ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors

Science Signaling

Volumn 4, Issue 162, 2011, Pages

  Schenk, Ursula ^a,g   Frascoli, Michela ^a   Proietti, Michele ^a   Geffers, Robert ^b   Traggiai, Elisabetta ^c   Buer, Jan ^d   Ricordi, Camillo ^e   Westendorf, Astrid M ^d   Grassi, Fabio ^a,f  

^a INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Switzerland)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c G GASLINI INSTITUTE   (Italy)

^d UNIVERSITY HOSPITAL ESSEN   (Germany)

^e UNIVERSITY OF MIAMI   (United States)

^f UNIVERSITY OF MILAN   (Italy)

^g Pharmanalytica SA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; INTERLEUKIN 17; INTERLEUKIN 6; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2 RECEPTOR;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOCRINE EFFECT; CD4+ T LYMPHOCYTE; CELL ENERGY; CELL FUNCTION; CELL LINE; CELL MATURATION; CONTROLLED STUDY; EFFECTOR CELL; IMMUNOSUPPRESSIVE TREATMENT; IN VIVO STUDY; MICROENVIRONMENT; MOLECULAR STABILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; TH17 CELL; HUMAN; IMMUNOLOGY; METABOLISM; PHYSIOLOGY;

MAMMALIA;

ADENOSINE TRIPHOSPHATE; HUMANS; RECEPTORS, PURINERGIC P2; T-LYMPHOCYTES, REGULATORY;

EID: 79952329655     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001270     Document Type: Article

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55. Acknowledgments: We thank D. Jarrossay for cell sorting and E. Mira Cató for technical assistance with mice. Funding: This work was supported by the Swiss National Science Foundation (grant 310030-124745), Fondazione Leonardo, Fondazione Ticinese per la Ricerca sul Cancro, European School of Oncology Foundation, Swiss Cancer League, Fondazione per la ricerca sulla trasfusione e sui trapianti, AGD Italia (Coordinamento Associazioni Italiane Giovani con Diabete), Leo Club Italia, Converge Biotech, and the Sixth Research Framework Program of the European Union, Project MUGEN (MUGEN LSHG-CT-2005-005203) to F.G. Author contributions: U.S., M.F., M.P., and E.T. performed the experiments; M.P. performed the histochemical analysis of intestines; R.G., J.B., and A.M.W. performed microarray and computational work; C.R. provided intellectual input; U.S. and F.G. designed the experiments, analyzed the data, and wrote the paper. Competing interests: The authors declare that they have no competing interests.