycoprotein on the expression of inflammation-related cytokines through p38 MAP kinase and JNK in lipopolysaccharide-stimulated RAW264.7 cells Inflammation Research 58 2009 184 191
19. N.J. Lapara, and B.L. Kelly Suppression of LPS-induced inflammatory responses in macrophages infected with Leishmania Journal of Inflammation 7 2010 1 9
20. Lee, J. J.; Liu, C. L.; Tsai, P. S.; Yang, C. L.; Lao, H. C.; & Huang, C. J. Platonin inhibits endotoxin-induced MAPK and AP-1 up-regulation. Journal of Surgical Research, in press, doi:10.1016/j.jss.2009.11.738.
21. H.T. Liu, W.M. Li, P. Huang, W.J. Chen, Q.S. Liu, and X.F. Bai Chitosan oligosaccharides inhibit TNF-α-induced VCAM-1 and ICAM-1 expression in human umbilical vein endothelial cells by blocking p38 and ERK1/2 signaling pathways Carbohydrate Polymers 81 2010 49 56
22. J.O. Martins, M. Ferracini, N. Ravanelli, R.G. Landgraf, and S. Jancar Insulin inhibits LPS-induced signaling pathways in alveolar macrophages Cellular Physiology and Biochemistry 21 2008 297 304 (Pubitemid 351591421)
23. S. Mendes Sdos, A. Candi, M. Vansteenbrugge, M.R. Pignon, H. Bult, and K.Z. Boudjeltia Microarray analyses of the effects of NF-kappaB or PI3K pathway inhibitors on the LPS-induced gene expression profile in RAW264.7 cells: Synergistic effects of rapamycin on LPS-induced MMP9-overexpression Cellular Signalling 21 7 2009 1109 1122
24. P.C. Ortiz-Lazareno, G. Hernandez-Flores, J.R. Dominguez-Rodriguez, J.M. Lerma-Diaz, L.F. Jave-Suarez, and A. Aguilar-Lemarroy MG132 proteasome inhibitor modulates pro-inflammatory cytokines production and expression of their receptors in U937 cells: Involvement of nuclear factor-κB and activator protein-1 Immunology 124 2008 534 541 (Pubitemid 351962549)
25. J. Ock, S. Kim, and K. Suk Anti-inflammatory effects of a fluorovinyloxyacetamide compound KT-15087 in microglia cells Pharmacological Research 59 2009 414 422
26. C.R. Parish Fluorescent dyes for lymphocyte migration and proliferation studies Immunology and Cell Biology 77 6 1999 499 508
27. G. Pearson, F. Robinson, T. Beers Gibson, B. Xu, M. Karandikar, and K. Berman Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions Endocrine Reviews 22 2 2001 153 183 (Pubitemid 32458157)
28. P.J. Park, J.Y. Je, and S.K. Kim Free radical scavenging activity of chitooligosaccharides by electron spin resonance spectrometry Journal of agricultural and Food Chemistry 51 2003 4624 4627
29. M.H. Pan, M.C. Hsieh, P.C. Hsu, S.Y. Ho, C.S. Lai, and H. Wu 6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages Molecular Nutrition & Food Research 52 2008 1467 1477
30. R.R. Schumann, D. Pfeil, N. Lamping, C. Kirschning, G. Scherzinger, and P. Schlag Lipopolysaccharide induces the rapid tyrosine phosphorylation of the mitogen-activated protein kinases erk-1 and p38 in cultured human vascular endothelial cells requiring the presence of soluble CD14 Blood 87 7 1996 2805 2814 (Pubitemid 26102230)
31. E. Shohami, I. Ginis, and J.M. Hallenbeck Dual role of tumor necrosis factor alpha in brain injury Cytokine & Growth Factor Reviews 10 1999 119 130 (Pubitemid 29446376)
32. C.N. Serhan, and J. Savill Resolution of inflammation: The beginning programs the end Nature Immunology 6 12 2005 1191 1197 (Pubitemid 43045627)
33. N.M.J. Schwerbrock, E.A. Karlsson, Q. Shi, P.A. Sheridan, and M.A. Beck Fish oil-fed mice have impaired resistance to influenza infection The Journal of Nutrition 139 2009 1588 1594
34. K. Tsukamoto, K. Hazeki, M. Hoshi, K. Nigorikawa, N. Inoue, and T. Sasaki Critical roles of the p110β subtype of phosphoinositide 3-kinase in lipopolysaccharide-induced Akt activation and negative regulation of nitrite production in RAW264.7 cells The Journal of Immunology 180 2008 2054 2061
35. G.J. Wu, and G.J. Tsai Chitooligosaccharides in combination with interferon-γ increase nitric oxide production via nuclear factor-κB activation in murine RAW264.7 macrophages Food and Chemical Toxicology 45 2007 250 258 (Pubitemid 44854309)
36. G.J. Wu, T.L. Chen, Y.F. Ueng, and R.M. Chen Ketamine inhibits tumor necrosis factor-α and interleukin-6 gene expressions in lipopolysaccharide-stimulated macrophages through suppression of toll-like receptor 4-mediated c-Jun N-terminal kinase phosphorylation and activator protein-1 activation Toxicology and Applied Pharmacology 228 2008 105 113
37. H.J. Yoon, M.E. Moon, H.S. Park, S.Y. Im, and Y.H. Kim Chitosan oligosaccharide (COS) inhibits LPS-induced inflammatory effects in RAW 264.7 macrophage cells Biochemical and Biophysical Research Communications 358 2007 954 959 (Pubitemid 46802483)
38. H. Yin, Y.G. Du, and J.Z. Zhang Low molecular weight and oligomeric chitosans and their bioactivities Current Topics Medicinal Chemistry 9 2009 1546 1559
39. W.J. Yoon, J.Y. Moon, G. Song, Y.K. Lee, M.S. Han, and J.S. Lee Artemisia fukudo essential oil attenuates LPS-induced inflammation by suppressing NF-κB and MAPK activation in RAW264.7 macrophages Food and Chemical Toxicology 48 2010 1222 1229
40. H. Zhang, Y.G. Du, X. Yu, M. Mitsutomi, and S. Aiba Preparation of chitooligosaccharides from chitosan by a complex enzyme Carbohydrate Research 320 1999 257 260 (Pubitemid 29488509)