Protein Thermal Shifts to Identify Low Molecular Weight Fragments

Methods in Enzymology

Volumn 493, Issue , 2011, Pages 277-298

  Kranz, James K ^a   Schalk Hihi, Celine ^b  

^a GLAXOSMITHKLINE   (United States)

^b Johnson and Johnson Research and Development LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CHLOROTHIAZIDE; DEATH ASSOCIATED PROTEIN KINASE; DEATH ASSOCIATED PROTEIN KINASE 1; DICLOFENAMIDE; ETHOXZOLAMIDE; FUROSEMIDE; METHAZOLAMIDE; NUCLEOTIDE DERIVATIVE; SULFANILAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BIOASSAY; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RESEARCH; ENTHALPY; ENTROPY; FLUORESCENCE SPECTROSCOPY; FLUOROMETER; FRAGMENT BASED DRUG DISCOVERY; LIGAND BINDING; METHODOLOGY; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; RAPID THERMAL SHIFT ASSAY; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION; TEMPERATURE DEPENDENCE; THERMODYNAMICS; THERMOSTABILITY;

EID: 79952428084     PISSN: 00766879     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-381274-2.00011-X     Document Type: Chapter

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